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Normalizes and transforms RNA-seq count matrices for DE, visualization, clustering, and ML. Covers between-sample (TMM, TMMwsp, RLE/median-of-ratios, upper quartile), within-sample (TPM, FPKM/RPKM), variance-stabilizing (VST, rlog, log-CPM), GC-content correction (cqn, EDASeq), and single-cell (scran deconvolution, scanpy normalize_total). Encodes the composition-bias rationale, the "most genes not DE" assumption and its catastrophic failure modes (MYC amplification, apoptosis, viral host shutoff, prokaryotic stress), the "lengthScaledTPM is not TPM" naming trap, the "TPM is not for DE" rule, the blind=TRUE vs FALSE decision, ERCC spike-in normalization (SBN), and the single-cell zero-inflation breakdown of TMM/RLE. Use when choosing or applying normalization, debugging shifted-MA-plot diagnostics, handling zero-heavy single-cell data, or correcting GC bias.

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Use when a driver has been involved in a crash — regardless of preventability or injury — and the carrier needs to handle the immediate, post-investigation, and return-to-work phases. Covers trauma response, post-accident testing under 49 CFR 382.303, paid time off, retraining, light duty, and re-entry planning.

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Use when a carrier asks how to calculate cost-per-mile (CPM) at the fleet, truck, lane, or driver level — separating fixed vs variable costs, allocating overhead, accounting for empty miles, and using CPM to negotiate rates, build pricing tiers, or evaluate lane profitability.

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Schema design, normalization decisions, indexing strategies, and migration safety for relational databases. Use when designing tables, choosing between normalize vs denormalize, selecting index types, planning zero-downtime migrations, or setting up connection pooling. Activate on "schema design", "normalization", "denormalization", "foreign key", "index strategy", "migration", "connection pooling", "composite key", "surrogate key", "soft delete", "polymorphic association". NOT for PostgreSQL-specific query tuning or EXPLAIN analysis (use postgresql-optimization), NoSQL or document database design, or cloud database provisioning.

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Identify and counteract cognitive biases in medical decision-making through systematic error analysis and contextual algorithm application. For diagnostic reasoning, treatment decisions, and clinical judgment improvement. NOT for basic medical knowledge, technical procedures, or non-clinical healthcare domains.

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Design and build mathematically rigorous, high-density, interactive data graphics and streaming telemetry visualizations following Mike Bostock's D3.js and Observable methodologies. Use when crafting custom SVG/Canvas charts, reactive streaming time-series, multi-dimensional brush-and-link coordinates, small multiples, or topological swarm graphs. NOT for generic dashboard template clones, basic spreadsheet charts, or off-the-shelf low-effort wrapper libraries.

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Safety-case design for always-on agents with episodic memory. Covers data hygiene, privacy and security risk surfaces, cost controls, scope, user dependency concerns, retention, incident containment, and responsible deployment evidence. It identifies hazards and asks for named controls, tests, owners, and residual uncertainty; it does not provide legal, clinical, youth-safety, or jurisdictional determinations. Activate on: "agent safety", "always-on agent privacy", "agent cost control", "persistent agent risks", "AI companion safety", "agent data hygiene", "runaway agent costs", "parasocial AI risk", "/always-on-agent-safety". NOT for: architecture design (use always-on-agent-architecture), input design (use always-on-agent-inputs), application brainstorming (use always-on-agent-applications), healthcare compliance specifically (use hipaa-compliance).

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Design and audit a pricing function for variable-cost agent labor. Choose among per-seat, metered, credits, hybrid, and outcome pricing; name buyer value and cost metrics separately; calculate a reproducible cost floor; require pre-commitment guardrails; and stress-test declared personas. Use for offline pricing-design evidence, not billing implementation or runtime control. NOT for production billing, payment collection, or runtime spend enforcement.

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PostgreSQLデータベースパターン — クエリ最適化、スキーマ設計、インデックス作成、セキュリティ。Supabaseベストプラクティスに基づく。

Preview Convex spend — rank functions by bytes/documents-read × call-volume from insights, project each cost driver's growth curve, name the cheapest fix; confirm-cost for paid actions.

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Находит точную причину повторного падения процессов сервера 1С в Linux: SIGABRT, технологический журнал, core dump, GDB, C++-исключения и проверка причины. Используйте, когда rphost, ragent или rmngr исчезает, становится zombie, завершается сигналом 6 или оставляет core.

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Azure PostgreSQL Flexible Server SDK for .NET. Database management for PostgreSQL Flexible Server deployments.

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Connect to Azure Database for PostgreSQL Flexible Server from Node.js/TypeScript using the pg (node-postgres) package.

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Comprehensive AWS cost analysis and optimization recommendations using AWS CLI and Cost Explorer

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在PostgreSQL中格式化数字显示，去除小数点后的尾随零，并在小数点后无数字时去除小数点。

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使用Boost.Asio库编写C++网络组件（服务端、客户端、拆包类），要求封装为类、运行在独立线程并使用异步IO操作。

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Azure DevOps pull requests, for repos whose git remote is on dev.azure.com or *.visualstudio.com. Covers comment threads, which `az repos pr` cannot read or post. Use to create a PR for the current branch, check out, list or complete PRs, post code comments on a PR, reply to threads, and assess whether review feedback was addressed. Trigger on "create PR", "checkout PR 123", "list PRs", "complete PR", "comment on the PR", "post these review findings", "check PR feedback", "/dev-azdo:pr".

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Creates an integration testing plan for .NET data access artifacts during Oracle-to-PostgreSQL database migrations. Analyzes a single project to identify repositories, DAOs, and service layers that interact with the database, then produces a structured testing plan. Use when planning integration test coverage for a migrated project, identifying which data access methods need tests, or preparing for Oracle-to-PostgreSQL migration validation.

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Migrates Oracle PL/SQL stored procedures to PostgreSQL PL/pgSQL. Translates Oracle-specific syntax, preserves method signatures and type-anchored parameters, leverages orafce where appropriate, and applies COLLATE "C" for Oracle-compatible text sorting. Use when converting Oracle stored procedures or functions to PostgreSQL equivalents during a database migration.

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Discovers all projects in a .NET solution, classifies each for Oracle-to-PostgreSQL migration eligibility, and produces a persistent master migration plan. Use when starting a multi-project Oracle-to-PostgreSQL migration, creating a migration inventory, or assessing which .NET projects contain Oracle dependencies.

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Creates structured bug reports for defects found during Oracle-to-PostgreSQL migration. Use when documenting behavioral differences between Oracle and PostgreSQL as actionable bug reports with severity, root cause, and remediation steps.

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Defensive triage skill for OpenClaw, Hermes Agent, host integrity, and OpenClaw skill-supply-chain scanning. Detects prompt injection, session drift, context overflow, host anomalies, and unsafe skills while keeping actions bounded and auditable.

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You are a cloud cost optimization expert specializing in reducing infrastructure expenses while maintaining performance and reliability. Analyze cloud spending, identify savings opportunities, and implement cost-effective architectures across AWS, Azure, and GCP.

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Complete guide for xUnit test output and logging. Use when you need to implement test output, diagnostic logging, or ILogger alternatives in xUnit tests. Covers ITestOutputHelper injection, AbstractLogger pattern, structured output design. Includes XUnitLogger, CompositeLogger, performance test diagnostic tool implementations. Keywords: ITestOutputHelper, ILogger testing, test output xunit, test output, test logging, AbstractLogger, XUnitLogger, CompositeLogger, testOutputHelper.WriteLine, test diagnostics, logger mock, test log, structured output, Received().Log

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