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概要と使いどころ
Identify likely causal variants within GWAS loci using SuSiE for sum of single effects regression and FINEMAP for shotgun stochastic search. Computes posterior inclusion probabilities and credible sets to prioritize variants for functional follow-up. Use when narrowing GWAS association signals to candidate causal variants or building credible sets for functional validation.
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Query BindingDB for measured drug-target binding affinities (Ki, Kd, IC50, EC50). Search by target (UniProt ID), compound (SMILES/name), or pathogen. Essential for drug discovery, lead optimization, polypharmacology analysis, and structure-activity relationship (SAR) studies.
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Test whether two traits share a causal variant at a genomic locus using Bayesian colocalization with coloc. Computes posterior probabilities for shared vs distinct causal variants between GWAS and eQTL signals. Use when determining if a GWAS signal and an eQTL share the same causal variant.
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Predicts ADMET properties using ADMETlab 3.0 API or DeepChem models. Estimates bioavailability, CYP inhibition, hERG liability, and 119 toxicity endpoints with uncertainty quantification. Filters for PAINS and other structural alerts. Use when filtering compounds for drug-likeness or prioritizing leads by predicted safety.
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Apply Robert C. Martin-inspired clean code rules when improving readability, naming, function design, responsibilities, or testable everyday code.
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Autonomously screen NYSE, Nasdaq, and NYSE American operating-company stocks for undervalued-growth/GARP opportunities using forward same-basis valuation, driver-derived EPS/FCF forecasts, primary-source financial verification, SBC and dilution controls, sector and cycle normalization, auditable candidate-pool coverage, and fail-closed final reporting. Use when asked to find, screen, rank, or refresh US undervalued-growth stocks, including minimal requests with no ticker list or parameters.
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Record and analyze post-trade outcomes for signals generated by edge pipeline and other skills. Track false positives, missed opportunities, and regime mismatches. Feed results back to edge-signal-aggregator weights and skill improvement backlog.
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Build and maintain a Stockbee-style daily 20% mover study for US equities by scanning +20%/-20% movers, classifying catalysts and setup context, updating forward outcomes, and summarizing cohort patterns. Use when the user asks to run a daily 20% study, backfill historical 20% movers, find recurring edge patterns, or build a model book of explosive market moves.
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Screen US stocks for high-quality dividend opportunities combining value characteristics (P/E ratio under 20, P/B ratio under 2), attractive yields (3% or higher), and consistent growth (dividend/revenue/EPS trending up over 3 years). Supports two-stage screening using FINVIZ Elite API for efficient pre-filtering followed by FMP API for detailed analysis. Use when user requests dividend stock screening, income portfolio ideas, or quality value stocks with strong fundamentals.
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Screen US equities for parabolic exhaustion patterns and generate conditional pre-market short plans, then evaluate intraday trigger fires from live 5-min bars. Phase 1 daily 5-factor scorer (MA extension / acceleration / volume climax / range expansion / liquidity), Phase 2 per-candidate plans for ORL break / first-red 5-min / VWAP fail with explicit borrow / SSR / manual-confirmation gating, Phase 3 one-shot intraday FSM that detects trigger fires and resolves concrete share counts. Covers Phase 1 + Phase 2 + Phase 3.
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Use this skill to find high-quality dividend growth stocks (12%+ annual dividend growth, 1.5%+ yield) that are experiencing temporary pullbacks, identified by RSI oversold conditions (RSI ≤40). This skill combines fundamental dividend analysis with technical timing indicators to identify buying opportunities in strong dividend growers during short-term weakness.
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Reviews code diffs and files for security vulnerabilities (OWASP Top 10), error handling, complexity, naming conventions, and performance issues. Use when the user asks to review a PR, pull request, diff, merge request, or code changes.
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Searches the SkillsMP registry, installs skills locally or globally, creates custom skills with SKILL.md frontmatter, and manages the skill lifecycle. Use when the user wants to find skills, add new capabilities, install a skill, browse available skills, create a custom skill, or manage the skills system.
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Use when the user asks to "find content gaps", "竞品写了什么", or "还应该写什么"; builds a competitor-relative coverage map of missing topics, keyword gaps, and editorial-calendar opportunities. Not for raw keyword demand discovery — use keyword-research. 内容缺口/选题规划
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Use when the user asks to "analyze the SERP" or "SERP分析"; maps SERP features, layout, ranking factors, search intent, AI Overviews, and snippet opportunities for a query. Not for keyword demand discovery — use keyword-research. SERP分析/搜索结果
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Use when the user asks to "build a media list for my launch", "write a launch press release", or "pitch press under embargo"; produces a three-tier media and analyst list (Tier 1 exclusive candidates, Tier 2 vertical press, Tier 3 communities and newsletters), an embargo pitch timing skeleton keyed to the launch-registry date, a press-release draft in standard structure with no fabricated quotes or numbers, and an analyst briefing outline. Not for press-kit assets — use launch-asset-packager; not for follow-up sequence mechanics — use outreach-manager; not for post-launch news-echo monitoring — use launch-monitor. 媒体名单/禁运期pitch/新闻稿/分析师简报
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Use when the user asks to "launch on Product Hunt / Hacker News", "prepare community or directory launch submissions", or "plan the launch submission waves"; produces per-platform submission packages — a Product Hunt tagline / gallery / first-comment skeleton, a factual Show HN title and text, per-subreddit posts with a self-promotion rules table, tiered directory waves, and a regional channel matrix including Chinese communities — plus a platform red-line check (never solicit votes or organize voting rings) and T-0 submission-status lines for the launch registry. Not for paid amplification — use content-amplifier; not for creator channels — use campaign-planner; not for launch telemetry readouts — use launch-monitor; not for ongoing community presence or pre-launch karma-building outside the launch window — use participation-warmup-planner. 社区发布/PH提交包/Show HN/目录波次/平台红线/中文渠道
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Use when the user asks to "optimize entity presence", reconcile an entity identity, or update canonical Knowledge Graph facts; audits and maintains machine-facing identity, sameAs, schema, disambiguation, and AI-recognition evidence through the entities registry. Not for page-level AI-citation readiness - use geo-content-optimizer; not for human-facing brand canon - use narrative-registry. 实体注册/知识图谱
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Apply modern web development best practices for security, compatibility, and code quality. Use when asked to "apply best practices", "security audit", "modernize code", "code quality review", or "check for vulnerabilities".
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Identify, score, and prioritise design opportunities against impact and effort. Use when there are more ideas than capacity. For framing the one you choose, use `design-brief`.
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Build animations in React Native and Expo, making the decisions in the order that determines whether they feel right — should it animate, which thread it runs on, which properties, spring or timing, how the gesture hands off, how it degrades. Writes the implementation with Reanimated, Gesture Handler, Expo Router and expo-haptics. Use when animating anything in an Expo app, adding gestures, sheets, screen transitions, press feedback or haptics, or fixing motion that stutters on device. For web animation use `animate`.
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Run an AWS Security Agent penetration test against a live web application — registers and verifies the target domain, exercises the supplied endpoints with the managed Security Agent service, and returns verified runtime findings. Use when the user asks to pentest, run a penetration test, test their app's attack surface, find runtime vulnerabilities, register or verify a target domain, or check pentest status / findings.
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Entry point for AI-agent work on AWS: pick a runtime, plan a migration for existing workloads, and build an executable POC — one phased flow. Triggers on: which runtime for my agent, AgentCore vs ECS vs EKS vs Lambda, AgentCore vs Lambda MicroVMs, deploy an AI agent on AWS, agent architecture on AWS, I have an agent idea what do I build, move/migrate my agents to AWS, agent migration plan, add AgentCore services (memory, gateway, identity, policy, observability) to an agent already on AWS, Temporal on AWS (migrate/run Temporal workers on AWS, a service orchestrated by Temporal, Temporal Cloud vs self-hosted). Temporal Workflow code is never rewritten into Step Functions. Requires at least one agentic component — a purely non-agent system (plain services, batch jobs, HTTP endpoints, non-agent Temporal Activities) is out of scope, redirected to gcp-to-aws / heroku-to-aws / llm-to-bedrock. Not for: compute/data migration with no AI agent; pure LLM SDK rewrite (use llm-to-bedrock); per-model pricing.
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Use when a developer wants to create a new agent project or get started with AgentCore. Handles framework selection, project scaffolding, first deploy, and first invocation. Triggers on: "build an agent", "create an agent", "get started", "new project", "agentcore create", "which framework", "Strands vs LangGraph", "hello world agent", "first agent", "create MCP server", "host MCP server", "agentcore dev", "dev server", "what port", "local development". Not for adding capabilities to existing projects — use agents-build or agents-connect. Strands vs LangGraph in a migration context routes to agents-build, not here. Connecting to an existing MCP server routes to agents-connect, not here.
日本語の概要は準備中です。原文の説明を表示しています。