「driven」の検索結果

Prioritizes rare-disease variants from trio/quad WES/WGS with de novo (DeNovoGear, Triodenovo), compound-heterozygous phasing (WhatsHap), mosaic VAF tiering, phenotype-driven ranking (Exomiser, Phen2Gene, AMELIE), ClinGen gene-disease validity gating, and ACMG SF v3.2 secondary findings reporting. Use when running diagnostic exome / genome pipelines, identifying candidate Mendelian disease genes, screening for incidental findings, or auditing VUS reclassification cycles. The ACMG/AMP classification framework (PVS1 decision tree, Pejaver PP3/BP4 calibration, Tavtigian point system) is in clinical-databases/acmg-classification.

日本語の概要は準備中です。原文の説明を表示しています。

Resolve the architecture of focal oncogene amplifications — extrachromosomal DNA (ecDNA), breakage-fusion-bridge (BFB) cycles, homogeneously staining regions (HSR), and linear amplification — from whole-genome sequencing with AmpliconArchitect, the AmpliconSuite pipeline, and AmpliconClassifier. Covers copy-number seed selection, breakpoint-graph reconstruction, balanced-flow optimization, ecDNA classification, and the limits of depth-only amplification calls. Use when a focal amplification needs structural characterization, when distinguishing ecDNA from chromosomal amplification, suspecting ecDNA-driven oncogene amplification or therapy resistance, or selecting copy-number seeds for amplicon reconstruction.

日本語の概要は準備中です。原文の説明を表示しています。

Test whether two or more traits share a causal variant at a locus using Bayesian colocalization (coloc.abf, coloc.susie, HyPrColoc, moloc, eCAVIAR, SMR/HEIDI, PWCoCo, SharePro). Use when integrating GWAS with eQTL/sQTL/pQTL/mQTL, distinguishing shared causal variants from LD-driven coincidence, handling allelic heterogeneity, choosing between single-causal vs multi-causal methods, picking PP.H4 thresholds, running sensitivity over p12, or harmonising summary statistics for colocalization.

日本語の概要は準備中です。原文の説明を表示しています。

Visualizes ChIP-seq data using deepTools (computeMatrix, plotHeatmap, plotProfile, bamCoverage, bamCompare), pyGenomeTracks (modern INI-driven track plots), Gviz (R browser-style), EnrichedHeatmap (ComplexHeatmap-based), ChIPseeker tag heatmaps, and IGV batch screenshots. Handles bigWig normalization choices (CPM, BPM, RPGC, spike-in scaled), bamCompare operations (log2 ratio, subtract) with SES scaling, k-means clustering of heatmaps for biological subgrouping, and spike-in-scaled tracks for global-shift experiments. Use when generating publication-quality ChIP-seq signal heatmaps, profile plots, genome-browser tracks, or comparing samples visually.

日本語の概要は準備中です。原文の説明を表示しています。

Collection of AWS development skills covering CDK infrastructure as code, cost optimization, and serverless/event-driven architectures with integrated MCP servers.

日本語の概要は準備中です。原文の説明を表示しています。

Master Bash Automated Testing System (Bats) for comprehensive shell script testing. Use when writing tests for shell scripts, CI/CD pipelines, or requiring test-driven development of shell utilities.

日本語の概要は準備中です。原文の説明を表示しています。

Implement proven backend architecture patterns including Clean Architecture, Hexagonal Architecture, and Domain-Driven Design. Use when architecting complex backend systems or refactoring existing applications for better maintainability.

日本語の概要は準備中です。原文の説明を表示しています。

This skill suggests using real-time continuous glucose monitoring (CGM) and algorithm-driven insulin pumps (ADIPs) rather than multiple daily injections (MDIs) with self-monitoring of blood glucose (SMBG) three or more times daily for adults and children with type 1 diabetes (T1D). Trigger phrases include "Should I use RT-CGM+ADIP or MDI+SMBG for this T1D patient?" or "Is intensive pump therapy indicated for this patient?"

日本語の概要は準備中です。原文の説明を表示しています。

The skill suggests using real-time continuous glucose monitoring (CGM) combined with algorithm-driven insulin pumps (ADIPs) rather than multiple daily injections (MDIs) with self-monitoring of blood glucose (SMBG) three or more times daily for adults and children with type 1 diabetes (T1D) to lower hypoglycemia incidence. Clinical triggers include discussions about insulin pump therapy, CGM use, or reducing hypoglycemia in T1D patients on intensive insulin regimens.

日本語の概要は準備中です。原文の説明を表示しています。

Recommends continuing a patient’s personal continuous glucose monitor (CGM) in the hospital with or without algorithm-driven insulin pump (ADIP) therapy rather than discontinuing it for individuals already using CGM outpatient. Use when deciding whether to maintain personal CGM during admission or when a patient requests to keep their device, particularly in those at high risk for hypoglycemia.

日本語の概要は準備中です。原文の説明を表示しています。

Work up Malignancy-Associated Hypercalcemia (MAH) — distinguish humoral hypercalcemia of malignancy (HHM, PTHrP-driven), local osteolytic hypercalcemia, 1,25(OH)2D-mediated lymphoma hypercalcemia, ectopic PTH secretion, and multiple myeloma — and pick the right confirmatory tests and therapy direction. Trigger when a clinician asks "is this hypercalcemia from cancer", "PTHrP positive what now", "hypercalcemia in lung cancer / breast cancer / lymphoma / myeloma", "humoral hypercalcemia of malignancy", "MAH workup", or any hypercalcemia case with suppressed PTH and a known or suspected malignancy.

日本語の概要は準備中です。原文の説明を表示しています。

The sprint completeness oracle — a mechanical, exit-code-driven check that every feature in a sprint manifest is provably complete across three dimensions (a done-record reference, resolvable edge tests, and a resolvable wiring test). Fails loud with a per-feature gap list naming the missing dimension. Read-only. Use to gate a sprint before it is called done (Slice A of the sprint-mode epic), or any time you want a completeness reading.

日本語の概要は準備中です。原文の説明を表示しています。

Build event-driven applications with Azure Event Grid SDK for Java. Use when publishing events, implementing pub/sub patterns, or integrating with Azure services via events.

日本語の概要は準備中です。原文の説明を表示しています。

Azure Event Grid SDK for .NET. Client library for publishing and consuming events with Azure Event Grid. Use for event-driven architectures, pub/sub messaging, CloudEvents, and EventGridEvents.

日本語の概要は準備中です。原文の説明を表示しています。

Build real-time streaming applications with Azure Event Hubs SDK for Java. Use when implementing event streaming, high-throughput data ingestion, or building event-driven architectures.

日本語の概要は準備中です。原文の説明を表示しています。

Azure Event Grid SDK for Python. Use for publishing events, handling CloudEvents, and event-driven architectures.

日本語の概要は準備中です。原文の説明を表示しています。

Specialized skill for building production-ready serverless applications on AWS. Covers Lambda functions, API Gateway, DynamoDB, SQS/SNS event-driven patterns, SAM/CDK deployment, and cold start optimization.

日本語の概要は準備中です。原文の説明を表示しています。

First-principles assumption auditor. Classifies each hidden assumption (fact / convention / belief / interest-driven), ranks by fragility × impact, and rebuilds conclusions from verified premises. Bilingual: auto-detects Chinese or English.

日本語の概要は準備中です。原文の説明を表示しています。

AI-driven data extraction from 55+ Actors across all major platforms. This skill automatically selects the best Actor for your task.

日本語の概要は準備中です。原文の説明を表示しています。

Master proven backend architecture patterns including Clean Architecture, Hexagonal Architecture, and Domain-Driven Design to build maintainable, testable, and scalable systems.

日本語の概要は準備中です。原文の説明を表示しています。

Use when a coding task should be driven end-to-end from issue intake through implementation, review, deployment, and acceptance verification with minimal human re-intervention.

日本語の概要は準備中です。原文の説明を表示しています。

Use when writing C# / VB.NET / F# code that reads, writes, manipulates, or exports Excel (.xlsx / .xls) files, generates PDF or HTML from Excel, or produces data-driven reports with FlexCel Studio for .NET (TMS Software). Triggers include Excel/xlsx from C#, XlsFile, FlexCelReport, FlexCelPdfExport, FlexCelHtmlExport, FlexCelImgExport, ExcelFile, PdfWriter, .NET Excel export, ASP.NET Excel generation, .NET MAUI Excel, Native AOT + Excel, and Excel reporting from .NET.

日本語の概要は準備中です。原文の説明を表示しています。

Use when writing Delphi / FreePascal / C++Builder code that reads, writes, manipulates, or exports Excel (.xlsx / .xls) files, generates PDF or HTML from Excel, or produces data-driven reports with FlexCel Studio for VCL and FireMonkey (TMS FlexCel). Triggers include Excel/xlsx from Delphi, TXlsFile, TFlexCelReport, TFlexCelPdfExport, TFlexCelHtmlExport, FireMonkey Excel export, Lazarus Excel, and Excel reporting from Pascal.

日本語の概要は準備中です。原文の説明を表示しています。

Use fresh agents for focused subtasks to avoid context pollution

日本語の概要は準備中です。原文の説明を表示しています。