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Expert in designing and optimizing growth loops - self-reinforcing systems where the output of one cycle becomes the input for the next. Covers viral loops, content loops, paid loops, sales loops, and product loops. Knows how to identify, measure, and accelerate the specific loop mechanics that drive sustainable growth. Use when "growth loop, viral loop, content loop, flywheel, compounding growth, acquisition loop, referral loop, " mentioned.

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Calls significant loops from protein-directed and targeted 3C assays (HiChIP, PLAC-seq, Capture Hi-C/PCHi-C, ChIA-PET) where the contact background is peak-anchored and coverage-biased, so generic Hi-C loop callers (cooltools dots, Juicer HiCCUPS) use the wrong null. Covers FitHiChIP (config-driven coverage+distance-decay spline regression, peak-to-peak vs peak-to-all foreground, loose vs stringent background, coverage vs ICE bias), MAPS (positive Poisson regression on bias factors for PLAC-seq/HiChIP), hichipper (restriction-site-distance bias model + library QC), CHiCAGO (Delaporte two-component Brownian+technical background for asymmetric bait x other-end Capture Hi-C), the with/without separate-ChIP anchor decision, and differential loops via diffloop. Use when calling loops from HiChIP/PLAC-seq/Capture Hi-C, choosing FitHiChIP/MAPS/CHiCAGO, picking peak-to-all vs peak-to-peak, setting the loop FDR, supplying ChIP peaks as anchors, QCing a HiChIP library, or comparing loops between conditions.

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Calls significant loops from protein-directed and targeted 3C assays (HiChIP, PLAC-seq, Capture Hi-C/PCHi-C, ChIA-PET) where the contact background is peak-anchored and coverage-biased, so generic Hi-C loop callers (cooltools dots, Juicer HiCCUPS) use the wrong null. Covers FitHiChIP (config-driven coverage+distance-decay spline regression, peak-to-peak vs peak-to-all foreground, loose vs stringent background, coverage vs ICE bias), MAPS (positive Poisson regression on bias factors for PLAC-seq/HiChIP), hichipper (restriction-site-distance bias model + library QC), CHiCAGO (Delaporte two-component Brownian+technical background for asymmetric bait x other-end Capture Hi-C), the with/without separate-ChIP anchor decision, and differential loops via diffloop. Use when calling loops from HiChIP/PLAC-seq/Capture Hi-C, choosing FitHiChIP/MAPS/CHiCAGO, picking peak-to-all vs peak-to-peak, setting the loop FDR, supplying ChIP peaks as anchors, QCing a HiChIP library, or comparing loops between conditions.

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Calls significant loops from protein-directed and targeted 3C assays (HiChIP, PLAC-seq, Capture Hi-C/PCHi-C, ChIA-PET) where the contact background is peak-anchored and coverage-biased, so generic Hi-C loop callers (cooltools dots, Juicer HiCCUPS) use the wrong null. Covers FitHiChIP (config-driven coverage+distance-decay spline regression, peak-to-peak vs peak-to-all foreground, loose vs stringent background, coverage vs ICE bias), MAPS (positive Poisson regression on bias factors for PLAC-seq/HiChIP), hichipper (restriction-site-distance bias model + library QC), CHiCAGO (Delaporte two-component Brownian+technical background for asymmetric bait x other-end Capture Hi-C), the with/without separate-ChIP anchor decision, and differential loops via diffloop. Use when calling loops from HiChIP/PLAC-seq/Capture Hi-C, choosing FitHiChIP/MAPS/CHiCAGO, picking peak-to-all vs peak-to-peak, setting the loop FDR, supplying ChIP peaks as anchors, QCing a HiChIP library, or comparing loops between conditions.

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Compare five growth loops, mechanisms where user activity brings in more users, to find a suitable approach for a product. Develop an implementation roadmap, measurement plan, and growth estimates based on sharing, collaboration, content, or referrals.

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• Designing product features that attract new users
• Planning growth with less reliance on paid acquisition
• Comparing sharing, collaboration, and referral mechanisms

Detects focal chromatin loops (point interactions / corner-dots) in balanced Hi-C and Micro-C contact maps and aggregates/validates a loop set. Covers de-novo calling with cooltools dots (HiCCUPS-style 4-background local enrichment with lambda-chunked FDR), chromosight (template-correlation), and Mustache (scale-space blob detection); aggregate peak analysis (APA) via cooltools pileup for confirmation; the depth/resolution prerequisite (de-novo needs ~5-10kb resolution = hundreds of millions to billions of valid pairs); consensus across callers and convergent-CTCF support as validation; and differential loops via union anchors plus chromosight quantify. Use when calling chromatin loops or dots from a cooler, deciding whether a map is deep enough to call de-novo vs running APA on known CTCF/cohesin anchors, building an aggregate peak pileup, comparing loops across conditions, or validating loop calls. For HiChIP/PLAC-seq/PCHi-C protein-anchored data use FitHiChIP/MAPS, not dots.

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Detects focal chromatin loops (point interactions / corner-dots) in balanced Hi-C and Micro-C contact maps and aggregates/validates a loop set. Covers de-novo calling with cooltools dots (HiCCUPS-style 4-background local enrichment with lambda-chunked FDR), chromosight (template-correlation), and Mustache (scale-space blob detection); aggregate peak analysis (APA) via cooltools pileup for confirmation; the depth/resolution prerequisite (de-novo needs ~5-10kb resolution = hundreds of millions to billions of valid pairs); consensus across callers and convergent-CTCF support as validation; and differential loops via union anchors plus chromosight quantify. Use when calling chromatin loops or dots from a cooler, deciding whether a map is deep enough to call de-novo vs running APA on known CTCF/cohesin anchors, building an aggregate peak pileup, comparing loops across conditions, or validating loop calls. For HiChIP/PLAC-seq/PCHi-C protein-anchored data use FitHiChIP/MAPS, not dots.

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Detects focal chromatin loops (point interactions / corner-dots) in balanced Hi-C and Micro-C contact maps and aggregates/validates a loop set. Covers de-novo calling with cooltools dots (HiCCUPS-style 4-background local enrichment with lambda-chunked FDR), chromosight (template-correlation), and Mustache (scale-space blob detection); aggregate peak analysis (APA) via cooltools pileup for confirmation; the depth/resolution prerequisite (de-novo needs ~5-10kb resolution = hundreds of millions to billions of valid pairs); consensus across callers and convergent-CTCF support as validation; and differential loops via union anchors plus chromosight quantify. Use when calling chromatin loops or dots from a cooler, deciding whether a map is deep enough to call de-novo vs running APA on known CTCF/cohesin anchors, building an aggregate peak pileup, comparing loops across conditions, or validating loop calls. For HiChIP/PLAC-seq/PCHi-C protein-anchored data use FitHiChIP/MAPS, not dots.

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设计或检查AI智能体的反复作业，明确机器可判定的完成条件、不可更改的边界、独立验证和重试上限，防止空转、失控或错误完成。

• 定义反复作业的完成条件
• 检查空转和验证漏洞
• 划分规划、实现与验证职责

将 GitHub、Discord 和 X 的社区增长措施整理为珊瑚色系 HTML 幻灯片，结合发布日历、增长循环与成果计算，说明计划和数值之间的关系。

• 提案社区增长计划
• 规划 GitHub、Discord 和 X 的发布
• 解释增长机制与相关数值

Design loops that improve an agent’s own prompts, workflows, or execution code from failure records. Define bounded edits, preserve candidate histories, and accept changes through independent tests that check improvements and regressions.

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• Designing agent self-improvement from failure records
• Defining acceptance checks for self-modifying workflows
• Diagnosing score gaming and stalled improvement

Design the controls around autonomous agents: what they can edit, how results are evaluated, how progress is logged, and when human approval is required. Build research and experiment loops with clear recovery and review rules.

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• Designing autonomous research and experiment loops
• Separating editable work from fixed evaluation rules
• Preserving progress and failed attempts across long runs

Optimize .NET loops with SIMD, which processes multiple values in one operation, or review existing SIMD code. Check behavioral equivalence, memory safety, platform fallbacks, and benchmarks to establish whether the optimization is correct and worthwhile.

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• Optimize numeric loops with SIMD
• Review existing vectorized code for correctness
• Test boundary lengths and overlapping buffers

Run, monitor, resume, merge, and debug Ralph loops. Use this skill whenever the user asks to operate `ralph run` or `ralph loops`, inspect loop state, recover suspended loops, analyze diagnostics, or unblock merge queue issues.

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Detect chromatin loops and point interactions from Hi-C data using cooltools, chromosight, and HiCCUPS-like methods. Identify CTCF-mediated loops and enhancer-promoter contacts. Use when detecting chromatin loops from Hi-C data.

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Read and write Loops: find and manage email contacts; send events and transactional emails. Trigger phrases: loops, email contacts.

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Expert en agent loops (ARIS, Ralph, recherche autonome, build-score-budget, guardrails)

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帮助编写和检查PyTorch模型与训练代码，涵盖数据加载、实验可复现性、训练状态保存与恢复，并提供改善GPU显存占用和运行速度的方法。

• 编写与审查PyTorch训练代码
• 排查实验结果不一致的原因
• 改善加载速度与GPU显存占用

帮助设计在 Claude Code 中反复推进开发工作的自主循环，涵盖顺序执行与并行任务，并梳理运行间的进度衔接、质量检查、变更合并和停止条件。

• 设计顺序执行的开发流程
• 在多次运行之间衔接进度
• 协调并行任务与变更合并

从指令、记忆、工具执行和界面显示等十二个层面排查人工智能代理故障，依据代码和日志梳理原因，按严重程度列出问题并提出修复方案。

• 排查仅在应用内出现的故障
• 调查旧对话混入回答的原因
• 核对工具漏执行或虚报执行

生成用于产品亮相、预告和氛围背景循环的3至10秒短视频。先整理主体、动作与灯光，再按指定时长和画面比例将MP4保存到项目文件夹。

• 制作产品亮相视频
• 制作带动态效果的短预告
• 制作营造氛围的背景循环

Simplify Rust code in RTK by replacing verbose loops, unnecessary copies, and excessive abstractions with common Rust patterns. Preserve behavior and project requirements, including error context, fallback handling, exit codes, and existing test modules.

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• Simplifying verbose loops and string construction
• Removing unnecessary string copies
• Reducing nested conditional and error handling code

Audit website redirects after URL migrations, domain changes, or CMS upgrades. Record each redirect path and HTTP status code, identify unnecessary steps or loops, and update redirects to point directly to the final destination.

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• Checking redirect paths after a URL migration
• Finding redirect chains and loops after a domain change
• Simplifying redirect rules accumulated through CMS upgrades

Review JavaScript loops and replace suitable ones with standard array and object methods. Make transformations, filtering, and aggregation easier to understand, with practical explanations and browser checks to confirm that changes preserve the intended behavior.

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• Refactoring manual loops into array methods
• Clarifying data transformation, filtering, and aggregation
• Reviewing object transformations and deep copying