「rules」の検索結果

Generates appellate-filing-ready Tables of Contents, Tables of Authorities, and Certificates of Compliance under FRAP 32(g) and related rules. Produces defensible word-count calculations with transparent exclusions and anti-hallucination guardrails for pagination and citations. Covers federal circuits, state appellate courts, and U.S. Supreme Court variations. Use when building TOC, TOA, compliance certificates, formatting briefs for filing, or when the user mentions word count calculation, FRAP 32 compliance, appellate brief assembly, or page numbering.

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AI compliance analysis for EU AI Act, ISO 42001, NIST AI RMF, GDPR, OECD, financial services regulations (SEC, FCA, FINRA, DORA, MiFID II), and other frameworks. Use when asked to generate a compliance checklist for an AI tool or use case, determine if a risk assessment is required, score an AI tool's risk level, identify where an AI tool or use case could run afoul of regulatory requirements, perform a gap analysis, recommend remediation steps, assess a vendor, draft an acceptable use policy, map training requirements, or review jurisdiction-specific AI rules. Triggers on phrases like "compliance checklist", "risk assessment", "risk score", "does this comply", "EU AI Act", "ISO 42001", "NIST AI RMF", "AI governance", "gap analysis", "vendor assessment", "acceptable use policy", "MNPI", "AI training requirements", or any request to evaluate an AI tool or use case for regulatory compliance or risk.

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Use when designing matrix builds (OS x version x dimension), composing reusable workflows, gating jobs on conditions, doing OIDC to AWS/GCP/Cloudflare without long-lived secrets, sharding tests across runners, or fixing cache invalidation. Triggers: workflow_call between repos, fail-fast: false tradeoffs, exclude/include matrix surgery, environment protection rules, OIDC trust policy setup, concurrency cancellation on duplicate pushes, artifact reuse across jobs, conditional job matrices computed at runtime. NOT for GitLab CI / CircleCI / Jenkins (different yaml dialects), self-hosted runner administration, or local act dev.

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Analyze bonded agent systems, escrow workflows, slashing rules, oracle trust, Sybil cost, and front-running risk in protocols where agents post bonds or stake reputation. Use for collateral sizing, griefing analysis, dispute design, and bonded-agent security reviews. NOT for smart contract auditing, DeFi tokenomics, blockchain consensus design, or trading strategy.

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Cryptographic security for agentic systems — zero-trust agent networking, signed message envelopes (JWS/JWE), capability-based security (ocaps), Merkle tree audit trails, WASM sandboxing, and formal verification. Covers CLI dev tool security, mTLS between agents, permission boundaries (least privilege for AI agents), and supply chain security for skills/plugins. Activate on: "agent security", "zero trust agents", "secure agent communication", "capability-based security", "ocap", "signed messages between agents", "agent audit trail", "sandbox agent execution", "agent permissions", "mTLS agents", "cryptographic verification", "agent supply chain", "OWASP agentic", "prove agent did X", "tamper-proof agent logs". NOT for: application-level SAST scanning (use security-auditor), network firewall rules (use infrastructure), SOC2/HIPAA compliance (organizational), or prompt injection defense (use prompt-engineer).

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Apply normative BDI reasoning to agents that must detect norms, choose which commitments to internalize, and resolve conflicts by comparing consequences. Use when obligations, prohibitions, or policies collide in autonomous systems. NOT for simple fixed-priority rules, pure constraint satisfaction, or domains where no real normative conflict exists.

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Detects task agent and complexity tier at Phase 0 orient. Invoked first in every workflow. Provider adapters select any model/runtime policy. NOT for runtime agent routing inside a single skill (see orchestration-rules.md).

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Apply Strunk's timeless writing rules to ANY prose humans will read—documentation, commit messages, error messages, explanations, reports, or UI text. Makes your writing clearer, stronger, and more professional.

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UI code review with 100+ rules for accessibility, performance, and UX

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React/Next.js performance optimization with 40+ rules in 8 categories

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Analyze project and auto-configure agents, skills, rules, and guides

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Initialize or safely upgrade a processor project's root AGENTS.md from a maintained baseline. Use when starting a processor project, adding project-level Agent collaboration rules, or comparing an existing AGENTS.md with the package baseline. This skill only handles AGENTS.md; it does not scaffold documentation, inspect or configure environments, install tools, or modify processor source.

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Use when splitting a domain Skill into Phase-Aware File Structure (SKILL.md / design.md / constraints.md). Defines the splitting criteria, procedures, sync procedures, and validation rules. Invoked by /skill-format command or manually when restructuring domain Skills.

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Stop AI agents from secretly bypassing your rules. Mechanical enforcement with git hooks, secret detection, deployment verification, and import registries. Born from real production incidents: server crashes, token leaks, code rewrites. Works with Claude Code, Clawdbot, Cursor. Install once, enforce forever.

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Aligns sample metadata with count matrices and constructs design matrices for downstream DE, handling the alphabetical-reference-level trap (relevel BEFORE DESeq), LRT reduced-model rules, the interaction-term resultsNames trap, continuous-covariate scaling and splines, repeated measures via duplicateCorrelation or dream, high-cardinality categorical pseudo-singular designs, sample swap detection via XIST/RPS4Y1 expression and somalier/NGSCheckMate genotypes, SABV (sex-as-biological-variable) mandate, Simpson's-paradox collapsing of technical replicates, and the `~ 0 + group` parameterization for clean contrasts. Use when building a design matrix, troubleshooting reversed fold-change direction, encoding paired or repeated-measures designs, detecting sample swaps, deciding sex-as-covariate, or aggregating technical replicates.

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Identify direct miRNA-target interactions from AGO HITS-CLIP, AGO-CLEAR-CLIP (chimeric reads), HEAP (Halo-Ago2 mouse), chimeric eCLIP / miR-eCLIP (deep miRNA-target profiling), or CLASH using chimeric-read processing pipelines, seed-pairing analysis, and 3' auxiliary pairing rules. Use when distinguishing direct miRNA targets from indirect, integrating CLIP-derived target maps with TargetScan / miRDB / DIANA predictions, applying canonical 7mer-8mer seed matching with 3' UTR context, or recovering miRNA-mRNA chimeras at scale.

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Generates 3D conformer ensembles using RDKit ETKDGv3 with knowledge-enhanced distance geometry, MMFF94/UFF force-field optimization, CREST + GFN2-xTB semi-empirical refinement, and macrocycle-aware torsion preferences. Provides explicit decision rules for single vs ensemble conformer use, RMSD pruning, energy windows, conformer count, and force-field choice. Use when preparing 3D ligands for docking, generating descriptor input for 3D QSAR, or sampling macrocycle/peptide conformational ensembles.

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Applies ACMG/AMP 2015 framework with ClinGen SVI specifications, Tavtigian 2018/2020 Bayesian point system, Abou Tayoun 2018 PVS1 decision tree, Pejaver 2022 and Bergquist 2025 calibrated PP3/BP4 thresholds for REVEL/BayesDel/AlphaMissense, Brnich 2020 PS3/BS3 OddsPath, Walker 2023 SpliceAI splicing framework, and AMP/ASCO/CAP 2017 tumor tiers. Use when classifying germline variants P / LP / VUS / LB / B, applying VCEP-specific CSpec rules, computing Whiffin BS1, or assigning cancer Tier I-IV per Li 2017.

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Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.

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Assesses ChIP-seq quality across antibody specificity, fragmentation, enrichment, replicate concordance, and library complexity. Computes FRiP, NSC/RSC (phantompeakqualtools), library complexity (NRF/PBC1/PBC2), deepTools plotFingerprint (JS distance, AUC, synthetic JS), ChIPQC, IDR with ENCODE Nself/Nt rules, and detects hyper-ChIPable artifacts. Use when validating an antibody, diagnosing failed peak calls, deciding whether to proceed with downstream analysis, grading against ENCODE thresholds, or auditing replicate concordance.

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Prepares statistical reports for clinical trials following CONSORT 2025, SPIRIT 2025, ICH E9(R1) estimands, and FDA 2023 covariate adjustment guidance. Covers Table 1 generation, analysis populations (ITT/FAS/PP/Safety), the 5 ICH E9(R1) intercurrent-event strategies, MMRM under MAR (mmrm), reference-based MI (rbmi J2R/CR/CIR), Permutt tipping-point sensitivity, and Rubin's-rules vs frequentist variance debate. Use when preparing regulatory submissions, defining estimands, or implementing missing-data sensitivity analyses.

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Implement authentication and authorization with Better Auth - a framework-agnostic TypeScript authentication framework. Features include email/password authentication with verification, OAuth providers (Google, GitHub, Discord, etc.), two-factor authentication (TOTP, SMS), passkeys/WebAuthn support, session management, role-based access control (RBAC), rate limiting, and database adapters. Use when adding authentication to applications, implementing OAuth flows, setting up 2FA/MFA, managing user sessions, configuring authorization rules, or building secure authentication systems for web applications.

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Build a differential-ready consensus peakset from per-replicate ATAC-seq peaks using iterative overlap removal, fixed-width re-centering, and majority-rule overlap. Use when generating a stable peak coordinate system for downstream differential accessibility, ML feature engineering, cross-sample comparison, or fixed-width peak counts; covers Corces 2018 iterative overlap (501 bp), DiffBind summit re-centering, and ENCODE consistency rules.

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Assesses patient’s knowledge of diabetic ketoacidosis prevention, recognition, and treatment. Triggered by clinician prompts such as 'Review sick-day rules and DKA signs' or 'Ensure patient knows when to seek help for hyperglycemia'.

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