「dating」の検索結果

Assesses ChIP-seq quality across antibody specificity, fragmentation, enrichment, replicate concordance, and library complexity. Computes FRiP, NSC/RSC (phantompeakqualtools), library complexity (NRF/PBC1/PBC2), deepTools plotFingerprint (JS distance, AUC, synthetic JS), ChIPQC, IDR with ENCODE Nself/Nt rules, and detects hyper-ChIPable artifacts. Use when validating an antibody, diagnosing failed peak calls, deciding whether to proceed with downstream analysis, grading against ENCODE thresholds, or auditing replicate concordance.

日本語の概要は準備中です。原文の説明を表示しています。

Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda window scheduling, soft-core potentials, REST2 enhanced sampling, MBAR/BAR analysis, and cycle closure validation. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.

日本語の概要は準備中です。原文の説明を表示しています。

Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

日本語の概要は準備中です。原文の説明を表示しています。

Detect and adjust for horizontal pleiotropy in two-sample Mendelian randomization by distinguishing uncorrelated (UHP) from correlated (CHP) pleiotropy and choosing among Egger, MR-PRESSO, MR-RAPS, CAUSE, LHC-MR, LCV, MR-Clust, MR-Mix, and contamination-mixture methods. Use when validating an MR causal claim, running the STROBE-MR sensitivity battery, suspecting a shared heritable confounder, working under weak-instrument or polygenic-exposure regimes, or reconciling discordant estimates across robust methods.

日本語の概要は準備中です。原文の説明を表示しています。

Creates sashimi-style plots showing RNA-seq read coverage and splice junction counts using ggsashimi (general-purpose, condition-grouped overlays), rmats2sashimiplot (rMATS-output-aware), MAJIQ-VOILA (LSV posteriors interactive HTML), leafviz (leafcutter clusters Shiny), Jutils (tool-agnostic heatmaps and sashimi for rMATS/leafcutter/SUPPA2/MAJIQ output), or pyGenomeTracks (multi-track publication figures). Tool choice depends on the upstream differential-splicing tool's output format and the publication vs interactive use case. Use when visualizing specific splicing events, validating differential splicing calls, or producing publication-quality figures.

日本語の概要は準備中です。原文の説明を表示しています。

Detect allele-specific chromatin accessibility from ATAC-seq using WASP, GATK ASEReadCounter, or RASQUAL. Use when mapping cis-regulatory genetic variants from heterozygous SNPs, separating cis from trans regulation, building chromatin QTL (caQTL) maps, validating GWAS variant function with allelic imbalance, or detecting reference allele mapping bias before downstream analysis.

日本語の概要は準備中です。原文の説明を表示しています。

Predict enhancer-gene regulatory connections from ATAC-seq using ABC, ENCODE-rE2G, HiChIP, or Cicero. Use when linking distal enhancers to target genes, choosing between contact-aware (ABC, ENCODE-rE2G), accessibility-only (Cicero), and orthogonal (HiChIP H3K27ac, EpiMap) approaches, validating predictions against CRISPRi-FlowFISH gold-standard, or building cell-type-specific regulatory maps for fine-mapping or therapeutic target discovery.

日本語の概要は準備中です。原文の説明を表示しています。

Detects aberrant splicing in single rare-disease patients vs a control panel using FRASER 2.0 (Bioconductor; Beta-binomial autoencoder on Intron Jaccard Index, default delta cutoff 0.1, q hyperparameter), OUTRIDER (gene-level outlier expression via autoencoder denoising), LeafcutterMD (Dirichlet-multinomial outlier mode of LeafCutter for annotation-free junctions), and DROP (Snakemake pipeline integrating FRASER2 + OUTRIDER + monoallelic expression for clinical diagnostics). The statistical model is fundamentally different from differential splicing — single-sample-vs-cohort outlier detection rather than two-group comparison. Standard tool in EU rare-disease (Solve-RD) and NIH UDN programs. Use when applying RNA-seq to undiagnosed Mendelian disease, validating predicted splice variants in clinical samples, or detecting cryptic splicing in disease tissue.

日本語の概要は準備中です。原文の説明を表示しています。

Use when configuring Spring Boot as an OAuth2 resource server, validating JWTs from an external auth provider (Keycloak, Auth0, Okta, Cognito), extracting claims, or implementing scope-based authorization.

日本語の概要は準備中です。原文の説明を表示しています。

Integrate and maintain Robelest Convex Auth in apps by always checking upstream before implementation. Use when adding auth setup, updating auth wiring, migrating between upstream patterns, or troubleshooting @robelest/convex-auth behavior across projects.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill any time a .pptx or .potx file is involved in any way — as input, output, or both. This includes: creating slide decks, pitch decks, or presentations as PowerPoint (.pptx) files; reading, parsing, or extracting text from any .pptx or .potx file (even if the extracted content will be used elsewhere, like in an email, summary, or creating a different type of slide deck); editing, modifying, or updating existing presentations; combining or splitting slide files; working with templates (.potx), layouts, speaker notes, or comments. Trigger whenever the user asks for a PowerPoint or .pptx file, or references a .pptx or .potx filename, regardless of what they plan to do with the content afterward. However, when the user asks for a deck, slides, a slide deck, or a presentation without naming a file format, default to using a dedicated slide-deck artifact type or a separate slides skill if this session offers one; otherwise, use this skill.

日本語の概要は準備中です。原文の説明を表示しています。

Sync the current machine's configuration into the dotfiles repo and update the React showcase page. Use this skill whenever the user says "sync dotfiles", "update dotfiles", "sync config", "actualizar dotfiles", "sincronizar config", "update the repo with my current setup", or anything about pulling their current machine state into the dotfiles repo. Also trigger when the user mentions updating the toolkit page, adding new tools to the page, syncing Claude Code or Codex config (AGENTS.md, codex agents/skills/hooks), or keeping the dotfiles repo in sync with what's actually installed.

日本語の概要は準備中です。原文の説明を表示しています。

Cascade merge changes through a chain of dependent branches. Use when updating stacked/chained PRs, propagating changes from a parent branch to all downstream branches, or when the user mentions "cascade merge", "propagate changes", "update dependent branches", or "merge to downstream branches".

日本語の概要は準備中です。原文の説明を表示しています。

Read-only sanity-check of EcoSIM plant_trait.*.desc parameter values for the first grid. Use when validating plant trait description files, enforcing clean C3/C4 physiological parameterization, reviewing photosynthetic kinetics, active leaf/root protein allocation, and root hydraulics such as RSRR, RVSR, and ARSRA, or checking ranges, units, and woody/herbaceous block consistency before running EcoSIM. Never edit or replace the `.desc` file.

日本語の概要は準備中です。原文の説明を表示しています。

Convert AmeriFlux ERA5 half-hourly meteorological CSV files into EcoSIM hourly climate forcing NetCDF files, compare generated forcing against overlapping measured tower meteorology when a FULLSET file is available, and report large biases or errors. Use when preparing or validating EcoSIM climate inputs for AmeriFlux sites, checking ERA5 against in situ records, diagnosing forcing discrepancies, or writing climate-quality reports. For non-AmeriFlux paper sites that need a fresh Copernicus CDS ERA5 point download by longitude/latitude, use era5-cds-point-download first.

日本語の概要は準備中です。原文の説明を表示しています。

Prepare, validate, and edit EcoSIM plant management inputs using pft_mgmt_in NetCDF, editable Excel workbooks, and optional PlantMgmtWriter.py JSON files. Use when creating or checking natural PFT management data, converting pft-mngt NetCDF to an Excel sheet for editing, converting edited Excel back to JSON or NetCDF, validating pft_type/pft_pltinfo/pft_mgmt entries, or preparing PlantMgmtWriter.py inputs for EcoSIM.

日本語の概要は準備中です。原文の説明を表示しています。

Create EcoSIM Fortran namelist files and workable EcoSIM run folders for AmeriFlux site runs from site-specific grid, plant management, climate forcing, and greenhouse-gas inputs. Use when preparing or updating an EcoSIM `.namelist`, run folder, runfolder, run directory, or executable-ready site case for AmeriFlux or FLUXNET sites, especially after generating `*_ecosim_grid.nc`, `*_ecosim_climate_<first>-<last>.nc`, and `*_pft_mgmt.nc` inputs.

日本語の概要は準備中です。原文の説明を表示しています。

Map observed site vegetation, species lists, land-cover descriptions, or plant management PFTs to EcoSIM vegetation codes using templates/ecosim_pftpar_20260303.nc.cdl. Use when choosing or validating EcoSIM pft_type values, pfts entries, pfts_short categories, pfts_long plant type meanings, or the combined short-code plus Koppen climate numerical code used by plant management inputs.

日本語の概要は準備中です。原文の説明を表示しています。

Prepare, validate, inspect, and edit EcoSIM soil management inputs using soil_mgmt_in NetCDF, editable Excel workbooks, and optional JSON files. Use when checking fertilizer, tillage, or irrigation management data; converting soil-mngt NetCDF to Excel for editing; converting edited Excel back to JSON or NetCDF; decoding fertf/tillf/irrigf selector variables; or validating EcoSIM ReadManagementMod.F90 soil-management inputs.

日本語の概要は準備中です。原文の説明を表示しています。

Premium pre-launch waitlist page template — dark charcoal canvas with subtle vignette, drifting portrait video-thumbnail cards, fade-up cascades, glass nav, live-updating join counter, single email form with success/error states. Built for creative-tool / AI / niche-SaaS invite-only launches with hushed exclusive tone, not loud growth-marketing.

日本語の概要は準備中です。原文の説明を表示しています。

Accessibility auditing and remediation skill for Vue 3 + Reka UI. Use when reviewing components, verifying WCAG 2.1 AA, fixing ARIA issues, or validating keyboard navigation in Reka UI components.

日本語の概要は準備中です。原文の説明を表示しています。

Write comprehensive end-to-end tests that verify complete user workflows, integration between components, and system behavior from user perspective using Playwright, Cypress, or similar frameworks. Use when testing user flows, verifying feature integration, testing across real browsers, ensuring UI interactions work correctly, validating form submissions end-to-end, testing authentication flows, catching regressions, automating QA processes, testing API integrations, or building confidence in production deployments.

日本語の概要は準備中です。原文の説明を表示しています。

Implement comprehensive security patterns to protect applications against OWASP Top 10 vulnerabilities including XSS, CSRF, SQL injection, authentication bypass, and data exposure. Use when handling user data, implementing authentication and authorization, validating input, encrypting sensitive data, preventing injection attacks, securing API endpoints, managing sessions and tokens, implementing rate limiting, configuring security headers, or building security-critical features that require defense-in-depth protection.

日本語の概要は準備中です。原文の説明を表示しています。

HTML -> UCUF (Cocos Creator UI) conversion skill. Use for turning a complete HTML source package with ui-design-tokens.json and colors_and_type.css into Cocos usable layout/skin/screen JSON, then validating with rule guard, visual fidelity risk, runtime interaction smoke, Cocos Editor final gate, and regression evidence.

日本語の概要は準備中です。原文の説明を表示しています。