「uis」の検索結果

Test whether two or more traits share a causal variant at a locus using Bayesian colocalization (coloc.abf, coloc.susie, HyPrColoc, moloc, eCAVIAR, SMR/HEIDI, PWCoCo, SharePro). Use when integrating GWAS with eQTL/sQTL/pQTL/mQTL, distinguishing shared causal variants from LD-driven coincidence, handling allelic heterogeneity, choosing between single-causal vs multi-causal methods, picking PP.H4 thresholds, running sensitivity over p12, or harmonising summary statistics for colocalization.

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Quantifies alternative splicing as PSI (percent spliced in) from RNA-seq using rMATS-turbo (BAM-based event), SUPPA2 (TPM-based event), MAJIQ V3 (LSV-based Bayesian), leafcutter (annotation-free intron clusters), VAST-TOOLS (cross-species with microexon support), Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage), or IRFinder-S (intron retention coverage-aware). Distinguishes the five canonical event classes (SE, A5SS, A3SS, MXE, RI), special classes (microexons, exitrons, AFE/ALE), intron retention subtypes (canonical RI vs detained introns), and applies effective-length normalization. Use when measuring splice-site usage or isoform inclusion ratios from short-read RNA-seq.

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Analyze TF motif accessibility variability across samples or single cells using chromVAR. Use when identifying TF motifs whose accessibility correlates with conditions, computing per-sample motif z-scores after matched background correction, comparing to ArchR / Signac equivalents, or distinguishing motif-accessibility signal from per-site footprinting.

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Analyzes differential transcript usage (DTU) and isoform switches with functional consequence prediction (NMD via 50nt rule, ORF disruption, protein domain loss/gain, signal peptide changes, IDR alterations, coding-potential shifts). Tools include IsoformSwitchAnalyzeR v2 (auto-selects satuRn for >5 reps else DEXSeq), the manual DRIMSeq -> DEXSeq/satuRn -> stageR DTU pipeline, and fishpond/swish for inferential-uncertainty-aware DTE. Distinguishes DTU from DGE and DTE; integrates external annotators (CPC2, Pfam, SignalP, IUPred2A or DeepTMHMM). Use when investigating how splicing differences alter protein function or trigger NMD-mediated degradation.

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Use this skill when the user asks how to recruit CDL drivers — sourcing channels (CDL schools, job boards, military, returning citizens, owner-operator pools), application + screening process, signing bonus structures, recruitment marketing, fleet ambassador programs, and what's working in the current driver market. Reference ATA Workforce Development.

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Use this skill when the user asks what emergency equipment a CMV must carry under 49 CFR 393.95 — reflectorized triangles, flares, fire extinguishers, spare fuses, exceptions for buses/passenger CMVs, where to mount/store equipment, and what roadside inspectors check. Cite 49 CFR 393.95 + 393.97.

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Dense UI posture — maximum information density with clear hierarchy. Use when building or reworking admin dashboards, data tables and grids, ops or monitoring views, settings-heavy panels, debug inspectors, state or log viewers, and multi-pane tool UIs someone drives all day.

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Collapsing every copy of one kind of thing (tables, UIs, utilities, hooks, APIs, renderers) into a single canonical one. Use when asked to unify, merge, converge, or 'make one X used everywhere', or before migrating callers onto a new canonical piece. NOT for docs (use docs).

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Locate CCSPlayerPawn::SetModelFromClass in CS2 server.dll / libserver.so via IDA Pro MCP and emit a fresh, minimal-unique signature or offset for the WeaponPaints gamedata entry "CCSPlayerPawn::SetModelFromClass" (symbol CCSPlayerPawn_SetModelFromClass). Shortlist via callers of CBaseModelEntity::SetModel inside pawn model-selection code: this variant takes the pawn's class model. The body resolves a cached model precache handle from the player class and calls SetModel. Distinguish from SetModelFromLoadout by the ABSENCE of loadout/inventory item lookups in the call chain. Trigger: CCSPlayerPawn_SetModelFromClass, CCSPlayerPawn::SetModelFromClass

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Locate CEconItemView::CEconItemView in CS2 server.dll / libserver.so via IDA Pro MCP and emit a fresh, minimal-unique signature or offset for the WeaponPaints gamedata entry "CEconItemView::CEconItemView" (symbol CEconItemView_CEconItemView). This is the CONSTRUCTOR of CEconItemView. Shortlist via allocation sites: callers of operator-new whose result is immediately stored with the CEconItemView vtable (RTTI), followed by zeroing and initialization of definition-index/quantity/attribute-list fields. Distinguish from subobject constructors of derived classes by the vtable identity. Trigger: CEconItemView_CEconItemView, CEconItemView::CEconItemView

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Expert in building browser extensions that solve real problems - Chrome, Firefox, and cross-browser extensions. Covers extension architecture, manifest v3, content scripts, popup UIs, monetization strategies, and Chrome Web Store publishing.

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Expert guidance for building modern Android UIs with Jetpack Compose, covering state management, navigation, performance, and Material Design 3.

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针对包含激励信号的10Hz采样电池数据，利用FFT（含去直流和加窗处理）计算特定频率的电化学阻抗并绘制奈奎斯特图。

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Maxim social-hook video — engineered for lead gen and top-of-funnel acquisition via 2-Second Hook Science + Zeigarnik + Variable Reward. Platform-optimized short-form that turns scrollers into followers, subscribers, and leads.

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Growth marketing and go-to-market — campaign, GTM, brand awareness, conversion, growth hacking, user acquisition, funnel, social media strategy. The CMO office's full-funnel growth domain.

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Build self-serve acquisition and expansion motions. Use when deciding PLG vs sales-led, optimizing activation, driving freemium conversion, building growth equations, or recognizing when product complexity demands human touch. Includes the parallel test where sales-led won 10x on revenue.

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Setup and initialization guide for developing AWS CDK (Cloud Development Kit) applications in Python. This skill enables users to configure environment prerequisites, create new CDK projects, manage dependencies, and deploy to AWS.

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Design, implement, and stabilize automated tests (unit, integration, E2E) for .NET/C#, Rust, APIs, and frontend flows. Use when the user asks to create tests, increase coverage, fix flaky tests, or validate behavior changes.

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Creates or updates the active planning artifact under planning/active/ for any change-bearing workstream. Consumes the active spec when one exists. Defines ordered tasks, target paths, commands, and checkpoints.

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Plan and sequence complex implementation work into deterministic, testable steps. Use when the user asks for planning, roadmap breakdown, execution strategy, effort estimation, or multi-step delivery coordination across domains.

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Use for non-trivial, design-bearing, or architecture-affecting work before execution planning. Creates or updates a versioned spec under planning/specs/active/ with design intent, alternatives, risks, and acceptance criteria.

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Assembles the minimal context pack for a given task. Use when the task spans multiple domains or the context set has obvious redundancy. Do not trim required working context by default.

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Route tasks using the repository's static routing catalog and load only the minimal context pack. Use before execution when the task spans multiple domains or the correct instruction set is unclear.

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Sync shared repo assets into local ~/.github, ~/.codex, and ~/.claude, and apply MCP settings from the shared canonical runtime catalog. Use when runtime assets are stale or after onboarding a new machine.

日本語の概要は準備中です。原文の説明を表示しています。