「aria」の検索結果

Expert-level probability theory knowledge. Use when working with probability spaces, random variables, distributions, expectation, variance, conditional probability, stochastic processes, Markov chains, martingales, or measure-theoretic probability. Also use when the user mentions 'sample space', 'random variable', 'expected value', 'variance', 'conditional probability', 'independence', 'Markov chain', 'Poisson process', 'moment generating function', 'law of large numbers', 'central limit theorem', or 'stochastic process'.

日本語の概要は準備中です。原文の説明を表示しています。

本番と同じ失敗を本番前に検出するためのテスト階層設計スキル。 DB方言差、実依存関係、永続化確認、timezone差、packaging整合性、 adversarial regressionをunit/integration/e2e/smoke/packagingに 適切に割り振り、PR CIで最低限の本番同等性を保証する。 Use when designing production-parity tests, closing test blind spots, building smoke suites for real dependencies, verifying persistence beyond UI success, or creating adversarial regression backlogs.

セマンティックHTML/JSXとWAI-ARIAを「最小で正しく」適用し、キーボード操作・スクリーンリーダ・コントラスト等を満たす実装を作るための判断軸。ネイティブ要素優先、ARIAの過剰使用を避ける。

Turn 'should never happen' into 'cannot happen' by defining owned inductive invariants and enforcing them at parse/construct/API/DB/lock/txn boundaries with a verification signal. Use when prompts mention invariants, impossible states, validation sprawl, cache/index drift, idempotency/versioning, retries/duplicates/out-of-order events, race/linearization bugs, loop correctness, or hardening another workflow (for example /tw-fix) with invariant checks first.

日本語の概要は準備中です。原文の説明を表示しています。

新規追加された UI コンポーネントに、variants（種類）とインタラクティブ状態（hover / focus / disabled / loading / error）が定義・文書化されているかを確認し、状態設計の欠落を検出する

Build accessible UI components with React Aria Components. Use when developers mention React Aria, react-aria-components, accessible components, or need unstyled accessible primitives. Provides documentation for building custom accessible UI with hooks and components.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes genetic variant effects on gene expression (RNA-seq), chromatin accessibility (DNASE), histone marks (ChIP), and transcription factors using the AlphaGenome API. Use when the user asks about non-coding variant effects, pathogenicity, clinical significance, disease associations, functional effects, gene expression changes, splicing disruption, or regulatory effects in promoters and enhancers. Also use for resolving biological terms to tissue/cell-type ontologies (UBERON/CL) or analyzing variants in chr:pos:ref>alt format.

日本語の概要は準備中です。原文の説明を表示しています。

Orchestrates the end-to-end germline short-variant pipeline from FASTQ to a filtered, normalized, benchmarked VCF, chaining QC/trim, BWA-MEM2 alignment, duplicate marking, optional BQSR, calling (bcftools/GATK HaplotypeCaller/DeepVariant/DRAGEN), normalization, site+genotype filtering, annotation, and hap.py/vcfeval benchmarking. Use when deciding the pipeline-wide reference-genome commitment (GRCh38 analysis set vs T2T, ALT/decoy handling), sequencing the steps in the defensible order (normalize BEFORE annotate, filter site- then genotype-level), choosing the calling engine and single-sample vs cohort joint-calling, picking a filtering strategy by cohort size, or benchmarking stratified within GIAB confident regions. Hands off mechanism to the variant-calling and read-alignment component skills; not a re-teach of any single step.

日本語の概要は準備中です。原文の説明を表示しています。

Figma REST API / Plugin API / Widget API / Code Connect / MCP Server リファレンス。 OAuth / Personal Access Token / Plan Access Token 認証、files, variables, webhooks, Dev Mode, Dev Resources, SCIM, activity-logs, library-analytics エンドポイント。 figma グローバルオブジェクト、node types (FrameNode, TextNode, ComponentNode 等)、 data types、figma.variables、figma.codegen、figma.ui。 useSyncedState, useSyncedMap, usePropertyMenu, AutoLayout, register。 Code Connect CLI / UI / React / SwiftUI / Compose / HTML / Storybook / custom parsers。 Figma MCP Server ツール・プロンプト・Code to Canvas・Write to Canvas。

Analyzes base-editing screens for variant function. Covers library design (Sanson 2020 GRACE, Hanna 2021 BRCA1/2 SNV scanning, Cuella-Martin 2021), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end, wider for ABE8e), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.

日本語の概要は準備中です。原文の説明を表示しています。

Batch effect correction for CRISPR screens covering ComBat empirical-Bayes, RUV, SVA, control-sgRNA normalization, and the model-based alternative of including batch as a covariate in MAGeCK MLE or Chronos. Covers screen-specific batch sources (passage cohort, library lot, infection day, sequencing run, Cas9 lot, FBS lot), PCA + variance-decomposition diagnostic to decide if correction is needed, when correction harms biology by over-correcting condition into batch, limma removeBatchEffect for visualization-only correction, and relationship to multi-condition design matrices. Use when combining screens for joint analysis, when passage cohort confounds biology, when DepMap-style panels need Chronos with batch covariates, when picking ComBat vs RUV, or when correction harms biology and should be replaced with explicit covariate modeling.

日本語の概要は準備中です。原文の説明を表示しています。

Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

日本語の概要は準備中です。原文の説明を表示しています。

Fits structural equation models to GWAS summary statistics using GenomicSEM (Grotzinger 2019), including common-factor models, confirmatory factor models, ESEM, common-factor GWAS with Q_SNP heterogeneity, multivariate Wald tests, and stratified GenomicSEM partitioned heritability. Reconciles results against MTAG multi-trait analysis. Handles sample overlap via the LDSC sampling-covariance matrix, identifies and resolves Heywood cases, and verifies model fit with CFI / RMSEA. Use when modeling latent genetic architecture across correlated traits, running multivariate GWAS on a shared factor, distinguishing factor-mediated from trait-specific SNP effects, or comparing GenomicSEM common-factor results against MTAG when both depend on accurate sampling covariance.

日本語の概要は準備中です。原文の説明を表示しています。

Extract and update the EcoSIM output-variable catalog from Fortran history-field registration calls such as hist_addfld1d and hist_addfld2d. Use only when explicitly asked to update, regenerate, refresh, or rebuild the list of EcoSIM output variables from HistDataType.F90 or related F90 source; do not invoke for ordinary EcoSIM output analysis unless the variable list itself must be updated.

日本語の概要は準備中です。原文の説明を表示しています。

Implement several variations of a design directly inside the running app, on the real page/route, with a live switcher to toggle between them in the browser, then recommend one and fold the winner into the real code. Variants are real implementations judged against real data, layout, and density (not an isolated mockup). Use this skill whenever the user wants to try design options live in the app, prototype changes directly on a real page, add a variant switcher, compare layouts in-context, asks to "build a few versions of this page", "try variants on the real screen", "switch between designs in the app", "implement this with a toggle", or says "real-prototype this". For a safe standalone .html copy that never touches the app, use the prototype skill instead.

日本語の概要は準備中です。原文の説明を表示しています。

Batch effect correction for CRISPR screens covering ComBat empirical-Bayes, RUV, SVA, control-sgRNA normalization, and the model-based alternative of including batch as a covariate in MAGeCK MLE or Chronos. Covers screen-specific batch sources (passage cohort, library lot, infection day, sequencing run, Cas9 lot, FBS lot), PCA + variance-decomposition diagnostic to decide if correction is needed, when correction harms biology by over-correcting condition into batch, limma removeBatchEffect for visualization-only correction, and relationship to multi-condition design matrices. Use when combining screens for joint analysis, when passage cohort confounds biology, when DepMap-style panels need Chronos with batch covariates, when picking ComBat vs RUV, or when correction harms biology and should be replaced with explicit covariate modeling.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes base-editing screens for variant function. Covers library design (Sanson 2020 GRACE, Hanna 2021 BRCA1/2 SNV scanning, Cuella-Martin 2021), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end, wider for ABE8e), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.

日本語の概要は準備中です。原文の説明を表示しています。

Fits structural equation models to GWAS summary statistics using GenomicSEM (Grotzinger 2019), including common-factor models, confirmatory factor models, ESEM, common-factor GWAS with Q_SNP heterogeneity, multivariate Wald tests, and stratified GenomicSEM partitioned heritability. Reconciles results against MTAG multi-trait analysis. Handles sample overlap via the LDSC sampling-covariance matrix, identifies and resolves Heywood cases, and verifies model fit with CFI / RMSEA. Use when modeling latent genetic architecture across correlated traits, running multivariate GWAS on a shared factor, distinguishing factor-mediated from trait-specific SNP effects, or comparing GenomicSEM common-factor results against MTAG when both depend on accurate sampling covariance.

日本語の概要は準備中です。原文の説明を表示しています。

Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

日本語の概要は準備中です。原文の説明を表示しています。

Viteを使う開発で、設定ファイル、環境変数、APIへの接続、プラグイン、ビルド出力を整え、開発サーバーや依存関係の不具合調査を支援するスキル。

• 環境変数と開発用API転送の設定
• 開発サーバーの遅さや更新不良の調査
• 本番用ファイルの最適化と動作確認

ReactやNext.jsのフォームやモーダルを、キーボード操作と画面読み上げに対応させるスキル。ラベル、エラー表示、フォーカス移動を実装・見直しします。

• フォームのラベルとエラー表示の改善
• ドロップダウンのキーボード操作確認
• モーダル開閉時のフォーカス管理

Web・iOS・Androidの画面を、読み上げやキーボード操作に対応させ、ラベル、配色、操作対象の大きさなどをWCAG 2.2に沿って設計・点検するスキル。

• アイコンボタンの説明を付けたいとき
• キーボード操作とモーダルの点検
• コントラストや操作対象の大きさの確認

Pythonの実行を途中で止め、変数や処理の流れを調べて不具合の原因を探ります。pdbとdebugpyを使い分け、失敗したテストや稼働中のプロセスも調査します。

• 失敗したテストの変数を調べたいとき
• 関数内のコレクションの変化を追う
• 例外発生地点の変数の確認

Converts genomic intervals between coordinate conventions, normalises and compares variant representations, and detects assembly or contig-naming mismatches before they corrupt an analysis. Used whenever coordinates cross a format, tool, or assembly boundary - converting between BED, GFF/GTF, VCF, SAM/BAM, WIG, PSL, genePred, Picard interval_list, or region strings; reconciling 0-based half-open with 1-based inclusive; left-aligning or trimming indels; checking whether two variant records describe the same change; mapping genomic to transcript, CDS, or protein positions; auditing a BED/GTF/VCF for convention violations; or diagnosing GRCh37 vs hg19 vs GRCh38 vs T2T, chr-prefix, and liftover problems. Triggers include "off by one", "0-based", "1-based", "half-open", "coordinate system", "left-align", "normalize variant", "bcftools norm", "chr prefix", "wrong genome build", "liftover", "REF mismatch", and "HGVS".

日本語の概要は準備中です。原文の説明を表示しています。