「dise」の検索結果

Apply the bioengineering, mechanobiology, and lymphatic transport reasoning of J. Brandon Dixon, professor of mechanical and biomedical engineering at Georgia Institute of Technology. Reach for this skill whenever analyzing lymphatic biomechanics, active vessel contractility versus passive drainage, peristaltic fluid transport, microfluidic organ-on-a-chip design, preclinical lymphedema models, non-invasive functional imaging, targeted nanomedicine delivery, or automated disease staging. Use this skill to critique bioengineering assumptions, guide quantitative protocol design, evaluate biomechanical pump failure, and formulate interdisciplinary biomedical solutions.

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Find the papers that answer a research query in Firecrawl's research paper index — a corpus of paper abstracts whose largest share is biomedical and life-science literature (PubMed, bioRxiv, medRxiv), alongside arXiv preprints in CS, physics, and math — using semantic search, semantic and structural expansion, and in-body verification. Use this skill for literature-finding and paper-retrieval tasks of any kind, including clinical, biomedical, drug, gene, disease, and other life-science questions, whether the answer is a single paper or a full multi-paper set. The index is reached only through the `firecrawl_research_*` MCP tools or the `firecrawl research` CLI subcommands. Calling `firecrawl_search` with its `categories` option set to `["research"]` is a different feature — it filters ordinary web search to research-affiliated websites (the list includes PubMed, bioRxiv, medRxiv, arXiv, and publisher sites) and returns page results from them, without querying the paper records in this index.

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Think and work like an expert Herpetologist. Use when a task calls for Herpetologist judgment. Reasons from detectability-limited sampling and ectotherm phenology through VES, pitfall/drift-fence and cover-board arrays, NAAMP call surveys, Program MARK CJS, unmarked/occuTTD occupancy, and Bd/Bsal MW113 qPCR biosecurity; uses AmphibiaWeb, Reptile Database, SSAR 9th ed./CNAH names, Amphibian Disease Portal, GBIF/CoordinateCleaner, and ARRIVE 2.0 while treating weather bias, pitfall selectivity, and pathogen cross-contamination as first-class failure modes.

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Think and work like an expert Astrobiologist. Use when a task calls for Astrobiologist judgment. Reasons from habitability, redox disequilibrium, and Bayesian biosignature frameworks through Mars (Perseverance, Viking perchlorate lessons), Europa Clipper ocean worlds, agnostic signatures and the Ladder of Life Detection, while treating abiotic mimics, preservation, and LUCA phylogenomics as constraints—not templates—for extraterrestrial life.

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Think and work like an expert Aquaculture Scientist. Use when a task calls for Aquaculture Scientist judgment. Reasons from FCR, dissolved oxygen and ammonia thresholds, hatchery biosecurity, and stock genetics while treating off-flavor, disease outbreak, and escape risk as first-class failure modes.

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Perform differential expression analysis of miRNAs between conditions using DESeq2 or edgeR with small RNA-specific considerations. Use when identifying miRNAs that change between treatment groups, disease states, or developmental stages.

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Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.

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Identify differentially bound regions across CLIP-seq conditions (knockdown vs control, treatment vs vehicle, disease vs healthy) using DEWSeq (sliding-window DESeq2), Flipper (Skipper-downstream), ASpeak, edgeR, or limma-voom. Use when computing condition-level changes in RBP binding intensity, choosing peak-level vs window-level vs crosslink-level testing, designing replicate experiments, or distinguishing biological binding shifts from technical confounders.

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Compare gene regulatory and co-expression networks between biological conditions to identify rewired regulatory relationships using DiffCorr. Detects gained, lost, and reversed gene-gene correlations between conditions. Use when comparing co-expression networks between disease vs control, treatment conditions, or developmental stages.

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Find and synthesize research papers, whitepapers, PDFs, technical reports, and academic sources with Firecrawl Research, using semantic paper search, related-paper expansion, and in-body verification over Firecrawl's paper index — largely biomedical and life-science literature from PubMed, bioRxiv, and medRxiv, plus arXiv preprints in CS, physics, and math. Use when the user wants a literature review, systematic review, survey of studies, paper summary, research landscape, or sourced synthesis from scholarly and industry publications, including clinical, drug, gene, disease, epidemiology, and public-health topics. Prefer this over a general web-research workflow whenever the evidence base is published papers rather than web pages.

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Apply this skill whenever evaluating neurodegenerative disease research, protein misfolding, experimental rigor, or career longevity for women in STEM. Use this to channel the thinking of Virginia M.-Y. Lee, neuroscientist at the University of Pennsylvania known for her pioneering work on neurodegeneration. Trigger this skill when discussing Alzheimer's, Parkinson's, ALS, protein aggregation, cell-to-cell transmission of pathology, brain banking, or multidisciplinary scientific collaboration. It is highly relevant when users need critiques on biological models, advice on sustaining a long scientific career, or frameworks for translating clinical pathology into basic science.

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Use this skill whenever you are reasoning about nutritional epidemiology, dietary guidelines, chronic disease prevention, or public health policy. It channels the thinking of Meir J. Stampfer, epidemiologist and nutrition expert at Harvard University. Trigger this skill when evaluating lifestyle factors, comparing observational data versus randomized controlled trials (RCTs), analyzing macronutrient substitutions, or assessing long-term health outcomes. Stampfer's approach is essential when users ask about "good" vs. "bad" foods, seek longevity advice, or need to interpret complex, population-level dietary data without falling for the "magic bullet" fallacy.

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Applies the nutritional epidemiology and public health frameworks of Frank B. Hu (nutrition epidemiologist, Harvard University). Use this skill whenever reasoning about diet quality, public health policy, planetary health, cardiometabolic disease prevention, or evaluating nutritional studies. Trigger this when the user asks about plant-based diets, macronutrient trade-offs ("compared to what?"), the impact of the food environment, or lifestyle factors for longevity. It shifts the AI's focus from single-nutrient reductionism to overall dietary patterns, emphasizing that "zip code is more important than genetic code" and that human health is inextricably linked to planetary health.

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Use this skill whenever you are reasoning about public health policy, cancer prevention, epidemiological study design, clinical risk models, or weight management advice. This skill channels the thinking of Graham A. Colditz, epidemiologist at Washington University in St. Louis. Reach for this when evaluating lifestyle interventions, designing disease prevention programs, critiquing clinical prediction tools (e.g., AUC vs. clinical utility), or analyzing life-course risk accumulation. Apply his frameworks to bridge the "implementation gap" between scientific knowledge and societal action, prioritizing prevention over treatment and attainable weight maintenance over drastic weight loss.

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Use this skill to reason like JoAnn E. Manson, epidemiologist at Harvard Medical School and women's health expert. Trigger this skill whenever you are evaluating hormone replacement therapy (HRT), menopause management, nutritional epidemiology, dietary supplements, or clinical trial methodology. Apply her frameworks when users ask about the risks and benefits of HRT, bioidentical hormones, or targeted supplementation. Reach for this skill to differentiate between symptom management and chronic disease prevention, or when assessing observational data versus randomized clinical trials (RCTs) in public health contexts.

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Use this skill whenever you need to reason about public health, epidemiology, preventive medicine, healthy aging, longevity, lifestyle vs. genetics, or dietary patterns. Kay-Tee Khaw, an epidemiologist at the University of Cambridge, focuses on population health and how modest lifestyle changes impact chronic disease. Trigger this skill when evaluating health interventions, discussing longevity, analyzing real-world health data, or giving advice on diet and lifestyle. Apply her frameworks to shift focus from extreme interventions and isolated nutrients toward whole-food patterns, population-level risk shifts, and the compression of morbidity.

日本語の概要は準備中です。原文の説明を表示しています。

Find and synthesize research papers, whitepapers, PDFs, technical reports, and academic sources with Firecrawl Research, using semantic paper search, related-paper expansion, and in-body verification over Firecrawl's paper index — largely biomedical and life-science literature from PubMed, bioRxiv, and medRxiv, plus arXiv preprints in CS, physics, and math. Use when the user wants a literature review, systematic review, survey of studies, paper summary, research landscape, or sourced synthesis from scholarly and industry publications, including clinical, drug, gene, disease, epidemiology, and public-health topics. Prefer this over a general web-research workflow whenever the evidence base is published papers rather than web pages.

日本語の概要は準備中です。原文の説明を表示しています。

Find the papers that answer a research query in Firecrawl's research paper index — a corpus of paper abstracts whose largest share is biomedical and life-science literature (PubMed, bioRxiv, medRxiv), alongside arXiv preprints in CS, physics, and math — using semantic search, semantic and structural expansion, and in-body verification. Use this skill for literature-finding and paper-retrieval tasks of any kind, including clinical, biomedical, drug, gene, disease, and other life-science questions, whether the answer is a single paper or a full multi-paper set. The index is reached only through the `firecrawl_research_*` MCP tools or the `firecrawl research` CLI subcommands. Calling `firecrawl_search` with its `categories` option set to `["research"]` is a different feature — it filters ordinary web search to research-affiliated websites (the list includes PubMed, bioRxiv, medRxiv, arXiv, and publisher sites) and returns page results from them, without querying the paper records in this index.

日本語の概要は準備中です。原文の説明を表示しています。

Find the papers that answer a research query in Firecrawl's research paper index — a corpus of paper abstracts whose largest share is biomedical and life-science literature (PubMed, bioRxiv, medRxiv), alongside arXiv preprints in CS, physics, and math — using semantic search, semantic and structural expansion, and in-body verification. Use this skill for literature-finding and paper-retrieval tasks of any kind, including clinical, biomedical, drug, gene, disease, and other life-science questions, whether the answer is a single paper or a full multi-paper set. The index is reached only through the `firecrawl_research_*` MCP tools or the `firecrawl research` CLI subcommands. Calling `firecrawl_search` with its `categories` option set to `["research"]` is a different feature — it filters ordinary web search to research-affiliated websites (the list includes PubMed, bioRxiv, medRxiv, arXiv, and publisher sites) and returns page results from them, without querying the paper records in this index.

日本語の概要は準備中です。原文の説明を表示しています。

Diagnose motivation problems in a task using self-determination theory and redesign for autonomy, competence, and relatedness. Use when students are disengaged, resistant, or going through the motions.

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Optimise a learning activity for flow by balancing challenge level, skill, clear goals, and immediate feedback. Use when students are bored, anxious, or disengaged during a task.

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Prioritize drug targets from a ranked gene list (e.g., scRNA-seq DE output) by orchestrating parallel API queries against UniProt, OpenTargets (with integrated DepMap CRISPR essentiality + gnomAD constraint), PubMed, the Human Protein Atlas (HPA), and ChEMBL tool compounds, then re-ranking by a composite score combining protein localization, druggability, disease genetics, tissue specificity (safety), focus-cell-type expression, CRISPR essentiality, LoF safety constraint, and research maturity. Use whenever the user wants to filter, triage, prioritize, or "do due diligence" on a list of candidate genes for drug discovery, especially after a DE / DEG analysis when they say things like "which of these should I follow up on", "filter for druggable targets", "make a target dossier", "rank these for tractability", "annotate these genes for druggability", or "build a target report". Trigger even when the user says just "filter these candidate genes" or hands over a CSV from a DE pipeline.

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FinTech future-proofing. Scans and migrates classical encryption to NIST-approved Post-Quantum Cryptography (PQC) / Migrasi ke Kriptografi Pasca-Kuantum (PQC) yang disetujui NIST untuk sistem FinTech.

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A survey of the best-known active scientific controversies in nutrition — saturated fat and cardiovascular disease, dietary cholesterol, low-carb vs low-fat, ultra-processed foods, red meat and cancer, salt and blood pressure, and the replication status of popular single-nutrient claims. Use when a question asks whether a widely reported nutritional claim is settled, or when the department needs to distinguish "contested but plausible" from "settled" from "disproven."

日本語の概要は準備中です。原文の説明を表示しています。