3,587 件 ・ 関連度順
概要と使いどころ
Use when judging whether a manuscript's landing point is an ACCOUNTING issue (accounting information / disclosure / audit / standards) versus a corporate-finance mechanism, before drafting for 《会计研究》 (Accounting Research). Use this to decide fit and to re-route finance-mechanism papers to a finance journal before any other acr-* skill.
日本語の概要は準備中です。原文の説明を表示しています。
Extract and score leads from GitHub repositories by analyzing stars, forks, issues, PRs, comments, and contributions. Produces unified multi-repo CSV with deduplicated user profiles. No paid API credits required.
日本語の概要は準備中です。原文の説明を表示しています。
Use when SLCI code inspection has failed due to compatibility issues and you need to diagnose the incompatibilities. Traces inspection failures back to root-cause incompatibility settings or known limitations by matching failed code lines against known incorrect code generation patterns and documented limitation scenarios. Hands off to slci-compatibility-analysis for fixes. Trigger keywords: inspect, inspection failed, trace inspection errors, why did inspection fail, SLCI verification failures, limitation.
日本語の概要は準備中です。原文の説明を表示しています。
Diagnose and fix .NET HTTPS dev certificate trust issues on Linux. Covers the full certificate lifecycle from generation to system CA bundle inclusion, with distro-specific guidance for Ubuntu, Fedora, Arch, and WSL2.
日本語の概要は準備中です。原文の説明を表示しています。
Extracts cfDNA fragmentomics features (DELFI genome-wide short/long ratios, WPS nucleosome positioning, Griffin GC-corrected accessibility profiles, end-motifs/MDS, OCF) for cancer detection and tissue-of-origin from plasma WGS. Centers on the nuclease-footprint reframe (every feature re-reads one nucleosome object), the mandatory GC correction, and the cross-protocol non-comparability that breaks naive classifiers. Runs FinaleToolkit (real CLI/Python, MIT) and the Griffin Snakemake pipeline; DELFI is a method, not a package. Use when deriving fragment-based signal from cfDNA, choosing a feature family for detection vs subtyping, or diagnosing why a fragmentomic model failed validation.
日本語の概要は準備中です。原文の説明を表示しています。
Analyze spatial cell-cell interactions, neighborhoods, and niches in IMC/MIBI data with squidpy and imcRtools, covering neighborhood-enrichment permutation nulls, the abundance-vs-density confound, inhomogeneous Ripley's K, cellular-neighborhood discovery, graph-construction (contact vs proximity), and edge effects. Use when testing whether cell types co-locate, choosing a spatial null, building a neighbor graph, discovering tissue niches, or deciding whether a spatial pattern is real or a density/segmentation artifact.
日本語の概要は準備中です。原文の説明を表示しています。
Segment single cells from multiplexed IMC/MIBI tissue images using Mesmer/DeepCell, Cellpose, or ilastik+CellProfiler, covering whole-cell vs nuclear segmentation, the summed-membrane-channel decision, nuclear-expansion bias, lateral spillover, resolution-floor parameters, and downstream-proxy evaluation. Use when delineating cells after preprocessing, choosing a segmentation model, building a cell mask for quantification, diagnosing impossible double-positive populations, or troubleshooting over/under-segmentation.
日本語の概要は準備中です。原文の説明を表示しています。
Calculates tumor mutational burden from WES/WGS/panel data with Friends of Cancer Research harmonization equations, per-assay calibration (FDA 10/Mb = 7.8 TSO500 = 8.4 OncomineTML), synonymous/indel/germline filtering, hypermutator tiering, blood TMB, and integration with HLA-LOH and neoantigen quality (Luksza 2017 fitness). Use when assessing ICI eligibility under tumor-specific cutoffs (McGrail 2021), comparing tissue vs bTMB, or auditing TMB-H reporting against ESMO 2024 and FDA pembrolizumab pan-tumor 2020.
日本語の概要は準備中です。原文の説明を表示しています。
Estimates SNP heritability and partitions it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes. Implements LDSC, stratified LDSC with the baseline-LD model, Finucane 2018 cell-type prioritization, LDAK SumHer, HDL, HESS local heritability, BOLT-REML, GCTA-GREML, graphREML, and Popcorn cross-population genetic correlation. Use when computing total h2_SNP from summary stats, partitioning heritability across functional categories, prioritizing trait-relevant tissues or cell types from ENCODE/Roadmap chromatin marks, reconciling LDSC vs LDAK enrichment estimates, computing local heritability with HESS, estimating genetic correlation between traits, or producing publication-grade enrichment with calibrated sensitivity to model assumptions.
日本語の概要は準備中です。原文の説明を表示しています。
Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021), MAGMA gene-based association (de Leeuw 2015), FUMA SNP2GENE, cS2G combined SNP-to-gene scores (Gazal 2022), Polygenic Priority Scores (PoPS, Weeks 2023), FLAMES, INQUISIT, DEPICT, and enhancer-gene predictors (ABC, ENCODE-rE2G). Use when narrowing a GWAS lead locus to a candidate causal gene, picking between proximity, eQTL-based, and similarity-based prioritizers, integrating multi-evidence streams (fine-mapping, colocalization, ABC enhancer-gene, distance, chromatin), reconciling discordant L2G vs PoPS calls, prioritizing tissue-specific eQTL evidence, or triangulating across at least three independent lines of evidence for a publication-grade effector-gene nomination.
日本語の概要は準備中です。原文の説明を表示しています。
Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.
日本語の概要は準備中です。原文の説明を表示しています。
Detects aberrant splicing in single rare-disease patients vs a control panel using FRASER 2.0 (Bioconductor; Beta-binomial autoencoder on Intron Jaccard Index, default delta cutoff 0.1, q hyperparameter), OUTRIDER (gene-level outlier expression via autoencoder denoising), LeafcutterMD (Dirichlet-multinomial outlier mode of LeafCutter for annotation-free junctions), and DROP (Snakemake pipeline integrating FRASER2 + OUTRIDER + monoallelic expression for clinical diagnostics). The statistical model is fundamentally different from differential splicing — single-sample-vs-cohort outlier detection rather than two-group comparison. Standard tool in EU rare-disease (Solve-RD) and NIH UDN programs. Use when applying RNA-seq to undiagnosed Mendelian disease, validating predicted splice variants in clinical samples, or detecting cryptic splicing in disease tissue.
日本語の概要は準備中です。原文の説明を表示しています。
Use when an Apple-platform app feels slow, memory grows, battery drains, or ANY performance issue needs diagnosing. Covers memory leaks, profiling, Instruments workflows, retain cycles, optimization.
日本語の概要は準備中です。原文の説明を表示しています。
Use when the user mentions SPM resolution failures, "no such module" errors, duplicate symbol linker errors, version conflicts between packages, or Swift 6 package compatibility issues.
日本語の概要は準備中です。原文の説明を表示しています。
Use when the user mentions iCloud sync issues, CloudKit errors, ubiquitous container problems, or asks to audit cloud sync.
日本語の概要は準備中です。原文の説明を表示しています。
Use when the user mentions SwiftData review, @Model issues, SwiftData migration safety, or SwiftData performance checking.
日本語の概要は準備中です。原文の説明を表示しています。
Use when the user mentions in-app purchase review, IAP audit, StoreKit issues, purchase bugs, transaction problems, or subscription management.
日本語の概要は準備中です。原文の説明を表示しています。
Use when the user mentions SwiftUI architecture review, separation of concerns, testability issues, or "logic in view" problems.
日本語の概要は準備中です。原文の説明を表示しています。
Use when the user mentions SwiftUI navigation issues, deep linking problems, state restoration bugs, or navigation architecture review.
日本語の概要は準備中です。原文の説明を表示しています。
Use when the user mentions Foundation Models review, on-device AI audit, LanguageModelSession issues, or @Generable/guardrail problems — including missing availability checks, manual JSON parsing, and guardrail handling.
日本語の概要は準備中です。原文の説明を表示しています。
Use when fixing or auditing ANY accessibility issue — VoiceOver, Dynamic Type, color contrast, touch targets, WCAG compliance, App Store accessibility review.
日本語の概要は準備中です。原文の説明を表示しています。
Use when the user mentions UX flow issues, dead-end views, dismiss traps, missing empty states, broken user journeys, or wants a UX audit of their iOS app.
日本語の概要は準備中です。原文の説明を表示しています。
Use when ANY iOS or macOS build fails, a crash log needs diagnosing, a test run crashes, Xcode misbehaves, or an environment issue blocks work before code is the suspect. Covers build failures, dependency conflicts, simulator diagnostics.
日本語の概要は準備中です。原文の説明を表示しています。
Use when the user mentions Xcode build failures, build errors, or environment issues.
日本語の概要は準備中です。原文の説明を表示しています。