「hig」の検索結果

Clarify the brief BEFORE any design work to avoid building the wrong thing. Interrogates goal, user, constraints, success criteria, and scope, then writes a short context doc the other design skills consume. Use when the user says "let's design X", "build a UI for Y", "get context", "clarify the brief", or kicks off any product-design task without a clear spec. First stage of the Product Design set — highest leverage for reducing rework.

日本語の概要は準備中です。原文の説明を表示しています。

Orchestrator for the Creative Production skill set — turn a brief into reviewable visual assets. Routes to the right sub-skill (explore, moodboard, positioning, offer, ads-explorer, scene, shot, polish) based on where you are in the creative process. Use when the user gives a high-level creative goal like "make campaign assets", "I need visuals for X", "produce ad creative", "design product shots", or isn't sure which creative step they need. Delegates to creative-* skills.

日本語の概要は準備中です。原文の説明を表示しています。

Judge subskill for simmer. Scores a candidate artifact against user-defined criteria on a 1-10 scale and produces ASI (highest-leverage direction) for the next generator round. Supports judge-only, runnable evaluator, and hybrid evaluation modes. Do not invoke directly — dispatched as a subagent by the simmer orchestrator.

日本語の概要は準備中です。原文の説明を表示しています。

Guide for creating high-quality MCP (Model Context Protocol) servers that enable LLMs to interact with external services through well-designed tools. Use when building MCP servers to integrate external APIs or services, whether in Python (FastMCP) or Node/TypeScript (MCP SDK).

日本語の概要は準備中です。原文の説明を表示しています。

Patterns for vibe coding that produce production-quality output instead of garbage. Covers prompt engineering for AI coding, verification without reading every line, accept/reject/refine decision framework, architectural guardrails, context management (CLAUDE.md, .cursor/rules), TDD-driven vibe coding, screenshot-driven development, diff review discipline, and the anti-patterns that destroy quality. Activate on: "vibe coding", "AI coding quality", "Claude Code workflow", "AI-assisted development", "how to use AI for coding", "coding with AI", "agentic engineering workflow", "AI code quality", "vibe code without garbage", "production quality AI code", "CLAUDE.md setup", "cursorrules setup", "pre-commit hooks for AI", "TDD with AI", "test-driven vibe coding". NOT for: multi-person collaborative coding sessions (use cooperative-vibe-coding), building AI/LLM applications (use ai-engineer), prompt engineering for non-coding LLM use cases (use prompt-engineer).

日本語の概要は準備中です。原文の説明を表示しています。

Prepare high-quality datasets for LLM fine-tuning with filtering, deduplication, augmentation, and RLHF data formatting. Activate on: fine-tuning data, training data curation, RLHF dataset, data quality filtering, SFT dataset. NOT for: model training infrastructure (ai-engineer), prompt engineering without fine-tuning (prompt-engineer).

日本語の概要は準備中です。原文の説明を表示しています。

Use when CPU usage is high, memory grows unboundedly, goroutines leak, mutex contention shows in traces, or escape analysis suggests excess heap allocation. Triggers: net/http/pprof endpoint exposure, go tool pprof analysis, flamegraph generation, allocs vs inuse_space heap profiles, runtime/trace event timeline, mutex profiling, block profiling, goroutine dumps, GC pressure measurement. NOT for non-Go languages, distributed tracing (use OpenTelemetry skill), or production telemetry pipelines.

日本語の概要は準備中です。原文の説明を表示しています。

Design and implement systematic checklists that reduce errors by 30-50% in complex, high-stakes domains (medicine, aviation, construction, finance). NOT for simple tasks or when comprehensive instruction is needed.

日本語の概要は準備中です。原文の説明を表示しています。

Design roadside signs and large-format ads for businesses, especially automotive dealers. Use for pylon signs, monument signs, lot banners, highway billboards, digital roadside boards, service-lane signage, used-car event signs, lease or finance campaign concepts, and other driver-at-speed messaging where legibility, offer hierarchy, and dealer ad compliance matter. Activate on "road sign", "billboard", "dealership sign", "car dealer ad", "pylon sign", "monument sign", "service lane signage", "automotive billboard", "roadside ad", "dealer lease offer", or "drive-by signage". NOT for fabrication drawings, permitting or local sign-code review, web or social ad campaigns, or full brand identity systems.

日本語の概要は準備中です。原文の説明を表示しています。

Calculates statistical power for high-dimensional genomics experiments (bulk RNA-seq, scRNA-seq, ATAC-seq, ChIP-seq, methylation, proteomics) under negative-binomial count models using RNASeqPower, PROPER, and simulation via powsimR, distinguishing per-gene from marginal (transcriptome-wide) power, the role of mean expression and dispersion, and the sequencing-depth-versus-replicate tradeoff. Covers simulation as the honest default for overdispersed counts, FDR-aware average power versus single-test power, observed/post-hoc power as an anti-pattern, and the winner's-curse / Type-S / Type-M consequences of underpowering. Use when planning replicate number for a sequencing experiment, deciding whether to add depth or samples, choosing closed-form versus simulation power, estimating power from pilot dispersions, or justifying replication in a grant. For clinical-trial power see clinical-biostatistics/power-and-sample-size; for the inverse sample-size question see experimental-design/sample-size.

日本語の概要は準備中です。原文の説明を表示しています。

Unsupervised clustering and cell-type identification for high-dimensional flow, spectral, and mass cytometry - FlowSOM, PhenoGraph, FlowSOM-via-CATALYST, with UMAP/tSNE for visualization. Covers the type-vs-state marker distinction (cluster on lineage, test state within clusters), over-provision-then-metacluster, the Weber-Robinson benchmark, seed dependence and metacluster stability, why embeddings are for looking not measuring, and median-heatmap annotation/merging. Use when discovering populations without predefined gates, choosing a clustering algorithm, selecting the number of metaclusters, or annotating clusters into cell types.

日本語の概要は準備中です。原文の説明を表示しています。

Aligns sample metadata with count matrices and constructs design matrices for downstream DE, handling the alphabetical-reference-level trap (relevel BEFORE DESeq), LRT reduced-model rules, the interaction-term resultsNames trap, continuous-covariate scaling and splines, repeated measures via duplicateCorrelation or dream, high-cardinality categorical pseudo-singular designs, sample swap detection via XIST/RPS4Y1 expression and somalier/NGSCheckMate genotypes, SABV (sex-as-biological-variable) mandate, Simpson's-paradox collapsing of technical replicates, and the `~ 0 + group` parameterization for clean contrasts. Use when building a design matrix, troubleshooting reversed fold-change direction, encoding paired or repeated-measures designs, detecting sample swaps, deciding sex-as-covariate, or aggregating technical replicates.

日本語の概要は準備中です。原文の説明を表示しています。

Bead-based signal normalization and cross-batch harmonization for CyTOF and high-parameter cytometry - EQ four-element bead normalization of instrument sensitivity drift (CATALYST normCytof, premessa), and reference-anchor cross-batch normalization (CytoNorm, per-cluster quantile splines). Covers the distinction between within-run drift correction and between-batch correction, the mandatory anchor/reference sample, why normalization is per-cluster with many quantiles, and the over-correction risk. Use when correcting CyTOF signal drift, harmonizing multi-batch or multi-site studies, or deciding whether to normalize data versus model batch in the design.

日本語の概要は準備中です。原文の説明を表示しています。

Build UpSet plots to visualize set intersections beyond 4 sets (where Venn fails) using ComplexUpset (modern, ggplot2-grammar) or the unmaintained UpSetR, with explicit cardinality vs degree sorting, attribute panels, and query highlighting. Use when comparing overlap across many gene sets, peak sets, variant lists, or any set membership matrix where Venn diagrams become illegible.

日本語の概要は準備中です。原文の説明を表示しています。

Detect syntenic blocks and structural rearrangements between genomes using MCScanX (Wang 2012), JCVI/MCScan (Tang 2008 Python), GENESPACE (Lovell 2022) for orthology-anchored riparian visualization, SyRI for structural variation, AnchorWave for sequence-level synteny, i-ADHoRe 3.0 for highly diverged species, SynNet for synteny networks, and ntSynt for multi-genome macrosynteny. Use when identifying collinear gene blocks across species, distinguishing macrosynteny from microsynteny, detecting inversions/translocations/duplications, anchoring orthology in WGD lineages, producing publication riparian plots, computing synteny block age via Ks (cross-references whole-genome-duplication), or running synteny-aware ortholog inference in polyploids.

日本語の概要は準備中です。原文の説明を表示しています。

Estimates bivariate genetic correlation (rg) between traits from GWAS summary statistics or individual-level genotypes using cross-trait LDSC, HDL, LAVA, rho-HESS, GREML-bivariate, Popcorn, and HDL-L. Use when quantifying shared genetic architecture between two traits, screening MR validity before causal inference, distinguishing global from locus-level rg, estimating trans-ancestry rg, separating partial from full causation via LCV gcp, or producing a STROBE-MR-compliant cross-trait sensitivity battery. Cross-trait LDSC intercept absorbs sample overlap and is NOT a bias; HDL is biased under sample overlap above ~5%. High rg between exposure and outcome motivates CHP-aware MR sensitivity (CAUSE, LHC-MR).

日本語の概要は準備中です。原文の説明を表示しています。

End-to-end binder design using BindCraft hallucination. Use this skill when: (1) Designing protein binders with built-in AF2 validation, (2) Running production-quality binder campaigns, (3) Using different design protocols (fast, default, slow), (4) Need joint backbone and sequence optimization, (5) Want high experimental success rate. For backbone-only generation, use rfdiffusion. For QC thresholds, use protein-qc. For tool selection guidance, use binder-design.

日本語の概要は準備中です。原文の説明を表示しています。

Master Python asyncio, concurrent programming, and async/await patterns for high-performance applications. Use when building async APIs, concurrent systems, or I/O-bound applications requiring non-blocking operations.

日本語の概要は準備中です。原文の説明を表示しています。

Assesses Tanner stage to determine if physical changes of puberty have begun (stage G2/B2 or higher) for considering pubertal suppression. Triggered when a clinician evaluates pubertal development in an adolescent patient.

日本語の概要は準備中です。原文の説明を表示しています。

Suggests real-time CGM over no CGM for outpatients with type 2 diabetes who use insulin and/or sulfonylureas and are at high risk for hypoglycemia to detect and prevent low glucose events. Consider when initiating CGM in T2D patients on insulin/SU with a history of severe hypoglycemia or impaired awareness of hypoglycemia (IAH).

日本語の概要は準備中です。原文の説明を表示しています。

Recommends real-time CGM with confirmatory POC-BG for insulin dosing adjustments in insulin-treated hospitalized adults at high risk of hypoglycemia when resources and training are available. Triggers include: "Should we use CGM for insulin adjustments?" or "Is CGM appropriate for this patient?

日本語の概要は準備中です。原文の説明を表示しています。

This skill suggests continuing personal CGM with or without ADIP rather than discontinuation for inpatients already using it who are at high risk for hypoglycemia. Trigger phrases include "Should I continue or discontinue personal CGM for this inpatient who is already using it?" and "Is it appropriate to maintain personal CGM during hospitalization?"

日本語の概要は準備中です。原文の説明を表示しています。

Assesses that CGM low- and high-glucose alarm thresholds are individualized to optimize patient benefit and minimize alarm fatigue. Triggered by clinician prompts to 'Review low-glucose alarm thresholds' or 'Ensure alarms are individualized and not excessive'.

日本語の概要は準備中です。原文の説明を表示しています。

Recommends continuous subcutaneous insulin infusion (CSII) over multiple daily injections (MDI) for adults with type 1 diabetes who have achieved their A1C goal but experience severe hypoglycemia or high glucose variability, provided the patient and caregivers are willing and able to use the device. Consider CSII when clinicians hear 'A1C is at goal but patient has severe lows or glucose swings' or think 'pump for hypoglycemia-prone controlled T1DM'.

日本語の概要は準備中です。原文の説明を表示しています。