「compare」の検索結果

Visualises RNA-modification data with transcript-feature metagene plots (Guitar GuitarPlot with 5'UTR / CDS / 3'UTR scaling; MetaPlotR; deepTools `computeMatrix scale-regions`), peak-centred heatmaps (ComplexHeatmap; deepTools plotHeatmap), IP-vs-input paired browser tracks (bigWig of log2 IP/input via deepTools `bamCompare`; ggcoverage; pyGenomeTracks; Gviz; IGV / UCSC track hubs), DRACH sequence-logo plots (ggseqlogo; MEME), 5'UTR / CDS / 3'UTR stacked-bar feature-distribution summaries, and volcano / MA plots for differential modification. Establishes stop-codon enrichment in the metagene plot as the biological QC anchor for any MeRIP dataset (Dominissini 2012 *Nature* 485:201; Meyer 2012 *Cell* 149:1635 — concurrent founding papers from different labs both showed this independently). Use when producing the canonical metagene plot with stop-codon enrichment as a QC anchor, building paired IP/input genome-browser tracks at single-locus resolution, plotting peak-centred heatmaps clustered by condition, summarising peak distribution across transcript features for figure 1, generating DRACH motif logos as sanity checks on the peak set, rendering volcano plots of differential m6A, or reproducing the Dominissini 2012 / Meyer 2012 stop-codon enrichment plot.

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Quantifies CRISPR editing outcomes with CRISPResso2 (Clement 2019 Nat Biotechnol) across Cas9-nuclease (indels, HDR), CBE and ABE base editors (target conversion + bystander), and prime editor (pegRNA-templated) modes. Covers single-amplicon (CRISPResso), multi-sample batch (CRISPRessoBatch), pooled-amplicon (CRISPRessoPooled), WGS off-target (CRISPRessoWGS), and sample-comparison (CRISPRessoCompare) workflows; quantification-window math that controls what is called edited; substitution-vs-indel diagnostic to distinguish BE from Cas9 contamination; MMEJ deletion pattern interpretation; allele-frequency tables; and failure modes from amplicon misalignment or contamination. Use when quantifying editing from amplicon sequencing, choosing CRISPResso mode by design, distinguishing intended edits from bystanders and indel byproducts, debugging low-alignment runs, or generating publication-grade editing reports.

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Standardizes molecular structures using ChEMBL chembl_structure_pipeline and RDKit rdMolStandardize covering sanitization, salt/solvent stripping, neutralization, tautomer canonicalization, stereochemistry standardization, mixture handling, and isotope normalization. Explicitly compares ChEMBL pipeline, canSARchem, and PubChem standardization choices. Use when preparing libraries for QSAR training, joining datasets across sources, deduplicating compound collections, or building canonical compound registries.

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Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda window scheduling, soft-core potentials, REST2 enhanced sampling, MBAR/BAR analysis, and cycle closure validation. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.

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Use this skill to evaluate which defensive driving program is best for your fleet. Compares Smith System, CarriersEdge, Compass-native training, and other options.

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Use this skill when the user asks the cost of pulling a Motor Vehicle Record (MVR) in a specific state, or wants to compare MVR fees across multiple states, or is budgeting annual compliance costs for a multi-state fleet. Reference the canonical fee table below; flag that fees change (re-verify with state DMV before annual budget planning).

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SEO drift monitoring: capture baselines of SEO-critical elements, detect changes, and track regressions over time. Git for SEO: baseline, diff, and track changes to your on-page SEO. Use when user says "SEO drift", "baseline", "track changes", "did anything break", "SEO regression", "compare SEO", "before and after", "monitor SEO changes", or "deployment check".

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Generate SEO-optimized competitor comparison and alternatives pages. Covers "X vs Y" layouts, "alternatives to X" pages, feature matrices, schema markup, and conversion optimization. Use when user says "comparison page", "vs page", "alternatives page", "competitor comparison", "X vs Y", "versus", "compare competitors", or "alternative to".

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Orchestrator that runs one UI brief through all four ui-* posture skills in parallel, then picks and merges a winner. Use when a screen matters enough to explore several directions, or the user says 'build it a few ways', 'design options', 'bake-off', 'show me variations', or 'compare approaches'.

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Search domains, compare prices, find promo codes, get purchase recommendations. Use when user wants to buy a domain, check prices, or find domain deals.

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Enables Claude Code to collaborate with OpenAI Codex CLI on Windows. Use this skill when the user wants to get a second opinion from Codex, compare approaches between Claude and Codex, or leverage both AI assistants for collaborative problem-solving. This skill supports both non-interactive mode (automatic response retrieval) and interactive mode (visual pane splitting with tmux).

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[22] UNDERSTAND. Deep research from all sources — internal (code, git, logs) AND external (web, docs, best practices). Use when choosing libraries, investigating solutions, understanding legal/technical questions, comparing approaches, or anytime you need comprehensive knowledge from both project context and world knowledge. Triggers on "research", "investigate", "find best approach", "what do others do", "compare options", or complex questions requiring multiple sources.

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This skill should be used when the user asks to "implement LLM-as-judge", "compare model outputs", "create evaluation rubrics", "mitigate evaluation bias", or mentions direct scoring, pairwise comparison, position bias, evaluation pipelines, or automated quality assessment.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill instead of WebSearch for ANY question requiring web research. Trigger on queries like "what is X", "explain X", "compare X and Y", "research X", or before content generation tasks. Provides systematic multi-angle research methodology instead of single superficial searches. Use this proactively when the user's question needs online information.

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Acts as a professional UX/UI specialist. Use to analyze web/app design, compare solutions, and identify potential UX problems. Provides expert advice on usability and accessibility for users with disabilities, including visual impairments.

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Research markets with sizing, segmentation, competitor mapping, pricing checks, and demand validation that turn fuzzy ideas into decision-ready evidence. Use when (1) you need TAM, SAM, SOM, whitespace, or category sizing; (2) you must compare competitors, pricing, positioning, or customer segments before acting; (3) the user asks whether a niche, launch, expansion, or go-to-market bet is actually worth pursuing.

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Compare cross-border e-commerce shipping options, packaging tactics, customs-risk signals, and speed-versus-cost tradeoffs for sellers, operations teams, and marketplace operators. Use when choosing routes, carriers, declaration practices, or packaging plans for parcel shipments without relying on live carrier APIs.

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Backtest crypto and traditional trading strategies against historical data. Calculates performance metrics (Sharpe, Sortino, max drawdown), generates equity curves, and optimizes strategy parameters. Use when user wants to test a trading strategy, validate signals, or compare approaches. Trigger with phrases like "backtest strategy", "test trading strategy", "historical performance", "simulate trades", "optimize parameters", or "validate signals".

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Legal contract analysis using CUAD dataset (41 risk categories). Supports NDA, SaaS, M&A, employment, payment/merchant, and finder/broker agreements. Identifies red flags, suggests redlines, compares to market standards.

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Track what a competitor actually shipped — "watch this competitor", "track what they ship", "what changed at". Compares against the last snapshot and reports only real moves: launches, pricing changes, positioning shifts.

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Analyze V8 heap snapshots to investigate memory leaks and retention issues. Use when given .heapsnapshot files, asked to compare before/after snapshots, asked to find what retains objects, or investigating why objects survive GC. Provides snapshot parsing, comparison, retainer-path helpers, and scratchpad scripts.

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Use when you need to check feature flag states, compare channels, or debug why a feature behaves differently across release channels.

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Fetches real-time Azure retail pricing using the Azure Retail Prices API (prices.azure.com) and estimates Copilot Studio agent credit consumption. Use when the user asks about the cost of any Azure service, wants to compare SKU prices, needs pricing data for a cost estimate, mentions Azure pricing, Azure costs, Azure billing, or asks about Copilot Studio pricing, Copilot Credits, or agent usage estimation. Covers compute, storage, networking, databases, AI, Copilot Studio, and all other Azure service families.

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Run agent-driven VS Code performance or memory investigations. Use when asked to launch Code OSS, automate a VS Code scenario, run the Chat memory smoke runner, capture renderer heap snapshots, take workflow screenshots, compare run summaries, or drive a repeatable scenario before heap-snapshot analysis.

日本語の概要は準備中です。原文の説明を表示しています。