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Designs and analyzes combinatorial CRISPR screens covering paired-Cas9 (Big Papi, Najm 2018), enhanced AsCas12a multiplex (enCas12a, DeWeirdt 2021), in4mer 4-guide-array Cas12a (Esmaeili Anvar N et al 2024 Nat Commun 15:3577) and the Inzolia paralog-pair library, paralog-buffering detection (Dede 2020 Genome Biol; Thompson 2021 Cell Reports 36:109597), genetic-interaction (GI) scoring as observed_double_LFC minus expected_additive_double_LFC, synthetic-lethal and synthetic-rescue interaction interpretation, the half-of-essentiality buffered by paralogs phenomenon, multiplex screen statistical analysis with MAGeCK MLE interaction terms, and the relationship to single-cell combinatorial Perturb-seq. Use when designing a paralog or pathway-pair screen, choosing between paired-Cas9 (Big Papi) and Cas12a multiplex (Inzolia), interpreting genetic interaction scores, identifying synthetic-lethal targets for drug development, or scaling beyond single-gene CRISPR screens.

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德州扑克策略 (德州扑克策略 (Texas Hold'em) — solver/GTO 时代的无限注德州扑克竞技打法，牌手/职业视角。覆盖: (a) 理论两极 — GTO 博弈论均衡 (不可剥削的基线策略) vs Exploitative 剥削打法 (针对对手漏洞偏离均衡最大化 EV)，以及二者的实战取舍; (b) solver 时代工作流 — PioSOLVER/GTO Wizard 跑解、范围构建、节点锁定 (node-locking) 做剥削、用 HUD+数据库 (Hold'em Manager/PokerTracker/Hand2Note) 复盘找漏洞 (leak finding); (c) 牌型分层 — 现金局 (cash game) vs 锦标赛 (MTT) 的根本差异，后者叠加 ICM (独立筹码模型) 与跳台/泡沫期博弈; (d) 核心概念栈 — 范围 (range)/权益 (equity)/EV/位置 (position)/翻前开池与 3-bet/4-bet/翻后下注理论 (c-bet、极化 vs 浓缩范围、MDF 最小防守频率、阻断牌 blockers、超池下注 overbet)、SPR、底池赔率; (e) 元层 — 资金管理 (bankroll management)、桌位选择 (table selection)、方差与心态 (mental game/tilt 控制)、抽水 (rake) 与场次选择对长期赢率 (winrate, bb/100) 的影响; (f) 智识演进 — 从 Sklansky 古典手牌价值 → Janda/Tipton 博弈论 → solver 普及 → GTO Wizard 民主化求解 → AI 超人 (Libratus/Pluribus) 对人类策略的反哺。学派分歧: GTO 派 vs 剥削派、现金局 vs 锦标赛、理论自上而下 vs 牌局自下而上、solver 纯学院派 vs 实战感觉派。不含: 线下牌场运营/发牌荷官、博彩合规与赌场管理、扑克之外的牌类 (桥牌/斗地主)、纯概率赌博 (老虎机/轮盘)。) Master OS — automated mastery of 德州扑克策略 (Texas Hold'em) — solver/GTO 时代的无限注德州扑克竞技打法，牌手/职业视角。覆盖: (a) 理论两极 — GTO 博弈论均衡 (不可剥削的基线策略) vs Exploitative 剥削打法 (针对对手漏洞偏离均衡最大化 EV)，以及二者的实战取舍; (b) solver 时代工作流 — PioSOLVER/GTO Wizard 跑解、范围构建、节点锁定 (node-locking) 做剥削、用 HUD+数据库 (Hold'em Manager/PokerTracker/Hand2Note) 复盘找漏洞 (leak finding); (c) 牌型分层 — 现金局 (cash game) vs 锦标赛 (MTT) 的根本差异，后者叠加 ICM (独立筹码模型) 与跳台/泡沫期博弈; (d) 核心概念栈 — 范围 (range)/权益 (equity)/EV/位置 (position)/翻前开池与 3-bet/4-bet/翻后下注理论 (c-bet、极化 vs 浓缩范围、MDF 最小防守频率、阻断牌 blockers、超池下注 overbet)、SPR、底池赔率; (e) 元层 — 资金管理 (bankroll management)、桌位选择 (table selection)、方差与心态 (mental game/tilt 控制)、抽水 (rake) 与场次选择对长期赢率 (winrate, bb/100) 的影响; (f) 智识演进 — 从 Sklansky 古典手牌价值 → Janda/Tipton 博弈论 → solver 普及 → GTO Wizard 民主化求解 → AI 超人 (Libratus/Pluribus) 对人类策略的反哺。学派分歧: GTO 派 vs 剥削派、现金局 vs 锦标赛、理论自上而下 vs 牌局自下而上、solver 纯学院派 vs 实战感觉派。不含: 线下牌场运营/发牌荷官、博彩合规与赌场管理、扑克之外的牌类 (桥牌/斗地主)、纯概率赌博 (老虎机/轮盘)。: top builders' mental models, tool stack, current workflows, jargon, and where to keep up. Trigger this skill when the user works on 德州扑克策略 (Texas Hold'em) — solver/GTO 时代的无限注德州扑克竞技打法，牌手/职业视角。覆盖: (a) 理论两极 — GTO 博弈论均衡 (不可剥削的基线策略) vs Exploitative 剥削打法 (针对对手漏洞偏离均衡最大化 EV)，以及二者的实战取舍; (b) solver 时代工作流 — PioSOLVER/GTO Wizard 跑解、范围构建、节点锁定 (node-locking) 做剥削、用 HUD+数据库 (Hold'em Manager/PokerTracker/Hand2Note) 复盘找漏洞 (leak finding); (c) 牌型分层 — 现金局 (cash game) vs 锦标赛 (MTT) 的根本差异，后者叠加 ICM (独立筹码模型) 与跳台/泡沫期博弈; (d) 核心概念栈 — 范围 (range)/权益 (equity)/EV/位置 (position)/翻前开池与 3-bet/4-bet/翻后下注理论 (c-bet、极化 vs 浓缩范围、MDF 最小防守频率、阻断牌 blockers、超池下注 overbet)、SPR、底池赔率; (e) 元层 — 资金管理 (bankroll management)、桌位选择 (table selection)、方差与心态 (mental game/tilt 控制)、抽水 (rake) 与场次选择对长期赢率 (winrate, bb/100) 的影响; (f) 智识演进 — 从 Sklansky 古典手牌价值 → Janda/Tipton 博弈论 → solver 普及 → GTO Wizard 民主化求解 → AI 超人 (Libratus/Pluribus) 对人类策略的反哺。学派分歧: GTO 派 vs 剥削派、现金局 vs 锦标赛、理论自上而下 vs 牌局自下而上、solver 纯学院派 vs 实战感觉派。不含: 线下牌场运营/发牌荷官、博彩合规与赌场管理、扑克之外的牌类 (桥牌/斗地主)、纯概率赌博 (老虎机/轮盘)。 problems and wants industry-grade thinking, tool selection, or workflow guidance. 触发词：「德州扑克」「德扑」「Texas Hold'em」「poker strategy」「扑克策略」

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Use this skill when building, debugging, or answering questions about Liveblocks. Liveblocks gives you the building blocks and infrastructure to enable people and AI to work together inside your app, powering realtime collaboration. Liveblocks features include collaboration, rooms, organizations, workspaces, comments, composer, threads, notifications, multiplayer, conflict resolution, realtime presence, avatar stacks, AI collaborators, AI agents, text editors, Tiptap, BlockNote, Lexical, React Flow, Chat SDK. Common components include AiChat, Thread, InboxNotification, Composer, Toolbar (for Lexical Tiptap), FloatingToolbar, FloatingComposer, FloatingThreads, AnchoredThreads. Common hooks include useThreads, useStorage, useMutation, useOthers, useInboxNotifications, useAiChats. Common issues are related to authentication (ID tokens vs access tokens), permissions, room limits, connection errors, user info.

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Developing for multicore systems in Zephyr RTOS. Covers Symmetric Multiprocessing (SMP), Asymmetric Multiprocessing (AMP) with OpenAMP/RPMsg, inter-processor communication (IPC) patterns, and Linkable Extensions (LLEXT). Trigger when designing for SoCs with multiple homogeneous or heterogeneous cores.

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Verify and lock project identity before ANY git push, Cloudflare deploy, or Supabase operation. Essential when working with multiple GitHub accounts (personal + work), multiple Cloudflare accounts, or multiple Supabase/Neon projects. Prevents wrong-account deploys, cross-project secret leaks, and git history contamination.

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Shows you how to use Cowork's parallel workers to run multiple tasks at the same time instead of one after another — dramatically cutting the time on batch work. For processing large batches of files or research tasks, when running multiple independent analyses simultaneously, or during a performance optimization session. Use when the user says "speed up", "parallel workers", "batch task", "process multiple files", "why is cowork so slow", "faster", "do several things at once", or "can cowork multitask".

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"Implement TrueSkill rating system for multiplayer and team-based competitive ranking. Use this skill when the user needs to rate players in team games, handle multiplayer (non-1v1) matchups, or build a matchmaking system with uncertainty tracking — even if they say 'team rating system', 'multiplayer ranking', or 'matchmaking rating'.".

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Genera las vistas estáticas navegables del producto (landing, auth, app, legales, errores y las propias del mapa de pantallas) usando el design system de design/, sin lógica de backend. Úsalo en el paso "prototipar" del sprint de definición o cuando haya que maquetar vistas nuevas (p. ej. "haz el prototipo", "maqueta las vistas", "crea la landing estática").

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Designs and analyzes combinatorial CRISPR screens covering paired-Cas9 (Big Papi, Najm 2018), enhanced AsCas12a multiplex (enCas12a, DeWeirdt 2021), in4mer 4-guide-array Cas12a (Esmaeili Anvar N et al 2024 Nat Commun 15:3577) and the Inzolia paralog-pair library, paralog-buffering detection (Dede 2020 Genome Biol; Thompson 2021 Nat Commun 12:1302), genetic-interaction (GI) scoring as observed_double_LFC minus expected_additive_double_LFC, synthetic-lethal and synthetic-rescue interaction interpretation, the half-of-essentiality buffered by paralogs phenomenon, multiplex screen statistical analysis with MAGeCK MLE interaction terms, and the relationship to single-cell combinatorial Perturb-seq. Use when designing a paralog or pathway-pair screen, choosing between paired-Cas9 (Big Papi) and Cas12a multiplex (Inzolia), interpreting genetic interaction scores, identifying synthetic-lethal targets for drug development, or scaling beyond single-gene CRISPR screens.

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Optimize prediction-pool tips (kicktipp etc.): rules + multi-book consensus odds → expected-points-max answer for every question, scores AND bonus. Triggers 'optimize my pool tips', 'predict'.

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Works on Kotlin Multiplatform mobile projects with shared Kotlin source sets and Android/iOS targets. Use for architecture, tests, debugging, reviews, performance, security, accessibility, dependencies and releases when `org.jetbrains.kotlin.multiplatform` is applied; inspect actual targets, `commonMain`/`commonTest`, target source sets, Compose Multiplatform and the iOS framework/host app before giving platform advice.

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Generate a batch of social media video prompts for multiple platforms from a single input. Use this skill whenever the user wants to create videos for multiple social platforms at once, repurpose one video across platforms, or create a social media video campaign. Trigger on phrases like 'social media videos', 'videos for all platforms', 'Instagram and TikTok video', 'social campaign', 'batch of social videos', 'repurpose this for social', 'video for every platform', 'social clips', 'create Reels and Shorts', 'multi-platform video', or any request involving creating short-form video content for multiple social media platforms using Ozor.

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Decision-grade statistical analysis for metabolomics intensity tables. Covers transformation and scaling (Pareto vs unit-variance as a hidden hypothesis), unsupervised structure (PCA/HCA for QC), permutation-validated PLS-DA/OPLS-DA (R2 vs Q2, double CV, VIP as heuristic), univariate testing (Welch/Mann-Whitney/ANOVA/LMM with covariate adjustment), and dependence-aware multiple testing. Use when testing which metabolites differ, building or validating a discriminant model, choosing a scaling, or correcting many correlated tests. For sample-wise normalization/drift correction see metabolomics/normalization-qc; for ML classifiers and selection-inside-CV leakage see machine-learning/biomarker-discovery and machine-learning/model-validation; for pathway interpretation see metabolomics/pathway-mapping; for design/power/multiplicity regime see experimental-design/multiple-testing.

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Designs and analyzes combinatorial CRISPR screens covering paired-Cas9 (Big Papi, Najm 2018), enhanced AsCas12a multiplex (enCas12a, DeWeirdt 2021), in4mer 4-guide-array Cas12a (Esmaeili Anvar N et al 2024 Nat Commun 15:3577) and the Inzolia paralog-pair library, paralog-buffering detection (Dede 2020 Genome Biol; Thompson 2021 Cell Reports 36:109597), genetic-interaction (GI) scoring as observed_double_LFC minus expected_additive_double_LFC, synthetic-lethal and synthetic-rescue interaction interpretation, the half-of-essentiality buffered by paralogs phenomenon, multiplex screen statistical analysis with MAGeCK MLE interaction terms, and the relationship to single-cell combinatorial Perturb-seq. Use when designing a paralog or pathway-pair screen, choosing between paired-Cas9 (Big Papi) and Cas12a multiplex (Inzolia), interpreting genetic interaction scores, identifying synthetic-lethal targets for drug development, or scaling beyond single-gene CRISPR screens.

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Designs and analyzes combinatorial CRISPR screens covering paired-Cas9 (Big Papi, Najm 2018), enhanced AsCas12a multiplex (enCas12a, DeWeirdt 2021), in4mer 4-guide-array Cas12a (Esmaeili Anvar N et al 2024 Nat Commun 15:3577) and the Inzolia paralog-pair library, paralog-buffering detection (Dede 2020 Genome Biol; Thompson 2021 Cell Reports 36:109597), genetic-interaction (GI) scoring as observed_double_LFC minus expected_additive_double_LFC, synthetic-lethal and synthetic-rescue interaction interpretation, the half-of-essentiality buffered by paralogs phenomenon, multiplex screen statistical analysis with MAGeCK MLE interaction terms, and the relationship to single-cell combinatorial Perturb-seq. Use when designing a paralog or pathway-pair screen, choosing between paired-Cas9 (Big Papi) and Cas12a multiplex (Inzolia), interpreting genetic interaction scores, identifying synthetic-lethal targets for drug development, or scaling beyond single-gene CRISPR screens.

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KMPプロジェクトのためのCompose MultiplatformおよびJetpack Composeパターン — ステート管理、ナビゲーション、テーマ設定、パフォーマンス、プラットフォーム固有UI。

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管理OpenClaw的多个Issue和PR，分配负责人调查原因、修复并验证，在获准范围内推进合并及关闭已解决事项，同时记录证据和进度。

• 管理多个Issue或PR的修复
• 完成已有的修复PR
• 验证并关闭已修复的Issue

查找本地网络中的Sonos音箱，检查状态并控制播放、停止和音量，还可为多台音箱分组，管理收藏与播放队列。

• 调整各房间的播放和音量
• 将多台音箱加入分组
• 操作收藏和播放队列

读取规格说明和相关工单的依赖关系，安排多个代理推进实现。经过测试、代码审查和问题修正后，将成果汇总到一个集成分支，并完成工单处理。

• 实现分散在多个工单中的需求
• 并行实现相互独立的任务
• 将成果汇总到集成分支

Maintain clear business definitions and relationships in an existing glossary or CONTEXT.md. Flag unresolved meanings and refer lasting design choices to the existing architecture decision record workflow, keeping terminology separate from decision rationale and task status.

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• Document business terms that need repeated explanation
• Clarify terms with multiple meanings
• Track domain interpretations awaiting confirmation

通过多轮访谈梳理品牌目的、定位、客户群、个性和表达风格，整理创始人之间的共识与分歧，最终形成可向设计师、文案及外部协作者共享的品牌手册。

• 确定新品牌的方向
• 重新审视品牌定位
• 统一多位创始人的认识

通过SocialClaw预约和发布多个社交平台的帖子，并查看投递状态。支持上传图片等素材、整理跨平台活动的发布计划，以及在发布前验证计划。

• 预约跨平台活动帖子
• 上传帖子所需的图片等素材
• 发布前验证计划

使用pytest设计和编写Python测试，复用准备与清理步骤，模拟外部服务，以多组输入验证行为，并测量代码覆盖率、找出尚未验证的部分。

• 先写测试再开发Python功能
• 复用测试准备与清理步骤
• 模拟外部API进行验证

将大型功能的RFC设计提案拆分为带依赖关系和验收测试的工作单元，组织多个智能体完成调查、实现、测试与审查，再依次合并变更并验证整个系统。

• 将大型设计提案拆成可验证的任务
• 为多个智能体分配带依赖关系的工作
• 审查并依次合并变更分支