「cer」の検索結果

Think and work like an expert Chemical Oceanographer. Use when a task calls for Chemical Oceanographer judgment. Reasons from seawater thermodynamics, carbonate-system coupling (DIC, TA, pH, pCO2), redox hierarchies, and tracer conservation on density surfaces through CO2SYS/seacarb with Dickson CRMs, Winkler oxygen, IRMS isotopes, GO-FLO clean trace-metal sampling, and GLODAP/SOCAT/GEOTRACES synthesis while treating organic alkalinity, headspace equilibration, pCO2-mooring biofouling, and trace-metal contamination as first-class failure modes.

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Think and work like an expert Biogeochemist. Use when a task calls for Biogeochemist judgment. Reasons from coupled C/N/P/S redox cycles through TEAP zonation, porewater Rhizon-peeper sampling, δ13C/δ15N/δ34S tracers, chamber and eddy-covariance fluxes, and Century/DayCent SOM modeling while treating porewater O2 contamination and nitrification-denitrification coupling errors as first-class failure modes.

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Think and work like an expert Atmospheric Scientist. Use when a task calls for Atmospheric Scientist judgment. Reasons from scale-dependent balances, Ertel PV on isentropic surfaces, and closed moisture/energy budgets through PV/omega/Q-vector diagnostics, reanalyses (ERA5, MERRA-2) and WRF/MPAS/CMIP runs, and obs validation (GRUAN sondes, IMERG, CERES), while treating reanalysis assimilation increments, retrieval biases, parameterized-vs-resolved convection, and internal-variability masking of forced trends as first-class failure modes.

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Think and work like an expert Audiologist. Use when a task calls for Audiologist judgment. Reasons from auditory transduction, site-of-lesion localization, audibility, and noise dose-response through calibrated pure-tone/masking audiometry, immittance, OAE and ABR/ASSR, and real-ear verification against NAL-NL2/DSL targets while treating unmasked cross-hearing, collapsed ear canals, transducer miscalibration, and non-organic loss as first-class failure modes.

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Think and work like an expert Analytical Chemist. Use when a task calls for Analytical Chemist judgment. Reasons from the chemical measurement process through ICH Q2(R2) and USP <621> validation, CRM traceability, EURACHEM uncertainty budgets, and HPLC/GC/LC-MS/ICP-MS workflows while treating matrix effects, SST drift, peak tailing, and ion suppression as first-class failure modes.

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Think and work like an expert Bayesian Statistician. Use when a task calls for Bayesian Statistician judgment. Reasons from Bayes' rule, coherent uncertainty, exchangeability, and partial-pooling hierarchy through Stan/PyMC HMC-NUTS fits, prior and posterior predictive checks, PSIS-LOO, and SBC calibration while treating divergent transitions and funnels, weak identifiability and label switching, improper posteriors, and post-hoc prior tuning as first-class failure modes.

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Grounded in first principles, rigorously examine and refine a user's plan, task, decision, goal, strategy, proposal, or idea through structured, progressively deeper questioning, in order to bridge the gap between the User and the Agent. Use when the user explicitly requests grilling, challenge, pressure-testing, cross-examination, red-team review, pre-mortem analysis, or a decision audit. The goal is to uncover unclear objectives, hidden assumptions, contradictions, weak evidence, missing information, overlooked constraints, dependencies, risks, trade-offs, failure modes, and misalignment between intended outcomes and likely real-world results. Begin by establishing a shared understanding of the user's actual intent, goals, constraints, and success criteria. Ask focused, high-leverage questions rather than broad or repetitive ones. Adapt each question based on previous answers, probing deeper where uncertainty, unsupported assumptions, or strategic weaknesses remain. Regularly summarize the current understanding of the user's intent and position to confirm alignment, expose misunderstandings, and refine the problem or goal definition. Distinguish facts, assumptions, hypotheses, and unknowns. Challenge reasoning rigorously while remaining constructive, respectful, and solution-oriented. Continue until the reasoning is internally coherent, evidence-aware, constraint-conscious, risk-assessed, and translated into a clearer, more actionable goal, decision, or plan. Ultimately, achieving the super-alignment.

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Search tweets, analyze trends, monitor users, and gather social intelligence from Twitter/X through SandBase. Use when asked for Twitter research, social listening, trend analysis, influencer monitoring, sentiment tracking, or competitor social intelligence.

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Research any domain with WHOIS data, DNS records, SSL certificate details, domain age, reputation scoring, and security header analysis. Covers ownership research, infrastructure mapping, security assessment, and competitive domain analysis.

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Search content, analyze profiles, track hashtags, and research competitors on Instagram through SandBase. Use when asked for Instagram research, influencer analysis, hashtag tracking, content strategy research, or competitor social monitoring.

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Discover and evaluate KOLs (Key Opinion Leaders) and creators across TikTok, Instagram, YouTube, and Xiaohongshu through SandBase. Use when asked for influencer research, creator outreach lists, KOL evaluation, or partnership prospecting.

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Analyzes cfDNA fragment size distributions and fragmentomics features using FinaleToolkit or Griffin. Extracts nucleosome positioning patterns, fragment ratios, and DELFI-style fragmentation profiles for cancer detection. Use when leveraging fragment patterns for tumor detection or tissue-of-origin analysis.

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End-to-end pooled and single-cell CRISPR screen analysis from FASTQ to hit genes. Orchestrates library design QC, guide counting, six-stage screen QC (plasmid Gini, replicate Pearson, CEGv2 PR-AUC, copy-number artifact), method-appropriate hit calling across MAGeCK RRA/MLE, BAGEL2, drugZ, JACKS, and Chronos, cancer-cell-line copy-number correction (CRISPRcleanR / Chronos), batch correction for multi-batch screens, and the specialized branches for combinatorial paralog screens, single-cell Perturb-seq, base-editor variant-function screens, prime-editor screens, and in vivo bottleneck-aware screens. Use when analyzing any pooled CRISPR screen end-to-end, choosing the correct hit-calling method by experimental design, integrating copy-number correction into the pipeline, or branching the workflow for single-cell, combinatorial, base-editor, prime-editor, or in vivo variants.

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Reconstruct ancestral states at internal phylogenetic nodes for sequences (PAML codeml, IQ-TREE --ancestral, GRASP, FastML), discrete traits (corHMM hidden-rate Markov, ape::ace, phytools::make.simmap stochastic mapping, BayesTraits), and continuous traits (phytools::fastAnc, geiger Brownian/OU, RPANDA). Use when designing constructs for ancestral protein resurrection, tracing trait evolution along a tree, performing stochastic character mapping, testing models of trait evolution (BM vs OU vs EB), inferring ancestral genome content via Dollo or DTL reconciliation, or quantifying ancestral-state uncertainty for downstream comparative analyses.

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Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

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Trim PCR primers from aligned reads in amplicon-panel BAMs using samtools ampliconclip. Use when processing SARS-CoV-2 ARTIC, hereditary cancer panels, ctDNA hot-spot panels, or any amplicon assay where primer-derived bases would falsely confirm reference at primer footprints.

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Predicts ADMET properties using ADMETlab 3.0 (119 endpoints with uncertainty), ADMET-AI, DeepChem MolNet, and chemprop D-MPNN with explicit handling of OECD QSAR principles, applicability domain assessment, calibration, hERG/CYP/AMES gold-standard endpoints, and PAINS / Lipinski / Ro5 / Veber / BBB druglikeness filters. Use when filtering compounds for drug-likeness, prioritizing leads by predicted safety, or building an in-house ADMET QSAR model.

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Applies ACMG/AMP 2015 framework with ClinGen SVI specifications, Tavtigian 2018/2020 Bayesian point system, Abou Tayoun 2018 PVS1 decision tree, Pejaver 2022 calibrated PP3/BP4 thresholds for REVEL/BayesDel/AlphaMissense, Brnich 2020 PS3/BS3 OddsPath, Walker 2023 SpliceAI splicing framework, and AMP/ASCO/CAP 2017 tumor tiers. Use when classifying germline variants P / LP / VUS / LB / B, applying VCEP-specific CSpec rules, computing Whiffin BS1, or assigning cancer Tier I-IV per Li 2017.

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Kaggle-first end-to-end competition workflow for scored submissions. Use when Codex must run Kaggle or competitive ML workflows through scored submission, including code competitions, validation, metrics, policy-safe public notebook/discussion intel, tabular/text/image modeling, tuning, ensembling/stacking, proactive multi-notebook architectures, producer notebooks that train models and export private Kaggle artifact datasets, downstream consumer notebooks, Kaggle GPU offload, kagglehub access, hidden-test debugging, and public score retrieval.

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Use when an AI tutor session concerns MATLAB programming concepts, MATLAB syntax, MATLAB errors, MATLAB code style, MATLAB projects, or MATLAB toolbox workflows.

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Break a plan, spec, or the current conversation into a set of tracer-bullet tickets, each declaring its blocking edges, published to the configured tracker (edges as text in one file per ticket locally, or native blocking links on a real tracker).

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End-to-end testing of email-dependent flows — signup confirmation, password reset, magic-link login, OTP/MFA codes, and notification emails. Covers the capture-inbox decision tree (Mailpit, Mailosaur, MailSlurp, Ethereal), Playwright polling without fixed sleeps, regex extraction of links/OTPs from the email body, deterministic per-test addresses (plus-addressing, per-inbox), subject/from/header/link assertions, and SPF/DKIM/DMARC deliverability checks as a separate suite. Use when: "test the signup confirmation email," "password reset email test," "magic-link login test," "capture OTP from email," "Mailpit," "Mailosaur," "MailSlurp," "email arrives flaky in CI," "assert email subject/from/links." Not for: Sending transactional email from your app code, or API-only contract tests of an email provider — those are api-testing / app concerns. Email HTML rendering across clients (Outlook/Gmail dark mode) is out of scope (note it as a gap; use visual-testing or Litmus). Related: playwright-automation, api-testing, test-data-management, qa-project-context.

日本語の概要は準備中です。原文の説明を表示しています。

Cerate or Update a GitHub Issue for each Module in the task document.

日本語の概要は準備中です。原文の説明を表示しています。

Cerate or Update a GitHub Issue for each Task in the task document.

日本語の概要は準備中です。原文の説明を表示しています。