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Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.

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Generate MATLAB Grader assessment item sets. Use when the user asks to create MATLAB Grader assessment items, generate MATLAB assessment materials, build MATLAB homework assessment items, QTI 3 portable assessment items, or mentions "grader assessment items". Produces complete assessment item folders with description, solution, template, tests, Function call blocks, and optional QTI 3 interchange files.

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Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3 with constraints), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.

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Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3 with constraints), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.

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Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3 with constraints), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.

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Evaluate a Claude Managed Agent against a written rubric, a set of checkable criteria, and guide improvements within a fixed attempt limit. After a version passes, prepare separate evaluation cases to check performance beyond the examples used for revision.

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• Defining checkable criteria for agent outputs
• Improving an agent within a fixed attempt limit
• Testing a passing version on unseen cases

Fine-tune models on Microsoft Foundry using SFT (supervised), DPO (preference), or RFT (reinforcement with graders). Covers dataset preparation, training job submission, deployment, and evaluation. USE FOR: fine-tune, SFT, DPO, RFT, training data, grader, distillation, fine-tuned model, training job, large file upload, calibrate grader, deploy fine-tuned model, evaluate fine-tuned model. DO NOT USE FOR: general model deployment without fine-tuning (use deploy-model), agent creation (use agents), prompt optimization without training (use prompt-optimizer).

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Fine-tune models on Microsoft Foundry using SFT (supervised), DPO (preference), or RFT (reinforcement with graders). Covers dataset preparation, training job submission, deployment, and evaluation. USE FOR: fine-tune, SFT, DPO, RFT, training data, grader, distillation, fine-tuned model, training job, large file upload, calibrate grader, deploy fine-tuned model, evaluate fine-tuned model. DO NOT USE FOR: general model deployment without fine-tuning (use deploy-model), agent creation (use agents), prompt optimization without training (use prompt-optimizer).

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Build custom LLM evaluation pipelines using the OpenJudge framework. Covers selecting and configuring graders (LLM-based, function-based, agentic), running batch evaluations with GradingRunner, combining scores with aggregators, applying evaluation strategies (voting, average), auto-generating graders from data, and analyzing results (pairwise win rates, statistics, validation metrics). Use when the user wants to evaluate LLM outputs, compare multiple models, design scoring criteria, or build an automated evaluation system.

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Generate MATLAB Grader assessment items that are suitability-gated, profile-driven, feedback-aware, and validated through MATLAB MCP. Produces Script, Function, Class Definition, Class Inheritance, Object Usage, and Class Methods items with MATLAB Grader assessment setup instructions.

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Use when an instructor asks for a MATLAB Grader assessment setup guide, adoption guide, pilot plan, course-specific rollout, QTI 3 sharing workflow, or recommended MATLAB Grader assessment-item-generation configuration based on a learning objective, course title, course description, module description, lab description, or assessment goal.

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Use when a task needs the judgment of an Agricultural Grader/Sorter — calling a defect grade on a moving packing line, deciding whether a lot with a marginal QC sample gets accepted, hand re-sorted, downgraded, or held, choosing where to station a human grader relative to an optical sorter, or diagnosing why a lot's cull rate or customer chargebacks spiked.

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Guide changes to gh-aw internals, including workflow validation, session scoring, and GitHub output handling. Find implementation locations and design rules for configuration checks, YAML compatibility, and limits on log responses returned to agents.

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• Choose where to add workflow validation
• Review changes to session scoring
• Investigate YAML parsing differences

Use when the user has evaluation principles or a dataset but needs help choosing the right graders, designing evaluation metrics, creating LLM-as-judge prompts, combining multiple metrics into a composite score, or building an automated evaluation pipeline. Also use when the user mentions grader selection, metric design, judge prompt engineering, rubric design, evaluation pipeline code, or "how to evaluate [X] automatically." Outputs executable OpenJudge pipeline code.

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Suede-owned launch-appeal grader for public pages. Grades findability, first-screen clarity, CTA pull, proof quality, design signal, and AI citation readiness. Use when a public page needs a fast A-F visibility grade before or after launch. NOT FOR: the deep nine-lane SEO audit with rewrite fixes (use suede-seo-audit); implementing conversion changes (use suede-site-alchemy); getting cited by AI answer engines (use suede-ai-seo).

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Work on bifunctional degraders and molecular glues, where potency comes from a ternary complex rather than occupancy. Use this skill to apply the property rules that govern this beyond-rule-of-five space, reason about linker length, attachment vector and E3 ligase choice, prepare inputs for ternary complex structure prediction, and interpret degradation readouts — DC50, Dmax, cooperativity, and the hook effect that makes a dose-response curve turn over. Also trigger on PROTAC, molecular glue, targeted protein degradation, E3 ligase, cereblon, VHL, ternary complex, DC50, Dmax, hook effect, cooperativity, or PROTAC-DB.

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Use when testing whether the jevaluate rubric and instructions lead graders to the right answers: after a rubric or instruction change, before freezing a rubric, before publishing ratings, or when a grader's calls look wrong.

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在AI开发前定义成功条件，使用代码、规则、模型或人工评估新功能并检查既有功能是否正常，再记录多次尝试的可靠性指标与报告，用于比较提示词、代理或模型版本的变化。

• 在AI实现前确定成功条件
• 检查提示词或代理变更后的回归问题
• 通过多次尝试衡量可靠性

Learn AI engineering by building a project one stage at a time. The tutor guides predictions, learner-written code, automated checks, and reflection, then records progress so the next session can continue from the right stage.

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• Learn AI engineering through hands-on projects
• Resume a project from the next unfinished stage
• Find coding mistakes with step-by-step hints

Plan and evaluate free calculators, generators, or assessment tools for marketing. Compare ideas against audience needs, search demand, development effort, and maintenance, then define an initial version and a path toward your paid product.

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• Comparing free tool ideas for attracting prospects
• Defining the first version of an ROI calculator
• Deciding when to request an email address

Prepare an evaluation framework before fine-tuning a language model. Build labeled examples, checks for each failure type, and a base-model benchmark, while calibrating model-based judges against human labels to support comparisons after training.

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• Build an evaluation set from agent traces
• Create separate checks for each failure type
• Calibrate an LLM judge against human labels

Plan free calculators, generators, and checkers for marketing. Compare ideas by search demand, competition, and effort, then define the user flow, lead capture, landing page, launch activities, and measurement plan to assess results.

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• Compare free tool ideas before committing development time
• Design useful results and an email capture flow
• Plan a tool landing page and launch activities

Create Vally evaluation specifications for skills, custom agents, and workflow packages. Design distinct test requests, prepare fixture files, define automated checks and outcome rubrics, and size comparisons to provide meaningful evidence without favoring the skill’s wording.

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• Create an eval.yaml for a skill or custom agent
• Define outcome-based checks and judging rubrics
• Prepare fixture files that reproduce specific failures

Restructure an existing SKILL.md into v5 Hybrid format. Four agents use indexed reference books to identify workflow states, actions, decision rules, constraints, and completion conditions, then combine their findings into an upgraded skill and validation report.

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• Converting an existing SKILL.md to v5 Hybrid format
• Clarifying workflow states and available actions
• Defining decision rules and completion conditions