デザインのスキル

Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3 with constraints), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.

日本語の概要は準備中です。原文の説明を表示しています。

Designs covalent inhibitors and warheads targeting cysteine (most common, 98% of covalent drugs), lysine, serine, threonine, tyrosine, and aspartate residues, with explicit handling of warhead reactivity (acrylamide, chloroacetamide, vinyl sulfone, sulfonyl fluoride, fluorosulfate, aldehyde, boronate, nitrile), reversibility (kinact/Ki, t_residence), glutathione (GSH) stability, intrinsic reactivity assays, and covalent docking (DOCKovalent, GOLD, HCovDock). Use when designing covalent inhibitors for targeted covalent inhibition (TCI), KRAS G12C-style approaches, or rationalizing covalent SAR.

日本語の概要は準備中です。原文の説明を表示しています。

Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based generators (DiGress, DiffSMol), and JT-VAE with explicit handling of multi-parameter optimization (MPO), goal-directed scoring functions, transfer/reinforcement/curriculum learning, synthetic accessibility scoring, and chemical space exploration vs exploitation. Use when designing new chemical matter against a target, decorating a scaffold, linking fragments, or optimizing a hit for multiple ADMET / activity properties simultaneously.

日本語の概要は準備中です。原文の説明を表示しています。

Performs retrosynthetic planning using AiZynthFinder (MCTS, template-based), Chemformer (template-free transformer), ASKCOS, and emerging RetroSynFormer with explicit handling of route scoring, building-block availability (eMolecules, Enamine, Mcule), forward prediction validation (Molecular Transformer), and disconnection-aware multi-objective search (MO-MCTS). Use when assessing synthetic feasibility of generated or selected molecules, planning multi-step syntheses, building synthesis-aware design pipelines, or screening libraries for retro-route feasibility.

日本語の概要は準備中です。原文の説明を表示しています。

Predicts whether a DNA variant alters mRNA splicing using sequence-based deep-learning tools — SpliceAI (10kb context dilated CNN, clinical default), Pangolin (multi-tissue), MMSplice (modular per-region CNN with calibrated ΔPSI), SpliceTransformer/TrASPr (tissue-aware transformers), SpliceVault (empirical 300K-RNA lookup of likely mis-splicing outcomes), CADD-Splice (composite score). Applies the ClinGen SVI 2023 framework for ACMG/AMP variant interpretation (PVS1, PP3, BP4 evidence codes), HGVS splicing nomenclature (c.123+1G>A, c.123-3T>G, r.spl?), extended-window scoring for deep-intronic pseudoexons, tissue-specific predictions, branchpoint variant detection (BPHunter, LaBranchoR), and splice-switching ASO design. Use when interpreting splice impact of clinical variants, prioritizing VUS, identifying deep-intronic pathogenic variants, or designing ASOs.

日本語の概要は準備中です。原文の説明を表示しています。

Add MAUI DevFlow to a .NET MAUI project with agent package references, MauiProgram.cs registration, Blazor WebView support, GTK variants, Central Package Management guidance, and verification commands. USE FOR: first-time DevFlow setup, reviewing what files to edit, choosing DevFlow packages, or continuing after `maui devflow init` installs skills. DO NOT USE FOR: troubleshooting an already-integrated app that cannot connect, iterative app debugging, UI inspection, or generic MAUI build failures (use maui-devflow-debug). INVOKES: maui devflow CLI and dotnet CLI.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks how to design or improve a Preventive Maintenance (PM) program for a fleet — mileage vs time intervals, A/B/C/D inspection levels, ATA standards, common PM tasks, scheduling software, cost tracking, and how PM affects roadside inspections + CSA scores. Reference ATA Equipment Maintenance Council standards.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill to design an annual driver refresher training program. Covers what to cover, frequency, documentation, and ROI.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill to design a vehicle preventive maintenance schedule. Covers manufacturer recommendations, industry-standard intervals, and how to set carrier-specific triggers.

日本語の概要は準備中です。原文の説明を表示しています。

Use when a dispatcher, operations manager, or owner asks how to plan loads to minimize empty (deadhead) miles, sequence freight efficiently, balance regional capacity, design dedicated loops, or build a load-pairing strategy across customers. Covers loaded-ratio math, lane balance, region-pair pricing, and software-supported optimization.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks about trucking dispatch software — McLeod, TMW (Trimble), Tailwind, Truckbase, AscendTMS — vs load boards — DAT, Truckstop, 123Loadboard, Convoy, Uber Freight. Covers the workflow (find load, book, dispatch, run, settle), how dispatch software integrates with ELDs + accounting + customer EDI, and what small fleets vs larger fleets typically use.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks how to design or improve a fleet safety scorecard — what KPIs to track, how to weight them, telematics signals vs document compliance vs roadside outcomes, monthly cadence, driver-facing vs admin-facing dashboards, gamification considerations, peer-comparison metrics, and how a scorecard ties to insurance premiums + retention. Reference SMS Methodology v3.20 for industry-standard weights.

日本語の概要は準備中です。原文の説明を表示しています。

Design and create a simulation persona for testing an AI agent. Guides through use case selection, voice and language configuration, behavior prompt crafting, and interruption calibration. Use when user says "create a persona", "design a persona", "set up a test persona", "configure simulation persona", or "build a caller profile".

日本語の概要は準備中です。原文の説明を表示しています。

Propose a new change with all artifacts generated in one step. Use when the user wants to quickly describe what they want to build and get a complete proposal with design, specs, and tasks ready for implementation.

日本語の概要は準備中です。原文の説明を表示しています。

Dense UI posture — maximum information density with clear hierarchy. Use when building or reworking admin dashboards, data tables and grids, ops or monitoring views, settings-heavy panels, debug inspectors, state or log viewers, and multi-pane tool UIs someone drives all day.

日本語の概要は準備中です。原文の説明を表示しています。

Orchestrator that runs one UI brief through all four ui-* posture skills in parallel, then picks and merges a winner. Use when a screen matters enough to explore several directions, or the user says 'build it a few ways', 'design options', 'bake-off', 'show me variations', or 'compare approaches'.

日本語の概要は準備中です。原文の説明を表示しています。

Refine UI posture — improve an existing screen without reinventing it. Use when the current page is roughly right but needs polish (hierarchy, spacing, labels, loading/empty/error states, mobile breakage), or when consistency with the rest of the app matters more than novelty.

日本語の概要は準備中です。原文の説明を表示しています。

Reimagine UI posture — bold from-scratch reinvention of a screen. Use when asked to rethink or reinvent a UI, merge screens, change its core interaction model, break the frame rather than polish, or generate surprising new concepts.

日本語の概要は準備中です。原文の説明を表示しています。

Lean, sharp UI posture — the everyday default for building or redesigning a UI. Use when asked to build or make a page, panel, list, form, or dashboard good, cleaner, or nicer, or for a fast confident refresh where the agent uses its judgment instead of asking for a spec.

日本語の概要は準備中です。原文の説明を表示しています。

THE full UI surface checklist (S1–S18) run on one assigned surface. Use for a named surface check, `/surface-check <surface>`, or a claimed `surface-certification` Work Loop item. NOT for fleet selection or claims (use surface-certification-loop).

日本語の概要は準備中です。原文の説明を表示しています。

Continuous localhost UI iteration loop with Arman, through full surface certification. Use when he asks to fix, refine, review, or iterate on a page, route, panel, overlay, or other UI while he may inspect localhost. NOT for a report-only UI audit.

日本語の概要は準備中です。原文の説明を表示しています。

Recipe for THE DOOR LAW (every record the UI names opens; every detected problem ships its fix) and THE INVENTORY LAW. Use before building or fixing a surface that names a record or flags a problem (cell, row, dialog, badge, warning, id, count), or on 'no link to X', 'why can't I click this', 'dead end', EntityRef, peek. NOT for page chrome (use core-route-headers).

日本語の概要は準備中です。原文の説明を表示しています。

Emoji and Unicode-glyph removal for Lucide-only UI (Pattern Patrol P6). Use when running a P6 patrol, a UI edit meets an emoji or icon glyph in TSX, or asked to enforce Lucide-only icons.

日本語の概要は準備中です。原文の説明を表示しています。

The one skill for taking a page to done: its agent surface and its UI/UX, in one pass. Use when assigned pages or routes to pass, on `/page-pass <route>`, or when a campaign brief says 'do the page pass'. NOT for certification ledger writes (use surface-certification-loop).

日本語の概要は準備中です。原文の説明を表示しています。