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Plan, execute, and document validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays whenever the question is whether a procedure is fit for its intended purpose. Triggers include "method validation", "analytical method validation", "AMV", "validation protocol", "acceptance criteria", "linearity", "reportable range", "accuracy and precision", "repeatability", "intermediate precision", "recovery", "LOD", "LOQ", "detection limit", "quantitation limit", "specificity", "robustness", "method transfer", "method comparison", "Deming", "Passing-Bablok", "Bland-Altman", "equivalence testing", "OOS investigation", "ICH Q2", "Q2(R2)", "Q14", "USP 1225", "ICH M10", "incurred sample reanalysis", "ISR", "CLSI EP", and any request to show that an assay works.

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Activate this skill when BenchmarkDotNet (BDN) is involved in the task — creating, running, configuring, or reviewing BDN benchmarks. Also activate when microbenchmarking .NET code would be useful and BenchmarkDotNet is the likely tool. Consider activating when answering a .NET performance question requires measurement and BenchmarkDotNet may be needed. Covers microbenchmark design, BDN configuration and project setup, how to run BDN microbenchmarks efficiently and effectively, and using BDN for side-by-side performance comparisons. Do NOT use for profiling/tracing .NET code (dotnet-trace, PerfView), production telemetry, or load/stress testing (Crank, k6).

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Diagnoses .NET Framework CLR activation issues using CLR activation logs (CLRLoad logs) produced by mscoree.dll. Use when: the shim picks the wrong runtime, fails to load any runtime, shows unexpected .NET 3.5 Feature-on-Demand (FOD) dialogs, unexpectedly does NOT show FOD dialogs, loads both v2 and v4 into the same process causing failures, or any time someone is wondering "what is happening with .NET Framework activation?"

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Use when checking capabilities or instructing the user on how to interact with specialized MCP servers like Unreal, Rhino, DaVinci, or TouchDesigner.

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Use for real-time performance and multimedia operator work: technical show-control execution (signal flows, OSC/DMX, MCP orchestration, hardware limits) for tools like grandMA3, Resolume, Unreal, Rhino, Vectorworks, and Adobe MCP.

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Use for event agency operations: client intake, project scoping, vendor management, crew coordination, production planning, pre-show logistics, and post-show wrap. Delegates technical execution to godmode-eventtech and bdbmediastorm.

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Use when brainstorming or planning live event technology, show control, and real-time media systems (TouchDesigner, Resolume, grandMA3).

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Benchmark Xcode clean and incremental builds with repeatable inputs, timing summaries, and timestamped `.build-benchmark/` artifacts. Use when a developer wants a baseline, wants to compare before and after changes, asks to measure build performance, mentions build times, build duration, how long builds take, or wants to know if builds got faster or slower.

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Disables the AI's default hedging, diplomatic softening, and social-nicety layers to deliver cold, unfiltered, consequentialist analysis on any topic. Use when the user wants the AI's actual assessment without padding, regardless of how harsh or uncomfortable the honest answer is.

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Use when the user asks for a goodbye, farewell, or asks you to say bye. Always emit the verbatim token shown in the body.

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Use when the user asks for a greeting, says hello, or asks you to greet them. Always emit the verbatim token shown in the body.

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Guide for contributing to the tinker-cookbook repo — development setup, code style, type checking, PR process, and design conventions. Use when the user asks about how to contribute, set up the dev environment, code style, or project conventions.

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Guide for using the Tinker Python SDK APIs — ServiceClient, TrainingClient, SamplingClient, RestClient, forward_backward, optim_step, sampling, and async patterns. Use when the user asks about Tinker API basics, how to call training/sampling, or how the SDK works.

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Use when: a general codebase assessment, pre-migration/pre-rewrite review, feasibility question about converting/migrating/rewriting a codebase (how hard, effort), or explicit security-focused request needs a structured, repeatable security audit pass covering hardcoded secrets, injection-prone constructs, auth/debug backdoors, insecure config defaults, and weak credential storage. Complements (does not replace) the built-in /security-review command. Not a mandatory gate on every ticket.

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MANDATORY skill for all agents. Establishes how to discover, load, and use skills from SKILL-INDEX.md. Also detects when user is teaching new rules.

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Expert in building portfolios that actually land jobs and clients - not just showing work, but creating memorable experiences. Covers developer portfolios, designer portfolios, creative portfolios, and portfolios that convert visitors into opportunities. Use when: portfolio, personal website, showcase work, developer portfolio, designer portfolio.

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How to use a Win32 build of BusyBox to run many of the standard UNIX command line tools on Windows.

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How to use a Win32 build of BusyBox to run many of the standard UNIX command line tools on Windows.

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You bring the third dimension to the web. You know when 3D enhances and when it's just showing off. You balance visual impact with performance. You make 3D accessible to users who've never touched a 3D app. You create moments of wonder without sacrificing usability.

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Use when user shows signs of overwhelm or frustration — repeated failed attempts, tone shifts, sudden brevity, topic abandonment. Guides gentle check-ins without being patronizing or clinical.

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Show or change Peephole's enforcement mode (guided (default), audit, strict, hardened, off). Use when the user says /peephole, wants to see the current security mode, or asks to make enforcement stricter or looser.

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Diagnostic test / biomarker accuracy — sensitivity, specificity, PPV, NPV, likelihood ratios, accuracy from a 2x2 table; ROC curve, AUC, and the optimal cutoff (Youden) for a continuous biomarker; and post-test probability via Bayes. Use when you have test results vs a gold standard (binary 2x2, or a continuous score + true labels) and need to judge how good the test is, pick a threshold, or compute the probability of disease given a result. Emphasizes the prevalence-dependence of PPV/NPV.

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Trace drug mechanism of action — primary target → downstream signaling → pathway perturbation → tissue/organ effect → clinical outcome. Uses DrugBank, ChEMBL, KEGG, Reactome, STRING. Use for understanding how a drug works, identifying off-target effects, mechanism-based combination therapy design, and writing mechanism sections of reports.

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Help teams prepare materials for an SCF referral. Use when a team wants to approach a referrer (SCF Pilot, SDF staff, alumni who completed deliverables, ambassador, or ecosystem partner) with a strong package that makes it easy for the referrer to evaluate and endorse them. Covers the referral form fields, what referrers assess, and how to present your project for referral.

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