583 skills · sorted by relevance
Processamento escalável de dados para workloads de ML. Execução em streaming em CPU/GPU, suporta Parquet/CSV/JSON/imagens. Integra-se com Ray Train, PyTorch, TensorFlow. Escala de uma única máquina para centenas de nós. Use para inferência em lote, pré-processamento de dados, carregamento de dados multi-modal ou pipelines distribuídos de ETL.
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Implementa e valida dados estruturados schema.org em JSON-LD — Organization, Article, FAQPage, Product, BreadcrumbList. Use quando o usuário disser "schema", "dados estruturados", "JSON-LD", "rich snippet", "FAQ schema", "schema.org".
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Compare release changes with project documentation, then update files such as README and CHANGELOG to reflect what shipped. The skill also checks architecture diagrams, maps missing documentation, and records remaining documentation work in the pull request.
Build threat actor profiles from public reports, social media, code repositories, and other intelligence sources. Correlates indicators, maps related infrastructure and attack techniques, and produces structured dossiers with confidence assessments about who may be responsible.
Set up a task list, working memory files, and a dashboard for a productivity system. Use existing todos to clarify nicknames, acronyms, and project codenames, then organize that context into reusable people, terminology, and project notes.
Set up a task list, workplace memory files, and a dashboard. Use existing todos to clarify nicknames, abbreviations, and project names, then save that context for future conversations with the agent.
Retrieve genes, genetic variants, clinical annotations, and dosing guidelines from the PharmGKB API, then turn the results into concise summaries. Save the full response when you need the underlying data.
Use when the user asks to "codify how our founder sounds", "build a founder voice dossier", or "set our content pillars"; runs an 80%-extraction interview over the user's OWN posts, emails, and decks (never competitor scraping, never an invented persona) and produces the versioned voice record — a per-platform register map (incl. 小红书/微信公众号), banned phrases, per-context disclosure lines (the ECHO C2 upstream), a few-shot bank built exclusively from own posts, and 3-5 content pillars with Estimated %-allocations — submitted via memory/events/channels.ndjson for channel-registry to store as voice-dossier.md, the record every Craft-phase skill reads first. Not for the brand-level voice canon — use brand-language-codifier; not for audience/persona research — use audience-mapper. 声音档案/品牌语气/创始人语气/内容支柱/披露声明
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Configures AWS Shield Advanced for enhanced Distributed Denial of Service (DDoS) protection: subscribing accounts and adding resource protections, enabling automatic application layer (layer 7) mitigation through AWS WAF, configuring health-based detection with Route 53 health checks, setting up Shield Response Team (SRT) access and proactive engagement, reviewing DDoS events and requesting cost protection credits, and aggregating resources into protection groups. Applicable when the user wants stronger DDoS protection for internet-facing resources (CloudFront, Application or Network Load Balancers, Elastic IP addresses, Global Accelerator, or Route 53 hosted zones), wants expert help during an attack, or wants to recover attack-driven scaling charges. Routes to the right per-task procedure in references. Not applicable for authoring AWS WAF rules (waf skill), creating Route 53 health checks (route53 skill), or org-wide Shield Advanced rollout with Firewall Manager (firewallmanager skill).
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Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.
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Use when the user asks what is pending, what to do next, or to list todos (optionally filtered by area). Lists pending todos, loads full context for the selected one, and routes to work now, add to a phase, brainstorm, or create a phase.
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This skill should be used when managing the file-based todo tracking system in the todos/ directory. It provides workflows for creating todos, managing status and dependencies, conducting triage, and integrating with slash commands and code review processes.
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Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.
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Dose-response modeling — EC50 estimation, curve fitting, synergy analysis, and benchmark-dose methods.
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Verifica la paridad de internacionalización — que cada clave de traducción exista en todos los idiomas y que no haya cadenas visibles para la persona usuaria codificadas de forma fija — siguiendo las convenciones de i18n del proyecto. Úsalo cuando la persona pida revisar las traducciones, verificar la paridad entre idiomas, encontrar cadenas faltantes/codificadas o auditar la i18n (p. ej. "revisa la i18n", "¿están todos los idiomas sincronizados?").
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Audita una vista o componente frente al design system en lo que un script no puede comprobar — estados de interacción, los cuatro estados de datos, primitivas nativas frente a componentes reinventados y jerarquía visual. Úsalo cuando la persona pida revisar el cumplimiento del design system o si un componente sigue las guías (p. ej. "¿esta tarjeta sigue nuestro sistema?", "audita la vista de ajustes").
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Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.
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This skill determines whether confirmatory testing can be omitted after a positive aldosterone-to-renin ratio (ARR) in patients with suspected primary aldosteronism. It is applied when a patient exhibits spontaneous hypokalemia, undetectable renin, and a plasma aldosterone concentration ≥20 ng/dL (550 pmol/L).
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Calculates salmon calcitonin dose based on patient weight for rapid calcium lowering in hypercalcemia of malignancy. Triggered when a clinician considers rapid calcium lowering and asks about weight‑based calcitonin dosing.
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Recommends fludrocortisone 100 µg daily for children with primary adrenal insufficiency and confirmed aldosterone deficiency; for infants under 12 months, adds sodium chloride supplementation. Triggered by PAI with aldosterone deficiency, evidenced by salt craving, hyponatremia, hyperkalemia, or elevated renin with low aldosterone.
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Suggests using a low-dose (1 µg) corticotropin stimulation test to diagnose primary adrenal insufficiency when the standard 250 µg corticotropin is unavailable due to drug shortage. Consider this approach when clinicians encounter a corticotropin shortage or when the standard dose cannot be obtained.
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Determines if primary aldosteronism is confirmed based on upright plasma aldosterone ≤6 ng/dL (170 nmol/L) on day 4 at 10 AM of fludrocortisone suppression test, provided plasma renin activity ≥1 ng/mL/h and plasma cortisol concentration lower than the 7 AM value to exclude ACTH confounding. Use when reviewing FST results to diagnose PA; triggers include "FST", "upright aldosterone ≤6 ng/dL", "PRA ≥1 ng/mL/h", and "cortisol drop".
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Determines whether to perform adrenal venous sampling (AVS) to lateralize aldosterone excess in patients with confirmed primary aldosteronism (PA) who are being evaluated for surgical treatment. Indicated when surgery is feasible and desired by the patient, or when subtype workup is planned for a surgical candidate, especially in those younger than 35 years with spontaneous hypokalemia, marked aldosterone excess, and unilateral adrenal lesions on CT.
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The Endocrine Society recommends a standard-dose corticotropin (ACTH) stimulation test to confirm primary adrenal insufficiency when clinical suspicion arises from symptoms such as hypotension, hyponatremia, hyperkalemia, or unexplained fatigue. Dosing is weight/age based: 250 µg for adults and children ≥2 years, 15 µg/kg for infants, and 125 µg for children <2 years.
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