294 件 ・ 関連度順
概要と使いどころ
Core Python library for astronomy/astrophysics: units with dimensional analysis, celestial coordinate transforms (ICRS/Galactic/AltAz/FK5), FITS I/O, tables (FITS/HDF5/VOTable/CSV), cosmology (Planck18, distance/age), precise time (UTC/TAI/TT/TDB, Julian, barycentric), WCS pixel-world mapping, model fitting. For general tables use pandas/polars; for radio interferometry use CASA.
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Core Python library for astronomy and astrophysics workflows that need Astropy APIs, including units/quantities, coordinates, FITS I/O, tables, time systems, WCS, and cosmology. Use when implementing or debugging astronomical data analysis code with Astropy.
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Migrate a .NET 9 project or solution to .NET 10 and resolve all breaking changes. USE FOR: upgrading TargetFramework from net9.0 to net10.0, fixing build errors after updating the .NET 10 SDK, resolving source and behavioral changes in .NET 10 / C# 14 / ASP.NET Core 10 / EF Core 10, updating Dockerfiles for Debian-to-Ubuntu base images, resolving obsoletion warnings (SYSLIB0058-SYSLIB0062), adapting to SDK/NuGet changes (NU1510, PrunePackageReference), migrating System.Linq.Async to built-in AsyncEnumerable, fixing OpenApi v2 API changes, cryptography renames, and C# 14 compiler changes (field keyword, extension keyword, span overloads). DO NOT USE FOR: .NET Framework migrations, upgrading from .NET 8 or earlier (use migrate-dotnet8-to-dotnet9 first), greenfield .NET 10 projects, or cosmetic modernization. LOADS REFERENCES: csharp-compiler, core-libraries, sdk-msbuild (always); aspnet-core, efcore, cryptography, extensions-hosting, serialization-networking, winforms-wpf, containers-interop (selective).
日本語の概要は準備中です。原文の説明を表示しています。
Migrate a .NET 10 project or solution to .NET 11 and resolve all breaking changes. This is a MIGRATION skill — use it when upgrading from .NET 10 to .NET 11, NOT for writing new programs. USE FOR: upgrading TargetFramework from net10.0 to net11.0, fixing build errors after updating the .NET 11 SDK, resolving source-breaking and behavioral changes in .NET 11 runtime, C# 15 compiler, and EF Core 11, adapting to updated minimum hardware requirements (x86-64-v2, Arm64 LSE), and updating CI/CD pipelines and Dockerfiles for .NET 11. DO NOT USE FOR: .NET Framework migrations, upgrading from .NET 9 or earlier, greenfield .NET 11 projects, or cosmetic modernization unrelated to the upgrade. NOTE: .NET 11 is in preview. Covers breaking changes through Preview 3.
日本語の概要は準備中です。原文の説明を表示しています。
Study how products evolve over time using archived versions. The decisions that survive redesigns are the taste decisions. Use when understanding what's essential vs. cosmetic in a design, or learning from product evolution.
日本語の概要は準備中です。原文の説明を表示しています。
Azure Tables SDK for Python (Storage and Cosmos DB). Use for NoSQL key-value storage, entity CRUD, and batch operations.
日本語の概要は準備中です。原文の説明を表示しています。
Build table storage applications using the Azure Tables SDK for Java. Works with both Azure Table Storage and Cosmos DB Table API.
日本語の概要は準備中です。原文の説明を表示しています。
Analyzes UEFI bootkit persistence mechanisms including firmware implants in SPI flash, EFI System Partition (ESP) modifications, Secure Boot bypass techniques, and UEFI variable manipulation. Covers detection of known bootkit families (BlackLotus, LoJax, MosaicRegressor, MoonBounce, CosmicStrand), ESP partition forensic inspection, chipsec-based firmware integrity verification, and Secure Boot configuration auditing. Activates for requests involving UEFI malware analysis, firmware persistence investigation, boot chain integrity verification, or Secure Boot bypass detection.
日本語の概要は準備中です。原文の説明を表示しています。
Identify recurrent and driver copy number alterations across a tumor cohort with GISTIC2 (G-score, Ziggurat deconstruction, focal vs broad/arm-level analysis, q-values from permutation) and quantify copy-number signatures with the Steele 2022 COSMIC framework and the Drews 2022 CINSignatures framework. Covers driver-gene localization from recurrence peaks, distinguishing focal drivers from arm-level passengers, and the caller-sensitivity caveats of copy-number signatures. Use when finding recurrently amplified or deleted regions in a cohort, localizing driver genes, separating focal from broad events, running GISTIC2, or extracting copy-number mutational signatures.
日本語の概要は準備中です。原文の説明を表示しています。
Analyzes base-editing screens for variant function. Covers library design (Sanson 2020 GRACE, Hanna 2021 BRCA1/2 SNV scanning, Cuella-Martin 2021), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end, wider for ABE8e), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.
日本語の概要は準備中です。原文の説明を表示しています。
Annotate copy number variant segments with overlapping genes, dosage-sensitivity scores, cancer driver databases, population frequencies, and clinical-variant content. Covers bedtools/pybedtools interval intersection, AnnotSV comprehensive annotation and ranking, ClinGen haploinsufficiency/triplosensitivity scoring, gnomAD-SV/DGV frequency filtering, COSMIC Cancer Gene Census, and ClinVar overlap. Use when interpreting which genes a CNV affects, distinguishing the driver gene of a focal event from passengers, filtering against population CNVs, separating whole-gene from partial-gene overlap, or preparing CNVs for clinical classification.
日本語の概要は準備中です。原文の説明を表示しています。
Extracts and assigns COSMIC v3.4 mutational signatures (84 SBS / 11 DBS / 18 ID / 24 CN / 16 SV) from somatic VCFs using SigProfilerSuite, MutationalPatterns, MuSiCal mvNMF, SigNet, or HRDetect. Use when characterizing DNA-damage etiology (BRCA1/2 HRD, MMR-D, POLE, APOBEC3A, UV, tobacco, aflatoxin, 5-FU/SBS17b, platinum, colibactin SBS88), routing PARP inhibitor decisions, or auditing de novo extraction vs refit choice for cohort size.
日本語の概要は準備中です。原文の説明を表示しています。
Queries myvariant.info BioThings aggregator for ClinVar, gnomAD, dbSNP, dbNSFP, COSMIC, CADD, and CIViC annotations in batched, version-tracked requests. Use when annotating variant lists from multiple databases simultaneously without managing per-source APIs, and when reproducibility-grade analyses require recording source data versions via _meta.
日本語の概要は準備中です。原文の説明を表示しています。
Build table storage applications using the Azure Tables SDK for Java. Works with both Azure Table Storage and Cosmos DB Table API.
日本語の概要は準備中です。原文の説明を表示しています。
Azure Tables SDK for Python (Storage and Cosmos DB). Use for NoSQL key-value storage, entity CRUD, and batch operations.
日本語の概要は準備中です。原文の説明を表示しています。
Futuristic sci-fi aesthetic with dark themes, vibrant neon accents, and immersive spatial elements.
日本語の概要は準備中です。原文の説明を表示しています。
Systematically QA test a web application and fix bugs found. Runs QA testing, then iteratively fixes bugs in source code, committing each fix atomically and re-verifying. Use when asked to "qa", "QA", "test this site", "find bugs", "test and fix", or "fix what's broken". Proactively suggest when the user says a feature is ready for testing or asks "does this work?". Three tiers: Quick (critical/high only), Standard (+ medium), Exhaustive (+ cosmetic). Produces before/after health scores, fix evidence, and a ship-readiness summary. For report-only mode, use /qa-only. (gstack) Voice triggers (speech-to-text aliases): "quality check", "test the app", "run QA".
日本語の概要は準備中です。原文の説明を表示しています。
Azure Tables SDK for Python (Storage and Cosmos DB). Use for NoSQL key-value storage, entity CRUD, and batch operations.
日本語の概要は準備中です。原文の説明を表示しています。
Build table storage applications using the Azure Tables SDK for Java. Works with both Azure Table Storage and Cosmos DB Table API.
日本語の概要は準備中です。原文の説明を表示しています。
Analyzes base-editing screens for variant function. Covers library design (Sanson 2020 GRACE, Hanna 2021 BRCA1/2 SNV scanning, Cuella-Martin 2021), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end, wider for ABE8e), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.
日本語の概要は準備中です。原文の説明を表示しています。
Identify recurrent and driver copy number alterations across a tumor cohort with GISTIC2 (G-score, Ziggurat deconstruction, focal vs broad/arm-level analysis, q-values from permutation) and quantify copy-number signatures with the Steele 2022 COSMIC framework and the Drews 2022 CINSignatures framework. Covers driver-gene localization from recurrence peaks, distinguishing focal drivers from arm-level passengers, and the caller-sensitivity caveats of copy-number signatures. Use when finding recurrently amplified or deleted regions in a cohort, localizing driver genes, separating focal from broad events, running GISTIC2, or extracting copy-number mutational signatures.
日本語の概要は準備中です。原文の説明を表示しています。
Annotate copy number variant segments with overlapping genes, dosage-sensitivity scores, cancer driver databases, population frequencies, and clinical-variant content. Covers bedtools/pybedtools interval intersection, AnnotSV comprehensive annotation and ranking, ClinGen haploinsufficiency/triplosensitivity scoring, gnomAD-SV/DGV frequency filtering, COSMIC Cancer Gene Census, and ClinVar overlap. Use when interpreting which genes a CNV affects, distinguishing the driver gene of a focal event from passengers, filtering against population CNVs, separating whole-gene from partial-gene overlap, or preparing CNVs for clinical classification.
日本語の概要は準備中です。原文の説明を表示しています。
Queries myvariant.info BioThings aggregator for ClinVar, gnomAD, dbSNP, dbNSFP, COSMIC, CADD, and CIViC annotations in batched, version-tracked requests. Use when annotating variant lists from multiple databases simultaneously without managing per-source APIs, and when reproducibility-grade analyses require recording source data versions via _meta.
日本語の概要は準備中です。原文の説明を表示しています。
Extracts and assigns COSMIC v3.4 mutational signatures (84 SBS / 11 DBS / 18 ID / 24 CN / 16 SV) from somatic VCFs using SigProfilerSuite, MutationalPatterns, MuSiCal mvNMF, SigNet, or HRDetect. Use when characterizing DNA-damage etiology (BRCA1/2 HRD, MMR-D, POLE, APOBEC3A, UV, tobacco, aflatoxin, 5-FU/SBS17b, platinum, colibactin SBS88), routing PARP inhibitor decisions, or auditing de novo extraction vs refit choice for cohort size.
日本語の概要は準備中です。原文の説明を表示しています。