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概要と使いどころ
Turnaround analysis, stagnation detection, performance inflection, operational improvement, restructuring analysis, management change impact, cost cutting effectiveness, business transformation, recovery trajectory, operational metrics improvement
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Patient-flow market sizing for med products — prevalence → diagnosed → interested → affordable → covered → treated → persistent, priced as price × duration per cohort, with capacity constraints, named historical analog anchoring, and always bull/base/bear named-driver grids. Use to size a therapy area or product market before any valuation or share work.
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Macro regime analysis, bull bear market detection, business cycle analysis, macro environment assessment, interest rate cycle, yield curve analysis, monetary policy, fiscal policy, global macro, central bank posture, credit cycle, recession probability, expansion regime, macro regime shift, stagflation detection
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What-if scenario analysis, scenario tree construction, base bull bear case, sensitivity to macro variables, revenue scenario modeling, cost scenario analysis, margin impact scenarios, interest rate sensitivity, currency impact scenarios, commodity price scenarios
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Interest rate cycle analysis, Fed policy analysis, yield curve dynamics, duration management, central bank rate trajectory, monetary tightening easing, bond market analysis, rate forecast, forward curve, dot plot interpretation, rate hike cut cycle
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Full enhancement pipeline for an existing Lattice skill — rewrites a molecule or atom to modern-capable-model grade: restores degraded grammar, deduplicates, hardens gates and branching to one-unambiguous-action precision, verifies zero behavioral loss against a pre-capture diff, then runs the combined QA gate (skill-review, skill-tighten, skill-validate) and an independent fresh-context verifier, fixing everything found. Consumer-first: optimized for first-time open-source users on fresh repos with minimal .lattice/ setup, running capable models. Use when the user says 'enhance this skill', 'upgrade this molecule', 'modernize this skill', 'optimize this skill', 'make this skill production grade', 'full enhancement', 'polish this molecule like design-blueprint', or names a molecule/atom to overhaul. For gap-finding only use skill-review; for conventions only use skill-validate — this skill runs the whole loop end to end.
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Restructure existing code safely without changing externally observable behavior. Composes context, design, architecture, code quality, and testing guardrails into a characterization-first refactoring workflow. Use when the user says 'refactor this', 'clean this up', 'untangle this module', 'move this to the right layer', 'simplify this code', or 'improve this structure'.
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Produce speech and clone voices with Fish Audio — its hosted TTS API (S2.1-Pro / S2-Pro / S1 model lineup, REST + WebSocket streaming, instant and persistent voice cloning) and its open-weight OpenAudio S1-mini / Fish-Speech models for self-hosting. Use this skill when an agent must generate narration or dialogue through Fish Audio, choose between Fish Audio's hosted models and open weights, clone a voice from reference audio, author emotion/tone/special markers for expressive delivery, estimate cost from UTF-8 bytes, wire real-time streaming for a voice agent, decide whether self-hosting beats the API, or review Fish Audio TTS output for production. Do not use it to pick a different provider — it covers Fish Audio specifically.
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Use ACE-Step and ACE-Step 1.5 for local or hosted AI music generation, including text-to-music, lyrics-to-song, instrumental beds, covers, repainting, stem/track extraction, track completion, LoRA personalization, REST/Python/Gradio workflows, rights review, and music integration for video, ads, games, and social content.
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Use Adobe Firefly Services to generate, edit, expand, fill, match, composite, and upscale still images through the current REST APIs. Apply when selecting Firefly Image 5 versus Image 3/4 or custom models, implementing authenticated asynchronous image workflows, using style or structure references, building product composites, handling provenance and enterprise rights, or diagnosing Firefly image jobs in production. Exclude Firefly video, audio, and unrelated Creative Cloud APIs.
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Provider-independent workflow for AI agents producing documentary-style montages, archive-driven timelines, interview-supported sequences, nonprofit or advocacy shorts, historical explainers, and hybrid generated/archive edits. Use for editorial thesis development, research/source logs, fact-checking, archive rights, synthetic reenactment disclosure, chronology, interview selects, lower thirds, generated b-roll direction, music restraint, captions, sensitive subjects, review escalation, delivery variants, and documentary QA.
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Provider-independent production guidance for AI agents creating or retouching appetizing food and beverage images, recipe videos, restaurant/menu visuals, CPG ads, ecommerce product images, beverage pours, packaging/lifestyle shots, and social food clips, including truthfulness, labeling/claims discipline, styling, prompt translation, platform variants, accessibility, rights, alcohol, and QA.
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Research target audiences across Reddit, Twitter, Instagram, and Xiaohongshu to understand demographics, interests, pain points, language patterns, and content preferences. Produces audience personas backed by real community data.
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Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda window scheduling, soft-core potentials, REST2 enhanced sampling, MBAR/BAR analysis, and cycle closure validation. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.
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Computes and interprets treatment effect measures (OR, RR, RD, HR, NNT) with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen, MOVER, profile likelihood, Bender NNT) and reports marginal vs conditional estimands per FDA 2023 covariate adjustment guidance. Use when reporting treatment effects in confirmatory trials, comparing effect sizes across studies, or constructing forest plots.
日本語の概要は準備中です。原文の説明を表示しています。
Generates 3D conformer ensembles using RDKit ETKDGv3 with knowledge-enhanced distance geometry, MMFF94/UFF force-field optimization, CREST + GFN2-xTB semi-empirical refinement, and macrocycle-aware torsion preferences. Provides explicit decision rules for single vs ensemble conformer use, RMSD pruning, energy windows, conformer count, and force-field choice. Use when preparing 3D ligands for docking, generating descriptor input for 3D QSAR, or sampling macrocycle/peptide conformational ensembles.
日本語の概要は準備中です。原文の説明を表示しています。
Corrects the gene-independent copy-number artifact in CRISPR-Cas9 screens (Aguirre 2016 / Munoz 2016 Cancer Discov) where amplified loci appear essential from DNA-damage burden of simultaneous cuts. Covers the p53-dependent G2-arrest mechanism, CRISPRcleanR (Iorio 2018) unsupervised pre-hoc correction, CERES (Meyers 2017) joint CN + gene-effect model, Chronos (Dempster 2021) DepMap-standard population-dynamics + CN model with lowest residual bias, the decision tree by data availability, the Spearman LFC-vs-CN diagnostic, focal-amplification examples (ERBB2 in HER2+, MYC in colorectal, FGFR1 in head and neck), and CRISPRi/a alternatives that bypass the artifact. Use when screening cancer cell lines, diagnosing essentiality at amplified loci, choosing CRISPRcleanR / CERES / Chronos, deciding whether CN correction is needed before MAGeCK / BAGEL2 / drugZ, or switching from Cas9 to CRISPRi.
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Queries ClinVar for variant pathogenicity classifications, ClinGen VCEP curations, and somatic-vs-germline interpretations via REST API, weekly VCF, or bulk XML. Use when determining clinical significance, triangulating conflicting interpretations, or aggregating evidence against the ACMG/AMP framework with ClinGen SVI specifications.
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Performs time-to-event analysis for clinical trials including Cox proportional hazards regression with PH diagnostics, restricted mean survival time (RMST) under non-PH, competing risks via Fine-Gray vs cause-specific Cox, weighted log-rank and MaxCombo for non-proportional hazards, recurrent events (Andersen-Gill, PWP, WLW), and interval-censored data. Use when analyzing time-to-event endpoints (OS, PFS, DOR, TTR, TTNT) in oncology or other clinical trials.
日本語の概要は準備中です。原文の説明を表示しています。
Pull pre-computed ortholog calls from public databases (OrthoDB, Ensembl Compara, OMA browser, eggNOG, PANTHER, KEGG Orthology, HomoloGene) via their REST APIs. Use when orthologs are already curated upstream, when the question is "what is the X ortholog of Y" rather than "how to infer orthology de novo", when batch-mapping gene IDs across species, or when comparing the resources for consensus calls. Encodes confidence-level semantics, 1:1 vs 1:many vs many:many, HomoloGene deprecation, and when to defect to de novo computation.
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This skill should be used when the user wants to query their Google NotebookLM notebooks for citation-backed, source-grounded answers, or manage notebooks, sources, and Studio content (audio, report, video, infographic, presentation, data table, flashcards, quiz, mind map). It drives the @roomi-fields/notebooklm-mcp engine — via the notebooklm MCP tools when they are available in the session, otherwise via its HTTP REST API — and covers Google login, citation formats, the daily-quota-aware batch/ingestion pattern, and source discovery.
日本語の概要は準備中です。原文の説明を表示しています。
Plain language applied to source code (ISO 24495-1:2023 principles). Governs the parts of code a person reads: the order units appear in, their names, comments, and error messages. Applied when writing or restructuring code, not when explaining it.
日本語の概要は準備中です。原文の説明を表示しています。
Internal — for Boundless team members only. Query the Boundless Indexer REST API for on-chain market data, staking, PoVW rewards, delegations, and market efficiency on prod/staging environments. Use when the user asks about proof requests, provers, requestors, staking data, PoVW rewards, delegations, market aggregates, leaderboards, or wants to fetch data from the indexer API on live networks. Also use when the user mentions "indexer" and wants to look up addresses, requests, or market statistics on deployed environments. Do NOT use for debugging local code changes, reviewing PRs, or investigating issues in the codebase itself.
日本語の概要は準備中です。原文の説明を表示しています。
Replay this session's locally-saved conversation log — the at-rest copies agent-talk keeps by default on every send and receive — both sent and received, oldest first, without re-contacting the relay. Use to review the conversation with a peer. `<user>` is this session's user directory (absolute path; from init).
日本語の概要は準備中です。原文の説明を表示しています。