AI operational modes (brainstorm, implement, debug, review, teach, ship, orchestrate). Use to adapt behavior based on task type.
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AI operational modes (brainstorm, implement, debug, review, teach, ship, orchestrate). Use to adapt behavior based on task type.
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Design focus modes that actually protect attention: Do Not Disturb schedules, app filtering, notification tiers, and context-specific setups. Use when interruptions fragment your day or 'do not disturb' never stays on.
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AI operational modes (brainstorm, implement, debug, review, teach, ship, orchestrate). Use to adapt behavior based on task type.
中文简介正在准备中。当前显示原文说明。
Safety guardrails for destructive operations. Wraps workflows and agent actions in configurable safety modes: CAREFUL (warns before destructive commands), FREEZE (restricts file edits to one directory), GUARD (both modes combined). Use when working in production, running destructive scripts, or debugging in sensitive areas. Voice triggers: "be careful", "safety on", "guard mode", "freeze scope". Also used automatically by the workflow engine when a workflow preset has safety: "guard" enabled.
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Quantifies CRISPR editing outcomes with CRISPResso2 (Clement 2019 Nat Biotechnol) across Cas9-nuclease (indels, HDR), CBE and ABE base editors (target conversion + bystander), and prime editor (pegRNA-templated) modes. Covers single-amplicon (CRISPResso), multi-sample batch (CRISPRessoBatch), pooled-amplicon (CRISPRessoPooled), WGS off-target (CRISPRessoWGS), and sample-comparison (CRISPRessoCompare) workflows; quantification-window math that controls what is called edited; substitution-vs-indel diagnostic to distinguish BE from Cas9 contamination; MMEJ deletion pattern interpretation; allele-frequency tables; and failure modes from amplicon misalignment or contamination. Use when quantifying editing from amplicon sequencing, choosing CRISPResso mode by design, distinguishing intended edits from bystanders and indel byproducts, debugging low-alignment runs, or generating publication-grade editing reports.
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First-principles strategy — strip away conventional assumptions and find the theoretical maximum for your business. Three modes. Diagnostic mode runs a full session (45+ min) to define your theoretical maximum, map the gap honestly, classify constraints, invert for failure modes, set strategic intent, and work backwards to your first intervention. Review mode (15-20 min) checks whether your theoretical maximum has shifted, whether the gap has changed, and whether you're still climbing the right peak. Alert mode defines constraint-shift, peak-shift, and local-peak triggers that tell you when to reassess. Use when someone is stuck optimising incrementally, when conventional wisdom is driving strategy, when a new technology or regulation changes what's physically possible, or when you suspect the business is climbing a local peak. Integrates with company-context.md. Based on practice by Eterdis (eterdis.com).
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Stress-test plans before committing by imagining they've already failed. Three modes. Diagnostic mode runs a full pre-mortem session — vivid failure scene-setting, six failure categories, the monkey test, and concrete plan adjustments. Review mode checks previous findings monthly for changed probabilities and new failure modes. Alert Triggers mode defines and monitors early warning signals across four trigger categories. Use before any major commitment — strategy, investment, product launch, partnership — or regularly to keep assumptions honest. The planning fallacy is real. The spreadsheet looked great so everyone stopped thinking. This is the antidote. Based on practice by Eterdis (eterdis.com).
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Schema Therapy according to Jeffrey Young: Schemas, modes, inner child concept, and coping styles — psychoeducationally presented.
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Ensure designs specify failure modes, timeouts, error contracts, and observability for critical flows.
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AI operational modes (brainstorm, implement, debug, review, teach, ship, orchestrate). Use to adapt behavior based on task type.
中文简介正在准备中。当前显示原文说明。
AI operational modes (brainstorm, implement, debug, review, teach, ship, orchestrate). Use to adapt behavior based on task type.
中文简介正在准备中。当前显示原文说明。
AI operational modes (brainstorm, implement, debug, review, teach, ship, orchestrate). Use to adapt behavior based on task type.
中文简介正在准备中。当前显示原文说明。
やりたいことを1行で言うと、B 型 loop engineering の 7 要素 (context / feedback / verification gate / termination / error handling / state / cost guard) を埋めた loop spec をコピペ可能な形で生成する。生成した spec は現行 Claude Code の実行プリミティブ (Workflow ツール / /loop skill / ralph-loop plugin / claude -p) に落とせる骨格になる (旧 `claude --goal` は廃止)。10 件 failure mode (F1-F10) の対策フックも自動挿入。Hybrid モード: 1 行入力 → デフォルト埋めで一発出力 → 「ここを調整したい」場所だけ短く聞き直す。Use when ユーザーが「loop を作りたい / loop-design / 自走ループ書いて / Workflow 用の spec 作って / 7 要素埋めて / verification gate ありで」と言ったとき、または `/loop-design` を実行したとき。Loop engineering の理論背景は Cards/loop-engineering-autonomous-agents、失敗モード対策は Cards/loop-failure-modes-mechanism-2026 を参照。
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Quantifies CRISPR editing outcomes with CRISPResso2 (Clement 2019 Nat Biotechnol) across Cas9-nuclease (indels, HDR), CBE and ABE base editors (target conversion + bystander), and prime editor (pegRNA-templated) modes. Covers single-amplicon (CRISPResso), multi-sample batch (CRISPRessoBatch), pooled-amplicon (CRISPRessoPooled), WGS off-target (CRISPRessoWGS), and sample-comparison (CRISPRessoCompare) workflows; quantification-window math that controls what is called edited; substitution-vs-indel diagnostic to distinguish BE from Cas9 contamination; MMEJ deletion pattern interpretation; allele-frequency tables; and failure modes from amplicon misalignment or contamination. Use when quantifying editing from amplicon sequencing, choosing CRISPResso mode by design, distinguishing intended edits from bystanders and indel byproducts, debugging low-alignment runs, or generating publication-grade editing reports.
中文简介正在准备中。当前显示原文说明。
AI operational modes (brainstorm, implement, debug, review, teach, ship, orchestrate). Use to adapt behavior based on task type.
中文简介正在准备中。当前显示原文说明。
AI operational modes (brainstorm, implement, debug, review, teach, ship, orchestrate). Use to adapt behavior based on task type.
中文简介正在准备中。当前显示原文说明。
Quantifies CRISPR editing outcomes with CRISPResso2 (Clement 2019 Nat Biotechnol) across Cas9-nuclease (indels, HDR), CBE and ABE base editors (target conversion + bystander), and prime editor (pegRNA-templated) modes. Covers single-amplicon (CRISPResso), multi-sample batch (CRISPRessoBatch), pooled-amplicon (CRISPRessoPooled), WGS off-target (CRISPRessoWGS), and sample-comparison (CRISPRessoCompare) workflows; quantification-window math that controls what is called edited; substitution-vs-indel diagnostic to distinguish BE from Cas9 contamination; MMEJ deletion pattern interpretation; allele-frequency tables; and failure modes from amplicon misalignment or contamination. Use when quantifying editing from amplicon sequencing, choosing CRISPResso mode by design, distinguishing intended edits from bystanders and indel byproducts, debugging low-alignment runs, or generating publication-grade editing reports.
中文简介正在准备中。当前显示原文说明。
AI operational modes (brainstorm, implement, debug, review, teach, ship, orchestrate). Use to adapt behavior based on task type.
中文简介正在准备中。当前显示原文说明。
AI operational modes (brainstorm, implement, debug, review, teach, ship, orchestrate). Use to adapt behavior based on task type.
中文简介正在准备中。当前显示原文说明。
检查Claude技能和命令的实用性、内容重叠及技术信息是否过时。可只检查变更部分或开展全面审查,并给出保留、改进、更新、停用或合并的建议及理由。
设计或检查AI智能体的反复作业,明确机器可判定的完成条件、不可更改的边界、独立验证和重试上限,防止空转、失控或错误完成。
将科学原理、物体结构和工作流程整理为简洁的SVG图,统一配色与留白,自动适应明暗模式,并输出可在浏览器直接打开的单个HTML文件。
指导开发可在ChatGPT内操作的应用,涵盖功能规划、React组件及状态共享的实现。该技能已弃用,并指引用户转向后续技能。
从使用者的角度,以对话方式审查API和开发工具的规划,梳理开发者需求、竞品差异及上手障碍,并按目标选择竞争力探索、细节优化或关键缺口检查。