4,590 件 ・ 関連度順
Resolves rsIDs, navigates RsMergeArch/SNPHistory merge chains, and converts between rsID, SPDI, HGVS, and VCF representations using the dbSNP Build 156 JSON architecture. Use when normalizing variant identifiers, joining variant databases by cluster ID, or tracking deprecated rsIDs through historical merges.
日本語の概要は準備中です。原文の説明を表示しています。
Performs gene-level association from GWAS summary statistics via genetically predicted tissue expression using FUSION, PrediXcan, S-PrediXcan, S-MultiXcan, UTMOST, MOSTWAS, kTWAS, EpiXcan, TIGAR-V2, and probabilistic fine-mapping with FOCUS and MA-FOCUS. Use when running TWAS from GWAS sumstats, prioritising candidate causal genes from a GWAS lead locus, picking single-tissue vs cross-tissue models, identifying LD-induced TWAS false positives, choosing ancestry-matched prediction weights, fine-mapping co-regulated TWAS hits, or triangulating TWAS with cis-eQTL Mendelian randomization and colocalization to nominate a causal gene.
日本語の概要は準備中です。原文の説明を表示しています。
Builds and applies 3D pharmacophore models using RDKit Pharm3D, the apo2ph4 receptor-based workflow (Heider et al 2022/2023 J Chem Inf Model 63:147-158), Pharmer / Pharmit (search), and PharmacoForge (diffusion-based generation, Flynn et al 2025 Front Bioinform), covering ligand-based pharmacophore (from active set alignment) and receptor-based pharmacophore (from binding pocket geometry). Explicit handling of feature types, geometric tolerances, partial matching, and pharmacophore-based virtual screening. Use when identifying scaffold-hopping candidates, building shape-and-feature search queries, or transferring SAR across chemotypes.
日本語の概要は準備中です。原文の説明を表示しています。
Performs structure-based virtual screening using AutoDock Vina, SMINA, GNINA (CNN scoring), and DiffDock-L hybrid workflows with explicit choice rules across rigid vs flexible docking, cross-docking vs self-docking, binding-site detection (P2Rank, fpocket), receptor preparation (PDB2PQR, PROPKA), ligand preparation (meeko, OpenBabel), and ultralarge-library screening (ZINC22, Enamine REAL). Use when screening chemical libraries against a protein target to find candidate binders, ranking docking poses, or selecting a docking workflow for a specific scenario.
日本語の概要は準備中です。原文の説明を表示しています。
Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3 with constraints), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.
日本語の概要は準備中です。原文の説明を表示しています。
Generates 3D conformer ensembles using RDKit ETKDGv3 with knowledge-enhanced distance geometry, MMFF94/UFF force-field optimization, CREST + GFN2-xTB semi-empirical refinement, and macrocycle-aware torsion preferences. Provides explicit decision rules for single vs ensemble conformer use, RMSD pruning, energy windows, conformer count, and force-field choice. Use when preparing 3D ligands for docking, generating descriptor input for 3D QSAR, or sampling macrocycle/peptide conformational ensembles.
日本語の概要は準備中です。原文の説明を表示しています。
Validates docked / generated protein-ligand poses using PoseBusters physical-validity tests, strain energy quantification, geometric checks (planarity, vdW overlap, bond/angle distortion), and pose-energy reasonableness. Filters AI-docking outputs (DiffDock, EquiBind, NeuralPLexer) where ~50% of poses fail physical-validity tests. Use when QC-ing docking results, comparing classical vs ML docking outputs, or filtering pose lists before SAR analysis.
日本語の概要は準備中です。原文の説明を表示しています。
Analyzes differential transcript usage (DTU) and isoform switches with functional consequence prediction (NMD via 50nt rule, ORF disruption, protein domain loss/gain, signal peptide changes, IDR alterations, coding-potential shifts). Tools include IsoformSwitchAnalyzeR v2 (auto-selects satuRn for >5 reps else DEXSeq), the manual DRIMSeq -> DEXSeq/satuRn -> stageR DTU pipeline, and fishpond/swish for inferential-uncertainty-aware DTE. Distinguishes DTU from DGE and DTE; integrates external annotators (CPC2, Pfam, SignalP, IUPred2A or DeepTMHMM). Use when investigating how splicing differences alter protein function or trigger NMD-mediated degradation.
日本語の概要は準備中です。原文の説明を表示しています。
Use when a driver has been involved in a crash — regardless of preventability or injury — and the carrier needs to handle the immediate, post-investigation, and return-to-work phases. Covers trauma response, post-accident testing under 49 CFR 382.303, paid time off, retraining, light duty, and re-entry planning.
日本語の概要は準備中です。原文の説明を表示しています。
Use this skill when the user asks where to find specific information at fmcsa.dot.gov — the SAFER (Safety and Fitness Electronic Records System), Carrier Snapshot, Compliance Safety Accountability (CSA) data, PSP (Pre-Employment Screening Program), Clearinghouse, Unified Carrier Registration (UCR), MCS-150 update, complaints, DataQs, and the FMCSA Portal login. Reference fmcsa.dot.gov.
日本語の概要は準備中です。原文の説明を表示しています。
Use this skill when the user asks about DOT audits, FMCSA compliance reviews, new entrant safety audits (NESA), focused investigations, what auditors actually ask for, audit document checklists, common audit failures, the audit ratings (Satisfactory / Conditional / Unsatisfactory), or how to prepare for an upcoming audit. Cite 49 CFR 385.
日本語の概要は準備中です。原文の説明を表示しています。
Use this skill when the user asks about Americans with Disabilities Act (ADA) accommodation for CDL drivers — interaction between ADA + FMCSA medical certification, when DOT-disqualifying conditions trigger ADA analysis, reasonable accommodation case examples, employer obligations, and how to handle a driver with a condition that may affect CDL status. Cite Title I ADA + 49 CFR 391.41.
日本語の概要は準備中です。原文の説明を表示しています。
Use this skill when the user asks about accident claims management — first-notice-of-loss procedures, working with insurance adjusters, claim severity classification, subrogation, claim closure timelines, and how to influence claim outcomes. Different from accident-investigation-playbook (which covers facts); this covers the insurance + claim side.
日本語の概要は準備中です。原文の説明を表示しています。
Expert in drone systems, computer vision, and autonomous navigation. Specializes in flight control, SLAM, object detection, sensor fusion, and path planning. Activate on "drone", "UAV", "SLAM", "visual odometry", "PID control", "MAVLink", "Pixhawk", "path planning", "A*", "RRT", "EKF", "sensor fusion", "optical flow", "ByteTrack". NOT for domain-specific inspection tasks like fire detection, roof damage assessment, or thermal analysis (use drone-inspection-specialist), GPU shader optimization (use metal-shader-expert), or general image classification without drone context (use clip-aware-embeddings).
日本語の概要は準備中です。原文の説明を表示しています。
Investigates DAG incidents with a precise top event, timeline, competing hypotheses, barriers, propagation, and bounded recovery. NOT for automated root-cause classification, trace collection, or performance profiling.
日本語の概要は準備中です。原文の説明を表示しています。
Conduct Critical Decision Method (CDM) interviews to elicit expert reasoning strategies (L3 knowledge) from practitioners about specific challenging past incidents. Use when capturing expertise for skill development, preserving knowledge before practitioner departure, building post-incident learning artifacts, or investigating decisions in complex sociotechnical systems. Outputs structured incident reconstructions with cues, decisions, alternatives considered, and counterfactual analysis suitable for distillation into skills or training material.
日本語の概要は準備中です。原文の説明を表示しています。
Design an agent's handling of obligations, prohibitions, permissions, and conflicts among norms and goals. Use when an autonomous agent must decide which norms apply and what to do when they conflict. NOT for simple fixed policy checks, ordinary BDI commitment design, or organizational metaphor.
日本語の概要は準備中です。原文の説明を表示しています。
Designs and audits deterministic, authority-filtered partitions of trust-typed context for already admitted bodies or abstract continuation slots. Use when causal context, obligations, disclosure boundaries, vector-space identity, capacity, and omission proofs must survive partitioning. NOT for spawning or admitting agents, choosing worker count, retrieving arbitrary knowledge, writing successor prompts, or granting tools, leases, identity, or effect authority.
日本語の概要は準備中です。原文の説明を表示しています。
Android background task specialist for WorkManager, Foreground Services, Doze mode, and battery optimization. Activate on: WorkManager, background task Android, Foreground Service, Doze mode, battery optimization, periodic work, background sync Android, JobScheduler. NOT for: iOS background tasks (use swiftui-data-flow-expert), React Native background (use mobile-offline-sync-architect), UI architecture (use jetpack-compose-navigation-expert).
日本語の概要は準備中です。原文の説明を表示しています。
Audit a compliance-ladder design (C0-C6) and transcript-fidelity ladder (T0-T5) plus their adapter conformance fixtures — Codex, Claude Code, Cloudflare, Ollama/LM Studio, custom stdio/HTTP agents — for the two failure modes that make a C-badge or T-fidelity label a lie: the ladder disagreeing with itself across doc/schema/ui/probe surfaces, and a level being reachable by self-report because no daemon-witnessed negative probe actually tries to forge it. Use when designing or freezing a compliance ladder, wiring an adapter conformance probe suite, deciding whether a numeric C-badge or T-label is safe to ship, or investigating a self-attestation or observed-to-controlled bypass risk. NOT for auditing a cryptographic protocol or whitepaper for adversarial soundness (`redteam-review`), writing TLA+/formal invariants for a daemon monitor (`runtime-verification-for-agents`), or agent identity, successor linkage, and reputation across restarts (`agent-identity-continuity-reputation`).
日本語の概要は準備中です。原文の説明を表示しています。
Enter explore mode - a thinking partner for exploring ideas, investigating problems, and clarifying requirements. Use when the user wants to think through something before or during a change.
日本語の概要は準備中です。原文の説明を表示しています。
Filesystem auto-discovery of App Router pages into navigable index pages. Use when creating an index/listing page, adding route directories, converting hard-coded route configs to auto-discovery, or adding a route-listing display variant.
日本語の概要は準備中です。原文の説明を表示しています。
Find and patch the g_pNavMesh null-check inside CCSBotManager_AddBot in CS2 binary using IDA Pro MCP. This patch removes the navigation mesh requirement so bots can be added even without a nav mesh loaded. Use this skill when reverse engineering CS2 server.dll or libserver.so to locate and patch the nav mesh check in AddBot. Trigger: bot nav ignore, AddBot nav mesh patch, bot without nav, CCSBotManager nav ignore
日本語の概要は準備中です。原文の説明を表示しています。
Repository-grounded threat modeling that enumerates trust boundaries, assets, attacker capabilities, abuse paths, and mitigations, and writes a concise Markdown threat model. Use when the user explicitly asks to threat model a codebase or path, enumerate abuse paths, or perform AppSec threat modeling.
日本語の概要は準備中です。原文の説明を表示しています。