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Annotate speech/TTS datasets with per-clip quality metrics (MOS, SNR, STOI, pitch, bandwidth, speaking rate, WER/CER, gender/emotion), multi-ASR consensus transcription and speaker labeling using the audiogear pipeline; then filter clips by quality and build listenable HTML QA reports. Use when asked to compute audio dataset metrics, build extended_metadata.csv, transcribe unlabeled audio, select clean TTS training data, or QA a speech dataset.

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Jev/TypeSafe System One 模型用法参考库，收录 124 条 JEV 实战案例（68 条 X 帖子 + 56 个开源项目，9 大场景），含 Jev 独立评分/精选标记/看点标签/原帖截图/X 链接。当用户提到 Jev/JEV/TypeSafe 的用途、玩法、案例、示例，或需要为 Jev 选型、评估能力边界、回答"Jev 能干什么"，或 Agent 想在用户不主动说明时主动推荐 Jev 玩法时使用。

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Up-to-date Zig programming language patterns for version 0.17.0-dev (0.16.0 stable APIs plus the 0.17 deltas). Use when writing, reviewing, or debugging Zig code, working with build.zig and build.zig.zon files, or using comptime metaprogramming. Critical for avoiding outdated patterns from training data - especially std.net→std.Io.net (requires Io instance), std.time timestamps removed (use clock_gettime), std.Thread.Mutex/Condition/sleep removed (use pthreads), std.crypto.random removed, build system APIs (root_module, Compile methods→Module methods), I/O APIs (buffered writer pattern), container initialization (.empty/.init), allocator selection (DebugAllocator), ArrayList now unmanaged by default, @typeInfo lowercase fields (.@"struct" not .Struct), and removed language features (async/await, usingnamespace). Also covers 0.17.0-dev deltas: b.args→run_cmd.addPassthruArgs(), std.gpu→std.spirv, @bitCast logical-bit (endian-agnostic) semantics, build configurer/maker split, and the zig-pkg/ package directory. Also covers quality tooling Zig does not ship: coverage with kcov (and why in-file tests wreck the denominator), detecting unused private functions (neither the compiler nor zlint's unused-decls finds them), duplicate detection with jscpd, zlint (NOT the same-named X.509 linter in Homebrew), and the built-in fuzzer whose testOne now takes *std.testing.Smith rather than []const u8.

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Hypertree decomposition approach to planning problems for reduced computational complexity

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Choose what kind of knowledge to transfer between teacher and student models: response, feature, or relational, and decide among offline, online, self, or cross-modal distillation schemes. Best for distillation strategy selection, capacity-gap diagnosis, and transfer planning. Activate on "knowledge distillation", "teacher-student", "soft labels", "feature distillation", "online distillation", or "cross-modal transfer". NOT for generic compression checklists or unrelated training work.

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Build image generation pipelines with Stable Diffusion, FLUX, ControlNet, LoRA, and ComfyUI workflows. Activate on: image generation pipeline, ComfyUI workflow, ControlNet, LoRA training, diffusion model. NOT for: video generation (ai-video-production-master), image classification (computer-vision-pipeline).

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Design deployment-focused distillation systems that balance model size, accuracy, calibration, and cascade escalation under real resource limits. Best for teacher-student compression, threshold design, and failure-aware deployment. Activate on "model compression", "teacher- student", "distillation score", "cascade model", "edge deployment", or "model calibration". NOT for generic deep-learning overviews, prompt optimization, or training work without a concrete distillation objective.

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Apply rapport-based elicitation to resistant or semi-cooperative humans and agents. Use when coercive prompting or brittle handoffs damage cooperation. NOT for routine cooperative tasks, pure technical debugging, or already reliable exchanges.

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Expert data engineer for ETL/ELT pipelines, streaming, data warehousing. Activate on: data pipeline, ETL, ELT, data warehouse, Spark, Kafka, Airflow, dbt, data modeling, star schema, streaming data, batch processing, data quality. NOT for: API design (use api-architect), ML training (use ML skills), dashboards (use design skills).

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Wave-based parallel scheduling for DAG execution. Manages execution order, resource allocation, and parallelism constraints. Activate on 'schedule dag', 'execution waves', 'parallel scheduling', 'task queue', 'resource allocation'. NOT for building DAGs (use dag-graph-builder) or actual execution (use dag-parallel-executor).

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Use when applying Cloudflare D1 migrations, fighting Supabase migration history vs SQL execution, choosing direct psql over CLI, designing idempotent migrations, debugging schema drift between local and remote, or recovering after a half-applied migration. Triggers: supabase migration repair instructions appearing, table missing after "applied" status, "Tenant or user not found" when running psql, --remote vs --local D1 confusion, NOT NULL on a populated column, foreign key constraint failures, drift between staging and prod schemas. NOT for Mongo/document migrations, ORM-managed migrations specifically (Prisma/Drizzle have their own conventions), or pure data backfills.

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Analyze hierarchical DAG-like systems by separating undirected substrate from ordering metadata, then classifying diamonds, mixers, shortcuts, and hidden cycle structure. Use for workflow architecture, citation or genealogy DAG comparison, and information-flow diagnosis. NOT for ordinary cycle detection in arbitrary graphs, one-node runtime debugging, or systems with no real ordering constraint.

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Apply normative BDI reasoning to agents that must detect norms, choose which commitments to internalize, and resolve conflicts by comparing consequences. Use when obligations, prohibitions, or policies collide in autonomous systems. NOT for simple fixed-priority rules, pure constraint satisfaction, or domains where no real normative conflict exists.

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Systematic methodology for eliciting, representing, and operationalizing expert cognitive skills—pattern recognition, situation assessment, mental simulation—from practitioners without requiring research training. Bridges academic rigor and practical usability.

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Detects m6A modifications from Oxford Nanopore direct-RNA-seq (DRS) signal using m6Anet (multiple-instance-learning over DRACH 5-mer signal). Covers the upstream pipeline (Dorado/Guppy basecalling -> minimap2 map-ont -> nanopolish eventalign -> m6anet dataprep -> m6anet inference), per-site vs per-read probability including the mod_ratio stoichiometry column, the DRACH-only constraint, minimum-coverage thresholds (20-50 reads/site), multi-condition comparison via xPore/Nanocompore/ELIGOS, Dorado native modification calling (RNA004, 2024+), and the cDNA-vs-DRS distinction (cDNA Nanopore CANNOT detect modifications). Use when calling m6A from ONT DRS without immunoprecipitation, choosing m6Anet vs xPore vs Nanocompore vs ELIGOS vs Dorado native, interpreting probability_modified vs mod_ratio vs per-read probabilities, deciding between m6Anet (known DRACH sites) and Dorado/Remora (genome-wide screening), pinning RNA002 vs RNA004 chemistry and basecaller versions, or troubleshooting eventalign/dataprep failures.

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Designs genomics experiments so technical nuisance variation (batch, lane, plate, flow cell, operator, reagent lot, processing day) is balanced against the biological variable of interest and therefore estimable rather than confounded, using constrained sample-to-batch assignment (designit, OSAT), the confounder/mediator/collider distinction, and the principle that no post-hoc correction recovers a fully confounded design. Covers detecting hidden batches with surrogate variable analysis, a decision table for downstream correction (ComBat-seq, RUVSeq, SVA) whose execution is deferred to differential-expression/batch-correction, and reproducibility metadata. Use when assigning samples to sequencing batches/lanes/plates, avoiding batch-condition confounding, deciding whether a design is salvageable by correction, choosing a correction method, or estimating the number of hidden batches. For the experimental unit, randomization, and blocking concepts see experimental-design/randomization-blocking.

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Build publication-quality figures with matplotlib using the object-oriented Figure/Axes API, constrained_layout, rcParams customization, TrueType (Type-42) font embedding for journal submission, and CVD-safe palettes. Covers seaborn integration, common chart types, axis formatting, and the small gotchas that distinguish reproducible matplotlib from notebook scratch. Use when producing publication figures in Python — RNA-seq scatter, single-cell embeddings, generic biological plotting.

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Analyzes species-environment relationships with constrained ordination (CCA, RDA, db-RDA), variance partitioning, indicator species (indicspecies IndVal.g group-equalized), PERMANOVA paired MANDATORILY with PERMDISP (Anderson & Walsh 2013; dispersion confounds centroid tests), Joint Species Distribution Models (HMSC, sjSDM, gjam) with explicit rejection of "residual covariance equals biotic interaction", phylogenetic community ecology (SES_MPD/MNTD), trait-environment via RLQ + fourth-corner with corrected modeltype=6 (Dray 2014), bipartite network metrics (NODF, modularity) with curveball null (Strona 2014), and Mantel-test replacements (dbRDA, GDM) for spatial data. Use when testing how environmental gradients structure communities, identifying habitat indicator taxa, partitioning variance among predictors, deciding whether PERMANOVA significance is location vs dispersion, picking among HMSC/sjSDM/gjam, or replacing Mantel tests for landscape data.

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Estimates time-scaled phylogenies, molecular-clock rates, effective reproduction number R_e, and population dynamics from dated pathogen genomes using TreeTime (maximum-likelihood) and BEAST2 (Bayesian; strict/relaxed clocks; coalescent, Bayesian-Skyline, Skygrid, Birth-Death-Skyline, and sampled-ancestor priors; structured coalescent via MASCOT). Covers root-to-tip clock QC via TempEst, date-randomisation tests, recombination masking via Gubbins/ClonalFrameML before clock inference for recombining bacteria, BDSKY origin-vs-rootHeight pitfalls, sampling-bias correction, multi-chain convergence diagnostics, and reconciling phylodynamic R_e with case-based R_t. Use when dating outbreak origins, estimating substitution rates, inferring R_e through time, building time-calibrated Nextstrain Augur trees, choosing between strict and relaxed clocks, fitting Birth-Death-Skyline models, diagnosing temporal-signal failure, running MASCOT for structured-population analyses, or using UShER for pandemic-scale placement.

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Map N6-methyladenosine (m6A) RNA modifications at single-nucleotide resolution using miCLIP (Linder 2015), miCLIP2 + m6Aboost machine learning (Kortel 2021), GLORI (Liu 2023, antibody-free chemical conversion), DART-seq (Meyer 2019, APOBEC1-YTH fusion), m6Anet (nanopore direct RNA), or MeRIP-seq with calibration. Use when distinguishing antibody-based from antibody-free m6A detection methods, applying the DRACH motif constraint, reconciling cross-method disagreements (DART 44% in DRACH vs GLORI), or detecting m6Am at the cap.

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Predict RBP binding from RNA sequence using deep learning models (RBPNet sequence-to-signal, RNAProt RNN, GraphProt2 GCN with structure, DeepCLIP, DeepRiPe multi-modal CNN) for variant-effect prediction, in silico binding-site discovery, model interpretation, and transfer learning from CLIP and RBNS datasets. Use when computational prediction of RBP binding from sequence is needed, evaluating variant effects on binding without further wet-lab experiments, comparing model performance, or training a custom model on ENCODE eCLIP data.

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Trains and applies base-resolution deep learning models on ChIP-seq / ChIP-nexus / CUT&RUN data. Uses BPNet (Avsec 2021 Nat Genet 53:354; soft motif syntax from ChIP-nexus), chromBPNet (Pampari A et al 2024 bioRxiv; bias-factorized base-resolution profiles), EnFormer (Avsec 2021 Nat Methods 18:1196; 196 kb input, ~100 kb effective receptive field), DeepSEA (Zhou 2015; multi-task CNN), and JASPAR 2026 deep-learning collection (1259 BPNet ChIP models). Performs in silico mutagenesis for variant-effect prediction, DeepLIFT/Grad attribution, and TF-MoDISco motif discovery from attribution scores. Use when predicting variant effects on TF binding, discovering soft motif syntax / cooperativity, integrating ChIP-seq with sequence-only predictions, or applying precomputed JASPAR Deep Learning models to new variants.

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Sequence-based deep learning for ATAC-seq using chromBPNet, BPNet, scBasset, or Enformer. Use when correcting Tn5 bias with neural networks beyond k-mer models, predicting per-base accessibility profiles, scoring in silico variant effects at GWAS or rare-variant SNPs, discovering motifs via DeepLIFT/TF-MoDISco from a trained model, or generating cell-type-specific accessibility predictions for unobserved cell states.

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Create and manage database migrations with reversible changes, proper naming conventions, and zero-downtime deployment strategies. Use this skill when creating database migration files, modifying schema, adding or removing tables/columns, managing indexes, or handling data migrations. Apply when working with migration files (e.g., db/migrate/, migrations/, alembic/, sequelize migrations), schema changes, database versioning, rollback implementations, or when you need to ensure backwards compatibility during deployments. Use for any task involving database structure changes, index creation, constraint modifications, or data transformation scripts.

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