「bec」の検索結果

Keeps a project's to-do list and memory in GitHub issues — files each finding (from a review, an audit, or the user) as its own issue without duplicates, lists the open issues that bear on the current work, and closes an issue with a comment recording what was wrong, what was tried, what worked, and how it was fixed. Use when review findings or a list of problems should become tracked work (a paper's misleading claims, a codebase's bugs, improvements for later), when starting or resuming work and deciding what to do next, or when a fix has landed and its issue should be closed with a record. Needs the GitHub CLI; warns before posting to a public repository.

日本語の概要は準備中です。原文の説明を表示しています。

How episodic television actually gets made by a group (编剧室与制作现实) — merged from Goldberg & Rabkin (pitch as audition, leave-behind, cracking the story, beat sheet, notes discipline, production rewrites), Pamela Douglas (John Wells's room, staff-from-hell mistakes, the seven-rung ladder, step deal, the 14-day draft), Neil Landau's showrunner interviews (Lindelof, Mazzara, Katims, Bays), Evan Smith on sitcom staffing and roundtables, Richard Blum (dated), Kam Miller, and first-hand accounts by David Chase, Jesse Armstrong, Lucy Prebble, Aaron Sorkin, Julian Fellowes and Phoebe Waller-Bridge. Use when joining or running a writers' room, breaking an episode with a group, writing a leave-behind, beat sheet or outline on deadline, pitching episode ideas to an existing series, writing a spec episode, taking or giving notes, rewriting because of money, actors or locations, choosing between a staffed room and a single-author process, or asking 什么是 showrunner／编剧室怎么运作／怎么接 note.

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dontbesilent 目标清晰化。用维特根斯坦的语言哲学把模糊的目标审计成可检查的交付物。 触发方式：/dbs-goal、/目标、「帮我搞清楚目标」「我想做个人 IP」「我的目标是成为...」「我想变得更...」 Goal clarification using Wittgenstein's philosophy of language. Audits fuzzy goals into checkable deliverables. Trigger: /dbs-goal, "help me clarify my goal", "I want to become...", "my goal is..."

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Use when generating a single installable agent that should keep learning, track sources, refresh research, propose repairs, or improve itself over time without becoming a multi-agent team.

日本語の概要は準備中です。原文の説明を表示しています。

Debug Azure production issues on Azure using AppLens, Azure Monitor, resource health, and safe triage. WHEN: debug production issues, troubleshoot app service, app service high CPU, app service deployment failure, troubleshoot container apps, container app 503 or target port mismatch, troubleshoot functions, function telemetry missing or stopped after a config/connection-string change, troubleshoot AKS, VM RDP, Linux SSH, VM black screen, can't connect to VM, reset VM password, NSG or firewall blocking, kubectl cannot connect, kube-system/CoreDNS failures, pod pending, crashloop, node not ready, upgrade failures, analyze logs, KQL, insights, image pull failures, cold start issues, health probe failures, resource health, root cause of errors, troubleshoot event hubs, troubleshoot service bus, messaging SDK error, AMQP connection failure, message lock lost, lock renewal during long-running processing, service bus dead letter.

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Turn a source-bound company and market dossier into testable ideal-customer-profile hypotheses, buying roles, triggers, constraints, disqualifiers, standing, counterevidence, and research gaps. Use when a URL, company description, monitor profile, or evidence manifest needs to become defensible ICP inputs for buyer research or an AI-visibility prompt panel.

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Write a new Octane component in .tsrx, convert JSX to .tsrx, or add scoped <style> blocks and themes. Use when creating a .tsrx file rather than editing one, because the path-scoped tsrx-authoring rule only fires once such a file is open.

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Produces the reader-facing HTML artifact — report, dashboard, architecture view, data browser, or review workbench — evidence-backed, browser-verified. Use when the deliverable IS a visual HTML report, or the user asks for an HTML/web presentation. Load data-visualization-discipline for chart judgment. Not for chat status or Markdown prose unless asked to become a report; not for PowerPoint (deck-creator Route C).

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Make compound growth actually click — see how small, consistent amounts become large over time, and why starting now beats starting bigger later. Use when asked explain compound interest, how does compounding work, is it worth investing small amounts, or why should I start now. Produces an intuitive explanation of compounding with concrete illustrative examples for your situation, the outsized effect of time (why an early start beats a later larger one), how fees and inflation eat into it, and the honest caveats — turning an abstract concept into the motivation to start now. Educational, not financial advice.

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Calm a heated conflict — in person or in writing — before it does damage, by lowering the temperature instead of winning the point. Use when asked help me de-escalate this, this argument is getting heated, calm this situation down, or how do I respond without making it worse. Produces a read on what's actually driving the heat (often an unmet need under the surface argument), the de-escalation moves (acknowledge, slow down, find the shared ground), what to say and what to avoid, and how to steer toward resolution once the temperature drops — because you can't solve anything while everyone's activated.

日本語の概要は準備中です。原文の説明を表示しています。

Set a boundary with someone — a friend, family member, coworker, or partner — clearly and kindly, with the actual words and a plan for the pushback. Use when asked how do I set a boundary with, I need to say no to, someone keeps overstepping, or help me set limits with. Produces a read on the boundary you actually need, a warm-but-firm script to state it (without over-explaining or apologizing it away), how to hold it when they push back or guilt-trip, and what to do if they don't respect it — because a boundary you can't state and hold isn't a boundary.

日本語の概要は準備中です。原文の説明を表示しています。

Check whether you're burning out as a caregiver — and get a realistic plan to protect yourself before you can't keep going. Use when asked I'm exhausted from caregiving, am I burning out caring for my parent, caregiver stress help, or I have nothing left to give. Produces an honest read on your burnout signs and how depleted you are, permission and reasons to accept help (which caregivers resist), specific ways to get support and respite, the guilt and identity traps to address, and a realistic self-care plan that fits a caregiver's actual life — because a caregiver who collapses can't care for anyone. Not medical or mental-health treatment.

日本語の概要は準備中です。原文の説明を表示しています。

Surface the hidden assumptions a plan or belief rests on, then test what happens when each one is wrong. Use when asked what am I assuming here, check my assumptions, what if I'm wrong about, or stress-test my thinking. Produces the unstated assumptions your conclusion depends on (ranked by how load-bearing they are), a flip of each to see which one breaking would change everything, and the cheapest way to check the riskiest ones — because the assumption you didn't know you were making is what sinks plans.

日本語の概要は準備中です。原文の説明を表示しています。

Turn a client's wishes into an architectural brief that can actually be designed against — the accommodation schedule, the adjacencies, the budget reality, and the constraints named before they become change orders. Use when asked to write an architectural brief, prepare a project brief for a building, run a client briefing, or capture requirements for a new build or refurbishment. Produces the accommodation schedule with areas, the adjacency and circulation requirements, the site and statutory constraints, the budget and programme reality check, and the explicit exclusions.

日本語の概要は準備中です。原文の説明を表示しています。

Check AI output before you trust or use it — where it's likely wrong, what to verify, and how to catch confident-sounding errors. Use when asked can I trust this AI answer, how do I verify what AI told me, fact-check this AI output, or is this AI response reliable. Produces a risk read on the specific output (the claims most likely to be wrong or made up), the parts that need independent verification vs the parts that are low-risk, how to actually verify each, the tells of AI hallucination and overconfidence, and a habit for building verification into your AI use — because AI is confidently wrong often enough that unchecked trust is a real risk.

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Audit the choices an implementing agent made, not its diff — a pure decision audit that traces the session's history into a choices ledger, changes no code, and never blocks an unsupervised run. Working code still embeds architecture the user never chose; surface it because future work inherits it. Use when the user wants to review the decisions the AI made on their behalf, before merging or committing AI-implemented work, when integrating a delegated subagent's pass, or when a fix "works" but might be a point fix.

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Use when building the conceptual exhibits of an Academy of Management Review (AMR) manuscript — process models, 2x2 typologies, multi-level frameworks, and propositions tables that carry theoretical work. These are CONCEPTUAL figures, NOT data plots; AMR has no charts of results because it has no data.

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Predict B-cell and T-cell epitopes for vaccine antigen design and epitope mapping with BepiPred-3.0, DiscoTope-3.0, the IEDB tools, and EL-mode MHC presentation. Encodes the load-bearing asymmetry that T-cell epitope prediction is mature (it reduces to MHC presentation, AUC>0.9) while B-cell prediction is unreliable (linear predictors ~AUC 0.6 because ~90% of real epitopes are conformational) — so structure-based DiscoTope-3.0 on AlphaFold models is the only defensible B-cell path, propensity scales are obsolete, and NetChop is largely redundant on EL-trained models. Use when mapping epitopes or selecting vaccine antigens. MHC binding lives in mhc-binding-prediction.

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Designs cytosine (CBE, C-to-T) and adenine (ABE, A-to-G) base-editor guides by positioning the target base at the activity-peak of the editing window (protospacer positions ~5-7, PAM-distal numbering), minimizing bystander edits for product purity, reading dinucleotide context (APOBEC1 TC favored / GC disfavored), and selecting the editor variant (BE4max, ABEmax, ABE8e, YE1/SECURE, TadCBE, CGBE, SpG/SpRY-BE). Covers knockout by premature stop (CRISPR-STOP/iSTOP) and splice-site disruption, the three off-target classes (Cas-dependent, Cas-independent DNA, RNA), outcome prediction (BE-Hive/DeepBE), and the base-vs-prime-vs-HDR decision. Use when installing a transition mutation without a double-strand break, knocking out a gene without indels, or choosing CBE vs ABE. Generic guide scoring, prime editing, and HDR donors are separate skills.

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Infer or annotate TCR antigen specificity by unsupervised clustering (TCRdist/tcrdist3, GLIPH2, clusTCR, GIANA) and database lookup (VDJdb, IEDB, McPAS-TCR), and rank candidates with supervised predictors (ERGO-II, NetTCR-2.x, pMTnet) under explicit caveats. Encodes the central truth that general TCR-epitope prediction for UNSEEN epitopes essentially does not work (collapses to near-random; IMMREP22, Grazioli 2022) because labeled data is dominated by a few immunodominant epitopes and there is no true negative set — so clustering for discovery is the honest task and de-novo binding needs wet-lab validation. Use when annotating TCR specificity or grouping a repertoire. Epitope/MHC context lives in mhc-binding-prediction.

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Profiles a genome from raw reads BEFORE assembly with a k-mer spectrum (KMC or Jellyfish histogram), then models it with GenomeScope2 to estimate genome size, heterozygosity, repeat content, and ploidy, and Smudgeplot to infer ploidy from heterozygous k-mer pairs (diploid AB vs triploid AAB vs tetraploid AABB). Covers choosing k via Merqury best_k.sh, the k-mer-coverage vs sequencing-coverage confusion, reading het/repeat/contamination/organelle peaks, why noisy ONT must not be used for counting, and how the estimate becomes the NG50 denominator, the Flye -g value, the hifiasm --hom-cov/purge setting, and the 1.5-2x-too-big haplotig sanity check. Use when starting any de novo assembly, deciding whether short reads can work, estimating genome size for an unknown organism, diagnosing ploidy, or sanity-checking an assembly's size against expectation.

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Build UpSet plots to visualize set intersections beyond 4 sets (where Venn fails) using ComplexUpset (modern, ggplot2-grammar) or the unmaintained UpSetR, with explicit cardinality vs degree sorting, attribute panels, and query highlighting. Use when comparing overlap across many gene sets, peak sets, variant lists, or any set membership matrix where Venn diagrams become illegible.

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Designs pooled sgRNA libraries for CRISPR knockout, interference (CRISPRi), activation (CRISPRa), Cas12a multiplex, base-editor, and prime-editor screens. Covers on-target scoring (Rule Set 2, Azimuth, DeepSpCas9, CRISPRon), off-target scoring (CFD, MIT), TSS-relative positioning for CRISPRi/a (Horlbeck, Dolcetto, Calabrese), PAM-variant chemistries, control-guide composition, oligo cloning architecture, and library QC. Use when choosing a genome-wide library (GeCKOv2 vs Avana vs Brunello vs TKOv3 vs Inzolia), designing a focused or paralog-focused custom library, picking CRISPRi vs CRISPRa TSS windows, deciding control-guide proportions, or diagnosing library skew and dropout in a freshly cloned pool.

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Map N6-methyladenosine (m6A) RNA modifications at single-nucleotide resolution using miCLIP (Linder 2015), miCLIP2 + m6Aboost machine learning (Kortel 2021), GLORI (Liu 2023, antibody-free chemical conversion), DART-seq (Meyer 2019, APOBEC1-YTH fusion), m6Anet (nanopore direct RNA), or MeRIP-seq with calibration. Use when distinguishing antibody-based from antibody-free m6A detection methods, applying the DRACH motif constraint, reconciling cross-method disagreements (DART 44% in DRACH vs GLORI), or detecting m6Am at the cap.

日本語の概要は準備中です。原文の説明を表示しています。