“saturation”的搜索结果

Designs and analyzes pooled prime-editor (PE) screens for installing precise genetic variants without bystander confounding. Covers pegRNA design with PRIDICT and PRIDICT2 for predicting per-pegRNA editing efficiency, pegRNA architecture (spacer + scaffold + PBS + RTT), PE2/PE3/PE3b/PEmax variants, MOSAIC in situ saturation mutagenesis, the PRIME pooled-screen methodology (Ren 2023; ~3,699 ClinVar variant screens), chromatin context as a major locus-level determinant of PE efficiency, scaffold-incorporation and indel byproduct quantification with CRISPResso2, and the cross-modal validation strategy of PE + base-editor screens for variant function. Use when designing a pegRNA library for variant installation, choosing between BE and PE for a specific edit, predicting pegRNA efficiency before library synthesis, analyzing PE screen output, distinguishing intended-edit from scaffold-incorporation, or scaling PE screens to thousands of variants.

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Analyzes base-editing screens for variant function. Covers library design (Hanna 2021 ClinVar-scale CBE screen benchmarked on BRCA1/2, Cuella-Martin 2021 DDR saturation), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end; 4-7 for ABE7.10), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.

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Assesses RNA-seq data quality specifically for alternative splicing analysis. QC layers include experimental design audit (library prep, read length, depth, replicates), STAR 2-pass cohort-style alignment, junction saturation curves and discovery plateau detection, novel-vs-known junction ratio diagnostics, junction-overhang distribution, splice-site strength scoring (MaxEntScan intrinsic + SpliceAI context-aware), strandedness verification, GENCODE basic vs comprehensive choice, and rRNA contamination screening. Splicing analysis is more demanding than DGE on read length, depth, library prep, alignment strategy, and annotation choice — failures silently bias PSI estimates and inflate novel-junction false positives. Use when evaluating data suitability for splicing analysis, troubleshooting low event detection, or designing sequencing experiments where AS is a primary endpoint.

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Design and operationalize SRE dashboards that surface reliability, latency, error, saturation, and capacity signals across services. Use when building observability views for SLOs, incident response, and executive reliability reporting.

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Diagnose performance issues on Amazon SageMaker HyperPod clusters — uneven NCCL bandwidth across nodes and poor filesystem throughput. Read-only. Surfaces host-side signals (Xid, ECC, NVLink, EFA reachability, FSx saturation) and routes to the appropriate sibling skill (hyperpod-node-debugger, hyperpod-nccl, hyperpod-version-checker, hyperpod-issue-report) for any remediation. Triggers on uneven NCCL across nodes, straggler node, FSx slow, checkpoint slow, dataloader slow, filesystem bottleneck, FSx throughput, cross-AZ latency, topology mismatch.

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Recherche, cartographie et analyse des thèses de doctorat françaises via theses.fr (API ABES) et TEL (HAL). Spécialisée droit avec filtrage par sous-disciplines juridiques. Ouverte sur d'autres domaines universitaires. Capacités : (1) recherche multi-critères — sujet, directeur, jury, établissement, école doctorale, période, statut soutenue/en préparation, discipline ; (2) cartographie académique — qui dirige sur quel sujet, qui siège dans quels jurys, réseaux de co-direction, écoles doctorales productives ; (3) analyses temporelles — évolution d'un sujet, détection de saturation, calendrier des soutenances à venir ; (4) filtrage sous-discipline juridique — droit privé, public, social, affaires, international, etc. Déclencher dès que l'utilisateur mentionne thèse, doctorat, directeur de thèse, jury de thèse, école doctorale, soutenance, doctorant, ou demande une analyse d'écosystème doctoral. Pour articles ou ouvrages de doctrine, utiliser plutôt recherche-doctrine.

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Diagnose and fix video/image color OBJECTIVELY with the get_image (action:"analyze_color") tool (scopes/stats such as black/white points, contrast, saturation, clipping, cast) instead of eyeballing a contact sheet. Covers the "washed out" signature, why reference color-match (mkl/ColorMatch/ColorMatchAdobe) CAN'T add contrast a flat source lacks, the levels/contrast-stretch fix (core AdjustContrast / CurveEditor), the measure→fix→re-measure loop, the side-by-side sandbox pattern, and where to place the fix in a render graph (after decode, before save). Use when a render looks washed out / flat / dull / over-saturated / color-cast, or when deciding between a color-match and a contrast/levels fix.

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Use when looking for research topics a longitudinal cohort database can answer (NHIS, UK Biobank, an institutional EMR or registry). Profiles the cohort, matches PI expertise, scans literature saturation and returns ranked topic proposals with gap evidence.

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Design, derive, optimize, explain, and diagnose cinematic Eastern xianxia camera direction, storyboards, motion choreography, pacing, continuity locks, keyframes, and per-shot image-to-video prompts. Use for 仙侠运镜、镜头语言、分镜、推拉摇移、跟拍、环绕、航拍、打斗追逐、情绪镜头、首尾帧、视频提示词、参考视频诊断, when users ask “怎么运镜/不会运镜/给案例/帮我改运镜”, or when an input contains invalid, contradictory, physically implausible, non-camera, or off-topic instructions that need actionable feedback. Support 16:9, 21:9, 4:3, 3:2, 4:5, and 9:16; default to 30 seconds, 16:9, six shots, narrative-adaptive pacing, epic scale, and selective high saturation when unspecified.

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AI creative director with recursive self-assessment. Generates concepts using world-class methodologies (SIT, TRIZ, Lateral Thinking, bisociation), scores against 6 weighted criteria with Cannes/D&AD/HumanKind calibration, and recursively refines until the 9+ threshold is reached. Accepts briefs in any format — text, voice transcript, PDF, or raw notes. Use when the user asks to generate creative concepts, brainstorm campaign ideas, develop a Big Idea or campaign platform, evaluate or critique existing creative work, find consumer insights, or shares a brief for ideation — including activations, PR-stunts, brand utility, experiential, and non-advertising ideas. Calibrates against a library of 569 legendary campaigns (P01-P18 pattern map) to detect saturation and ensure originality. Do not use for media planning, production budgeting, brand identity/logo design, copywriting final drafts, or market research data collection.

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Think and work like an expert Heliophysicist. Use when a task calls for Heliophysicist judgment. Reasons from MHD, magnetic topology, reconnection, and IMF Bz coupling through SDO/HMI magnetograms, DEM and NLFFF analysis, coronagraph GCS fitting, and WSA-ENLIL/EUHFORIA ensembles while treating LOS foreshortening, AIA stray light, force-free NLFFF breakdown, and Dst/SYM-H saturation as first-class failure modes.

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Think and work like an expert Electric Machines Engineer. Use when a task calls for Electric Machines Engineer judgment. Reasons from magnetic circuit design, dq-frame machine models, FEM flux paths, and drive efficiency maps while treating saturation, cogging, thermal derating, and inverter harmonics as first-class failure modes.

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Think and work like an expert Control Systems Engineer. Use when a task calls for Control Systems Engineer judgment. Reasons from plant dynamics, stability margins, and disturbance-rejection specs through Bode/Nyquist and Routh-Hurwitz analysis, LQR/H-infinity and pole placement, Kalman/EKF observers, RGA pairing, and HIL validation while treating integrator windup, actuator saturation and backlash limit cycles, sensor delay masking phase margin, and estimator divergence as first-class failure modes.

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Provider-independent color grading and finishing direction for generated video, ads, trailers, product films, social clips, explainers, and mixed-source edits. Use when planning, directing, reviewing, or QAing color correction, shot matching, exposure, contrast, saturation, skin/product color protection, look development, LUT/reference use, SDR/HDR color management, delivery constraints, generated-media artifacts, editor/compositor handoff, and finishing QC.

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Strips AI-generation "smell" from prose before it ships (READMEs, docs, release notes, PR descriptions, posts, emails). Counts measurable tells first (keyword saturation, tricolons and anaphora, the "not X, it's Y" reflex, fragment-for-emphasis, bolded thesis lines, listicle-ization, signpost phrases, filler vocabulary, em-dashes, engineered-quotable closers), then applies a "doing work or reflex?" test to each instance so genuine voice survives. Use when asked to de-slop text or make it sound human, when text reads as machine-written, and as the final pass on prose the agent drafted.

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Calibrate Blender materials, lighting, camera crop, emission/glow, color management, and aura/HUD styling against supplied original/reference images using measurable color, brightness, saturation, bbox, and mask statistics. Use when a product must match the lighting/look of a source image or when audits say the product is too bright, desaturated, wrong hue, wrong glow, or wrong silhouette extent.

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PID/MPC/Kalman/anti-windup control primitives for feedback loops. Use when an autoscaler flaps, a controller overshoots after saturation, or budget pacing overspends at peak.

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Generate Muted Zine Poster v0.1 poetic paper-poster prompts and the matching generated image. Use when the user gives a theme, sentence, object, mood, article idea, photo, or content brief and wants a quiet Japanese/Korean zine-like editorial poster with large negative space, aged paper texture, experimental typography, and a restrained muted palette without high-chroma color blocks. This is the low-saturation sibling of gc-minimal-zine-poster-v0-1.

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Physical principles underlying diodes, bipolar junction transistors, and MOSFETs — carrier concentrations, drift and diffusion, the pn junction, forward and reverse bias, the Shockley diode equation, BJT operating regions, MOSFET threshold and saturation, small-signal models, and temperature effects. Use when reasoning about device-level behavior, designing bias networks, selecting transistor operating points, interpreting datasheets, or diagnosing nonlinear device failures.

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Color theory principles for art education. Covers the three color properties (hue, saturation, value), color mixing systems (subtractive and additive), color relationships (complementary, analogous, triadic, split-complementary), color temperature, simultaneous contrast and the relativity of color perception, and practical palette construction. Use when analyzing color in artworks, planning color schemes, understanding optical phenomena in painting, or investigating Albers's Interaction of Color experiments.

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Google Calendar management via CalendarACSet. Transforms scheduling operations into GF(3)-typed Interactions, routes to triadic queues, detects saturation for balanced-calendar-as-condensed-state.

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Investigate an alert, page, or production symptom in an incident channel or a team's oncall / monitoring channel, and report findings a human can verify. Ordinary conversation and chatter are not alerts; leave those alone. Use when an alert or page lands, when error rate, latency or saturation is up, when someone asks "why is X broken", "investigate", "what changed", "root cause this", pastes a monitor, dashboard, trace or error-tracker link, or reports production trouble; also by default when an alert lands in a covered channel unasked. Feed-level asks land here too ("which alerts matter", "triage today's alerts"), plus the scheduled alert-review routine and the ticket path ("customer X can't check out"). Runs a fast first pass posted as a short interim update with a TL;DR, every finding carrying the query or link to verify it, then proposes the fix and — with connector access and confirmation — carries it out, never unattended. Afterwards `incident-postmortem` writes it up.

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Reduce visual intensity, saturation, and noise while preserving hierarchy and character. Use when the structure is basically sound but the design feels too loud, bold, garish, aggressive, or overstimulating—not when the real problem is structural clutter, too many features, or not enough personality.

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Perform capacity planning using historical metrics and growth models. Use predict_linear for forecasting, identify resource constraints, calculate headroom, and recommend scaling actions before saturation. Use before seasonal traffic spikes or product launches, during quarterly capacity reviews, when resource utilization trends upward, or before budget planning cycles.

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