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概要と使いどころ
Apply GEODE's measured architecture, module and symbol naming, Python type/class, persisted schema, test, site, and versioning conventions. Use when adding or moving modules, choosing dataclass/Pydantic/Protocol/ABC forms, naming classes or files, designing stored data, reviewing convention compliance, or deciding compatibility and release version treatment.
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GEODE CHANGELOG.md management rules. Version releases, change logging, scope determination, format standards. Triggers on "changelog", "release", "version", "릴리스", "변경사항", "버전".
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Aligns sample metadata with count matrices and constructs design matrices for downstream DE, handling the alphabetical-reference-level trap (relevel BEFORE DESeq), LRT reduced-model rules, the interaction-term resultsNames trap, continuous-covariate scaling and splines, repeated measures via duplicateCorrelation or dream, high-cardinality categorical pseudo-singular designs, sample swap detection via XIST/RPS4Y1 expression and somalier/NGSCheckMate genotypes, SABV (sex-as-biological-variable) mandate, Simpson's-paradox collapsing of technical replicates, and the `~ 0 + group` parameterization for clean contrasts. Use when building a design matrix, troubleshooting reversed fold-change direction, encoding paired or repeated-measures designs, detecting sample swaps, deciding sex-as-covariate, or aggregating technical replicates.
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Maps between gene identifier systems (Ensembl, Entrez, HGNC symbol, UniProt, RefSeq, MANE) using AnnotationDbi, biomaRt, mygene, pyensembl, and Ensembl REST. Encodes Ensembl version stripping with GENCODE _PAR_Y preservation, the Ziemann 2016 Excel autocorrect debacle and Bruford 2020 HGNC renames (SEPT*->SEPTIN*, MARCH*->MARCHF*, MARC*->MTARC*, DEC1->DELEC1), OCT4/POU5F1 alias resolution, biomaRt archive endpoints for release pinning, the `filters` (plural) gotcha, MANE Select for clinical reporting, cross-species orthology via Ensembl Compara / OMA / OrthoDB, and tx2gene construction for tximport. Use when converting gene IDs across systems, handling renamed symbols, building tx2gene, pinning to a specific Ensembl release for reproducibility, or mapping cross-species orthologs.
日本語の概要は準備中です。原文の説明を表示しています。
Analyzes time-series and longitudinal RNA-seq for differential expression and trajectory structure. Covers DESeq2 LRT with reduced models, time as factor vs continuous vs natural splines, maSigPro (Nueda 2014 for RNA-seq), ImpulseDE2 with explicit impulse-model failure modes, DREAM for repeated measures via linear mixed models, pseudoreplication avoidance, conditional vs marginal modeling, and trajectory clustering with DPGP, Mfuzz (with Schwämmle 2010 fuzzifier estimation), and splines+k-means. Use when modeling time-course or longitudinal expression, choosing factor vs spline, handling repeated measures from the same subject, avoiding pseudoreplication, clustering temporal trajectories, or selecting between dedicated time-course tools and pairwise+LRT.
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Computes and interprets treatment effect measures (OR, RR, RD, HR, NNT) with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen, MOVER, profile likelihood, Bender NNT) and reports marginal vs conditional estimands per FDA 2023 covariate adjustment guidance. Use when reporting treatment effects in confirmatory trials, comparing effect sizes across studies, or constructing forest plots.
日本語の概要は準備中です。原文の説明を表示しています。
Use when a problem requires structured step-by-step reasoning before acting. Prevents jumping to conclusions or guessing root causes without evidence. Triggers on complex debugging, multi-step analysis, hypothesis verification, or when mk:fix invokes diagnosis phase. NOT for being stuck on approach (too many implementations, forced assumptions, innovation block) — use mk:problem-solving instead.
日本語の概要は準備中です。原文の説明を表示しています。
Post-ship documentation update. Reads all project docs, cross-references the diff, updates README/ARCHITECTURE/CONTRIBUTING/CLAUDE.md to match what shipped, polishes CHANGELOG voice, cleans up TODOS, and optionally bumps VERSION. Use when asked to "update the docs", "sync documentation", or "post-ship docs". Proactively suggest after a PR is created and before it merges.
日本語の概要は準備中です。原文の説明を表示しています。
Template for pre-reasoning → action → post-verification model allocation
日本語の概要は準備中です。原文の説明を表示しています。
Analyze release workflow findings and recommend follow-up actions — execute immediately or register as issues
日本語の概要は準備中です。原文の説明を表示しています。
Generate structured release notes from git history and closed issues within Claude Code session
日本語の概要は準備中です。原文の説明を表示しています。
Generate release-unit development plans from professor-triage completed (verify-done) issues, grouping by priority and size
日本語の概要は準備中です。原文の説明を表示しています。
Use when taking a repo open source, or hardening one that already is. Run /oss-launch and it scans the repo (stack, existing files, git remote, secrets), asks only what it cannot infer, then generates a tailored OSS file collection (README, LICENSE, CONTRIBUTING, CODE_OF_CONDUCT, SECURITY, CHANGELOG, .gitignore, .github/ issue + PR templates, CI/CD). Also covers launch (GitHub metadata, badges, Show HN, Reddit, YouTube), release cadence (SemVer + CHANGELOG), and demo-GIF generation. Triggers on "open source this", "OSS checklist", "prep for launch", "make this repo public", "add a license / contributing / security policy", "Show HN", "release workflow", "star growth", "get contributors".
日本語の概要は準備中です。原文の説明を表示しています。
Use this skill for ANY of the following — do not skip it even if the query seems simple: strategic decisions, business analysis, thesis building, complex problem solving, geopolitical analysis (non-market), philosophical reasoning, academic research, system design, decision under uncertainty, long-form thinking, or any question that benefits from First Principle deconstruction and multi-agent reasoning. ALWAYS use this skill when the user asks about: why something works the way it does, whether a decision is correct, how to think about a complex problem, what could go wrong, analyzing a situation from multiple angles, or any "should I..." question involving real-world trade-offs. This is NOT a market/trading skill — for financial markets, BTC, gold, stocks, forex, macro economics, use money-atlas-intelligence-os instead.
日本語の概要は準備中です。原文の説明を表示しています。
Assess package choices and generated dependency names, publisher or release anomalies, incident exposure, and changes in package risk reports. Use before trusting a new dependency, when a release changes unexpectedly, or when investigating a supply-chain alert.
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This skill suggests using real-time continuous glucose monitoring (CGM) rather than no CGM for outpatients with type 2 diabetes (T2D) who take insulin and/or sulfonylureas and are at high risk for hypoglycemia. It is triggered by clinician questions such as "Should I use CGM for this T2D patient on insulin or sulfonylureas with high hypoglycemia risk?" or "Is CGM indicated for this patient?"
日本語の概要は準備中です。原文の説明を表示しています。
Reassesses annually the patient’s CGM sensor site health and care practices, including skin integrity, rotation, and hygiene. Triggered by phrases such as 'Yearly sensor site inspection' or 'Annual review of CGM insertion site rotation and hygiene'.
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Reassesses annually the patient’s use of self-monitoring blood glucose to calibrate the CGM system. Triggered by ‘Yearly calibration practice review’ or ‘Annual check of SMBG calibration adherence’.
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Reassesses annually the patient’s ability to use CGM trend information to adjust insulin doses. Triggered by yearly CGM skills check or annual review of trend-based dosing competence.
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This skill confirms that medical therapy has normalized cortisol before initiating radiation therapy or radiosurgery for Cushing's syndrome to maintain disease control while awaiting radiation effect. It is triggered when planning pituitary RT/radiosurgery for a patient with persistent or recurrent Cushing's disease after transsphenoidal surgery (TSS) or when medical therapy is being used as a bridge to radiation.
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This skill suggests administering a glucocorticoid antagonist (e.g., mifepristone) in patients with Cushing's disease who have diabetes or glucose intolerance and are not surgical candidates or have persistent disease after transsphenoidal surgery. Consider when encountering persistent hypercortisolism after TSS, contraindications to surgery, or comorbid diabetes/glucose intolerance requiring medical control.
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This skill recommends measuring serum cortisol or urine free cortisol off-medication at 6- to 12-month intervals to assess radiation therapy effect in patients with Cushing's syndrome undergoing or post-radiotherapy. It is also indicated when patients on stable medical therapy develop new adrenal insufficiency symptoms such as fatigue, weight loss, or hypotension.
日本語の概要は準備中です。原文の説明を表示しています。
This skill suggests radiation therapy or radiosurgery for adult patients with Cushing's disease who have failed transsphenoidal surgery (TSS) or have recurrent disease after initial remission. Consider when postoperative urinary free cortisol or late-night salivary cortisol remains elevated, or when clinical recurrence is suspected.
日本語の概要は準備中です。原文の説明を表示しています。
This skill recommends using radiation therapy for corticotroph adenomas in Cushing's disease when imaging shows invasive features or mass‑effect concerns such as cavernous sinus invasion, suprasellar extension, or knobby protrusion. Consider RT when postoperative medical therapy has normalized cortisol but tumor progression or residual invasive disease is suspected.
日本語の概要は準備中です。原文の説明を表示しています。