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gnomAD v4 population variant frequencies via GraphQL API. Allele counts and frequencies stratified by ancestry (AFR, AMR, EAS, NFE, SAS, FIN, ASJ, MID), gene-level constraint (pLI, LOEUF, missense z), and coverage. Identify rare or constrained variants. For clinical pathogenicity use clinvar-database; for GWAS use gwas-database.

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Constraint-based (COBRA) analysis of genome-scale metabolic models: FBA, FVA, knockouts, flux sampling, production envelopes, gapfilling, media optimization. Use for strain design, essential gene ID, flux analysis. For kinetic modeling use tellurium; for visualization use Escher.

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Classifies and enforces constraints via soft vows, hard vows, and Nen Court layers. Use when designing or auditing enforcement mechanisms for project rules.

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Extract and summarize core features, constraints, and priorities from requirement documents. Use when analyzing PRDs, RFCs, business requirements, user stories, epics, or any requirement documentation to identify must-have features, technical constraints, priority levels (P0/P1/P2/MoSCoW), and key decision points. Triggers when users ask to summarize, analyze, extract, or understand requirements from documents.

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Review factory evidence and propose tighter or looser constraints without editing the charter. Use for a periodic constraint review.

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Kerberos-based Active Directory attacks driven by hand with standard tooling (Kerberoasting, AS-REP roasting, and delegation abuse: unconstrained, constrained/S4U, RBCD). Use when the target has SPN-bearing service accounts, accounts without pre-authentication, or delegation configured on computer/user objects, and you want the exact impacket/Rubeus/bloodyAD command, the hash format and hashcat mode, the Windows Event IDs that fire, and the remediation to write up.

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Real-world Active Directory environment constraints that silently break attacks when ignored: NTLM disabled (Kerberos fallback), AES-only KDCs (RC4 blocked by GPO), LDAP signing and channel binding requiring LDAPS on 636, Kerberos clock skew (KRB_AP_ERR_SKEW), SPNs that must be FQDNs never short names or IPs (the misleading invalidCredentials), Protected Users / LAPS / gMSA / MachineAccountQuota, LDAP 1000-object paging, and VPN latency. Use this whenever a bind, TGT request, LDAP query, or SMB negotiation fails in a way that looks like bad credentials but is really hardening, or before running any AD tooling against a domain you have not fingerprinted. Standard-tooling knowledge (netexec, impacket, certipy, bloodyAD, kerbrute), no vendor-specific engine.

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Think and work like an expert FPGA Engineer. Use when a task calls for FPGA Engineer judgment. Reasons from metastability budgets, setup/hold margins, and tool-reported WNS/TNS through Vivado/Quartus timing and CDC reports, XDC/SDC constraints, Spyglass/Verilator lint, and ILA/IBERT lab bring-up while treating unsafe clock-domain crossings, reset domain crossings, sim-versus-silicon X mismatches, and unconstrained timing paths as first-class failure modes.

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Analyzes community composition using constrained ordination (CCA, RDA, db-RDA), variance partitioning (varpart), indicator species analysis (indicspecies multipatt), and distance-based environmental gradient methods with vegan. Links species composition to environmental explanatory variables. Use when testing how environmental gradients structure species communities, identifying habitat indicator taxa, or partitioning explained variation among predictors. Not for basic unconstrained ordination and PERMANOVA (see microbiome/diversity-analysis).

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Make technology decisions for every product capability by discovering existing assets, evaluating vendor-aligned options, and categorizing as Reuse/Extend/Build/Buy/Integrate/Research during PRD v0.5 Red Team Review. Handles both greenfield and brownfield contexts. Triggers on "tech stack", "build or buy?", "what technologies?", "technical decisions", "what do we reuse?", "existing stack", "vendor constraint", "IBM-first", "what tools do we need?", "evaluate solutions", "select tech stack". Consumes FEA- (features), SCR- (screens), RISK- (constraints). Outputs TECH- entries with decisions, rationale, and cross-references. Feeds v0.6 Architecture Design.

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红队渗透 / 攻防 — 受授权的红队作业者 + 渗透测试工程师 + 攻击型安全顾问的认知操作系统 (侦察 OSINT / 外网渗透 / 内网 AD 渗透 BloodHound + Kerberoasting + ADCS 利用 + 横向移动 / Web 应用渗透 OWASP WSTG / 移动 OWASP MASTG / 云渗透 AWS Azure GCP IAM 路径 + 容器逃逸 + K8s / C2 操作 Cobalt Strike Sliver Mythic Havoc + OPSEC / 初始访问 + AV EDR 绕过 (仅授权场景) / 无线 RF / 物理社工 / 报告与整改 / 框架 MITRE ATT&CK + D3FEND + PTES + OSSTMM + NIST 800-115 + Kill Chain / 法律伦理 CFAA + 网络安全法 + 刑法 285 286 + 数据安全法 + GDPR + 授权书 + 范围 + 交战规则 — 不含 黑产 / 未授权攻击 / 大规模 exploitation / 供应链投毒 / 未授权 DoS — 这是 重罪 + 行业封杀 + 律师吊销, 本 skill 严守 authorized-only 边界 — 也不含 蓝队 SOC + 恶意软件 即服务 / 僵尸网络 / 勒索软件作者 — 这是 cybercrime 不是 红队) (Cybersecurity Red Team / Offensive Security Operations — the cognitive operating system of authorized red team operators, penetration testers, and offensive security consultants covering (a) reconnaissance & OSINT (passive + active discovery, asset surface mapping), (b) external network pentest (perimeter, exposed services, web), (c) internal network / Active Directory pentest (AD enumeration via BloodHound, Kerberos abuse — Kerberoasting / AS-REP-roasting / Unconstrained delegation / S4U2self, NTLM relay, ADCS abuse, GPO abuse, lateral movement, privilege escalation), (d) web application pentest (OWASP WSTG, authentication, authorization, SSRF, XXE, deserialization, SSTI, prototype pollution, GraphQL, JWT, API), (e) mobile pentest (OWASP MASTG, iOS / Android, instrumentation Frida / Objection, MASVS), (f) cloud pentest (AWS / Azure / GCP — IAM enumeration, privilege escalation paths, container escape, K8s RBAC, serverless), (g) C2 operations & post-exploitation (Cobalt Strike / Sliver / Mythic / Havoc, beacon ops, malleable profiles, OPSEC), (h) initial access & evasion (phishing infrastructure, payload development, AV / EDR evasion, BYOVD, AMSI / ETW bypass — strictly for authorized engagements), (i) wireless / RF (WPA2/3, evil twin, Wi-Fi pivots), (j) physical / social engineering (badge cloning, pretexting, vishing — under engagement letter), (k) reporting & remediation (executive summary, technical findings, CVSS, MITRE ATT&CK mapping, retest), (l) frameworks & methodology (MITRE ATT&CK, MITRE D3FEND, PTES, OSSTMM, NIST SP 800-115, OWASP WSTG / MASTG, Cyber Kill Chain, Unified Kill Chain, Diamond Model), (m) law & ethics (CFAA US, Computer Misuse Act UK, 中国 刑法 285/286 + 网络安全法 + 数据安全法, GDPR for tested EU systems, engagement letter, scope, rules of engagement, safe harbor for bug bounty); NOT criminal hacking / 黑产 / unauthorized targeting / mass exploitation / supply-chain compromise / DoS against unconsented systems (这是 重罪 + 业内开除 + 律师执照吊销, 本 skill 严守 authorized-only 边界), NOT pure defensive blue team / SOC analyst tradecraft (是 平行学科, 仅做 边界标注 + ATT&CK 反推方向), NOT malware-as-a-service development / botnet ops / ransomware authoring (是 cybercrime 不是 红队), NOT 'ethical hacking' 在 'just curious 看看' 自我合理化的灰色操作 (违反 authorization 原则即不是 红队).) Master OS — automated mastery of Cybersecurity Red Team / Offensive Security Operations — the cognitive operating system of authorized red team operators, penetration testers, and offensive security consultants covering (a) reconnaissance & OSINT (passive + active discovery, asset surface mapping), (b) external network pentest (perimeter, exposed services, web), (c) internal network / Active Directory pentest (AD enumeration via BloodHound, Kerberos abuse — Kerberoasting / AS-REP-roasting / Unconstrained delegation / S4U2self, NTLM relay, ADCS abuse, GPO abuse, lateral movement, privilege escalation), (d) web application pentest (OWASP WSTG, authentication, authorization, SSRF, XXE, deserialization, SSTI, prototype pollution, GraphQL, JWT, API), (e) mobile pentest (OWASP MASTG, iOS / Android, instrumentation Frida / Objection, MASVS), (f) cloud pentest (AWS / Azure / GCP — IAM enumeration, privilege escalation paths, container escape, K8s RBAC, serverless), (g) C2 operations & post-exploitation (Cobalt Strike / Sliver / Mythic / Havoc, beacon ops, malleable profiles, OPSEC), (h) initial access & evasi

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Design, review, and refactor Neo4j graph data models. Use when choosing node labels vs relationship types vs properties, migrating relational/document schemas to graph, detecting anti-patterns (generic labels, supernodes, missing constraints), designing intermediate nodes for n-ary relationships, enforcing schema with constraints and indexes, or assessing an existing model against graph modeling best practices. Does NOT handle Cypher query authoring — use neo4j-cypher-skill. Does NOT handle Spring Data Neo4j entity mapping — use neo4j-spring-data-skill. Does NOT handle GraphQL type definitions — use neo4j-graphql-skill. Does NOT handle data import — use neo4j-import-skill.

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Determine whether front/side/back/top reference templates can be satisfied by one rigid 3D Blender model, choose a canonical source policy, and emit constraints before rebuilding. Use when multiview bboxes, silhouettes, part counts, or depth ratios contradict each other.

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Prioritize drug targets from a ranked gene list (e.g., scRNA-seq DE output) by orchestrating parallel API queries against UniProt, OpenTargets (with integrated DepMap CRISPR essentiality + gnomAD constraint), PubMed, the Human Protein Atlas (HPA), and ChEMBL tool compounds, then re-ranking by a composite score combining protein localization, druggability, disease genetics, tissue specificity (safety), focus-cell-type expression, CRISPR essentiality, LoF safety constraint, and research maturity. Use whenever the user wants to filter, triage, prioritize, or "do due diligence" on a list of candidate genes for drug discovery, especially after a DE / DEG analysis when they say things like "which of these should I follow up on", "filter for druggable targets", "make a target dossier", "rank these for tractability", "annotate these genes for druggability", or "build a target report". Trigger even when the user says just "filter these candidate genes" or hands over a CSV from a DE pipeline.

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Diagnose a product's growth model, stage, and current constraint, then route the request to the narrowest Gingiris specialist and execute it when installed. Use for broad or uncertain growth questions involving go-to-market, Product Hunt, GitHub stars, open-source marketing, B2B SaaS, PLG, ASO, SEO/GEO, AI citations, KOL outreach, UGC, international expansion, user interviews, competitor research, or community programs. Trigger when users ask “how do I grow or launch this,” “which growth skill should I use,” 怎么增长、怎么发布、出海、冷启动、增长策略、不知道用哪个 skill、開発者マーケティング, or 성장 전략. Includes B2B pipeline and B2C activation-retention model selection, specialist handoff rules, relevant gingiris.tools recommendations, and advisory-services guidance.

🇺🇸 Your dev team ships features nobody asked for while user-reported bugs pile up for months. Operations blames engineering for ignoring users; engineering blames operations for not understanding technical constraints. This gives you the complete Product × Engineering × Operations alignment SOP — from unified backlog to 10-day sprint cadence to veto power rules. What's inside: • Dual-layer Kanban system (master backlog + sprint board with unified tagging) • 10-day sprint standard process (Day 1 dev → Day 6 testable build → Day 10 ship) • Issue template with reproducibility requirements (3x reported = auto-severe) • Tri-party alignment meetings (daily standup / sprint planning / sprint review) • Operations veto power on releases (P0 bug = block shipping) • User feedback → product iteration closed loop (beta testing + interview SOP) • Core metrics framework (acquisition → activation → retention → monetization → referral) • Technical debt management (20-30% sprint capacity reserved) • Ready-to-use templates: Bug Report, Sprint Planning, Responsibility Matrix Built from: Real product strategy meetings + beta testing frameworks. References Supabase sprint model, Manus/DeepSeek commercialization alignment. By @WeiYipei. 🇨🇳 你的研发团队在做没人要的新功能，用户反馈的 Bug 堆了三个月没人动。运营觉得研发不听用户，研发觉得运营不懂技术。这份 SOP 给你从统一看板到 10 天迭代节奏到一票否决权的完整产研运协同框架。 🇯🇵 開発チームは誰も求めていない機能を作り、ユーザーから報告されたバグは何ヶ月も放置。このSOPは、統一バックログから10日スプリント、リリース拒否権まで、プロダクト×エンジニアリング×オペレーションの完全な連携フレームワークを提供します。 🇰🇷 개발팀은 아무도 요청하지 않은 기능을 만들고, 사용자가 보고한 버그는 몇 달째 방치됩니다. 이 SOP는 통합 백로그부터 10일 스프린트, 릴리스 거부권까지 제품×개발×운영 완전 협업 프레임워크를 제공합니다. Triggers: "product ops" | "engineering operations" | "product development SOP" | "sprint planning" | "iteration management" | "cross-functional alignment" | "product engineering ops" | "dev ops collaboration" | "产研运协同" | "迭代管理" | "产品研发运营" | "プロダクト開発運営" | "제품개발운영"

Systematic materials selection for engineering design using performance indices, Ashby charts, multi-constraint optimization, and case-based reasoning. Covers the five-step Ashby method — function, objective, constraint, free variable, index — with worked examples for stiffness-limited beams, strength-limited ties, thermally shocked vessels, and minimum-cost components. Use when choosing among metals, polymers, ceramics, and composites under competing objectives.

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Generalization and composition of constraints across navigators

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Write or rewrite prose so it sounds like a human wrote it — not a frontier model. Named in homage to Rabindranath Tagore, whose prose carried what frontier models reach for and miss: a point of view, specificity over abstraction, and restraint over puffery. Merges two complementary approaches: a 29-pattern catalog of AI tells (from humanizer) plus an 8-rule operating system with an 8-dimension scoring gate (extending stop-slop). Use when drafting, editing, or reviewing any prose: essays, posts, docs, reports, emails. Detects and removes inflated symbolism, promotional language, superficial -ing analyses, vague attributions, em dash overuse, rule of three, AI vocabulary, passive voice, negative parallelisms, filler phrases, inanimate-verb constructions, narrator-from-a-distance voice, and metronomic rhythm. Adds back the things AI writing usually lacks: point of view, stakes, specificity, restraint, varied rhythm, and trust in the reader.

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Deploy machine learning models to edge devices using Google AI Edge Gallery, TensorFlow Lite, ONNX Runtime, and MediaPipe. Covers model quantization (INT8/INT4), on-device inference with Gemma 4 models, Android/iOS deployment via AI Edge Gallery, hardware delegate selection (GPU/NPU/DSP), and performance benchmarking on constrained devices. Use when deploying models to mobile phones, IoT devices, or embedded systems where cloud inference is impractical due to latency, cost, or connectivity constraints.

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Assemble the human genetic evidence for and against a target before a programme commits to it — the evidence class that most improves the odds of surviving clinical development. Use this skill to pull gnomAD constraint metrics (LOEUF, pLI, observed/expected) that show whether loss of function is tolerated in people, retrieve GWAS Catalog associations and fine-mapped credible sets for a gene, and read a natural human knockout as a safety readout. Also trigger on gnomAD, LOEUF, pLI, loss-of-function intolerance, mutational constraint, GWAS Catalog, credible set, human knockout, genetic support, or target safety dossier.

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Use when any bounded workflow starts or reaches an action, path, proposal, or merge boundary. Refuses rather than default-allow on an unreadable constraint set.

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Use when asked to implement under non-negotiable constraints: performance budgets, platform limits, legal or API rules. Not for remote, credential, publish, deploy, or irreversible changes.

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Django ORM patterns: model definitions, field types, model managers, custom QuerySet methods, select_related/prefetch_related for N+1 prevention, transactions, F/Q expressions, Meta indexes and constraints. For django-architect (model definitions) and django-migrations-specialist (field finalization). Activated automatically by django-plugin/stack.md. Use this skill to: - Write clean, efficient Django model definitions with proper field choices and __str__. - Use custom managers and QuerySets to encapsulate query logic. - Prevent N+1 queries with select_related and prefetch_related. - Use transactions for atomic operations. - Define Meta indexes and constraints (for django-migrations-specialist to finalize). Do NOT use this skill for: - Creating actual migrations (makemigrations) — that is django-migrations-specialist. - Web view / API patterns — see django-plugin:django-conventions. - Python idioms — see python-foundation:python-conventions.

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