「inu」の検索結果

Render a 'photo-grid promo card' video from a config — a real-DOM card with a FIXED header/footer and a CONTINUOUSLY SCROLLING 2-row grid of MIXED tiles (video clips, product/lifestyle stills, big-serif %-OFF, dark promo-code or CTA) + feature chips, frame-stepped via Playwright with real-time <video> playback and encoded with FFmpeg — deterministic assembly, FREE (the clips + music come from create-video-fal + create-music-elevenlabs), text stays pixel-crisp. Use for the photo-grid-promo-card format.

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Generate an AI creator talking to camera, saying an approved script, as one continuous track — H3 Max reference-to-video through the GooseWorks fal-proxy (bills the Ads agent). Plans takes on line boundaries under H3's 15s cap, dry-runs a cost estimate, generates the first take alone so its voice can be locked and passed to every later take, joins takes with measured 0.10s dissolves, and moves each line's timing onto the words actually spoken. Use for any format with a generated creator speaking a script (split-screen, screen inserts, talking-head ads).

日本語の概要は準備中です。原文の説明を表示しています。

Render a 'search-grid' (Pinterest search-moodboard) video from a config — a real-DOM page with four continuous beats (masonry search grid + typing hook with counter-drift columns → 3 cards slide in from the right and stack → the top card box-grows to fullscreen then swipe-left ×2 through captioned feature shots → end card), frame-stepped via Chromium and encoded with FFmpeg — deterministic assembly, FREE (real brand photos + logo; the optional music bed comes from create-music-elevenlabs), so type/logo/photos stay pixel-crisp. Use for the search-grid format.

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当用户询问 AgentDock 是什么、如何使用、配置在哪里、不同平台或安装方式怎样修改配置并生效、如何重启或验证配置、如何发现并配置 Codex/Claude/Grok 等 Coding Agent 的 ACP，以及常见运行问题时使用；覆盖 macOS Desktop、Windows Desktop、Linux 服务、Docker 和直接运行二进制，不用于源码开发与贡献流程。

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Manage Simulink Real-Time target computers from MATLAB — list available targets, check whether a target is connected, read its lifecycle status, add/remove/rename targets, set IP addresses and credentials, choose the default target, install TLS material, configure a startup application, and run target lifecycle ops (connect, reboot, RTOS update). Use whenever the user asks "which targets are available", "is my target connected", "what's the status of the target", "add a Speedgoat", "switch default target", "change the target IP", "reboot the box", "update the target", or works with `slrealtime.Targets`, `tg = slrealtime`, `addTarget`, `removeTarget`, `getTargetNames`, `getDefaultTargetName`, `setDefaultTargetName`, `connect`, `isConnected`, `status(tg)`, `setipaddr`, `setupTLSCertificate`, `setStartupApp`, `reboot`, `update`, or `slrealtime.testSetup`. Covers Speedgoat target computers and Simulink Real-Time Linux devices.

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Build, deploy, run, monitor, tune, and stop Simulink Real-Time applications. Use when the user wants to build a Simulink Real-Time model, load/start/stop an `.mldatx` on a target, set stop time or start options, drive root inports/playback/parameter stimulation, inspect installed or running apps, tune parameters with `getparam`/`setparam`, read ad hoc signal values with `getsignal`, manage parameter sets, control recording, or choose between file logging, live streaming, and file-log import. Covers `slbuild`, `install`, `load`, `start`, `stop`, `setStopTime`, `tg.Stimulation`, `startRecording`/`stopRecording`, `tg.FileLog.import`, `slrealtime.exportRun`, `getparam`/`setparam`, `getsignal`, and installed app management for Speedgoat targets and Simulink Real-Time Linux devices.

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Cache Playwright browser binaries in CI/CD pipelines (GitHub Actions, Azure DevOps) to avoid 1-2 minute download overhead on every build.

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Diagnose and fix .NET HTTPS dev certificate trust issues on Linux. Covers the full certificate lifecycle from generation to system CA bundle inclusion, with distro-specific guidance for Ubuntu, Fedora, Arch, and WSL2.

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Detects TAD boundaries from balanced Hi-C contact matrices via the diamond-window insulation score (cooltools insulation) and HiCExplorer hicFindTADs, returning a continuous log2 insulation track, valley-prominence boundary_strength, and Li/Otsu-thresholded is_boundary flags across a list of window sizes. Covers the multi-scale window sweep (sub-TAD to compartment-domain), why the boundary is reproducible but the domain partition is not, cross-condition comparison via differential SCORE not differential partition, and the insulation-vs-compartment orthogonality. Use when calling TADs or domain boundaries, computing insulation scores, choosing a window size, ranking boundary strength, comparing boundaries across conditions, or annotating CTCF-backed boundaries; route domain rendering to hic-visualization and boundary-feature overlap to genome-intervals.

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Designs cytosine (CBE, C-to-T) and adenine (ABE, A-to-G) base-editor guides by positioning the target base at the activity-peak of the editing window (protospacer positions ~5-7, PAM-distal numbering), minimizing bystander edits for product purity, reading dinucleotide context (APOBEC1 TC favored / GC disfavored), and selecting the editor variant (BE4max, ABEmax, ABE8e, YE1/SECURE, TadCBE, CGBE, SpG/SpRY-BE). Covers knockout by premature stop (CRISPR-STOP/iSTOP) and splice-site disruption, the three off-target classes (Cas-dependent, Cas-independent DNA, RNA), outcome prediction (BE-Hive/DeepBE), and the base-vs-prime-vs-HDR decision. Use when installing a transition mutation without a double-strand break, knocking out a gene without indels, or choosing CBE vs ABE. Generic guide scoring, prime editing, and HDR donors are separate skills.

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Aligns sample metadata with count matrices and constructs design matrices for downstream DE, handling the alphabetical-reference-level trap (relevel BEFORE DESeq), LRT reduced-model rules, the interaction-term resultsNames trap, continuous-covariate scaling and splines, repeated measures via duplicateCorrelation or dream, high-cardinality categorical pseudo-singular designs, sample swap detection via XIST/RPS4Y1 expression and somalier/NGSCheckMate genotypes, SABV (sex-as-biological-variable) mandate, Simpson's-paradox collapsing of technical replicates, and the `~ 0 + group` parameterization for clean contrasts. Use when building a design matrix, troubleshooting reversed fold-change direction, encoding paired or repeated-measures designs, detecting sample swaps, deciding sex-as-covariate, or aggregating technical replicates.

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Plot per-group distributions of continuous data using boxplots, violins, beeswarms, quasirandom jitter, and raincloud plots with sample-size honesty (Weissgerber 2015), KDE-bandwidth awareness, and N-aware encoding choices. Use when comparing distributions across a small number of groups — expression per cluster, biomarker per arm, scores per condition — and the bar-of-mean default is misleading.

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Analyzes time-series and longitudinal RNA-seq for differential expression and trajectory structure. Covers DESeq2 LRT with reduced models, time as factor vs continuous vs natural splines, maSigPro (Nueda 2014 for RNA-seq), ImpulseDE2 with explicit impulse-model failure modes, DREAM for repeated measures via linear mixed models, pseudoreplication avoidance, conditional vs marginal modeling, and trajectory clustering with DPGP, Mfuzz (with Schwämmle 2010 fuzzifier estimation), and splines+k-means. Use when modeling time-course or longitudinal expression, choosing factor vs spline, handling repeated measures from the same subject, avoiding pseudoreplication, clustering temporal trajectories, or selecting between dedicated time-course tools and pairwise+LRT.

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Reconstruct ancestral states at internal phylogenetic nodes for sequences (PAML codeml, IQ-TREE --ancestral, GRASP, FastML), discrete traits (corHMM hidden-rate Markov, ape::ace, phytools::make.simmap stochastic mapping, BayesTraits), and continuous traits (phytools::fastAnc, geiger Brownian/OU, RPANDA). Use when designing constructs for ancestral protein resurrection, tracing trait evolution along a tree, performing stochastic character mapping, testing models of trait evolution (BM vs OU vs EB), inferring ancestral genome content via Dollo or DTL reconciliation, or quantifying ancestral-state uncertainty for downstream comparative analyses.

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Constructs and validates polygenic risk scores using LDpred2-auto, SBayesRC, MegaPRS, PRS-CS, PROSPER, MUSSEL, BridgePRS, JointPRS, PRSmix, or PGS Catalog Calculator with ancestry-aware reference panels (HapMap3, UKB-LD), ancestry-conditional calibration, and PRS-RS reporting standards. Use when computing PRS for cohorts, applying absolute-risk transformation, assessing cross-ancestry portability (Martin 2017 / Ding 2023 continuous ancestry), or auditing PRS manuscripts against the 22-item PRS-RS reviewer checklist.

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Designs and analyzes combinatorial CRISPR screens covering paired-Cas9 (Big Papi, Najm 2018), enhanced AsCas12a multiplex (enCas12a, DeWeirdt 2021), in4mer 4-guide-array Cas12a (Esmaeili Anvar N et al 2024 Nat Commun 15:3577) and the Inzolia paralog-pair library, paralog-buffering detection (Dede 2020 Genome Biol; Thompson 2021 Nat Commun 12:1302), genetic-interaction (GI) scoring as observed_double_LFC minus expected_additive_double_LFC, synthetic-lethal and synthetic-rescue interaction interpretation, the half-of-essentiality buffered by paralogs phenomenon, multiplex screen statistical analysis with MAGeCK MLE interaction terms, and the relationship to single-cell combinatorial Perturb-seq. Use when designing a paralog or pathway-pair screen, choosing between paired-Cas9 (Big Papi) and Cas12a multiplex (Inzolia), interpreting genetic interaction scores, identifying synthetic-lethal targets for drug development, or scaling beyond single-gene CRISPR screens.

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Extracts and assigns COSMIC v3.4 mutational signatures (86 SBS / 11 DBS / 18 ID / 21 CN / 16 SV) from somatic VCFs using SigProfilerSuite, MutationalPatterns, MuSiCal mvNMF, SigNet, or HRDetect. Use when characterizing DNA-damage etiology (BRCA1/2 HRD, MMR-D, POLE, APOBEC3A, UV, tobacco, aflatoxin, 5-FU/SBS17b, platinum, colibactin SBS88), routing PARP inhibitor decisions, or auditing de novo extraction vs refit choice for cohort size.

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Discovers de novo motifs and tests known motif enrichment in ChIP-seq, ATAC-seq, or other peak sequences using HOMER, MEME-ChIP (STREME, CentriMo, TOMTOM, FIMO), monaLisa, and AME. Handles background selection (GC-matched, dinucleotide-shuffled, Markov order-2, peak-flanks), motif databases (JASPAR 2024 CORE PWMs, JASPAR 2026 deep-learning collection, HOCOMOCO v12, HOMER built-in), centrally-enriched motif testing, and differential motif analysis. Use when identifying TF binding motifs in peaks, testing for known TF enrichment, scanning for motif instances, comparing motif content between conditions, or interpreting motifs from deep learning models.

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Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate HMM on binarized signal, v1.27), Segway (Dynamic Bayesian Network on continuous signal), EpiSegMix (flexible-distribution HMM with duration modeling, 2024), EpiLogos (multi-biosample visualization), IDEAS (cell-type-aware joint), and full-stack ChromHMM (Vu Ernst 2022) for cross-cell-type segmentations. Handles state-count selection (15 vs 18 vs 25 states), binarization choice, OverlapEnrichment / NeighborhoodEnrichment downstream analysis, and cross-biosample integration. Use when learning chromatin states from a histone mark panel, characterizing learned states by genomic feature enrichment, or comparing chromatin landscapes across cell types.

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Computes sample size and power for clinical trials including continuous, binary, and time-to-event endpoints; superiority, non-inferiority, and equivalence designs; FDA 2016 non-inferiority margin selection with M1/M2 framework; Schoenfeld 1981 and Lakatos 1988 for survival; Schuirmann TOST and 80-125% bioequivalence; minimum clinically important difference (MCID) vs δ distinction. Use when justifying trial size in protocol or SAP per CONSORT 2025 item 16a.

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Estimates SNP heritability and partitions it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes. Implements LDSC, stratified LDSC with the baseline-LD model, Finucane 2018 cell-type prioritization, LDAK SumHer, HDL, HESS local heritability, BOLT-REML, GCTA-GREML, graphREML, and Popcorn cross-population genetic correlation. Use when computing total h2_SNP from summary stats, partitioning heritability across functional categories, prioritizing trait-relevant tissues or cell types from ENCODE/Roadmap chromatin marks, reconciling LDSC vs LDAK enrichment estimates, computing local heritability with HESS, estimating genetic correlation between traits, or producing publication-grade enrichment with calibrated sensitivity to model assumptions.

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Use when the user mentions battery drain, energy optimization, power consumption audit, or pre-release energy check — timer abuse, polling patterns, continuous location, animation leaks, and background mode misuse.

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Fetch WeatherKit current, minute, hourly, and daily forecasts; weather alerts; iOS 18+ changes, historical comparisons, summaries, and statistics; and required Apple Weather attribution. Use when integrating weather data, showing forecasts or alerts, caching WeatherKit responses, displaying attribution, or reviewing WeatherKit query limits in iOS apps.

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在 Windows/macOS/Linux 上使用 `uv` 执行 Python 运行、依赖同步、锁文件管理、Python 版本管理与工具命令（`uv run`、`uv sync`、`uv lock`、`uv python`、`uv tool`）。当任务涉及“用 uv 运行脚本/命令”“临时依赖（`--with`）”“锁文件一致性（`--locked`/`--frozen`）”“跨平台 shell（bash/zsh/PowerShell）下排查 uv 执行问题”时使用此 skill。

日本語の概要は準備中です。原文の説明を表示しています。