2,118 件 ・ 関連度順
概要と使いどころ
Synthesizes multiple case summaries into one unified Case Summary Report. Triggers when the user has two or more case summaries, document analyses, or memoranda and needs them consolidated into a single report with patterns, contradictions, and gaps identified.
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Manages end-to-end workflow for multi-organization amicus coalition briefs in appellate courts. Covers single-pen drafting governance, position alignment, conflict resolution, documented sign-offs, FRAP 29/Rule 37.6 disclosures, FRAP 26.1 corporate disclosures, cover formatting for multiple amici, and compliant filing. Use when coordinating coalition amicus briefs, managing sign-offs, drafting joint friend-of-court briefs, handling multi-amici filing, or resolving inter-organization conflicts. Triggers on phrases like "coalition brief," "12 orgs joining this amicus," or "coordinate the amicus."
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Manages multi-organization appellate amicus briefs with single-pen drafting, coalition sign-offs, conflict triage, and compliant disclosures. Use when coordinating a coalition amicus brief, managing amicus sign-on, handling FRAP 29 or Supreme Court Rule 37.6 disclosures, or preparing cover and interest sections for multiple amici.
日本語の概要は準備中です。原文の説明を表示しています。
Task claiming and file-ownership tracking for parallel execution: agents claim tasks from a shared queue with ownership enforced. Use during parallel phases with multiple simultaneous agents.
日本語の概要は準備中です。原文の説明を表示しています。
Generate or compare multiple technical approaches for one validated decision. NOT for product discovery or refining an existing plan.
日本語の概要は準備中です。原文の説明を表示しています。
Task claiming and ownership tracking for parallel agent execution. Agents claim tasks from a shared queue with file ownership enforcement. Use during parallel execution phases when multiple agents work simultaneously.
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Coordinates staged or parallel jobs across live-verified coding-agent runtimes (Claude Code, Codex, Cursor, and other installed CLIs) and in-session toolkit subagents. Routes each job by capability and risk tier, isolates parallel writers in git worktrees, captures redacted output, resumes interrupted runs, and blocks completion until an independent arbiter verifies the results. Use when work should be split across multiple runtimes or subagents, run as staged or parallel jobs, and reviewed before handoff. NOT for a single-agent task or the in-session 7-phase flow (use mk:cook / mk:workflow-orchestrator).
日本語の概要は準備中です。原文の説明を表示しています。
Session-persistent browser automation via Playwright CLI — form filling, screenshots, data extraction, multi-step flows. Use when the user needs to navigate websites, interact with web pages, fill forms, take screenshots, test web applications, or extract information across multiple requests. NOT for AI-driven long-autonomous flows (see mk:agent-browser); NOT for generating .spec.ts E2E code (see mk:qa-manual).
日本語の概要は準備中です。原文の説明を表示しています。
Generate or compare multiple technical approaches for one validated decision. Do not use for product discovery or an existing plan.
日本語の概要は準備中です。原文の説明を表示しています。
Parallel code verification using multiple models with severity classification
日本語の概要は準備中です。原文の説明を表示しています。
Use this skill for ANY of the following — do not skip it even if the query seems simple: strategic decisions, business analysis, thesis building, complex problem solving, geopolitical analysis (non-market), philosophical reasoning, academic research, system design, decision under uncertainty, long-form thinking, or any question that benefits from First Principle deconstruction and multi-agent reasoning. ALWAYS use this skill when the user asks about: why something works the way it does, whether a decision is correct, how to think about a complex problem, what could go wrong, analyzing a situation from multiple angles, or any "should I..." question involving real-world trade-offs. This is NOT a market/trading skill — for financial markets, BTC, gold, stocks, forex, macro economics, use money-atlas-intelligence-os instead.
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Generate multiple angles and shot types of a single product for ecommerce-ready image sets. Produces a coherent set (hero 3/4, front, side, back, detail macro, scale, packaging, in-hand) keeping product identity consistent across shots. Use when the user says "different angles", "product shots", "ecommerce image set", "shot list", "PDP gallery", or needs a multi-view set of one product. Part of the Creative Production set.
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Use when user says "simmer this", "refine this", "hone this", "iterate on this", or asks to improve a specific artifact over multiple rounds. Runs an iterative refinement loop with investigation-first judges that read the code, understand the problem, and propose evidence-based improvements. Auto-selects single judge or multi-judge board based on complexity. Works on any artifact type: documents, prompts, specs, emails, creative writing, API designs, pipelines, codebases. Supports multi-file workspace targets, runnable evaluators, and open-ended optimization (model selection, pipeline topology, prompt tuning).
日本語の概要は準備中です。原文の説明を表示しています。
Design desktop window systems that feel native on macOS and Windows: split views, inspectors, auxiliary windows, tiling, snap-safe sizes, default placement, and chrome density. Use when a Tauri/Electron/WinUI/SwiftUI app feels awkward, overlapping, over-chromed, or generic, or when you need a real geometry contract for multiple surfaces. NOT for mobile layouts, marketing pages, or CSS-only component styling without multi-window or multi-pane behavior.
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Assigns confidence scores to agent outputs based on multiple factors including source quality, consistency, and reasoning depth. Produces calibrated confidence estimates. Activate on 'confidence score', 'how confident', 'certainty level', 'output confidence', 'reliability score'. NOT for validation (use dag-output-validator) or hallucination detection (use dag-hallucination-detector).
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Compare gene co-expression and regulatory networks between biological conditions to find rewired relationships using DiffCorr, DiffCoEx, DINGO/iDINGO, and CoDiNA. Covers the differential-connectivity-is-not-differential-expression distinction, the pairwise multiple-testing explosion, marginal vs partial (direct) rewiring, and the underpowered-rewiring failure mode. Use when comparing co-expression networks between disease vs control, treatment, or developmental stages, or finding hub genes that rewire without changing mean expression. For single-condition modules see coexpression-networks; for differential expression of means see differential-expression/de-results.
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Detects m6A modifications from Oxford Nanopore direct-RNA-seq (DRS) signal using m6Anet (multiple-instance-learning over DRACH 5-mer signal). Covers the upstream pipeline (Dorado/Guppy basecalling -> minimap2 map-ont -> nanopolish eventalign -> m6anet dataprep -> m6anet inference), per-site vs per-read probability including the mod_ratio stoichiometry column, the DRACH-only constraint, minimum-coverage thresholds (20-50 reads/site), multi-condition comparison via xPore/Nanocompore/ELIGOS, Dorado native modification calling (RNA004, 2024+), and the cDNA-vs-DRS distinction (cDNA Nanopore CANNOT detect modifications). Use when calling m6A from ONT DRS without immunoprecipitation, choosing m6Anet vs xPore vs Nanocompore vs ELIGOS vs Dorado native, interpreting probability_modified vs mod_ratio vs per-read probabilities, deciding between m6Anet (known DRACH sites) and Dorado/Remora (genome-wide screening), pinning RNA002 vs RNA004 chemistry and basecaller versions, or troubleshooting eventalign/dataprep failures.
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Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based generators (DiGress, DiffSMol), and JT-VAE with explicit handling of multi-parameter optimization (MPO), goal-directed scoring functions, transfer/reinforcement/curriculum learning, synthetic accessibility scoring, and chemical space exploration vs exploitation. Use when designing new chemical matter against a target, decorating a scaffold, linking fragments, or optimizing a hit for multiple ADMET / activity properties simultaneously.
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Estimates time-scaled phylogenies, molecular-clock rates, effective reproduction number R_e, and population dynamics from dated pathogen genomes using TreeTime (maximum-likelihood) and BEAST2 (Bayesian; strict/relaxed clocks; coalescent, Bayesian-Skyline, Skygrid, Birth-Death-Skyline, and sampled-ancestor priors; structured coalescent via MASCOT). Covers root-to-tip clock QC via TempEst, date-randomisation tests, recombination masking via Gubbins/ClonalFrameML before clock inference for recombining bacteria, BDSKY origin-vs-rootHeight pitfalls, sampling-bias correction, multi-chain convergence diagnostics, and reconciling phylodynamic R_e with case-based R_t. Use when dating outbreak origins, estimating substitution rates, inferring R_e through time, building time-calibrated Nextstrain Augur trees, choosing between strict and relaxed clocks, fitting Birth-Death-Skyline models, diagnosing temporal-signal failure, running MASCOT for structured-population analyses, or using UShER for pandemic-scale placement.
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Detects somatic mutations in circulating tumor DNA, treating low-VAF detection as a signal-versus-noise problem set by error suppression and molecules sampled, not by the choice of caller. Distinguishes de novo CALLING (scanning a panel for unknown variants, bounded by per-locus error and multiple testing) from tumor-informed DETECTION (tracking a pre-specified variant set, where panel integration reaches single-ppm). Covers VarDict and Mutect2 for de novo calling, UMI-aware callers, and a pysam-based known-variant VAF tracker, with matched-WBC subtraction as the mandatory defense against clonal hematopoiesis (the dominant false positive). Use when calling or tracking tumor mutations from plasma cfDNA, setting a VAF threshold, or deciding whether a low-VAF call is tumor versus CHIP.
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Add p-value brackets, significance asterisks, and effect-size annotations to distribution plots using ggpubr, ggsignif, and statannotations with correct test selection (parametric vs non-parametric vs paired), multiple-testing adjustment, and rendering of negative results. Use when a boxplot/violin/raincloud needs in-figure statistical comparisons between groups.
日本語の概要は準備中です。原文の説明を表示しています。
Compose multi-panel publication figures with patchwork, cowplot, gridExtra (R), or matplotlib GridSpec/subfigures (Python) including shared axes/legends/guides collection, panel labels in Nature/Cell convention, and journal-spec sizing. Covers patchwork ≥1.2.0 axes='collect' feature, Type-42 font embedding, and the cairo_pdf save path. Use when composing 2+ subpanels into a single figure for journal submission.
日本語の概要は準備中です。原文の説明を表示しています。
Designs pooled sgRNA libraries for CRISPR knockout, interference (CRISPRi), activation (CRISPRa), Cas12a multiplex, base-editor, and prime-editor screens. Covers on-target scoring (Rule Set 2, Azimuth, DeepSpCas9, CRISPRon), off-target scoring (CFD, MIT), TSS-relative positioning for CRISPRi/a (Horlbeck, Dolcetto, Calabrese), PAM-variant chemistries, control-guide composition, oligo cloning architecture, and library QC. Use when choosing a genome-wide library (GeCKOv2 vs Avana vs Brunello vs TKOv3 vs Inzolia), designing a focused or paralog-focused custom library, picking CRISPRi vs CRISPRa TSS windows, deciding control-guide proportions, or diagnosing library skew and dropout in a freshly cloned pool.
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Extracts, filters, annotates, and exports differential expression results from DESeq2 or edgeR with proper handling of padj=NA (independent filtering, Cook's outliers, all-zero), multiple-testing correction choice (BH vs Storey q-value vs IHW vs lfsr), TREAT vs post-hoc fold-change filtering, p-value histogram diagnostics, gene annotation via org.db/biomaRt/mygene, GSEA preranked input, ORA background construction, replication reality (Schurch 2016 small-n result), and SABV/sex-stratified reporting. Use when extracting and interpreting DE results, troubleshooting padj=NA, choosing FDR method, preparing ranked lists for pathway analysis, annotating gene IDs, or comparing DESeq2 vs edgeR outputs.
日本語の概要は準備中です。原文の説明を表示しています。