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概要と使いどころ
Run the extended Corpo Net range suite across many models on one remote host with parallel isolated range instances, local Langfuse recording, bounded spend, and verified teardown. Use when asked to run, rerun, or scale a Corpo Net campaign; use run-ephemeral-hosts for the host contract and manage-remote-resources for billable resource ownership.
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Normalizes and transforms RNA-seq count matrices for DE, visualization, clustering, and ML. Covers between-sample (TMM, TMMwsp, RLE/median-of-ratios, upper quartile), within-sample (TPM, FPKM/RPKM), variance-stabilizing (VST, rlog, log-CPM), GC-content correction (cqn, EDASeq), and single-cell (scran deconvolution, scanpy normalize_total). Encodes the composition-bias rationale, the "most genes not DE" assumption and its catastrophic failure modes (MYC amplification, apoptosis, viral host shutoff, prokaryotic stress), the "lengthScaledTPM is not TPM" naming trap, the "TPM is not for DE" rule, the blind=TRUE vs FALSE decision, ERCC spike-in normalization (SBN), and the single-cell zero-inflation breakdown of TMM/RLE. Use when choosing or applying normalization, debugging shifted-MA-plot diagnostics, handling zero-heavy single-cell data, or correcting GC bias.
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Creates DE-specific diagnostic and result visualizations using DESeq2/edgeR built-in functions and lightweight ggplot2 wrappers. Covers MA plot (with the shrunken-LFC compression effect), volcano (with the apeglm caveat that p-values are unchanged), PCA on VST/rlog (never raw counts), sample distance heatmaps, top-DE-gene heatmaps with the row-scaling trap, dispersion / BCV plot interpretation, p-value histogram diagnostics, plotCounts for individual genes, blind=TRUE vs FALSE rationale, and the n=3 visualization stake. Use when generating DE diagnostic plots, choosing VST vs rlog for visualization, troubleshooting suspicious plot patterns (shifted MA cloud, batch-dominated PCA, anti-conservative p-value histogram), or building a standard QC figure panel.
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This skill provides AWS cost optimization, monitoring, and operational best practices with integrated MCP servers for billing analysis, cost estimation, observability, and security assessment.
日本語の概要は準備中です。原文の説明を表示しています。
Recommends postpartum endocrine care (diabetes management) in addition to usual obstetric care for individuals with preexisting diabetes (including those with pregnancy loss or termination). Triggered by postpartum care planning for patients with diabetes after delivery.
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This skill recommends re-evaluating the need for treatment of other pituitary hormone deficiencies in the postoperative period following surgical intervention for Cushing's syndrome. It is triggered when assessing a post-op CS patient for ongoing pituitary function, evaluating for hypopituitarism, or checking HPA axis recovery with morning cortisol/ACTH stimulation tests and pituitary MRI within 1–3 months.
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This skill recommends obtaining a postoperative pituitary MRI within 1–3 months after successful transsphenoidal surgery (TSS) to establish a new baseline for future recurrence assessment. Use when a Cushing’s syndrome patient has achieved biochemical remission post‑TSS and is entering routine follow‑up.
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This skill guides postoperative management after Cushing's syndrome surgery by classifying patients into hypocortisolism, hypercortisolism, or eucortisolism based on serum cortisol levels. Use when postoperative cortisol is <5 µg/dL (hypocortisolism), >20 µg/dL (hypercortisolism), or 5-20 µg/dL (eucortisolism) to direct glucocorticoid replacement, further treatment, or monitoring.
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This skill determines whether confirmatory testing can be omitted after a positive aldosterone-to-renin ratio (ARR) in patients with suspected primary aldosteronism. It is applied when a patient exhibits spontaneous hypokalemia, undetectable renin, and a plasma aldosterone concentration ≥20 ng/dL (550 pmol/L).
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Evaluates likelihood of primary aldosteronism by measuring plasma aldosterone suppression after oral captopril; normal suppression ≥30% makes PA unlikely, while lack of suppression with persistently suppressed plasma renin activity suggests PA. Use when assessing captopril challenge test (CCT) results for PA diagnosis in patients with positive aldosterone-to-renin ratio.
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This skill interprets the oral sodium loading test for primary aldosteronism by evaluating 24‑hour urinary aldosterone excretion after a high‑sodium diet. Use when reviewing results of an "oral sodium loading test" for PA diagnosis; trigger phrases include "urinary aldosterone excretion ≤10 g/24 h" (PA unlikely) or "≥12 g/24 h (Mayo) / ≥14 g/24 h (Cleveland)" (PA highly likely).
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Determines whether to perform adrenal venous sampling (AVS) to lateralize aldosterone excess in patients with confirmed primary aldosteronism (PA) who are being evaluated for surgical treatment. Indicated when surgery is feasible and desired by the patient, or when subtype workup is planned for a surgical candidate, especially in those younger than 35 years with spontaneous hypokalemia, marked aldosterone excess, and unilateral adrenal lesions on CT.
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Recommends fludrocortisone 100 µg daily for children with primary adrenal insufficiency and confirmed aldosterone deficiency; for infants under 12 months, adds sodium chloride supplementation. Triggered by PAI with aldosterone deficiency, evidenced by salt craving, hyponatremia, hyperkalemia, or elevated renin with low aldosterone.
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Determines if primary aldosteronism is confirmed based on upright plasma aldosterone ≤6 ng/dL (170 nmol/L) on day 4 at 10 AM of fludrocortisone suppression test, provided plasma renin activity ≥1 ng/mL/h and plasma cortisol concentration lower than the 7 AM value to exclude ACTH confounding. Use when reviewing FST results to diagnose PA; triggers include "FST", "upright aldosterone ≤6 ng/dL", "PRA ≥1 ng/mL/h", and "cortisol drop".
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Determines unilateral vs bilateral aldosterone excess based on cortisol-corrected aldosterone ratios from adrenal venous sampling, with ratio >4:1 indicating unilateral excess, ratio 3:1 suggestive of bilateral hypersecretion, and interpretation dependent on cosyntropin stimulation protocol used during sampling. Use when analyzing AVS results to guide surgical vs medical treatment decisions; triggers include 'AVS lateralization ratio', 'cosyntropin-stimulated AVS', 'aldosterone-to-cortisol ratio >4:1', and 'ratio 3:1 suggestive of bilateral disease'.
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In patients with normal preoperative adrenal function, suggests an individualized clinical approach for postoperative glucocorticoid administration until HPA axis evaluation can be performed. Triggers include managing postoperative patient with normal preoperative adrenal function needing glucocorticoid management.
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Comprehensive AWS cost analysis and optimization recommendations using AWS CLI and Cost Explorer
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Use before non-trivial coding work to pick a task-appropriate working mode — debug, fix, review, test-first, refactor, optimize, migrate, upgrade, integrate, spike, or unstuck — then follow its checklist. Modes are procedures, not personas. Not needed for trivial one-line edits or non-coding tasks.
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Build the locked Slack TL;DR JSON payload from a completed weekly report. Saves to /tmp/slack-msg.json with the exact curl command for Nathan to post manually. Triggers on "draft Slack TL;DR", "Slack post", "build the Slack message".
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Creates LinkedIn posts, thought leadership content, and editorial calendars for SME marketing. Covers 7 post types (Awareness, Personal Story, Education, Conversion, How We Do It, Building In Public, Lead Magnet) with complete graphic prompts, first comments, and CTAs. Use when user asks to write social media posts, plan content calendars, create LinkedIn content, or develop thought leadership pieces.
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LLM and cloud cost awareness — model tiering, token budgets, right-sizing, and when a cheaper model suffices. Trigger before finalising any architecture that calls LLMs, before scaling a workload, or when a cost estimate is needed.
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Provisione instantaneamente bancos de dados PostgreSQL prontos para produção com Neon Instagres. Use ao configurar bancos de dados, quando usuários mencionam PostgreSQL/Postgres, configuração de banco de dados, ou precisam de um banco de desenvolvimento. Funciona com Drizzle, Prisma, SQL puro.
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Otimização de performance do Postgres e boas práticas do Supabase. Use essa skill ao escrever, revisar ou otimizar queries Postgres, designs de schema ou configurações de banco de dados.
日本語の概要は準備中です。原文の説明を表示しています。
INTERNAL/HELPER skill — do NOT invoke directly from a user query. This is the shared formatter/poster used by answer-issue-questions and breakdown-issues. It formats a scope GitHub Issue body (label cc-triage-scope, used before code analysis), runs the pre-posting checklist, and executes `gh issue create`. Invoke this skill ONLY from one of the parent skills via the Skill tool, after the parent has finalized the task breakdown. If a user asks to 'create a scope issue' or similar, route them to the appropriate parent skill (/breakdown-issues for fresh breakdowns, /answer-issue-questions for derived sub-tasks) rather than invoking this one directly.
日本語の概要は準備中です。原文の説明を表示しています。