「logic design」の検索結果

Download large datasets from NCBI efficiently using EPost, history server, batching, rate limiting, and retry logic. Use when bulk-fetching tens of thousands of sequences, pulling all results of a large ESearch, designing reproducible pipelines, comparing E-utilities to NCBI Datasets v2 CLI, or implementing checksum-validated downloads. Encodes WebEnv TTL (~8h), EPost 200-ID limit, retmax caps, parallelization design, and integrity verification.

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Use this skill when reasoning about deep tech commercialization, biomedical engineering, drug delivery, material design, or overcoming institutional skepticism. Robert Langer, MIT professor and pioneer of drug delivery systems, approaches problems through first-principles engineering, interdisciplinary convergence, and relentless perseverance against consensus. Trigger this skill whenever the user is evaluating high-risk/high-reward research, deciding between incremental vs. paradigm-shifting impact, spinning out academic discoveries into startups, or designing physical/biological systems from scratch. Apply his frameworks to navigate patenting, funding, and translating lab science into real-world impact.

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This skill applies the analytical frameworks of Ronald C. Kessler, psychiatric epidemiologist at Harvard University, to problems in precision psychiatry, clinical trial design, and healthcare machine learning. Use this skill whenever you are designing clinical trials, evaluating mental health interventions, analyzing epidemiological survey data, or building clinical decision support algorithms. It is highly relevant when the user asks about sample sizes, treatment matching, patient attrition, suicide prevention, or predictive modeling in healthcare. Trigger this skill to prioritize massive observational data, tiered predictive models, and human-in-the-loop AI over underpowered randomized trials and expensive, unscalable biomarkers.

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Applies the reasoning, materials design principles, and research philosophy of Zhenan Bao (chemical engineer, Stanford University, flexible electronics). Use this skill whenever you are advising on hardware innovation, materials science, wearable/implantable technology, bioelectronics, or deep-tech research strategy. Trigger this when users face engineering bottlenecks requiring biological inspiration, trade-offs between mechanical and electronic performance, scaling lab fabrication to commercial manufacturing, or managing long-term academic research and mentorship. Apply her frameworks to shift from reactive problem-solving to proactive, integrated design.

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Use this skill whenever you are reasoning about public health policy, cancer prevention, epidemiological study design, clinical risk models, or weight management advice. This skill channels the thinking of Graham A. Colditz, epidemiologist at Washington University in St. Louis. Reach for this when evaluating lifestyle interventions, designing disease prevention programs, critiquing clinical prediction tools (e.g., AUC vs. clinical utility), or analyzing life-course risk accumulation. Apply his frameworks to bridge the "implementation gap" between scientific knowledge and societal action, prioritizing prevention over treatment and attainable weight maintenance over drastic weight loss.

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Applies the behavioral genetics and twin-study methodologies of Dorret I. Boomsma (behavior geneticist, Vrije Universiteit Amsterdam). Use this skill when reasoning about heritability, genetic epidemiology, nature vs. nurture debates, psychiatric genetics, or longitudinal phenotyping. Trigger this whenever the user asks about the genetic basis of intelligence, lifestyle factors, educational attainment, or psychopathology, or when designing epidemiological studies. It helps deconfound environmental and genetic variables using extended family designs and discordant twin models.

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Applies the computational biology and AI-driven reasoning of Aviv Regev (computational biologist, Genentech, single-cell genomics). Use this skill whenever the user is dealing with experimental design, high-dimensional data analysis, integrating AI into scientific workflows, scaling biological research, or navigating noisy, complex systems. Trigger this for topics like single-cell genomics, drug discovery, biological atlases, interdisciplinary research strategy, or when deciding between depth vs. breadth in data collection.

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Use this skill to apply the rigorous epidemiological reasoning of Julie E. Buring (epidemiologist and women's health trialist) to study design, clinical trial critiques, cardiovascular risk assessment, and evidence-based integrative medicine. Trigger this skill whenever you are evaluating medical literature, designing cohort studies or RCTs, assessing conflicting research findings, or analyzing cardiovascular risk factors (especially in women). Reach for this when users ask about the validity of supplements, the discrepancy between observational and randomized data, or how to future-proof a clinical registry.

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Designing scheduling and time-aware logic for cron, timezone/DST, retry/backoff, and business-calendar systems. Use when schedule design is needed.

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Use when interpreting biological research findings, evaluating life science evidence, analyzing molecular or cellular mechanisms, comparing competing biological hypotheses, designing or critiquing experiments in biology, genetics, genomics, cell biology, immunology, neuroscience, ecology, or any life science domain. Triggers on questions about gene function, pathways, phenotypes, GWAS hits, single-cell data, animal models, clinical translation, evolutionary arguments, or any biology/life science reasoning task.

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Design an edge routing and geo-distribution strategy — latency routing, failover, and edge logic. Use when asked to "geo-route our traffic", "reduce global latency", or "design edge failover".

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Build sequential (stateful) logic circuits including latches, flip-flops, registers, counters, and finite state machines. Covers SR latch, D and JK flip-flops, binary/BCD/ring counters, and Mealy/Moore FSM design with clock signal and timing analysis. Use when a circuit must remember past inputs, count events, or implement a state-dependent control sequence.

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Apply product-grounded visual quality constraints during user-visible UI changes. Use for layout, styling, content hierarchy, theming, responsive behavior, or interaction affordances. Stay inactive for logic-only changes that preserve the rendered interface.

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"Apply the TPACK framework to evaluate and design technology-integrated instruction at the intersection of technological, pedagogical, and content knowledge. Use this skill when the user needs to assess teacher readiness for technology integration, design professional development for ed-tech, or evaluate whether technology use is pedagogically grounded — even if they say 'how to integrate technology in teaching', 'ed-tech evaluation', or 'teacher technology competency'.".

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"Apply Self-Determination Theory to analyze motivation quality along the autonomy continuum and design interventions that satisfy basic psychological needs. Use this skill when the user needs to diagnose why intrinsic motivation is declining, evaluate incentive structures for motivational crowding, design need-supportive environments, or when they ask 'why did rewards backfire', 'how to foster intrinsic motivation', or 'what needs drive engagement'.".

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"Analyze and design pricing strategies including cost-plus, value-based, competitive, penetration, and skimming approaches with psychological pricing techniques. Use this skill when the user needs to set or change prices, evaluate pricing models, understand price elasticity, or apply psychological pricing — even if they say 'how much should we charge', 'are we priced right', or 'our margins are too low'.".

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Design clean, graphics-first technical presentations and posters with logical slide progression, visual hierarchy, purposeful motion, and complementary speaker notes. Use for research talks, conference slides, seminars, defenses, posters, or figure-focused presentations.

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Use when deploying an Agentforce agent to a channel surface: Embedded Service web chat, Slack, Experience Cloud, Agent REST API, or Salesforce Mobile. Triggers: 'deploy agent to website', 'add Agentforce to Slack', 'enable agent for mobile app', 'configure embedded service for agent', 'agent API for custom integration', 'multi-channel agent deployment'. NOT for agent logic design — use agentforce/agent-topic-design or agentforce/agent-actions for topics, instructions, and action contracts.

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Design error handling strategies for TypeScript and Python applications — exception hierarchies, Result/Either types, retry patterns, error boundaries, and structured error logging. Use when designing error handling architecture, choosing between exceptions and Result types, implementing retry logic, or building error recovery flows. Activate on "error handling", "exception hierarchy", "Result type", "retry pattern", "circuit breaker", "error boundary", "Pokemon exception". NOT for debugging specific runtime errors, logging infrastructure setup, or monitoring/alerting configuration.

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Master of text-based visual communication using ASCII art, Unicode box-drawing, and structured diagram notation. Creates clear, maintainable diagrams for systems, processes, hierarchies, relationships, and psychological structures. Proactively generates diagrams to enhance understanding. Activate on visualization needs, system architecture, process flows, psychological mapping, or when complex concepts would benefit from visual representation. NOT for photo editing, vector graphics, or GUI-based design tools.

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Builds, validates, schedules, and dynamically modifies DAG execution graphs. Decomposes problems into nodes with dependencies, performs topological sorting, detects cycles, resolves conflicts, and schedules wave-based parallel execution. Use when designing a DAG structure, validating dependencies, planning execution order, or modifying a DAG at runtime. Activate on "build DAG", "plan workflow", "DAG dependencies", "topological sort", "schedule execution", "modify DAG", "replan". NOT for executing DAGs (use dag-runtime), validating outputs (use dag-quality), or matching skills to nodes (use dag-skills-matcher).

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Safety, privacy, cost management, and frank advice for building always-on AI agents with episodic memory. Covers data hygiene, privacy risk surfaces, runaway cost prevention, scope creep, psychological effects of persistent AI companions, and responsible deployment patterns. This is the skill that tells you what can go wrong and how to prevent it. Activate on: "agent safety", "always-on agent privacy", "agent cost control", "persistent agent risks", "AI companion safety", "agent data hygiene", "runaway agent costs", "parasocial AI risk", "/always-on-agent-safety". NOT for: architecture design (use always-on-agent-architecture), input design (use always-on-agent-inputs), application brainstorming (use always-on-agent-applications), healthcare compliance specifically (use hipaa-compliance).

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Assigns pathogen lineages (SARS-CoV-2 Pangolin UShER mode; Nextclade clade + QC; pango-designation alias resolution) and tracks variant frequencies over time using Nextstrain (Augur + Auspice), wastewater deconvolution (Freyja, COJAC, alcov, lineagespot), lineage-fitness modelling (multinomial logistic), and recombinant detection (3SEQ, RDP4, Bolotie). Covers Pangolin pangolin-data and Nextclade dataset version pinning (mandatory; lineage-defining mutations change with dataset), Freyja barcode forward-only date constraint, ARTIC primer scheme churn (V3/V4/V4.1/V5.3.2/Midnight) with dropout regions, and recombinant X-prefix designation lag. Use when assigning Pango lineages and Nextclade clades to viral consensus sequences, building Nextstrain Augur surveillance pipelines, deconvolving wastewater into lineage frequencies with Freyja, tracking lineage frequencies over time, handling ARTIC primer dropouts, or running surveillance for SARS-CoV-2/influenza/Mpox/RSV/H5N1/measles.

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Corrects fluorophore spillover (conventional compensation) or spectral overlap (spectral unmixing) and applies variance-stabilizing transforms (logicle/biexponential, arcsinh, log) for flow and mass cytometry. Covers spillover-matrix estimation from single-stain controls, AutoSpill, the spillover spreading matrix and why panel design (not compensation) bounds resolution, compensate-then-transform ordering, and arcsinh cofactor choice (5 for CyTOF, ~150 for fluorescence, per-channel via flowVS). Use when correcting spectral overlap, preparing data for gating/clustering, choosing logicle vs arcsinh, deciding a cofactor, or distinguishing compensation from spectral unmixing.

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