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Implements multiplicity control for confirmatory clinical trials using graphical procedures (Bretz-Maurer-Hommel), gatekeeping (parallel, serial, mixed), Hochberg/Hommel/Holm with PRDS, and the closed-testing principle (Marcus-Peritz-Gabriel; Goeman 2021 admissibility). Covers FDA Multiple Endpoints Final Guidance (October 2022), graphical procedures via R gMCP, primary + key-secondary + subgroup hierarchies, and FWER vs FDR distinction. Use when designing the multiplicity strategy for confirmatory trials with multiple primary or key secondary endpoints.

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Scaffold Hono API routes for Cloudflare Workers. Produces route files, middleware, typed bindings, Zod validation, error handling, and API_ENDPOINTS.md documentation. Use after a project is set up with cloudflare-worker-builder or vite-flare-starter, when you need to add API routes, create endpoints, or generate API documentation.

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Builds high-performance async Python APIs with FastAPI and Pydantic V2 including REST endpoints, authentication flows, async SQLAlchemy, and WebSocket endpoints.

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Generate or scaffold ASP.NET Core code — Razor Pages, Blazor components, MVC controllers, views, and Minimal API endpoints — without using ASP.NET Core CLI scaffolding/code-generation tools. Use when (1) adding CRUD pages, views, or API endpoints backed by Entity Framework (EF Core) and a database, (2) generating code to create, read, update, and delete data using a DbContext, (3) scaffolding UI components that match the project's existing CSS framework and coding patterns, or (4) creating data-driven forms, tables, and navigation for a model class. Do not use for non-ASP.NET projects or when CLI-based scaffolding is preferred.

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Guides creation and modification of ASP.NET Core Web API endpoints with correct HTTP semantics, OpenAPI metadata, and error handling. USE FOR: adding new API endpoints (controllers or minimal APIs), wiring up OpenAPI/Swagger, creating .http test files, setting up global error handling middleware. DO NOT USE FOR: general C# coding style, EF Core data access or query optimization (use optimizing-ef-core-queries), frontend/Blazor work, gRPC services, or SignalR hubs.

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FHIR API development guide for building healthcare endpoints. Use when: (1) Creating FHIR REST endpoints (Patient, Observation, Encounter, Condition, MedicationRequest), (2) Validating FHIR resources and returning proper HTTP status codes and error responses, (3) Implementing SMART on FHIR authorization and OAuth scopes, (4) Working with Bundles, transactions, batch operations, or search pagination. Covers FHIR R4 resource structures, required fields, value sets (status codes, gender, intent), coding systems (LOINC, SNOMED, RxNorm, ICD-10), and OperationOutcome error handling.

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Generates complete CRUD modules for NestJS applications with Drizzle ORM. Use when building server-side features in NestJS that require database operations, including creating new entities with full CRUD endpoints, services with Drizzle queries, Zod-validated DTOs, and unit tests. Triggered by requests like "generate a user module", "create a product CRUD", "add a new entity with endpoints", or when setting up database-backed features in NestJS.

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Generate REST API endpoints with proper structure, validation, error handling, and types. Use when creating new API routes, endpoints, or backend services.

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Recover data from archived REST APIs using Wayback Machine. Use when: (1) Recovering data from defunct services like Vine, Twitter, or other platforms, (2) Need to find which API endpoints were archived vs which require authentication, (3) Building data recovery pipelines from web.archive.org. Covers CDX API queries to discover archived endpoints, understanding what gets archived (public) vs what doesn't (authenticated), and extracting embedded JSON from archived web pages as a fallback.

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Health check endpoints for liveness, readiness, dependency monitoring. Use for Kubernetes, load balancers, auto-scaling, or encountering probe failures, startup delays, dependency checks, timeout configuration errors.

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Predicts ADMET properties using ADMETlab 3.0 (119 endpoints with uncertainty), ADMET-AI, DeepChem MolNet, and chemprop D-MPNN with explicit handling of OECD QSAR principles, applicability domain assessment, calibration, hERG/CYP/AMES gold-standard endpoints, and PAINS / Lipinski / Ro5 / Veber / BBB druglikeness filters. Use when filtering compounds for drug-likeness, prioritizing leads by predicted safety, or building an in-house ADMET QSAR model.

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API Endpoint Builder workflow skill. Use this skill when the user needs Builds production-ready REST API endpoints with validation, error handling, authentication, and documentation. Follows best practices for security and scalability and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.

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API Documentation Generator workflow skill. Use this skill when the user needs Generate comprehensive, developer-friendly API documentation from code, including endpoints, parameters, examples, and best practices and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.

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API Endpoint Builder workflow skill. Use this skill when the user needs Builds production-ready REST API endpoints with validation, error handling, authentication, and documentation. Follows best practices for security and scalability and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.

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Creates FastAPI endpoints with layered architecture (Router → Service → Repository). Use when creating new API endpoints, CRUD operations, or scaffolding a new domain module in a FastAPI project.

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Generates Minimal API endpoints following Microsoft's recommended approach. Creates fast, testable HTTP APIs with minimal code using MapGet/MapPost/MapPut/MapDelete. Preferred over controller-based APIs for new projects.

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Work with the @upstash/qstash TypeScript/JavaScript SDK, an HTTP-based message queue, task scheduler, and background job system for serverless and edge runtimes (Next.js, Vercel, Cloudflare Workers, Deno, Node.js). Use when publishing messages to HTTP endpoints or URL groups, running background jobs without a long-running worker process, scheduling with cron expressions, delaying messages, building FIFO queues with parallelism and flow control, configuring retries and callbacks, handling a dead letter queue (DLQ), deduplicating messages, fanning out to multiple endpoints, verifying QStash webhook signatures (Next.js App Router, Pages Router, and Edge Runtime), running a local QStash dev server, or migrating regions. Also use when the user asks for a serverless cron job, async task queue, job scheduler, delayed delivery, webhook delivery with retries, or event-driven messaging between services.

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Build applications and agents with Exa's API Platform: search, contents, answer, context, Agent API, monitors, websets, OpenAI-compatible endpoints, and exa-py / exa-js. Use when choosing Exa endpoints, writing Exa API calls, integrating semantic web search or research into products, or debugging Exa request shapes. Load references/ on demand for endpoint details.

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Route Microsoft Graph work from VS Code. Use when users want to read or write Outlook mail, calendar events, contacts, OneDrive or SharePoint files, Teams, Planner, To Do, users, groups, directory data, or arbitrary Microsoft Graph endpoints from VS Code. Prefer WorkIQ for common read scenarios. Use Microsoft Graph for write actions and gap-read scenarios that need exact Graph properties, filters, permissions, or endpoints.

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Use when testing file upload endpoints for unrestricted file upload, MIME type bypass, magic byte spoofing, polyglot files, SVG XSS, XXE via Office documents, ZIP slip, and path traversal in filenames. Trigger on: multipart/form-data endpoints, avatar/document upload flows, import-from-file features, profile image, CSV/Excel import, DOCX/XLSX parsing, image resizing pipelines, archive extraction, and any endpoint that stores or serves user-supplied files. Detects extension bypass (shell.php.jpg), null byte injection, double extension, ImageMagick exploits, and content-type confusion.

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Exploit exposed GraphQL introspection endpoints to map the entire API schema. This skill details how to extract available queries, mutations, types, and fields, which significantly aids in identifying hidden endpoints, Broken Object Level Authorization (BOLA/IDOR), and mass assignment vulnerabilities.

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Manages GenAI tuning jobs in Agent Platform. Use this to list, get, or cancel ongoing model tuning jobs. Don't use for fine-tuning models (use `agent-platform-tuning`), deploying models to endpoints (use `agent-platform-deploy`), or managing serving endpoints (use `agent-platform-endpoint-management`).

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Agent Platform Model Tuning. Use when you need to fine-tune open models or Gemini models using Agent Platform infrastructure. Don't use for model training outside Agent Platform, model deployment to endpoints (use `agent-platform-deploy`), or managing serving endpoints (use `agent-platform-endpoint-management`).

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Connects to and performs inference with Google Cloud Agent Platform GenAI models, including First-Party Gemini models and Third-Party OpenMaaS models (Llama, DeepSeek, Qwen, etc.). Use when asked to perform inference, ask a model a question, run a test prompt, execute chat completions, or generate code for calling Gemini or OpenMaaS models, authenticate with GenAI SDK, OpenAI SDK, or legacy Agent Platform SDK, configure base URLs and global/regional endpoints, or troubleshoot 429 Resource Exhausted (DSQ), 400 User Validation, or 404 Not Found errors. Don't use for deploying models to endpoints or for running model evaluations.

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