「spr」の検索結果

Query gnomAD (Genome Aggregation Database) for population allele frequencies, gene constraint scores, and variant annotations to interpret ENCODE regulatory variants. Use when the user needs allele frequencies for variants in ENCODE regulatory elements, wants to assess gene constraint (pLI, LOEUF) for ENCODE target genes, needs population-specific frequencies for GWAS variants overlapping cCREs, wants to filter variants by rarity before functional annotation, or is interpreting ENCODE CRISPR/MPRA results in the context of population genetics. Also use when the user mentions gnomAD, allele frequency, pLI, LOEUF, constraint, rare variants, population frequency, ExAC, or variant filtering.

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Discover and characterize regulatory elements (enhancers, promoters, silencers, insulators, super-enhancers) using ENCODE data and the cCRE catalog. Use when the user wants to find candidate regulatory elements, identify active enhancers in a tissue, map promoter states, classify chromatin states with ChromHMM, identify super-enhancers with ROSE, understand the functional validation hierarchy (CRISPR > MPRA > reporter), or characterize non-coding genomic regions. Covers the full workflow from ENCODE cCRE lookup through chromatin state segmentation to functional validation and enhancer-gene linkage. Use this skill for ANY regulatory element discovery, classification, or characterization task.

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Install Tilt and scaffold or audit Tiltfile + tilt/ configurations with ecosystem-aware templates. Auto-detects Java/Gradle (Spring Boot), Next.js, Python/uv, and external infrastructure; recommends single-file or modular tilt/*.star + service-config.yaml + environments.yaml patterns based on project complexity. Bakes in production-context safety guards, PVC persistence toggles, JDWP debug ports, and optional Prometheus/Grafana/Traefik scaffolds. Use when user runs /devtools:tilt-setup, mentions "tilt setup", "setup tilt", "scaffold tiltfile", "audit tiltfile", "tilt configure", "tilt project setup", "Tiltfile", "local kubernetes dev", or "kubernetes development environment".

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Use this skill whenever the user wants to create, read, edit, or manipulate Word documents (.docx files). Triggers include: any mention of 'Word doc', 'word document', '.docx', or requests to produce professional documents with formatting like tables of contents, headings, page numbers, or letterheads. Also use when extracting or reorganizing content from .docx files, inserting or replacing images in documents, performing find-and-replace in Word files, working with tracked changes or comments, or converting content into a polished Word document. If the user asks for a 'report', 'memo', 'letter', 'template', or similar deliverable as a Word or .docx file, use this skill. Do NOT use for PDFs, spreadsheets, Google Docs, or general coding tasks unrelated to document generation.

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Systematic technical debt analysis across architecture, testing, documentation, and infrastructure. Investigates the codebase, scores findings by impact and effort, and generates a prioritized TECH_DEBT.md remediation plan. Delegates to specialized skills for code quality (scout) and linting (lint-fix). Use when assessing overall project health, planning cleanup sprints, or onboarding to an unfamiliar codebase.

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Spreadsheet automation — reading, writing, and analyzing Excel workbooks — use for xlsx generation, parsing, and data workflows.

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Build financial models — revenue forecasts, unit economics, scenario analysis, and investor-grade spreadsheets.

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Create, read, edit, or manipulate Word documents (.docx) and Word templates (.dotx). Use whenever a build task's artifact kind is document with the default docx output, or the task mentions a Word doc, .docx, or .dotx, extracts or reorganizes content from one, inserts or replaces images, does find-and-replace in one, or works with tracked changes (redlines) or comments. Covers python-docx generation, raw OOXML editing of existing files, document structure and formatting, and render verification. Not for PDFs, spreadsheets, or Google Docs.

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Read and manage software issues, tickets, projects, and planning data in Linear. Use to review sprints and cycles, identify ticket rollover and release blockers, and update issue status, assignees, priorities, and milestones through Linear's official MCP server.

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Generate OpenAPI 3.1 documentation from your API codebase. Auto-detects Express, Fastify, NestJS, Django, FastAPI, Flask, Rails, Spring, Go, and more. Triggers: you need API documentation, OpenAPI spec, Swagger docs, endpoint reference, or REST API docs.

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Run a full retrospective and dev cycle analysis. Chains /recall → /new-features to reconstruct what went wrong, extract lessons learned, identify rework patterns, and synthesize feature ideas from the findings. Triggers: retrospective, retro, dev cycle analysis, what went wrong, lessons learned, postmortem, sprint retro.

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Deep codebase cleanup — kills dead code, fixes all lint/format warnings, removes orphaned files, cleans stale TODOs, strips security hazards, tightens TypeScript strict mode, and organizes imports. Triggers: clean up, dead code, unused imports, lint, technical debt cleanup.

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Audit a product codebase for growth readiness using the AARRR pirate metrics framework. Triggers: launching a new product, diagnosing low conversion, or planning a growth sprint.

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Capture learnings from a campaign, launch, sprint, or initiative using Five Whys (Taiichi Ohno, Toyota Production System) for root cause analysis and Start-Stop-Continue for action planning. Append reusable insights to knowledge/learnings.md so future runs of the OS get smarter. Use when the user asks for a retro, retrospective, post-mortem, "what did we learn", "campaign wrap-up", "lessons learned", or after a campaign or launch ends. Critical feedback loop that makes the OS compound over time. For the numbers review itself, see kpi-review. For planning the next campaign, see campaign-brief.

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Build QA quality dashboards, calculate defect metrics, analyze escape rates, and produce quality trend reports. Use this skill whenever a QA lead or manager needs to measure and communicate quality outcomes. Trigger on phrases like "quality metrics", "defect density", "escape rate", "bug trends", "quality dashboard", "sprint quality report", "test coverage metrics", "QA KPIs", "how is quality trending", "defect leakage", "production bugs this quarter", "mean time to detect", "quality scorecard", or any request to quantify, visualize, or report on the quality of a product or testing process. Also trigger when a manager asks "how is QA performing?" or an engineering lead asks "what does our defect data tell us?".

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Write user stories with acceptance criteria. Use when the user says "write user stories", "convert this to stories", "create acceptance criteria", "break this into tickets", "story map", "walking skeleton", "story for this feature", or wants to translate a feature idea into sprint-ready items - even if they don't explicitly say "user stories".

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Scope a milestone to a fixed time window with variable scope. Use when the user says "scope this milestone", "what fits in the sprint", "cut scope for the release", "define the MVP for this milestone", "we need to ship by [date] what do we cut", "shape the work to fit the cycle", or needs to make hard scope decisions under a time constraint - even if they don't explicitly say "milestone scoping". Based on "Shape Up" by Ryan Singer (appetite, shaping, betting table) and "The Art of Project Management" by Scott Berkun (milestones as forcing functions, scope as a variable).

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List Airtable bases, read table records, and add records. Trigger phrases: airtable, my base, add a record, spreadsheet.

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**WORKFLOW SKILL** — Generate formatted documents from Markdown or structured content. USE FOR: creating PowerPoint presentations, Word documents, Excel spreadsheets, MS Project files, PDFs from Markdown/JSON/chat context using templates. DO NOT USE FOR: converting documents TO Markdown (use doc-to-markdown), general file I/O, web scraping.

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One-command multilingual blog creation. Writes a blog post, translates it into user-specified languages, applies cultural adaptation, and emits hreflang tags, sitemap entries, and a CMS-ready language map. The complete write-to-publish pipeline for international content. Orchestrates blog-write, blog-translate, blog-localize, and (optionally) seo-hreflang. Use when user says "multilingual blog", "blog multilingual", "write in multiple languages", "international blog", "mehrsprachiger Blog", "blog multilingue", "blog multilingue", "create blog in German and French".

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Picks random winners from lists, spreadsheets, or Google Sheets for giveaways, raffles, and contests. Ensures fair, unbiased selection with transparency.

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Improves GKE workload reliability, using PDBs, health probes, and topology spread constraints. Use when configuring GKE workload reliability, setting up PDBs, or configuring GKE health probes (liveness, readiness, startup). Don't use for disaster recovery setup or full cluster backups (use gke-backup-dr instead).

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Use when designing or reasoning about an Agentforce Grid worksheet — the spreadsheet-like Agentforce workspace where rows are jobs and columns are sequential Data / AI / Action steps that process left to right — to run bulk record updates, generate insights, or test multi-turn AI conversations over CRM or Data Cloud (Data 360) data without Apex or Flow. Trigger keywords: Agentforce Grid, workbook, worksheet, grid column, data column, AI column, action column, bulk AI update, Flex Credits per row, metered compute. NOT for building the agent, its topics, or its actions themselves (use agentforce/* action and topic skills), NOT for single-record prompt design (use the prompt-builder skills), NOT for deployable metadata/Apex (Grid is a no-code Studio tool, not a metadata type), and NOT for AI governance/ethics policy (use admin/ai-ethics-and-governance-requirements).

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Use this skill when authoring INVEST-compliant Salesforce user stories from gathered requirements: shaping the As-A/I-Want/So-That stem, writing Given-When-Then acceptance criteria, sizing complexity (S/M/L/XL), splitting stories that are too large for a sprint, and emitting handoff metadata that names the next downstream agent. Trigger keywords: user story, INVEST, story splitting, story sizing, As-A I-Want So-That, story handoff, recommended_agents, backlog item shape. NOT for requirements elicitation or stakeholder interviews (use admin/requirements-gathering-for-sf). NOT for the Given-When-Then technique itself in depth (use admin/acceptance-criteria-given-when-then). NOT for UAT test case design (use admin/uat-test-case-design). NOT for backlog prioritization (use admin/moscow-prioritization-for-sf-backlog).

日本語の概要は準備中です。原文の説明を表示しています。