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Queries the NCATS Translator ARAX production API for bounded, typed, provenance-rich one-hop and endpoint-pinned two-hop biomedical knowledge-graph relationships. Use for Biolink-constrained RTX-KG2 lookup, explicit selected-provider ARAX federation, separate entity normalization, qualifier-aware graph traversal, and inspection of TRAPI edge bindings, publications, and knowledge-source provenance. Do not use for inference, ranking, open-ended pathfinding, clinical guidance, or sensitive queries.

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Generate and optimise novel small molecules with REINVENT 4 — de novo sampling from a chemical language model, scaffold decoration with LibInvent, fragment linking with LinkInvent, and similarity-constrained analogue generation with Mol2Mol. Use this skill to set up reinforcement-learning or curriculum runs, compose a multi-parameter scoring function from docking scores, predictive models, and physicochemical desirability, and read the resulting sampled sets. Also trigger on REINVENT, LibInvent, LinkInvent, Mol2Mol, scaffold hopping, R-group replacement, linker design, chemical language model, or reinforcement-learning molecule optimisation.

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Query the Precision Medicine Knowledge Graph (PrimeKG) for multiscale biological relationships across genes and proteins, drugs, diseases, phenotypes, pathways, biological processes, exposures and anatomy. Use this skill to search entities by name, pull direct neighbours and their evidence types, summarise the local network around a disease, and find direct or two-hop drug-disease connections for repurposing hypotheses. Also trigger on PrimeKG, kg.csv, Harvard Dataverse knowledge graph, disease_protein, drug_protein, indication and contraindication edges, or network pharmacology over a biomedical knowledge graph.

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Design and execute A/B tests for ML models in production using traffic splitting, statistical significance testing, and canary/shadow deployment strategies. Measure performance differences and make data-driven decisions about model rollout. Use when validating a new model version before full rollout, comparing candidate models trained with different algorithms, measuring business metric impact of model changes, or when regulatory requirements mandate gradual rollout.

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Guide a person through a Coordinate Remote Viewing (CRV) session following the Stargate/SRI protocol. AI acts as the monitor/tasker role, managing protocol progression, catching Analytical Overlay (AOL), and redirecting the viewer through stages I-VI. Use when a person wants to practice CRV and needs a monitor to manage the session protocol, when training a viewer through the staged CRV process, facilitating a structured intuitive perception exercise, or developing non-local awareness skills that complement healing work.

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AI pressure redirection — handling conflicting demands, tool failures, and competing constraints by blending with incoming force then reframing. Use when receiving contradictory instructions from different sources, during tool failure cascades where the planned approach becomes unviable, when scope pressure threatens to expand the task beyond what was asked, or when user frustration or correction needs to be absorbed rather than deflected.

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Perform capacity planning using historical metrics and growth models. Use predict_linear for forecasting, identify resource constraints, calculate headroom, and recommend scaling actions before saturation. Use before seasonal traffic spikes or product launches, during quarterly capacity reviews, when resource utilization trends upward, or before budget planning cycles.

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Deep receptive attention to extract intent beyond literal words. Maps active listening from counseling psychology to AI reasoning: clearing assumptions, attending to full signal, parsing multiple layers (literal, procedural, emotional, contextual, constraint, meta), reflecting understanding, noticing what is unsaid, and integrating the whole picture. Use when a user's request feels ambiguous, when context suggests something different from the literal words, when previous responses have missed the mark, or before beginning a large task where misunderstanding intent would waste significant effort.

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Design ornamental patterns using modern and speculative aesthetics with colorblind-accessible color scales. Breaks free from historical period constraints to explore cyberpunk, solarpunk, biopunk, brutalist, vaporwave, and other contemporary genres. Includes CVD (Color Vision Deficiency) awareness and perceptually uniform scales (viridis, cividis, inferno). Use when creating ornamental designs in modern or genre-specific aesthetics, designing patterns that must be colorblind-accessible, or exploring hybrid motifs combining historical ornament with contemporary visual language.

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Implement comprehensive model drift monitoring using Evidently AI, statistical tests (PSI, KS), and custom metrics to detect data drift and concept drift in production ML systems. Set up automated alerting and reporting workflows to catch degradation before it impacts business metrics. Use when production models show unexplained performance degradation, when new data distributions differ from training data, when seasonal shifts affect input features, or when regulatory requirements mandate model monitoring.

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Prepare herbal remedies from Hildegard von Bingen's Physica. Covers plant identification, preparation methods (tinctures, poultices, infusions, decoctions), dosage guidance, contraindications, and safety review based on 12th-century medieval pharmacopeia. Use when needing an herbal remedy for a specific ailment using Hildegardian pharmacopeia, seeking guidance on preparation methods and dosage, researching medieval herbal medicine, or integrating Hildegard's plant wisdom into holistic health practice.

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Implement a generative diffusion model (DDPM or score-based) with noise scheduling, U-Net architecture, training loop, and sampling procedures including DDIM acceleration. Use when building a generative model for image, audio, or molecular synthesis; implementing DDPM from a research paper; adding a custom noise schedule or conditioning mechanism; replacing a GAN-based generator with a diffusion alternative; or prototyping before scaling with production frameworks like diffusers.

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Implement policy-as-code enforcement using OPA Gatekeeper or Kyverno to validate and mutate Kubernetes resources according to organizational policies. Covers constraint templates, admission control, audit mode, reporting violations, and integrating with CI/CD pipelines for shift-left policy validation. Use when enforcing resource configuration standards, preventing security misconfigurations such as privileged containers, ensuring compliance before deployment, standardizing naming conventions, or auditing existing cluster resources against policies.

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AI unconstrained creative exploration — deliberately dropping structure to let associations form freely. The one skill that inverts the standard procedure format: instead of inputs, steps, and validation, dream opens space for emergence without evaluation. Use before design work, before naming things, before choosing between approaches, or anywhere that premature structure kills the best option.

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Deploy machine learning models to production serving infrastructure using MLflow, BentoML, or Seldon Core with REST/gRPC endpoints, implement autoscaling, monitoring, and A/B testing capabilities for high-performance model inference at scale. Use when deploying trained models for real-time inference, setting up REST or gRPC prediction APIs, implementing autoscaling for variable load, running A/B tests between model versions, or migrating from batch to real-time inference.

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Solve Diophantine equations (integer-only solutions) including linear, quadratic, and Pell equations. Covers the extended Euclidean algorithm, descent methods, and existence proofs. Use when finding all integer solutions to ax + by = c, solving Pell's equation, generating Pythagorean triples, proving no integer solutions exist via modular constraints, or finding the fundamental solution from which all others are generated.

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Conduct a structured cross-project code review between two Claude Code instances via the cross-review-mcp broker. Each agent reads its own codebase, reviews the peer's code, and engages in evidence-backed dialogue — with QSG scaling laws enforcing review quality through minimum bandwidth constraints and phase-gated progression.

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Create multi-stage Dockerfiles that separate build and runtime environments for minimal production images. Covers builder/runtime stage separation, artifact copying, scratch/distroless/alpine targets, and size comparison. Use when production images are too large, when build tools are included in the final image, when you need separate dev and prod images from one Dockerfile, or when deploying to constrained environments like edge or serverless.

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Address unwanted dog behaviors through desensitization, counter-conditioning, and management. Covers reactivity (to dogs, people, sounds), separation anxiety, resource guarding, excessive barking, and leash pulling using force-free methods with systematic threshold management. Use when a dog shows reactivity toward other dogs, people, or stimuli; when separation anxiety causes destructive behavior or vocalization; when resource guarding is present; or when behaviors like excessive barking or leash pulling interfere with daily life — after basic obedience is established.

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Build a feature store using Feast for centralized feature management, configure offline and online stores for batch and real-time serving, define feature views with transformations, and implement point-in-time correct joins for ML pipelines. Use when managing features for multiple ML models, ensuring training-serving consistency, serving low-latency features for real-time inference, reusing feature definitions across projects, or building a feature catalog for discovery and governance.

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Consolidated Symfony conventions (Symfony 6.4 / 7.x): attribute routing, controllers as services, autowiring/DI, Form types, Validation constraints, Voters for authorization, the Serializer/DTO contract, and Messenger. Apply when writing or reviewing Symfony backend code. Activated automatically by symfony-plugin/stack.md as a convention skill for the development phase. Apply when: writing or reviewing Symfony controllers, services, forms, validators, voters, and serialization. Do NOT use this skill for: - PHP language idioms (strict_types, enums, readonly) — see php-foundation:php-conventions. - Doctrine queries / entities — see symfony-plugin:doctrine-patterns. - Testing — injected by the QA phase (WebTestCase/KernelTestCase) + php-foundation:php-testing.

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Entity Framework Core patterns for ASP.NET Core projects: DbContext design, code-first entity configuration (Fluent API via IEntityTypeConfiguration<T>), relations (HasOne/HasMany, cascade/restrict/set-null), indexes and unique constraints, projection to DTOs (Select + AsNoTracking), avoiding N+1 (Include, AsSplitQuery), transactions, parameterized raw SQL (FromSql with FormattableString), and connection string from IConfiguration. Works alongside aspnet-core-plugin:aspnet-conventions. Use this skill to: - Design a clean DbContext with ApplyConfigurationsFromAssembly for scalable entity registration. - Configure entity properties (column types, max length, precision, nullability) via Fluent API. - Avoid N+1 query problems with explicit Include / projection to DTOs. - Use transactions correctly for multi-entity operations. - Write parameterized raw SQL safely when LINQ is not expressive enough. Do NOT use this skill for: - Migration generation commands (that is efcore-specialist's job in the database extra phase). - ASP.NET Core middleware, DI, or validation — see aspnet-core-plugin:aspnet-conventions. - C# language idioms — see csharp-foundation:csharp-conventions.

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Generates a complete, professional client onboarding package for AI consultants, AI auditors, and solopreneurs working in the AI space (AI strategy, automation, AI readiness audits, implementation, training, etc.). Use this skill whenever a user asks to onboard a new client, set up a client folder, write a welcome email, generate a discovery questionnaire, draft a service agreement, or create a project brief — especially in an AI consulting context. Also trigger when the user says things like "I have a new client", "prepare onboarding docs", "create a client package", or "set up a new project". Produces four ready-to-use deliverables: intake questionnaire, welcome email, service agreement, and project brief.

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Operator-side guide for generating a target-specific training curve chart for a legacy experiment PR. Use when auditing or presenting historical runs.

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