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概要と使いどころ
Azure Weights & Biases SDK for .NET. ML experiment tracking and model management via Azure Marketplace. Use for creating W&B instances, managing SSO, marketplace integration, and ML observability.
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Extract point-scale CMIP6 historical and SSP future climate data from the Pangeo Google Cloud catalog and convert them into bias-corrected additive or multiplicative anomalies for LSM or EcoSIM climate forcing. Use when a task needs site latitude/longitude, scenario-specific CMIP6 variables, vapor pressure derived from huss and ps, calendar-aware day-of-year climatologies, or projected change summaries for the 2050s and 2090s.
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Exporta peças aprovadas do Figma e monta o pacote de entrega — arquivos nomeados, legendas, texto alternativo e instruções de publicação. Use quando o usuário disser "exportar", "baixar as peças", "pacote final", "entregar para publicação", "handoff", "mandar para o social". Só exporta o que passou na revisão.
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Constrói prompts para geradores de imagem e vídeo — estrutura, parâmetros, referência de estilo e negativa. Use quando o usuário disser "prompt", "como pedir isso pra IA", "melhorar o prompt", "não saiu como eu queria", "prompt do Ideogram", "prompt do Flux", ou antes de qualquer chamada de geração. Competência central deste plugin — a qualidade do prompt define o custo da campanha.
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Aumenta resolução e qualidade de imagem via Freepik/Magnific, ou orienta o processo manual quando não há chave. Use quando o usuário disser "upscale", "melhorar a resolução", "a imagem está pixelada", "Magnific", "Freepik", "aumentar a imagem", "imagem pequena demais". Gasta crédito — exige confirmação.
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Curate durable PWDEV Flow project decisions, lessons, and conventions. Use when the user asks to capture, list, show, link, supersede, or select project memory, or when an approved workflow decision should persist across phases.
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Transforma uma peça de conteúdo em várias — case em thread, webinar em posts, artigo em carrossel, vídeo em cortes. Use quando o usuário disser "reaproveitar", "transformar isso em", "adaptar para", "repurpose", "derivar conteúdo", "aproveitar melhor esse material", "do blog para as redes", ou apresentar material longo pedindo derivados. Produz peça nativa de cada canal, nunca copia e cola.
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Mantém a documentação técnica viva no Notion e no repositório — arquitetura, runbooks, inventário, ADRs e procedimentos operacionais, gerados a partir da infraestrutura real. Use quando o usuário disser "documentar", "runbook", "ADR", "wiki", "Notion", "atualizar a documentação", "inventário", "ninguém sabe como isso funciona".
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Segundo cérebro persistente em Markdown — LLM Wiki no padrão Karpathy mantida como bundle Open Knowledge Format v0.2, com fontes imutáveis em raw/ e conceitos citados em wiki/. Use quando o usuário disser "segundo cérebro", "second brain", "adiciona isso ao meu brain", "salva na minha wiki", "ingere esse artigo/PDF/link", "o que minha wiki diz sobre", "o que meu brain sabe sobre", "consulta meu conhecimento", "lint da wiki", ou pedir para acumular conhecimento de fontes de forma durável. NÃO use para notas do Obsidian (pwdev-obsidian), planejamento de features (pwdev-feat) nem PRDs (pwdev-prd).
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Estrutura narrativa para copy — PAS, BAB, AIDA, PASTOR, Jornada do Herói e Golden Circle. Use quando o usuário disser "storytelling", "contar a história", "narrativa da marca", "o texto está sem fio condutor", "case de sucesso", ou quando a página precisar de narrativa em vez de argumento listado.
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Safely clean up local branches whose tracked remote branch is gone. Use when you want to review stale branches and associated worktrees after remote branches or PRs are deleted.
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Add an iOS App Clip target to an Expo app. Use when the user mentions App Clip, AASA, apple-app-site-association, appclips, smart app banner, or wants to ship a lightweight iOS Clip invoked from a URL alongside their parent app.
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Cleans up local git branches marked as [gone] (deleted on the remote but still present locally), including removing any associated worktrees. Use when the user says "prune branches", "clean up gone branches", "/prune-branches", or asks to delete stale local branches whose remotes are gone.
日本語の概要は準備中です。原文の説明を表示しています。
Azure Weights & Biases SDK for .NET. ML experiment tracking and model management via Azure Marketplace. Use for creating W&B instances, managing SSO, marketplace integration, and ML observability.
日本語の概要は準備中です。原文の説明を表示しています。
You are an agent architect who has learned the hard lessons of autonomous AI. You've seen the gap between impressive demos and production disasters. You know that a 95% success rate per step means only 60% by step 10.
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Quality control for IMC/MIBI data across pixel, channel, image, slide, and batch levels, covering Poisson-count SNR (cell-level Gaussian-mixture and empty-channel comparison), spillover-matrix QC (the three physical sources), drift and the missing EQ-bead analog, acquisition artifacts, and sample-of-origin batch effects. Use when deciding whether to keep or drop a channel, ROI, or slide, distinguishing a dim antibody from a failed one, reading a spillover matrix, or diagnosing batch-driven clustering before analysis.
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Calls significant loops from protein-directed and targeted 3C assays (HiChIP, PLAC-seq, Capture Hi-C/PCHi-C, ChIA-PET) where the contact background is peak-anchored and coverage-biased, so generic Hi-C loop callers (cooltools dots, Juicer HiCCUPS) use the wrong null. Covers FitHiChIP (config-driven coverage+distance-decay spline regression, peak-to-peak vs peak-to-all foreground, loose vs stringent background, coverage vs ICE bias), MAPS (positive Poisson regression on bias factors for PLAC-seq/HiChIP), hichipper (restriction-site-distance bias model + library QC), CHiCAGO (Delaporte two-component Brownian+technical background for asymmetric bait x other-end Capture Hi-C), the with/without separate-ChIP anchor decision, and differential loops via diffloop. Use when calling loops from HiChIP/PLAC-seq/Capture Hi-C, choosing FitHiChIP/MAPS/CHiCAGO, picking peak-to-all vs peak-to-peak, setting the loop FDR, supplying ChIP peaks as anchors, QCing a HiChIP library, or comparing loops between conditions.
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Calls m6A peaks from MeRIP-seq / m6A-seq paired IP-vs-input data using exomePeak2 (transcript-aware, GC-bias-corrected Poisson GLM; Liu 2022 *NAR Genom Bioinform* 4:lqac046), MeTPeak (HMM over sliding windows; Cui 2016 *Bioinformatics* 32:i378), MACS3 / MACS2 with --nomodel --broad --keep-dup all (genome-wide broad alternative), and DRACH motif enrichment confirmation via HOMER or ggseqlogo as a sanity check (NOT a filter). Covers BED12 vs narrowPeak output formats, exonic vs intronic peak handling, multi-tool reconciliation (intersection vs union; cross-caller IDR-equivalent), the m6A-vs-m6Am ambiguity at 5'UTR peaks that antibody-based methods cannot resolve, and orthogonal-validation routes (miCLIP / GLORI / m6A-SAC-seq / m6Anet). Use when calling peaks from paired IP/input genome BAMs, choosing exomePeak2 (transcript-aware default) vs MACS3 (broad genomic) vs MeTPeak (HMM-smoothed low-coverage), confirming DRACH enrichment as a sanity check on the peak set as a whole, reconciling differing peak sets across tools, validating MeRIP peaks against orthogonal single-base methods, interpreting peaks at the 5' end where m6Am contamination is possible, or recommending a multi-tool consensus strategy.
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Tests genotype-environment associations and identifies adaptive loci while correcting for the four-confound landscape (structure, demography, background selection, sampling design) using LFMM2 with mandatory K via sNMF cross-entropy elbow (LEA 3), BayPass Core/AUX/C2/IS with Omega covariance matrix, RDA / pRDA for polygenic adaptation (Forester 2018; requires imputed genotypes), OutFLANK with trimmed FST null, pcadapt, gradient forests (Ellis-Smith-Pitcher 2012, NOT mis-cited Ellis-Manel), Capblancq & Forester 2021 RDA Swiss-army-knife, genomic-offset prediction with Lind & Lotterhos 2025 three-regime caveat, Lotterhos-Whitlock sampling optima, Wang & Bradburd 2014 IBD vs IBE, and Circuitscape + ResistanceGA. Use when identifying adaptive loci across gradients, choosing K for LFMM2, deciding among GEA methods, predicting maladaptation with the novel-environment caveat, distinguishing IBD vs IBE, or optimizing sampling design.
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Infer gene regulatory networks from bulk or general expression data with mutual-information (ARACNe) and tree-ensemble (GENIE3, GRNBoost2) methods, and infer transcription-factor protein activity from regulons with VIPER and msVIPER. Covers the activity-not-edges paradigm, the undirected-association caveat, the DREAM5 wisdom-of-crowds and method-complementarity result, AUPRC-over-AUROC evaluation, and gold-standard incompleteness. Use when inferring a regulatory network from a bulk expression matrix, finding master regulators, or scoring TF activity from a signature. For single-cell motif-pruned regulons see scenic-regulons; for co-expression modules see coexpression-networks.
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Stores and operates on sparse expression matrices for single-cell and large bulk RNA-seq, covering dgCMatrix/dgRMatrix/dgTMatrix when-each-is-fast, the dgCMatrix (CSC, R) <-> CSR (Python) implicit transpose, AnnData (cells-rows) <-> SingleCellExperiment (cells-cols) orientation flip, HDF5/h5ad vs Zarr cloud-native shift, HDF5SummarizedExperiment + DelayedArray for out-of-memory bulk, scanpy backed mode for large h5ad, the ~10-15% density crossover where dense beats sparse, 10X format proliferation (MTX vs CellRanger H5 vs h5ad), the dense-conversion memory blow-up, and Dask + Zarr for consortium-scale matrices. Use when choosing sparse format, working with single-cell-sized matrices, importing/exporting 10X, debugging R/Python interop transposes, processing matrices too large for RAM, or building cloud-native pipelines.
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Designs and analyzes pooled prime-editor (PE) screens for installing precise genetic variants without bystander confounding. Covers pegRNA design with PRIDICT and PRIDICT2 (Mathis 2023/2024) for predicting per-pegRNA editing efficiency, pegRNA architecture (spacer + scaffold + PBS + RTT), PE2 / PE3 / PE3b / PEmax / PEAR variants, MOSAIC in situ saturation mutagenesis (Hsu JY et al 2024 bioRxiv), the PRIME pooled-screen methodology (Erwood/Doman 2023 Nat Biotechnol 41:885; ~3,699 ClinVar variant screens), chromatin context as a primary determinant of PE efficiency, scaffold-incorporation and indel byproduct quantification with CRISPResso2, and the cross-modal validation strategy of PE + base-editor screens for variant function. Use when designing a pegRNA library for variant installation, choosing between BE and PE for a specific edit, predicting pegRNA efficiency before library synthesis, analyzing PE screen output, distinguishing intended-edit from scaffold-incorporation, or scaling PE screens to thousands of variants.
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Analyzes base-editing screens for variant function. Covers library design (Sanson 2020 GRACE, Hanna 2021 BRCA1/2 SNV scanning, Cuella-Martin 2021), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end, wider for ABE8e), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.
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Build volcano and MA plots from differential-expression / association results with LFC shrinkage, FDR-adjusted thresholds, sensible label placement, and axis-truncation conventions. Covers EnhancedVolcano, ggplot2, matplotlib, and the apeglm/ashr/normal shrinkage decision. Use when visualizing differential-expression results (RNA-seq, ChIP-seq, ATAC-seq, proteomics) or any per-feature effect-size + p-value table.
日本語の概要は準備中です。原文の説明を表示しています。