「logic」の検索結果

Analyzes CUT&RUN (Skene Henikoff 2017) and CUT&Tag (Kaya-Okur 2019) chromatin profiling data. Handles SEACR vs MACS2 peak calling (with the btaf375 2025 benchmark guidance), pA-MNase vs pA-Tn5 vs pAG-Tn5 chimera differences, E. coli spike-in carryover normalization, IgG-only control logic (no input), characteristic fragment-size signatures (25-75 bp for CUT&Tag), and lower depth requirements (5M reads typical vs 25M for ChIP). Use when calling peaks from CUT&RUN/CUT&Tag, scaling by E. coli spike-in carryover, choosing SEACR norm mode, or comparing CUT&RUN/Tag results to traditional ChIP.

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Runs cis-pQTL Mendelian randomization for drug-target validation using UKB-PPP (Olink), deCODE (SomaScan), Fenland, INTERVAL, ARIC, and FinnGen-PPP proteomes plus colocalization triangulation, phenome-wide on-target adverse-effect scans, cross-platform Olink/SomaScan replication, and PAV (protein-altering variant) sensitivity. Use when nominating or de-risking a drug target from plasma-proteome GWAS, mimicking pharmacological inhibition via cis-pQTL instruments, separating shared-causal from LD-confounded signal under the Schmidt 2020 cis-MR framework, screening on-target adverse phenotypes pheWAS-style, or producing publication-grade STROBE-MR plus PP.H4 evidence for a target gene.

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Visualizes ChIP-seq data using deepTools (computeMatrix, plotHeatmap, plotProfile, bamCoverage, bamCompare), pyGenomeTracks (modern INI-driven track plots), Gviz (R browser-style), EnrichedHeatmap (ComplexHeatmap-based), ChIPseeker tag heatmaps, and IGV batch screenshots. Handles bigWig normalization choices (CPM, BPM, RPGC, spike-in scaled), bamCompare operations (log2 ratio, subtract) with SES scaling, k-means clustering of heatmaps for biological subgrouping, and spike-in-scaled tracks for global-shift experiments. Use when generating publication-quality ChIP-seq signal heatmaps, profile plots, genome-browser tracks, or comparing samples visually.

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Download large datasets from NCBI efficiently using EPost, history server, batching, rate limiting, and retry logic. Use when bulk-fetching tens of thousands of sequences, pulling all results of a large ESearch, designing reproducible pipelines, comparing E-utilities to NCBI Datasets v2 CLI, or implementing checksum-validated downloads. Encodes WebEnv TTL (~8h), EPost 200-ID limit, retmax caps, parallelization design, and integrity verification.

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Performs a structured pre‑prescription evaluation of mental/psychological status, prior diabetes self‑care adherence, willingness/interest in CSII, and availability for follow‑up visits. Triggers include: 'Evaluating pump candidacy', 'Pre‑pump checklist: psych, adherence, motivation, follow-up'.

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Recommends initiating intravenous bisphosphonate or denosumab for adults with hypercalcemia of malignancy compared with no treatment. Use when a clinician asks about first‑line pharmacologic therapy for HCM or when deciding to start antiresorptive agents.

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Educates patients with primary adrenal insufficiency on increasing glucocorticoid dosage during intercurrent illness, fever (≥38°C), or physiological stress, including recognition of precipitating symptoms (e.g., fever, vomiting, trauma) and actions to prevent impending adrenal crisis. Trigger phrases: fever, intercurrent illness, stress, vomiting, inability to tolerate oral meds, need for parenteral glucocorticoid.

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Select the right treatment tier for a child with obesity — behavioural, pharmacologic, or surgical — using the CMAJ 2025 pediatric obesity guideline. Trigger when a clinician asks what to do for a child with obesity, which intervention to start, whether to escalate treatment, or when to consider medication or surgery for pediatric obesity.

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Derive an execution roadmap from a project's vision/spec docs by first principles, then diff that fresh derivation against the existing roadmap to prove the task ORDER is correct. Use this whenever the user wants to review, validate, re-derive, or sanity-check an execution roadmap or delivery plan; asks whether the tasks/epics are "in the right order"; suspects a task is scheduled before its prerequisite (a producer-after-consumer / dependency-inversion error like "OpenAPI after the web client that consumes it", OR a cross-cutting inherited default like observability/auth/tenancy scheduled after the feature work that inherits it — a seam-after-consumer error); wants to find missing tasks, circular dependencies, or over-fragmented epics; or wants to compact a plan to raise velocity. Also trigger on "review the roadmap", "re-derive the plan from the spec", "is this the right build order", "check the dependency graph of our epics", "which task should come first". It reads the vision + spec corpus, decomposes actors → use-cases → modules → epics → typed tasks, identifies cross-cutting inherited-default seams, builds a real dependency graph with hard + soft (seam) edges (deterministic helper), breaks cycles, topologically orders, compacts, and emits a derived roadmap PLUS a delta report against the current one — it never blindly overwrites a hand-crafted roadmap.

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Multi-angle review of responses before delivery. Audits from 4 perspectives -- factual accuracy, logical consistency, completeness, and safety. Use for high-stakes responses where errors have real consequences.

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Master TypeScript's advanced type system including generics, conditional types, mapped types, template literals, and utility types for building type-safe applications. Use when implementing complex type logic, creating reusable type utilities, or ensuring compile-time type safety in TypeScript projects.

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Use for lateral thinking, or when ideas feel stuck or incremental: "we've tried everything", "need a surprising angle", "break the pattern", "give me a wild idea that could work". Uses provocations and reframes. Skip for rule lookups or strict logical proofs.

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Build a throwaway prototype to flush out a design before committing to it. Routes between two branches — a runnable terminal app for state/business-logic questions, or several radically different UI variations toggleable from one route. Use when the user wants to prototype, sanity-check a data model or state machine, mock up a UI, explore design options, or says "prototype this", "let me play with it", "try a few designs".

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Subjects every non-trivial decision to a fresh-context adversarial review before it stands. Use when correctness matters more than speed, when working in unfamiliar code, when stakes are high (production, security-sensitive logic, irreversible operations), or any time a confident output would be cheaper to verify now than to debug later.

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Drives development with tests. Use when implementing any logic, fixing any bug, or changing any behavior. Use when you need to prove that code works, when a bug report arrives, or when you're about to modify existing functionality.

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Review changed code for YAGNI, removable over-complexity, reuse, code quality, and efficiency, then apply worthwhile simplifications. Use when the user asks to simplify, clean up, tighten, de-hack recent changes, identify logic that can be dropped, or review whether added safeguards and edge-case handling are actually needed.

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Explains code in plain language for someone unfamiliar with the programming language. Use when asked to explain code, walk through logic, describe what a function does, or when the user says "explain this" or "walk me through this".

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Generic ad-hoc topic search across CopilotKit + AG-UI Discord/GitHub. "Find all reports about <topic> in the last <N> days." Returns a structured chronological list with reporter handles + 1-line summaries + optional enterprise enrichment. Triggers on "find all reports about", "search across both communities", "look for X in last N days".

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*An ecological skill for sustaining care, presence, and imagination across long horizons*.

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Expert-level VLSI design covering CMOS logic, custom layout, standard cell design, physical design flow, DRC, LVS, and advanced process nodes.

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Expert-level biophysics covering single molecule techniques, membrane biophysics, protein mechanics, motor proteins, ion channels, and biological imaging methods.

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Expert-level general relativity knowledge. Use when working with curved spacetime, Einstein field equations, geodesics, black holes, gravitational waves, cosmology, Schwarzschild metric, or tensor calculus. Also use when the user mentions 'Einstein field equations', 'curved spacetime', 'geodesic', 'black hole', 'event horizon', 'Schwarzschild', 'gravitational waves', 'spacetime curvature', 'Riemann tensor', 'metric tensor', 'cosmological constant', or 'gravitational lensing'.

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Split the most recent git commit into multiple logical commits without interactive rebase. Use when invoked as `$git-split` or when the user asks to split HEAD into smaller commits.

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Build a throwaway prototype to answer a design question. Use when the user wants to sanity-check whether a state model or logic feels right, or explore what a UI should look like.

日本語の概要は準備中です。原文の説明を表示しています。