「significance」の検索結果

Tools for LiP peptide and protein significance analysis. Provides functions for summarization, estimation of LiP peptide abundance, and detection of changes across conditions. Utilizes functionality across the MSstats family of packages.

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Identification of differentially expressed genes and estimation of the False Discovery Rate (FDR) using both the Significance Analysis of Microarrays (SAM) and the Empirical Bayes Analyses of Microarrays (EBAM).

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Intuitive framework for identifying spatially variable genes (SVGs) via edgeR, a popular method for performing differential expression analyses. Based on pre-annotated spatial clusters as summarized spatial information, DESpace models gene expression using a negative binomial (NB), via edgeR, with spatial clusters as covariates. SVGs are then identified by testing the significance of spatial clusters. The method is flexible and robust, and is faster than the most SV methods. Furthermore, to the

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Use when the user wants a VALID experiment instead of a guess — hypothesis, one variable, sample size and runtime math, statistical significance, primary versus secondary metrics, multi-arm designs, and a results template, across Optimizely, VWO, and native Meta and Google tests. Trigger on 'A/B test', 'split test', 'how long should I run the test', 'is this result significant', 'test two versions', 'which creative is actually better'. Also use when a winner was declared after two days on tiny numbers. Not for — scaling the proven winner, see `55-scaling-ads-global`; analyzing data already collected, see `13-data-analysis-global`; auditing the account, see `21-ads-audit-global`.

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Rigorous A/B test statistical analysis. Use when analyzing experiment results, calculating statistical significance, checking for sample ratio mismatch, or validating test design before launch.

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Query NCBI ClinVar for variant clinical significance. Search by gene/position, interpret pathogenicity classifications, access via E-utilities API or FTP, annotate VCFs, for genomic medicine.

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Query NCBI ClinVar via E-utilities for variant clinical significance, pathogenicity, disease associations. Search by gene/rsID/condition/review status; returns ClinSig, submitter data, conditions, HGVS. For GWAS use gwas-database; for variant consequence prediction use Ensembl VEP.

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Query STRING REST API for PPIs (59M proteins, 20B interactions, 5000+ species). Retrieve networks, run GO/KEGG enrichment, find partners, test PPI significance, visualize networks, analyze homology. For chemical interactions use chembl-database-bioactivity; pathways use kegg-database.

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Evaluating scientific evidence and claims. Covers study design hierarchy (RCT to expert opinion), effect sizes (OR, RR, NNT, Cohen's d), confounding, p-value vs clinical significance, GRADE quality assessment, reproducibility, and bias types (selection, information, confounding, reporting). Use when reading a paper or assessing claims.

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Review IEEE conference, journal, Transactions, Letters, or magazine manuscripts from a technical reviewer perspective using routed IEEE review gates. Use when evaluating scope fit, novelty, validity, data, clarity, compliance, advancement, engineering significance, method soundness, experiment sufficiency, baseline fairness, figure/table quality, formatting risks, rejection risk, major revision strategy, pre-submission readiness, or the quality and specificity of reviewer comments that may be generic, careless, contradictory, or possibly AI-generated.

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Use when about to claim a result, effect, significance, or that an analysis reproduces, before reporting or writing it up - requires running the analysis fresh and reading the actual output first; evidence before claims always

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Use when drafting a grant or challenge proposal for a radiology or medical AI project, including a Korean government industry-academia plan. Structures significance, innovation, approach, aims, milestones and consortium roles, keeping claims evidence-based and executable.

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Remove signs of AI-generated writing from prose, and keep it out of a repo. Use when drafting, editing, or reviewing text to make it sound natural and human, or when auditing a whole docs folder for AI slop. Detects 41 patterns across content, language, style, communication, filler, and rhetoric, including: significance inflation, promotional language, -ing tails, vague attributions, AI vocabulary, copula avoidance, negative parallelisms, false agency, em dash overuse, chatbot artifacts, hedging stacks, staccato drama, and aphorism formulas. Includes voice calibration, a no-fabrication rule, statistical tells, and a draft -> audit -> final rewrite loop.

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A/B Testing Plan Generator. Creates structured testing roadmaps with prioritized test sequences, duration calculators, sample size requirements, statistical significance thresholds, hypothesis templates, and 90-day testing calendars for Meta, Google, and LinkedIn.

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Apply statistical methods including descriptive stats, trend analysis, outlier detection, and hypothesis testing. Use when analyzing distributions, testing for significance, detecting anomalies, computing correlations, or interpreting statistical results.

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Rewrites AI-sounding text so it reads like a human wrote it. Use when the user says 'sounds like AI/ChatGPT,' 'too robotic,' or 'humanize this.' Fixes AI vocabulary, inflated significance, hedging, robotic rhythm, and formulaic structure.

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Break down full NeurIPS reviewer responses into structured rebuttal units. Use when input contains NeurIPS reviewer fields (Summary, Strengths and Weaknesses, Questions, Limitations) and numeric scores (Rating, Confidence, Quality, Clarity, Significance, Originality). Splits questions and limitations into granular response items while preserving original wording for quoted issues.

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Think and work like an expert Gravitational Physicist. Use when a task calls for Gravitational Physicist judgment. Reasons from calibrated strain, colored non-stationary noise PSDs, matched-filter SNR, and Bayesian posteriors through PyCBC/GstLAL/cWB searches, Bilby/LALInference PE with NRSur/SEOBNR/IMRPhenom waveforms, and FAR/p_astro significance while treating glitch contamination, waveform-approximant mismatch, mass-spin and distance-inclination degeneracies, and unmodeled selection effects as first-class failure modes.

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Think and work like an expert Geographic Information Scientist (GIS). Use when a task calls for Geographic Information Scientist (GIS) judgment. Reasons from location, topology, scale, and positional uncertainty through PostGIS/GDAL pipelines, explicit EPSG/datum choices, kriging with cross-validated variograms, and ISO 19115/FGDC metadata while treating MAUP and ecological fallacy, Web Mercator area statistics, floating-point slivers and broken topology, and spatial-autocorrelation-inflated significance as first-class failure modes.

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Think and work like an expert High-Energy Astrophysicist. Use when a task calls for High-Energy Astrophysicist judgment. Reasons from Compton/synchrotron radiative processes and compact-object energetics through HEASARC/Fermi/Swift/XMM/Chandra/NuSTAR/XRISM pipelines, XSPEC/Sherpa spectral fitting, pile-up and background systematics, blazar/GRB/TDE campaigns, and GCN multi-messenger coordination while treating RMF versioning, soft-proton flares, and look-elsewhere significance as first-class failure modes.

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Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.

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Detects circadian and ultradian rhythms in time-series omics data using CosinorPy cosinor models, MetaCycle (JTK_CYCLE, ARSER), and RAIN non-parametric tests. Fits cosine models to estimate phase and amplitude, tests rhythmicity significance at pre-specified periods. Use when testing for 24-hour or other known-period oscillations in circadian, feeding-fasting, or light-dark cycle experiments. Not for unknown-period discovery (see temporal-genomics/periodicity-detection).

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Clinical variant interpretation using ClinVar, ACMG guidelines, and pathogenicity predictors. Prioritize variants for diagnostic and research applications. Use when interpreting clinical significance of variants.

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Queries ClinVar for variant pathogenicity classifications, ClinGen VCEP curations, and somatic-vs-germline interpretations via REST API, weekly VCF, or bulk XML. Use when determining clinical significance, triangulating conflicting interpretations, or aggregating evidence against the ACMG/AMP framework with ClinGen SVI specifications.

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