2,010 件 ・ 関連度順
概要と使いどころ
Safely update an npm package by checking npmjs.com for the latest version, reading release notes, and handling minor vs major upgrades differently. For minor updates, just do it. For major updates, find the upgrade guide, validate breaking changes, and produce a detailed migration report.
日本語の概要は準備中です。原文の説明を表示しています。
Scan agent skills for security issues. Use when asked to "scan a skill", "audit a skill", "review skill security", "check skill for injection", "validate SKILL.md", or assess whether an agent skill is safe to install. Checks for prompt injection, malicious scripts, excessive permissions, secret exposure, and supply chain risks.
日本語の概要は準備中です。原文の説明を表示しています。
Document and type a Sentry API endpoint. Write or fix @extend_schema decorators, specify response TypedDicts, type request parameters, correct type drift between the declared schema and the runtime response, and validate the generated spec. Use when asked to "document an endpoint", "add OpenAPI docs", "add/fix @extend_schema", "type an endpoint response", "fix the response type", "fix type drift", "reuse a response type", "split an overloaded endpoint", "specify the response schema", "add a TypedDict response", "migrate a legacy api-docs path", "fix a parameter type", or "make an endpoint public" / "promote an endpoint" (promotion is one section here).
日本語の概要は準備中です。原文の説明を表示しています。
Reads, validates, and prepares CDISC SDTM and ADaM clinical trial data for analysis. Covers SDTM domain joins (DM, AE, EX, VS, LB, DS), ADaM architecture (ADSL, BDS, OCCDS, ADTTE) with traceability, treatment-emergent AE conventions, baseline derivation, SUPPQUAL/NSV handling, Define-XML 2.1, and Pinnacle 21 / CORE validation. Use when working with clinical trial datasets in CDISC SDTM/ADaM format, preparing analysis-ready data, or validating for regulatory submission.
日本語の概要は準備中です。原文の説明を表示しています。
Builds and validates predictive time-to-event models on clinical and omics data with penalized Cox, random survival forests, gradient-boosted and deep survival models, and prediction-grade evaluation (Uno's C, time-dependent AUC, integrated Brier, calibration, competing risks). Use when building an individualized risk predictor or prognostic omics signature, choosing a survival model, or evaluating one beyond the C-index. For Kaplan-Meier, log-rank, and classical Cox hazard-ratio inference in a trial see clinical-biostatistics/survival-analysis.
日本語の概要は準備中です。原文の説明を表示しています。
Explains ML predictions on omics data with SHAP, LIME, and permutation importance, handling the correlated-feature trap, the conditional-vs-interventional Shapley choice, and the attribution-is-not-causation boundary. Use when interpreting an omics classifier, debugging shortcut/batch learning, or deciding whether an attribution ranking can be trusted as biology. For validated feature selection see machine-learning/biomarker-discovery; explanations are not a selection method.
日本語の概要は準備中です。原文の説明を表示しています。
Validates predictive models on omics and biomedical data with nested cross-validation, group/batch/temporal-aware splits, the full data-leakage taxonomy, probability calibration, decision-curve net benefit, optimism correction, sample-size planning, and TRIPOD+AI reporting. Use when estimating model performance honestly, choosing a CV scheme, detecting leakage, or judging whether reported discrimination means the model is actually useful. For feature selection itself see machine-learning/biomarker-discovery; for confirmatory-trial inference see clinical-biostatistics/trial-reporting.
日本語の概要は準備中です。原文の説明を表示しています。
Authors portable, strongly-typed bioinformatics pipelines in the Common Workflow Language (CWL v1.2) as CommandLineTool/Workflow/ExpressionTool documents, validated with cwltool and run at scale on Toil/Arvados/Calrissian. Use when deciding CWL (portability/provenance/regulated) vs Nextflow/WDL/Snakemake; declaring secondaryFiles for indexed companions (.bai/.fai/.dict/.tbi and the caret rule); putting resources/containers under requirements (must-hold) vs hints (advisory) to avoid silent OOM; choosing scatterMethod (dotproduct vs flat_/nested_crossproduct); preferring $(...) parameter refs over ${...} JavaScript for portability; pinning DockerRequirement images; or emitting a CWLProv provenance object for audited/clinical settings.
日本語の概要は準備中です。原文の説明を表示しています。
Orchestrates the untargeted LC-MS metabolomics pipeline end-to-end (xcms 4.x feature extraction, QC/drift/normalization, confidence-stratified annotation, permutation-validated statistics, background-aware pathway mapping), naming what each stage decides and where it silently fails. Use when running a full LC-MS metabolomics study from raw mzML to enriched pathways and needing the honest handoffs between stages. Each stage defers to its component skill for parameters and traps; for stable-isotope flux (a separate branch, not this untargeted flow) see metabolomics/isotope-tracing.
日本語の概要は準備中です。原文の説明を表示しています。
End-to-end biomarker discovery workflow from expression data to validated biomarker panels. Covers feature selection with Boruta/LASSO, leakage-safe cross-validation, calibration, and SHAP interpretation. Use when building and validating diagnostic or prognostic biomarker signatures from omics data.
日本語の概要は準備中です。原文の説明を表示しています。
Automatically discover life science APIs online, create ToolUniverse tools, validate them, and prepare integration PRs. Performs gap analysis to identify missing tool categories, web searches for APIs, automated tool creation using devtu-create-tool patterns, validation with devtu-fix-tool, and git workflow management. Use when expanding ToolUniverse coverage, adding new API integrations, or systematically discovering scientific resources.
日本語の概要は準備中です。原文の説明を表示しています。
Transform GWAS signals into drug targets and repurposing opportunities. Connects GWAS-significant loci to causal genes via fine-mapping/eQTL, then to druggable proteins via DGIdb/OpenTargets, then to existing drugs via ChEMBL. Use for GWAS-to-target hypothesis generation, druggable-fraction analysis of disease loci, and human-genetics-validated drug-repurposing prioritization.
日本語の概要は準備中です。原文の説明を表示しています。
Validates docked / generated protein-ligand poses using PoseBusters physical-validity tests, strain energy quantification, geometric checks (planarity, vdW overlap, bond/angle distortion), and pose-energy reasonableness. Filters AI-docking outputs (DiffDock, EquiBind, NeuralPLexer) where ~50% of poses fail physical-validity tests. Use when QC-ing docking results, comparing classical vs ML docking outputs, or filtering pose lists before SAR analysis.
日本語の概要は準備中です。原文の説明を表示しています。
Designs and validates quantitative targeted metabolomics assays (MRM/SRM on triple-quadrupole, PRM on high-resolution instruments) to report absolute concentrations. Covers the internal-standard strategy (external cal -> global IS -> standard addition -> stable-isotope-labeled IS), weighted calibration judged by back-calculated %RE not R-squared, ion-ratio quantifier/qualifier confirmation, matrix-effect/recovery characterization, and ICH M10 method validation. Use when quantifying a closed panel of known metabolites with units, building or validating an LC-MS/MS assay, choosing an IS or calibration weighting, or judging whether a reported concentration is trustworthy. For untargeted feature detection see metabolomics/xcms-preprocessing; for group statistics see metabolomics/statistical-analysis; for flux/MID/tracing see metabolomics/isotope-tracing.
日本語の概要は準備中です。原文の説明を表示しています。
Decision-grade statistical analysis for metabolomics intensity tables. Covers transformation and scaling (Pareto vs unit-variance as a hidden hypothesis), unsupervised structure (PCA/HCA for QC), permutation-validated PLS-DA/OPLS-DA (R2 vs Q2, double CV, VIP as heuristic), univariate testing (Welch/Mann-Whitney/ANOVA/LMM with covariate adjustment), and dependence-aware multiple testing. Use when testing which metabolites differ, building or validating a discriminant model, choosing a scaling, or correcting many correlated tests. For sample-wise normalization/drift correction see metabolomics/normalization-qc; for ML classifiers and selection-inside-CV leakage see machine-learning/biomarker-discovery and machine-learning/model-validation; for pathway interpretation see metabolomics/pathway-mapping; for design/power/multiplicity regime see experimental-design/multiple-testing.
日本語の概要は準備中です。原文の説明を表示しています。
Create, update, or validate a product brief. Use when the user wants help producing, editing, or validating a brief.
日本語の概要は準備中です。原文の説明を表示しています。
Validate and analyze budgets for SCF Build Award submissions. Use when reviewing whether a submission's budget is proportional, justified, and well-structured based on patterns from 215 funded Build Awards.
日本語の概要は準備中です。原文の説明を表示しています。
Create, update, or validate a PRD. Use when the user wants help producing, editing, or validating a PRD.
日本語の概要は準備中です。原文の説明を表示しています。
Verify implementation matches change artifacts. Use when the user wants to validate that implementation is complete, correct, and coherent before archiving.
日本語の概要は準備中です。原文の説明を表示しています。
Validate, migrate, and atomically persist files and configuration with safe fallback and restart coverage.
日本語の概要は準備中です。原文の説明を表示しています。
Validate UI, command, text, numeric, entity, and configuration input with localized feedback and server authority.
日本語の概要は準備中です。原文の説明を表示しています。
Discover and reuse owner resource structure, then validate paths, RSI, audio, maps, attribution, and localization companions.
日本語の概要は準備中です。原文の説明を表示しています。
Create, inherit, compose, localize, and validate YAML prototypes in the correct resource root.
日本語の概要は準備中です。原文の説明を表示しています。
Search academic literature and generate, validate, or compare Knows paper sidecars. Use for claim/evidence analysis and literature synthesis.
日本語の概要は準備中です。原文の説明を表示しています。