273 件 ・ 関連度順
概要と使いどころ
Use when analyzing the material of an Accounting, Organizations and Society (AOS) manuscript — coding and interpreting qualitative field data, estimating experimental and survey models, or running theory-laden archival analyses, with an audit trail appropriate to each tradition. Analyzes and reports; it does not design the study (aos-methods).
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Check and improve your brand's visibility across AI search engines (ChatGPT, Perplexity, Gemini, Grok, Claude, DeepSeek). Set up tracking, run visibility analyses, audit your website for AI readability, and get actionable recommendations. Uses the npx goose-aeo@latest CLI.
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Generate a personal voice guide for X (Twitter) and/or LinkedIn by scanning a user's past posts and iteratively refining with sample-and-feedback loops. Produces a structured markdown voice guide that sibling skills (create-x-content, create-linkedin-content) consume to draft in-voice posts. Different from brand-voice-extractor, which analyses company blogs/landing pages — this skill is for personal social voice.
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Estimates time-scaled phylogenies, molecular-clock rates, effective reproduction number R_e, and population dynamics from dated pathogen genomes using TreeTime (maximum-likelihood) and BEAST2 (Bayesian; strict/relaxed clocks; coalescent, Bayesian-Skyline, Skygrid, Birth-Death-Skyline, and sampled-ancestor priors; structured coalescent via MASCOT). Covers root-to-tip clock QC via TempEst, date-randomisation tests, recombination masking via Gubbins/ClonalFrameML before clock inference for recombining bacteria, BDSKY origin-vs-rootHeight pitfalls, sampling-bias correction, multi-chain convergence diagnostics, and reconciling phylodynamic R_e with case-based R_t. Use when dating outbreak origins, estimating substitution rates, inferring R_e through time, building time-calibrated Nextstrain Augur trees, choosing between strict and relaxed clocks, fitting Birth-Death-Skyline models, diagnosing temporal-signal failure, running MASCOT for structured-population analyses, or using UShER for pandemic-scale placement.
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Reconstruct ancestral states at internal phylogenetic nodes for sequences (PAML codeml, IQ-TREE --ancestral, GRASP, FastML), discrete traits (corHMM hidden-rate Markov, ape::ace, phytools::make.simmap stochastic mapping, BayesTraits), and continuous traits (phytools::fastAnc, geiger Brownian/OU, RPANDA). Use when designing constructs for ancestral protein resurrection, tracing trait evolution along a tree, performing stochastic character mapping, testing models of trait evolution (BM vs OU vs EB), inferring ancestral genome content via Dollo or DTL reconciliation, or quantifying ancestral-state uncertainty for downstream comparative analyses.
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Queries myvariant.info BioThings aggregator for ClinVar, gnomAD, dbSNP, dbNSFP, COSMIC, CADD, and CIViC annotations in batched, version-tracked requests. Use when annotating variant lists from multiple databases simultaneously without managing per-source APIs, and when reproducibility-grade analyses require recording source data versions via _meta.
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Reconcile gene trees against a species tree under probabilistic models of duplication, transfer, and loss (DTL) using ALE (Szöllősi 2013 amalgamated likelihood), GeneRax (Morel 2020 ML reconciliation), AleRax (Morel 2024 co-estimation), Whale.jl (Bayesian DL+WGD), RANGER-DTL 2 parsimony, NOTUNG, ecceTERA, and Treerecs. Use when inferring ancestral gene-family content, distinguishing duplication from horizontal transfer from differential loss, rooting deep species trees from gene-content signals (STRIDE / Williams 2017 ALE-rooting), counting DTL events per branch, refining noisy gene trees against a species tree, modeling WGD events jointly with DTL, or producing publication-grade gene-family histories for phylogenomic / comparative analyses.
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Build whole-genome alignments using Progressive Cactus (Armstrong 2020 reference-free clade-level WGA), Minigraph-Cactus (Hickey 2024 pangenome-aware), LASTZ chain/net (UCSC pipeline), MUMmer4 (Marçais 2018 pairwise), minimap2 -x asm5/10/20 (Li 2018 fast pairwise), AnchorWave (Song 2022 WGD-aware), and Mauve / progressiveMauve (bacterial). Operates the HAL toolkit (Hickey 2013) for downstream extraction including halSynteny, halLiftover, halBranchMutations, and hal2maf. Use when constructing multi-species alignments for comparative-annotation projection (TOGA), synteny detection, conservation analyses (phyloP / PhastCons), or pangenome graph construction; selecting between reference-free (Cactus) and reference-anchored (LASTZ chains/nets) approaches; tuning sensitivity for closely vs distantly related genomes; or producing HAL files for genome-wide downstream tools.
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Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cui-Hung-Wang, Mehta-Pocock promising zone), seamless Phase 2/3 with treatment-arm selection, population enrichment, and response-adaptive randomisation. Covers FDA 2019 Final Adaptive Designs Guidance, FDA 2022 Master Protocols, and ICH E20 Step 2b/3 draft (June 2025, NOT final). Use when planning interim analyses, sample-size re-estimation, or master/platform-trial designs.
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Prepares statistical reports for clinical trials following CONSORT 2025, SPIRIT 2025, ICH E9(R1) estimands, and FDA 2023 covariate adjustment guidance. Covers Table 1 generation, analysis populations (ITT/FAS/PP/Safety), the 5 ICH E9(R1) intercurrent-event strategies, MMRM under MAR (mmrm), reference-based MI (rbmi J2R/CR/CIR), Permutt tipping-point sensitivity, and Rubin's-rules vs frequentist variance debate. Use when preparing regulatory submissions, defining estimands, or implementing missing-data sensitivity analyses.
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Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.
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Performs subgroup and heterogeneous treatment effect (HTE) analyses for clinical trials. Covers Mantel-Haenszel pooling, Breslow-Day, interaction tests in regression, RERI for additive interaction, modern data-adaptive HTE methods (STEPP, SIDES, causal forests, X/R-learners), Bayesian shrinkage (Dixon-Simon, MAP, EXNEX), graphical multiplicity (Bretz-Maurer), and credibility frameworks (Sun BMJ, EMA 2019). Use when analyzing treatment effects across patient subgroups for regulatory submissions or precision-medicine claims.
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Implements missing-data sensitivity analyses for confirmatory clinical trials including MMRM under MAR (with Kenward-Roger correction), reference-based multiple imputation (J2R, CR, CIR, LMCF per Carpenter-Roger 2013), Permutt delta-adjustment / tipping-point analysis, pattern-mixture identifying restrictions (CCMV, NCMV, ACMV), and the Cro vs Bartlett variance debate. Use when handling missing primary or secondary endpoint data in regulatory submissions following NRC 2010 and ICH E9(R1).
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Deep research and discovery before building something new. Explores local projects for reusable code, researches competitors, reads forums and reviews, analyses plugin ecosystems, investigates technical options, and produces a comprehensive research brief. Three depths: focused (30 min), wide (1-2 hours), deep (3-6 hours). Triggers: 'research this', 'discovery', 'explore the space', 'what should I build', 'competitive analysis', 'before I start building', 'research before coding'. Not for cited fact-checking research reports (a separate harness does those); this is pre-build product discovery.
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Analyse the vault's link graph and report on its shape: orphan rate, average degree, components, hubs, bridges and clusters, with what each number means for retrieval. Use this skill when the user asks about the health or structure of their graph, wants metrics, asks which pages are most connected or most isolated, or asks whether the vault is fragmented. Do NOT use for fixing what it finds, which is second-brain-lint, or for answering a content question.
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No Inference / Source-Locked Verification. Forces Claude to answer ONLY from user-provided materials and/or online sources actually accessed — no inference, no assumptions, no gap-filling. Every factual, legal, numerical, or procedural claim must be anchored to a cited source. Use whenever Claude reviews documents, summarises evidence, checks accuracy, drafts submissions, creates timelines, extracts facts, checks citations, analyses rules, prepares legal arguments, compares documents, verifies claims, produces chronologies, works from uploaded materials, performs legal research, checks case status, or does anything where evidential fidelity matters. Also trigger on: 'source-locked', 'no inference', 'only from the materials', 'don't assume', 'stick to the evidence', 'verify this', 'check this is right', 'work from the documents'. Overrides Claude's default tendency to fill gaps. If evidential accuracy matters, use this skill.
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Recherche académique dans les bases de données de doctrine juridique française, européenne et internationale. Utiliser cette skill lorsque l'utilisateur demande de rechercher des articles de doctrine, des thèses, des ouvrages académiques, ou des travaux universitaires en droit — y compris en droit comparé. Sources principales : ISIDORE (agrégateur SHS du CNRS incluant Cairn.info, Persée, OpenEdition), HAL (archive ouverte française), OpenAlex (base ouverte mondiale 250M+ travaux), Semantic Scholar, CrossRef, Persée (OAI direct), et CORE. Couvre la doctrine juridique francophone ET internationale avec workflow bilingue intégré pour le droit comparé. Déclencher aussi pour : bibliographie commentée, état de l'art, revue de littérature juridique, recherche d'auteur, vérification de citation, analyse bibliométrique.
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Assistant juridique expert en droit français. Recherches, consultations, rédaction d'actes, contre-argumentaires, analyses de contrats et de pièces, veille, vérification et harmonisation de références. Produit des documents Word (computer use) ou des réponses conversationnelles structurées. MCP : OpenLegi, Themia, LegalDataHunter. Déclencher pour toute question juridique, tout concept de droit français (contrat, responsabilité, jurisprudence, code civil, tribunal, indemnisation), toute question sur le droit de l'UE, la CJUE ou la CEDH, et toute demande de vérification ou harmonisation de références bibliographiques juridiques.
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Produces detailed law-school case briefs of United States judicial opinions in a fixed nine-section structure: memory jogger, facts, procedural history, judicial votes, holding, opinion-by-opinion analysis, five future-application hypotheticals, critique, and verified key quotations. Also builds vote tables, cross-case consistency tables, perspective-based critiques, and LaTeX in article, Beamer and casebook-chapter formats. Use whenever someone asks to brief a case, analyse or explain an opinion, summarise a decision for students, generate hypotheticals from a holding, critique a judgment, tabulate how justices voted, or convert case analysis to LaTeX. Triggers on "brief this case", "case brief", "explain the holding", "what did the court hold", "hypotheticals based on", "critique this opinion", "vote table", "Beamer presentation", "chapter brief", and on any reference to a judicial opinion or Supreme Court decision in a teaching context. Requires web search to verify quotations, votes and holdings.
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Analyses contracts for risk across five critical clauses (Limitation of Liability, Indemnities, IP Ownership, Data Protection, Termination). Built for founders with no legal background. Flags red flags, explains risks in plain language, and provides negotiation guidance.
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Analyzes how multiple regulations interact for a specific product, service, or business model. Identifies where obligations overlap, reinforce, complement, duplicate, or conflict; builds a priority matrix; produces an integrated compliance timeline; and estimates the total compliance burden. Use when (1) scoping a new product or service against the full regulatory landscape before launch, (2) conducting M&A due diligence on a target's multi-regulation exposure, (3) building a strategic compliance roadmap where single-regulation analyses miss the interactions, (4) advising on complex situations where regulations touch the same conduct from different angles, or (5) estimating budget and resourcing for multi-regulation compliance. Primary coverage of EU digital regulation (GDPR, Data Act, AI Act, CRA, NIS2, DORA, DMA, DSA, ePrivacy) and national implementations; the framework extends to any jurisdiction where overlapping regulatory regimes apply to the same activity.
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Analyse student work against criteria to identify specific gaps between current performance and learning objectives. Use when reviewing submissions, planning feedback, or diagnosing learning needs.
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This package enables the interpretation and analysis of results from a gene set enrichment analysis using network-based and text-mining approaches. Most enrichment analyses result in large lists of significant gene sets that are difficult to interpret. Tools in this package help build a similarity-based network of significant gene sets from a gene set enrichment analysis that can then be investigated for their biological function using text-mining approaches.
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Identification of differentially expressed genes and estimation of the False Discovery Rate (FDR) using both the Significance Analysis of Microarrays (SAM) and the Empirical Bayes Analyses of Microarrays (EBAM).
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