255 件 ・ 関連度順
概要と使いどころ
Searches molecular libraries for substructure matches using SMARTS patterns with explicit handling of recursive SMARTS, ring membership, aromaticity dialect, vector binding, atom map indices, and reactive/PAINS/REOS/Brenk filter catalogs. Use when filtering compounds by pharmacophore features, functional groups, scaffold matches, or screening for assay-interference / structural alerts.
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Performs molecular similarity searching using Tanimoto, Tversky, Dice, and cosine coefficients on bit/count fingerprints with explicit choice rules for symmetric vs asymmetric measures, scaffold-hopping vs lead-optimization regimes, activity-cliff diagnosis, and large-library nearest-neighbor methods (BulkTanimoto, MHFP6 LSH forest, USRCAT). Use when ranking compounds by structural resemblance to a query, clustering libraries, finding analogs, or diagnosing activity cliffs.
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Performs 3D shape-based similarity searching using ROCS (OpenEye), USRCAT (ultra-fast), Open3DAlign (RDKit), ESPSim (electrostatic), and ShaEP with explicit handling of Tanimoto-Combo (shape + color), shape vs ECFP4 complementarity, conformer-ensemble searching, alignment optimization, and scaffold hopping. Use when searching for shape-mimicking compounds with different scaffolds, identifying bioisosteric replacements, prospective scaffold hopping, or expanding hit series beyond 2D similarity.
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React composition patterns that scale. Use when refactoring components with boolean prop proliferation, building flexible component libraries, or designing reusable APIs. Triggers on tasks involving compound components, render props, context providers, or component architecture. Includes React 19 API changes.
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Codify a successful workflow from the current conversation into a permanent project-local skill. After you discover (e.g.) a cold-email sequence that converts, an ad-creative format that beats baseline, or a content-pipeline cadence that compounds — /money-skillify writes it as a SKILL.md under the project's local skills directory so future sessions can re-invoke it without re-discovery. Use when the user says: 'this worked, save it', 'codify this', 'turn this into a skill', '把这个固化下来', '存成 skill'.
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A platform decision framework for experimentation. When to use Statsig vs PostHog vs GrowthBook vs Optimizely vs Amplitude vs Eppo vs Kameleoon. How to migrate between them. How to coordinate when multi-platform is genuinely warranted. The decisions that compound for years and the ones you can defer. Triggers on which experimentation platform, choose Statsig vs PostHog, evaluate experimentation tools, switch experimentation platform, migrate from Optimizely, consolidate experimentation tools, multi-platform experimentation, experimentation platform decision, ab test platform selection, feature flag platform vs experiment platform, warehouse-native experiments, vendor lock-in experimentation. Also triggers when a team is asking about cost, governance, or migration cost across experimentation tools, or when an evaluation is starting.
日本語の概要は準備中です。原文の説明を表示しています。
Query PubChem for chemical compound and bioassay data
日本語の概要は準備中です。原文の説明を表示しています。
Cross-functional what-if modeling for compound adversity -- shows how one problem cascades into the next. Use when facing complex risk scenarios, strategic decisions with major downside, or multi-variable threats.
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MetaboCoreUtils defines metabolomics-related core functionality provided as low-level functions to allow a data structure-independent usage across various R packages. This includes functions to calculate between ion (adduct) and compound ma
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Use when a PERSONAL brand — founder, coach, or creator — needs a 12-month strategy: niche selection with Ikigai and a 3x3 matrix, positioning statement, a three-chapter story arc, four content pillars with 28 topics, a five-stage authority ladder, and a Q1 to Q4 growth plan. Trigger on 'personal brand strategy', 'founder brand plan', 'coach positioning', 'creator strategy', 'what niche should I own', 'I post constantly and nothing compounds'. Also use when the user has followers and no direction. Not for — a company brand, see `58-positioning-global` and `00-marketing-plan-global`; the context file this reads first, see `22-personal-brand-context-global`; turning it into revenue, see `27-personal-brand-monetize-global`.
日本語の概要は準備中です。原文の説明を表示しています。
React composition patterns that scale. Use when refactoring components with boolean prop proliferation, building flexible component libraries, or designing reusable APIs. Triggers on tasks involving compound components, render props, context providers, or component architecture. Includes React 19 API changes.
日本語の概要は準備中です。原文の説明を表示しています。
Run a portable sequential plan-work-verify-review-compound lifecycle. Use optional generic workers only when the runtime supports them.
日本語の概要は準備中です。原文の説明を表示しています。
Capture solved problems as searchable solution docs. Use after fixing bugs, when "that worked", or after successful /phx-review or /phx-investigate.
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Capture solved problems as searchable solution docs. Use after fixing bugs, when "that worked", or after successful /skill:phx-review or /skill:phx-investigate.
日本語の概要は準備中です。原文の説明を表示しています。
Searchable Elixir/Phoenix/Ecto solution documentation system with; Use when consulting past solutions…
日本語の概要は準備中です。原文の説明を表示しています。
Capture solved problems as searchable solution docs. Use after fixing bugs, when "that worked", or after successful…
日本語の概要は準備中です。原文の説明を表示しています。
Run a portable sequential plan-work-verify-review-compound lifecycle. Use optional generic workers only when Amp makes them available.
日本語の概要は準備中です。原文の説明を表示しています。
Capture solved problems as searchable solution docs. Use after fixing bugs, when "that worked", or after successful phx-review or phx-investigate.
日本語の概要は準備中です。原文の説明を表示しています。
Searchable Elixir/Phoenix/Ecto solution documentation system with YAML frontmatter. Builds institutional knowledge from solved problems. Use when consulting past solutions before investigating new issues.
日本語の概要は準備中です。原文の説明を表示しています。
Capture solved problems as searchable solution docs. Use after fixing bugs, when "that worked", or after successful /phx:review or /phx:investigate.
日本語の概要は準備中です。原文の説明を表示しています。
Autonomous skill lifecycle manager. Reviews skill-compounder drafts, promotes high-confidence patterns, merges duplicates, archives low-quality drafts. Zero manual review required - runs on every session start.
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Use when an agent needs to drive a real Chrome window via opencli — inspect a page, fill forms, click through logged-in flows, or extract data ad-hoc. Covers the selector-first target contract, compound form fields, stale-ref handling, network capture, and the agent-native envelopes the CLI returns. Not for writing adapters — see opencli-adapter-author for that.
日本語の概要は準備中です。原文の説明を表示しています。
Query ChEMBL's bioactive molecules and drug discovery data. Search compounds by structure/properties, retrieve bioactivity data (IC50, Ki), find inhibitors, perform SAR studies, for medicinal chemistry.
日本語の概要は準備中です。原文の説明を表示しています。
Capture solved problems as categorized documentation with YAML frontmatter for fast lookup
日本語の概要は準備中です。原文の説明を表示しています。