Design .NET types for performance. Seal classes, use readonly structs, prefer static pure functions, avoid premature enumeration, and choose the right collection types.
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Design .NET types for performance. Seal classes, use readonly structs, prefer static pure functions, avoid premature enumeration, and choose the right collection types.
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Guidelines for introducing and using nullable reference types (NRT) and System.Diagnostics.CodeAnalysis nullable attributes in C# / .NET codebases. Covers the nullability model, flow analysis, the null-forgiving operator, API design rules, the full attribute catalog (AllowNull, DisallowNull, MaybeNull, NotNull, NotNullWhen, MaybeNullWhen, NotNullIfNotNull, MemberNotNull, MemberNotNullWhen, DoesNotReturn, DoesNotReturnIf), the C# 14 field keyword, incremental migration of legacy codebases, and a code-generation checklist.
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Use the skill to control and verify the code interface configuration of your model — how Simulink® model elements are represented in the generated C or C++ code. This includes — (1) specifying names, types (storage classes), and placement of variables that represent model elements (for example, making a model parameter tunable as a global extern variable); (2) specifying names, types, and placement of functions that represent model algorithms; (3) selecting the deployment type (Component, Subcomponent, or Automatic); (4) selecting the interface configuration type (data or service interface); (5) linking a shared Embedded Coder dictionary to a model; (6) creating Embedded Coder dictionary entries and setting their properties; (7) for service interface configuration — specifying service interface definitions, including sender, receiver, client, and server services. Items 1 and 2 can be set per element or as a category-wide default. Item 1 applies to GRT and ERT models; the rest to ERT models only.
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Assign cell types from marker expression in IMC/MIBI data using clustering (PhenoGraph/FlowSOM/Leiden/Pixie), marker-based probabilistic classifiers (Astir), or image-context CNNs (CellSighter), covering the double-positive segmentation artifact, lineage-vs-state markers, the two spillover types, and why a "cell type" in imaging is conditioned on a segmentation guess. Use when phenotyping segmented IMC cells, choosing clustering vs classification, diagnosing implausible double-positive populations, separating lineage from functional markers, or transferring labels across a cohort.
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Builds and applies 3D pharmacophore models using RDKit Pharm3D, the apo2ph4 receptor-based workflow (Heider et al. 2023), Pharmer / Pharmit for search, and PharmacoForge for protein-pocket-conditioned pharmacophore generation (Flynn et al. 2025), covering ligand-based pharmacophores from active-set alignment and receptor-based pharmacophores from binding-pocket geometry. Explicitly handles feature types, geometric tolerances, partial matching, and pharmacophore-based virtual screening. Use when identifying scaffold-hopping candidates, building shape-and-feature search queries, or transferring SAR across chemotypes.
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Build and deploy AI agents with CloudBase Agent SDK (TypeScript & Python). Implements the AG-UI protocol for streaming agent-UI communication. Use when deploying agent servers, using LangGraph/LangChain/CrewAI adapters, building custom adapters, understanding AG-UI protocol events, or building web/mini-program UI clients. Supports both TypeScript (@cloudbase/agent-server) and Python (cloudbase-agent-server via FastAPI).
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Audit model delegation and subagent effectiveness for a session — which models handled which subagent types, per-type success rates and average durations, and wasted delegations (heavy models on trivial work or types that consistently fail) — using the Agent Monitor workflow intelligence API. Use when reviewing how a session delegated work across models and subagents.
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Send Google Chat messages via incoming webhooks — text, rich cards (cardsV2), threaded replies. TypeScript types, card builder utility, widget reference inline. Use whenever the user wants to post to Google Chat from a script, build a chatbot reply, send a notification card, build a Google Chat webhook integration, or troubleshoot card / threading issues.
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When the user wants to understand or optimize for SERP feature types (PAA, sitelinks, rich results, AI Overviews). Also use when the user mentions "SERP," "SERP features," "search result features," "People Also Ask," "PAA," "sitelinks," "knowledge panel," "local pack," "rich results," "zero-click," "SERP types," "AI Overviews," "Bing Copilot," or "Yandex AI." For JSON-LD and rich result implementation, use schema-markup. For organic strategy and roadmap, use seo-strategy.
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When the user wants to plan content marketing across channels, define content types and formats, or create a content repurposing strategy. Also use when the user mentions "content marketing strategy," "content types," "content formats," "content repurposing," "content calendar," "content mix," "owned content," "content distribution," "content funnel," or "content planning across channels." For SEO calendar, use content-strategy.
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Work with the Upstash Redis JavaScript/TypeScript SDK for serverless Redis operations. Use for caching, session storage, rate limiting, leaderboards, full-text search (querying, filtering, aggregating with @upstash/redis search extension), and all Redis data structures. Supports automatic serialization/deserialization of JavaScript types. Search also available via @upstash/search-redis and @upstash/search-ioredis adapters for TCP clients.
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Build and deploy full-stack web and mobile apps with AWS Amplify Gen2 (TypeScript code-first). Covers auth (Cognito), data (AppSync/DynamoDB including schema modeling, enum types, relationships, authorization rules), storage (S3), functions, APIs, and AI (Amplify AI Kit with Bedrock). Supports React, Next.js, Vue, Angular, React Native, Flutter, Swift, and Android. Always use this skill for Amplify Gen2 topics — even for questions you think you know — it contains validated, version-specific patterns that prevent common mistakes. TRIGGER when: user mentions Amplify Gen2; project has amplify/ directory or amplify_outputs; code imports @aws-amplify packages; user asks about defineBackend, defineAuth, defineData, defineStorage, or npx ampx. SKIP: Amplify Gen1 (amplify CLI v6), standalone SAM/CDK without Amplify (use aws-serverless), direct Bedrock without Amplify AI Kit (use bedrock).
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Frontend development for React, Next.js, TypeScript, and Tailwind CSS. Use when building React components, optimizing Next.js performance, analyzing bundle sizes, scaffolding projects, implementing accessibility, or reviewing frontend code.
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Use when authoring a Relayflows flow (@relayflows/surface / @relayflows/sdk, the journal-based v2 engine — the CLI is `flows`, package versions 2.0.x) in TypeScript or YAML/JSON. Covers the three-rung ladder (run/llm/agent), the resident verbs (human/dispatch/done), verification gates, TypeScript vs YAML authoring, per-step cli/model selection and its resolution order, flows.json, and `flows check`/`run`/`resume` with their real refusal shapes and exit codes. Not for the older, unrelated `@relayflows/core` WorkflowBuilder engine (`.pattern('dag')`/.agent()/.step() chains) that `writing-agent-relay-workflows` and `migrating-persona-to-relayflow` cover — that's a different product despite the similar name.
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Design, build, test, and distribute external Temps plugins with TypeScript/Bun; provide development and local-testing guidance for existing Rust plugins. Use for creating a plugin, adding an embedded console UI or deployment-event automation, testing host permissions and AI, installing from GitHub, or submitting a plugin to the public catalog. End-to-end publishing covers TypeScript GitHub-source plugins, not Rust native-package releases or in-process TempsPlugin backend crates.
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Shared TypeScript best practices for Designer and Electron subsystems.
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Provides a comprehensive suite of functions to design and annotate CRISPR guide RNA (gRNAs) sequences. This includes on- and off-target search, on-target efficiency scoring, off-target scoring, full gene and TSS contextual annotations, and SNP annotation (human only). It currently support five types of CRISPR modalities (modes of perturbations): CRISPR knockout, CRISPR activation, CRISPR inhibition, CRISPR base editing, and CRISPR knockdown. All types of CRISPR nucleases are supported, including
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Builds dashboards, reports, and data-driven interfaces requiring charts, graphs, or visual analytics. Provides systematic framework for selecting appropriate visualizations based on data characteristics and analytical purpose. Includes 24+ visualization types organized by purpose (trends, comparisons, distributions, relationships, flows, hierarchies, geospatial), accessibility patterns (WCAG 2.1 AA compliance), colorblind-safe palettes, and performance optimization strategies. Use when creating visualizations, choosing chart types, displaying data graphically, or designing data interfaces.
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Use ESLint in .NET repositories that ship JavaScript, TypeScript, React, or other Node-based frontend assets. USE FOR: the repo has package.json, eslint.config.*, .eslintrc*, tsconfig.json, or JS/TS/React frontend files; the user asks for JavaScript or TypeScript linting, React rule. DO NOT USE FOR: CSS ownership by itself; route that to stylelint; HTML-only checks on static output; route that to htmlhint. INVOKES: inspect the repository context, edit targeted files, and run relevant build, test, lint, or validation commands when changes are made.
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Use when you need to apply functional exception handling best practices in Java — including replacing exception overuse with Optional and VAVR Either types, designing error type hierarchies using sealed classes and enums, implementing monadic error composition pipelines, establishing functional control flow patterns, and reserving exceptions only for truly exceptional system-level failures. This should trigger for requests such as Improve the code with Functional Exception Handling; Apply Functional Exception Handling; Refactor the code with Functional Exception Handling; Model Java errors with Result or Either types; Replace exception-heavy flows with functional error handling. Part of Plinth Toolkit
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React 19 and TypeScript coding standards for Portfolio Buddy 2. Use when: writing new components, reviewing code, refactoring, or ensuring consistency. Contains component patterns, TypeScript rules, and best practices.
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Use when reading or writing TypeScript or JavaScript files (.ts, .tsx, .js, tsconfig.json).
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Next.js 15 애플리케이션을 위한 프론트엔드 개발 가이드라인. React 19, TypeScript, Shadcn/ui, Tailwind CSS를 사용한 모던 패턴. Server Components, Client Components, App Router, 파일 구조, Shadcn/ui 컴포넌트, 성능 최적화, TypeScript 모범 사례 포함. 컴포넌트, 페이지, 기능 생성, 데이터 페칭, 스타일링, 라우팅, 프론트엔드 코드 작업 시 사용.
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Convert PyTorch AT_DISPATCH macros to AT_DISPATCH_V2 format in ATen C++ code. Use when porting AT_DISPATCH_ALL_TYPES_AND*, AT_DISPATCH_FLOATING_TYPES*, or other dispatch macros to the new v2 API. For ATen kernel files, CUDA kernels, and native operator implementations.
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