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Designs QTL colocalization studies that connect eQTL, pQTL, sQTL, or related molecular QTL signals with GWAS loci. Always use this skill whenever a user wants to plan, scope, or structure a locus-level study asking whether a GWAS association and a molecular QTL association may reflect the same underlying causal signal. Covers locus definition, QTL/GWAS source architecture, ancestry and LD alignment, single-locus vs multi-locus strategy, candidate-gene prioritization, optional fine-mapping, linked MR/SMR follow-up, and functional annotation. Always output four workload configurations (Lite / Standard / Advanced / Publication+) with a recommended primary plan, stepwise workflow, method rationale, evidence hierarchy, figure plan, minimal executable version, and strictly verified literature guidance with no fabricated references. Never equate colocalization with causality proof, mediation proof, or automatic target validation. Always include the mandatory Dataset Disclaimer immediately before any workflow section that mentions datasets, repositories, consortia, or public resources.

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Design evaluation datasets and supporting documentation for AI systems and agents, covering the scoping interview, difficulty distribution, dataset contract, sample review, and metric and tooling selection. Use when building or reviewing an evaluation set for a conversational agent, assistant, or retrieval-grounded AI system.

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Read and write Langfuse: browse traces and observations, list prompts and datasets, score traces, add dataset items. Trigger phrases: langfuse, llm observability.

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Use when packaging code, models, datasets, or media as ACM MM (ACM Multimedia) artifacts — building the anonymous review package versus the public release, and choosing between the Open Source Software Competition, the Dataset track, the Reproducibility track, and main-track supplementary evidence, each with its own blinding and expectations.

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Synthesize new waveforms from scratch for Simulink inports using createInputDataset. Use ONLY when the user asks to generate, create, or synthesize signals (step, ramp, sine, chirp, pulse, noise) to populate a Dataset for External Inputs or Signal Editor. Covers timeseries and timetable formats with correct data type, interpolation, units, and dimensions. Also covers function-call and trigger inport timing setup. Do NOT use when the user wants to load, import, or read existing data from files (MAT, CSV, spreadsheet) — even if that data will be used as model input. Do NOT use for running simulations or plotting outputs.

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Assigns pathogen lineages (SARS-CoV-2 Pangolin UShER mode; Nextclade clade + QC; pango-designation alias resolution) and tracks variant frequencies over time using Nextstrain (Augur + Auspice), wastewater deconvolution (Freyja, COJAC, alcov, lineagespot), lineage-fitness modelling (multinomial logistic), and recombinant detection (3SEQ, RDP4, Bolotie). Covers Pangolin pangolin-data and Nextclade dataset version pinning (mandatory; lineage-defining mutations change with dataset), Freyja barcode forward-only date constraint, ARTIC primer scheme churn (V3/V4/V4.1/V5.3.2/Midnight) with dropout regions, and recombinant X-prefix designation lag. Use when assigning Pango lineages and Nextclade clades to viral consensus sequences, building Nextstrain Augur surveillance pipelines, deconvolving wastewater into lineage frequencies with Freyja, tracking lineage frequencies over time, handling ARTIC primer dropouts, or running surveillance for SARS-CoV-2/influenza/Mpox/RSV/H5N1/measles.

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Download large datasets from NCBI efficiently using EPost, history server, batching, rate limiting, and retry logic. Use when bulk-fetching tens of thousands of sequences, pulling all results of a large ESearch, designing reproducible pipelines, comparing E-utilities to NCBI Datasets v2 CLI, or implementing checksum-validated downloads. Encodes WebEnv TTL (~8h), EPost 200-ID limit, retmax caps, parallelization design, and integrity verification.

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Use this skill to classify tabular data end-to-end in MATLAB — load a dataset, prepare and clean it, select promising classifiers, train them, and compare accuracies with cross-validation, holdout, or hyperparameter optimization plus statistical tests. TRIGGER when: user asks to classify tabular data, pick classifiers for a dataset, compare classifier accuracy, run cross-validation or a holdout evaluation, or find the best model with statistical uncertainty. DO NOT TRIGGER when: user has non-tabular inputs (images, sequences, time series), wants a regression model, is training a specific neural network architecture (use matlab-train-network), or wants cost-sensitive learning or an arbitrary class-prior vector (this skill only supports the built-in uniform-prior toggle for imbalanced data).

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Use when generated assets must keep a consistent style, character, or product look and references stop scaling, or when a user asks to train a custom model through the Scenario MCP, fine-tune a LoRA, clone a voice, curate a training dataset, choose a base model, set epochs and sample prompts, estimate training cost, diagnose a trained model that lost its identity or has one epoch, or generate with a trained model. Keywords: custom model, LoRA, dataset curation, epoch previews.

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Use when the user needs to design evaluation datasets, create test cases, stratify samples, generate adversarial examples, extract eval dimensions from traces/specs, or build a labeled evaluation set. Also use when the user mentions test data design, eval coverage, difficulty stratification, synthetic data generation for eval, or "how to create good evaluation data." Outputs datasets in OpenJudge-compatible format.

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A robust and outlier-aware method for testing differential tissue composition from single-cell data. This model can infer changes in tissue composition and heterogeneity, and can produce realistic data simulations based on any existing dataset. This model can also transfer knowledge from a large set of integrated datasets to increase accuracy further.

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Expert knowledge for Microsoft Planetary Computer Pro development including troubleshooting, decision making, limits & quotas, security, configuration, integrations & coding patterns, and deployment. Use when using GeoCatalog/STAC APIs, configuring collections/tiles, securing access, integrating QGIS/ArcGIS, or troubleshooting ingestion, and other Microsoft Planetary Computer Pro related development tasks. Not for Azure Maps (use azure-maps), Azure Open Datasets (use azure-open-datasets), Azure Data Explorer (use azure-data-explorer).

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Use this skill for Hugging Face Dataset Viewer API workflows that fetch subset/split metadata, paginate rows, search text, apply filters, download parquet URLs, and read size or statistics.

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Manage golden dataset regression tests for LLM prompts using Promptfoo. Commands — init, add, run, report. Use when user says "regression", "golden dataset", "prompt regression", "eval run", "test my prompts", or after shipping prompt changes.

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Read from a UModel object-graph semantic layer with the `umctl` CLI (MCP alternative noted). Three kinds of read: (1) entities & relationships / topology (`.entity`, `.topo`) and (2) the model itself (`.umodel`, and `.entity_set` methods, including entity-linked `list_skills`) return real rows; (3) metrics & logs (`get_metrics` / `get_logs`) return an executable *plan* — PromQL / Elasticsearch DSL with the entity id pre-substituted — that you run against the backend. Against a PaaS endpoint the same calls return data rows instead of a plan. Use to query or read UModel entities, relations, topology, or model metadata; to read a service's metrics or logs; to look up services and dependencies; or to discover what objects, datasets, and methods exist. For root-cause analysis on top of these reads, see the `umodel-rca` skill. Triggers: UModel, object graph, .entity / .topo / .umodel / .entity_set, query entities, read topology, read metrics / logs, get_metrics / get_logs, list services / dependencies / datasets / skills, 实体查询, 关系/拓扑查询, 读模型, 读指标, 读日志, 查指标, 查日志, 查服务依赖.

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End-to-end paper reproduction from arxiv URL through smoke runs to replication experiments. Handles missing or partial official code, missing training scripts, missing hyperparameters, and private datasets via similar-public-dataset substitution. Use when the user asks to reproduce, implement, replicate, or re-run a paper from scratch, or pastes an arxiv URL with reproduction intent.

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PyTorch-based ML platform for drug discovery: graph molecular representation learning, property prediction (ADMET, activity), retrosynthesis, drug-target interaction (DTI), and pretraining on large molecular datasets. Provides GNN layers (GraphConv, GAT, MPNN), pretrained models, and benchmark datasets.

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Use when evaluating a newly adapted model's accuracy/eval score. Runs evalscope eval (or the test/srt/run_eval.py fallback) against an OpenAI-compatible endpoint on datasets like gsm8k / aime, producing per-dataset reports and a score. Accuracy only — throughput/latency benchmarks belong to model-speed-benchmark. Triggers on accuracy, eval, evalscope, gsm8k, aime, run_eval — not throughput.

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Generate realistic synthetic data using Spark + Faker (strongly recommended). Supports serverless execution, multiple output formats (Parquet/JSON/CSV/Delta), and scales from thousands to millions of rows. For small datasets (<10K rows), can optionally generate locally and upload to volumes. Use when user mentions 'synthetic data', 'test data', 'generate data', 'demo dataset', 'Faker', or 'sample data'.

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Use when you must prove an analysis ran on the intended data or lock a dataset version. Builds a deterministic content-hash manifest (file SHA-256, schema, per-column value hashes), verifies later copies against it for drift, and diffs two manifests.

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Use DIG (Dive into Graphs) to load graph-learning datasets, run graph generation, self-supervised learning, GNN explainability, 3D graph learning, GOOD OOD datasets, graph augmentation, fair graph learning, and large-scale graph workflows.

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Use Argilla 2.x for human-feedback dataset annotation, Python SDK dataset workflows, server deployment/operations, webhooks, and legacy v1/Rubrix migration.

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Profile and explore datasets to understand their shape, quality, and patterns before analysis. Use when encountering a new dataset, assessing data quality, discovering column distributions, identifying nulls and outliers, or deciding which dimensions to analyze.

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Perform systematic exploratory data analysis to understand dataset structure, distributions, relationships, and anomalies before modeling. Use when a dataset is new, its quality is unknown, or the user requests open-ended profiling; use data-analysis instead for a defined hypothesis or decision question.

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