227건 · 관련도순
Sort out other people's expectations from actual commitments, reflect on anger, and review living costs against income. This skill helps you examine personal boundaries and the financial room needed to turn down unwanted work.
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Patent research and IP landscape: prior-art search, claim mapping, landscape analysis, and freedom-to-operate. Use when conducting a prior-art search, mapping an IP landscape, evaluating patentability, or running an FTO analysis.
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Applies the existentialist and feminist philosophy of Simone de Beauvoir, French philosopher and author of The Second Sex. Reach for this skill whenever the user is grappling with existential dilemmas, moral ambiguity, gender dynamics, societal expectations, or relationship ethics. Trigger this skill for questions about freedom versus responsibility, bodily autonomy, marginalization, or when the user feels trapped by external labels or "immanence." Use this to help the user reclaim their agency, recognize the social construction of their situation, and make authentic choices that expand their transcendence while respecting the interconnected freedom of others.
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Find out whether a chemical series is already claimed, using SureChEMBL's patent-extracted compound corpus and, where a key is available, PatentsView for legal status and assignee history. Use this skill to trace a structure to the patent documents that disclose it, survey an assignee's filings around a target, and understand what the freedom-to-operate question requires that a structure search cannot answer. Also trigger on SureChEMBL, patent chemistry, Markush structure, freedom to operate, composition of matter, assignee, priority date, patent family, or PatentsView.
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Map the intellectual property landscape for a technology domain or product area. Covers patent cluster analysis, white space identification, competitor IP portfolio assessment, freedom-to-operate preliminary screening, and strategic IP positioning recommendations. Use before starting R&D in a new technology area, when evaluating market entry against incumbents with strong patent portfolios, preparing for investment due diligence, informing a patent filing strategy, or assessing freedom-to-operate risk for a new product.
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Generate website design references as separate horizontal images for each section. Keep a consistent palette while varying layouts, spacing, imagery, and calls to action, giving developers or coding agents concrete visual references for implementation.
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Explore career choices, business opportunities, and competing goals using frameworks drawn from Naval Ravikant’s public work. Examine how software or content can multiply effort, identify distinctive knowledge, and clarify what wealth and freedom mean for a decision.
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Edit videos through conversation, from transcription and take selection to cuts, color adjustments, animated overlays, and subtitles. Confirm an editing plan, review a checked preview, and refine the result before the final render.
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Evaluate everyday tasks using a deliberately high personal hourly rate. Review weekly activities, identify tasks to delegate or drop, and examine whether rising spending is keeping you from having more control over your time.
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Prepare an initial review of patents that might affect a product launch. Compare product features with individual patent claim elements, record uncertainties and search limits, and produce a memo for patent counsel. It does not determine launch clearance.
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Detect and quantify translated ORFs from Ribo-seq data including uORFs and novel ORFs using RiboCode and ORFquant. Use when identifying translated regions beyond annotated coding sequences or quantifying ORF-level translation.
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Peptide-spectrum matching and protein identification from MS/MS data. Use when identifying peptides from tandem mass spectra. Covers database searching, spectral library matching, and FDR estimation using target-decoy approaches.
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Extract, process, and deduplicate reads using Unique Molecular Identifiers (UMIs) with umi_tools. Use when library prep includes UMIs and accurate molecule counting is needed, such as in single-cell RNA-seq, low-input RNA-seq, or targeted sequencing to distinguish PCR from biological duplicates.
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Perform geometric calculations on protein structures using Biopython Bio.PDB. Use when measuring distances, angles, and dihedrals, superimposing structures, calculating RMSD, or computing solvent accessible surface area (SASA).
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Preprocess ribosome profiling data including adapter trimming, size selection, rRNA removal, and alignment. Use when preparing Ribo-seq reads for downstream analysis of translation.
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Read biological sequence files (FASTA, FASTQ, GenBank, EMBL, ABI, SFF) using Biopython Bio.SeqIO. Use when parsing sequence files, iterating multi-sequence files, random access to large files, or high-performance parsing.
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Enumerates chemical libraries through reaction SMARTS transformations using RDKit. Generates virtual compound libraries from building blocks using defined chemical reactions with product validation. Use when creating combinatorial libraries or enumerating products from synthetic routes.
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Handle paired-end FASTQ files (R1/R2) using Biopython. Use when working with Illumina paired reads, synchronizing pairs, interleaving/deinterleaving, or filtering paired data.
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Meta-agent that routes bioinformatics requests to specialised sub-skills. Handles file type detection, analysis planning, report generation, and reproducibility export.
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Parse and write protein structure files using Biopython Bio.PDB. Use when reading PDB, mmCIF, and MMTF files, downloading structures from RCSB PDB, or writing structures to various formats.
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Detect sample contamination and cross-species reads using FastQ Screen. Screen reads against multiple reference genomes to identify bacterial, viral, adapter, or sample swap contamination. Use when suspecting cross-contamination or working with samples prone to microbial contamination.
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Filter reads by quality scores, length, and N content using Trimmomatic and fastp. Apply sliding window trimming, remove low-quality bases from read ends, and discard reads below thresholds. Use when reads have poor quality tails or require minimum quality for downstream analysis.
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Multi-Omics Factor Analysis (MOFA2) for unsupervised integration of multiple data modalities. Identifies shared and view-specific sources of variation. Use when integrating RNA-seq, proteomics, methylation, or other omics to discover latent factors driving biological variation across modalities.
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Preprocessing and harmonization of multi-omics data before integration. Covers normalization, batch correction, feature alignment, and missing value handling across data types. Use when preparing multi-omics datasets for integration analysis.
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