「standard」の検索結果

Performs logistic regression for clinical trial outcomes (binary, ordinal, multinomial) with marginal-vs-conditional estimand reporting per FDA 2023 covariate adjustment guidance, g-computation/standardisation for marginal effects, modified Poisson for RR, Brant test for proportional odds, Firth penalty for separation, and Hauck-Donner detection. Use when modeling binary or ordinal endpoints in confirmatory or exploratory clinical trials.

日本語の概要は準備中です。原文の説明を表示しています。

Predicts ADMET properties using ADMETlab 3.0 (119 endpoints with uncertainty), ADMET-AI, DeepChem MolNet, and chemprop D-MPNN with explicit handling of OECD QSAR principles, applicability domain assessment, calibration, hERG/CYP/AMES gold-standard endpoints, and PAINS / Lipinski / Ro5 / Veber / BBB druglikeness filters. Use when filtering compounds for drug-likeness, prioritizing leads by predicted safety, or building an in-house ADMET QSAR model.

日本語の概要は準備中です。原文の説明を表示しています。

Reads, writes, and converts molecular file formats (SMILES, InChI, SDF V2000/V3000, MOL2, PDB, MMTF) using RDKit and Open Babel with rigorous handling of aromaticity perception, stereochemistry, implicit/explicit hydrogens, kekulization, and salt/fragment separation. Use when loading chemical libraries, debugging parse failures, or preparing molecules for downstream standardization, descriptor calculation, or docking.

日本語の概要は準備中です。原文の説明を表示しています。

Detects aberrant splicing in single rare-disease patients vs a control panel using FRASER 2.0 (Bioconductor; Beta-binomial autoencoder on Intron Jaccard Index, default delta cutoff 0.1, q hyperparameter), OUTRIDER (gene-level outlier expression via autoencoder denoising), LeafcutterMD (Dirichlet-multinomial outlier mode of LeafCutter for annotation-free junctions), and DROP (Snakemake pipeline integrating FRASER2 + OUTRIDER + monoallelic expression for clinical diagnostics). The statistical model is fundamentally different from differential splicing — single-sample-vs-cohort outlier detection rather than two-group comparison. Standard tool in EU rare-disease (Solve-RD) and NIH UDN programs. Use when applying RNA-seq to undiagnosed Mendelian disease, validating predicted splice variants in clinical samples, or detecting cryptic splicing in disease tissue.

日本語の概要は準備中です。原文の説明を表示しています。

ATAC-seq library quality control -- TSS enrichment, FRiP, fragment-size periodicity, library complexity (NRF/PBC1/PBC2), mitochondrial fraction, and ENCODE 4 thresholds. Use when assessing whether an ATAC-seq library passes ENCODE acceptance criteria, diagnosing transposition artefacts, comparing Omni-ATAC vs standard prep quality, or selecting which replicates to drop before peak calling.

日本語の概要は準備中です。原文の説明を表示しています。

Predict enhancer-gene regulatory connections from ATAC-seq using ABC, ENCODE-rE2G, HiChIP, or Cicero. Use when linking distal enhancers to target genes, choosing between contact-aware (ABC, ENCODE-rE2G), accessibility-only (Cicero), and orthogonal (HiChIP H3K27ac, EpiMap) approaches, validating predictions against CRISPRi-FlowFISH gold-standard, or building cell-type-specific regulatory maps for fine-mapping or therapeutic target discovery.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks how to build + manage direct shipper relationships — moving from spot market to dedicated lanes, customer scoring + credit assessment, contract terms, dedicated capacity agreements, KPI reporting, and how to handle customer disputes. Reference standard customer-carrier contract terms.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill to design a vehicle preventive maintenance schedule. Covers manufacturer recommendations, industry-standard intervals, and how to set carrier-specific triggers.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks about CMV roadside inspection levels (Level I through Level VIII), what each level inspects, average inspection times, CVSA decal eligibility, what triggers a level upgrade, and how to coach drivers through a roadside inspection. Reference CVSA North American Standard Inspection Program.

日本語の概要は準備中です。原文の説明を表示しています。

Use when a carrier asks about tire program design, when to retread vs replace, position management (steer vs drive vs trailer), inflation pressure standards, casing management, scrub rates, road-call prevention, or vendor program selection (Bridgestone, Michelin, Continental, Goodyear). Covers 49 CFR 393.75 and DOT roadside out-of-service criteria.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill to develop the capability to investigate crashes internally. Covers what to look for, when to escalate to outside experts, and documentation standards.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks about CMV oilfield operations — the 24-hour restart exemption (49 CFR 395.1(d)), oilfield-specific HOS rules, hot oil hauling, specialty equipment (winch trucks, kill trucks, frac sand haulers, water haulers), Texas Railroad Commission permitting, oilfield insurance specifics, and how oilfield operations differ from standard OTR trucking. Cite 49 CFR 395.1(d).

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill to understand FMCSA cardiac certification standards. Covers what cardiac conditions disqualify, time-to-clearance, and what documentation is needed for examiner certification.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks about Hours of Service (HOS) rules under 49 CFR 395 — the 11-hour driving limit, 14-hour on-duty window, 60/70 hour rule, 30-minute break, 10-hour off-duty reset, 34-hour restart, sleeper berth provisions, split sleeper berth, short-haul exemption (150-air-mile), agricultural exemption, adverse driving conditions, ELD malfunction handling, personal conveyance, yard moves, or anything related to driver duty status. Cite specific 49 CFR 395 subsection. If the question involves a non-standard operation (passenger carrier, oilfield, agricultural, military), confirm which set of rules applies.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when a driver does not meet federal medical standards and needs to apply for a variance. Covers application steps, required documentation, and review timeline.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks how to design or improve a fleet safety scorecard — what KPIs to track, how to weight them, telematics signals vs document compliance vs roadside outcomes, monthly cadence, driver-facing vs admin-facing dashboards, gamification considerations, peer-comparison metrics, and how a scorecard ties to insurance premiums + retention. Reference SMS Methodology v3.20 for industry-standard weights.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks how to pay CDL drivers — cents per mile (CPM), percentage of revenue, hourly, salary, sleeper-team rate, detention pay, driver-pay laws under FLSA (Fair Labor Standards Act), and how each model affects retention + recruitment. Cite FLSA + state wage laws.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill to evaluate which DataQ challenges have winning evidence and which don't. Covers documented vs anecdotal evidence and the 8 high-success patterns.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill to understand the FMCSA cargo securement standards. Covers § 393.100-§ 393.136 general rules, tiedown requirements, working load limits.

日本語の概要は準備中です。原文の説明を表示しています。

End-to-end Coval accent testing workflow. Creates one persona per accent (each using a distinct accent voice and mirroring your Standard Customer behavior), launches one run per accent against the same voice agent + test set + metrics, polls for completion, builds a per-persona comparison table from the results, and creates the saved multi-run report (grouped by Persona) via the public API. Use when a user wants to follow the Testing Across Accents cookbook (https://docs.coval.dev/guides/testing-across-accents) without doing each step by hand.

日本語の概要は準備中です。原文の説明を表示しています。

Bringing an existing table onto the platform base standard. Use when asked to canonicalize, retrofit, or 'Wave 3' a table, run apply_rls or an org backfill, retire a bespoke *_versions table, or move it onto platform comments/associations/permissions. NOT for a schema move (use db-move-table-schema).

日本語の概要は準備中です。原文の説明を表示しています。

Applies Anthropic brand colors and typography to artifacts that need a consistent look-and-feel. Use when brand colors, style guidelines, visual formatting, or company design standards apply.

日本語の概要は準備中です。原文の説明を表示しています。

Spring Bootサービスのためのコーディング規約: 命名規則、イミュータビリティ、Optional使用法、ストリーム、例外、ジェネリクス、プロジェクト構成。

TypeScript、JavaScript、React、Node.js開発のための汎用コーディング規約、ベストプラクティス、パターン。