1.3万 件 ・ 関連度順
概要と使いどころ
End-to-end ATAC-seq workflow from FASTQ files to differential accessibility and TF footprinting. Covers alignment, peak calling with MACS3, QC metrics, and optional TOBIAS footprinting. Use when running end-to-end ATAC-seq analysis from FASTQ to differential accessibility.
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ATAC-seq library quality control -- TSS enrichment, FRiP, fragment-size periodicity, library complexity (NRF/PBC1/PBC2), mitochondrial fraction, and ENCODE 4 thresholds. Use when assessing whether an ATAC-seq library passes ENCODE acceptance criteria, diagnosing transposition artefacts, comparing Omni-ATAC vs standard prep quality, or selecting which replicates to drop before peak calling.
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Remove sequencing adapters from FASTQ files using Cutadapt and Trimmomatic. Supports single-end and paired-end reads, Illumina TruSeq, Nextera, and custom adapter sequences. Use when FastQC shows adapter contamination or before alignment of short reads.
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All-atom protein design using BoltzGen diffusion model. Use this skill when: (1) Need side-chain aware design from the start, (2) Designing around small molecules or ligands, (3) Want all-atom diffusion (not just backbone), (4) Require precise binding geometries, (5) Using YAML-based configuration. For backbone-only generation, use rfdiffusion. For sequence-only design, use proteinmpnn. For structure validation, use boltz.
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Ligand-aware protein sequence design using LigandMPNN. Use this skill when: (1) Designing sequences around small molecules, (2) Enzyme active site design, (3) Ligand binding pocket optimization, (4) Metal coordination site design, (5) Cofactor binding proteins. For standard protein design, use proteinmpnn. For solubility optimization, use solublempnn.
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Internal — for Boundless team members only. Query the Boundless Indexer REST API for on-chain market data, staking, PoVW rewards, delegations, and market efficiency on prod/staging environments. Use when the user asks about proof requests, provers, requestors, staking data, PoVW rewards, delegations, market aggregates, leaderboards, or wants to fetch data from the indexer API on live networks. Also use when the user mentions "indexer" and wants to look up addresses, requests, or market statistics on deployed environments. Do NOT use for debugging local code changes, reviewing PRs, or investigating issues in the codebase itself.
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CesiumJS core utilities and networking - Resource, Color, Event, Request, RequestScheduler, error handling, helper functions, feature detection. Use when fetching remote data, managing HTTP requests, working with colors, handling events, debugging errors, or using utility functions like defined, clone, or buildModuleUrl.
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Use this skill for the architecture phases of an MBSE workflow in MATLAB, when writing idempotent buildXxx.m scripts that produce a three-layer RFLPV architecture (Functional, Logical, Physical) with interface dictionaries, stereotype profiles, allocation sets, and requirements Implement links. Trigger for defining stereotype properties, functional-to-logical / logical-to-physical allocation, mapping requirements to components via slreq Implement links, or running quantitative roll-up analysis on the architecture. Do NOT trigger for ad-hoc structural edits to an already-built System Composer model (adding one component, rewiring a port) — use `building-simulink-models` with `model_edit` for that. Works alongside the `system-composer` skill for detailed SC API patterns.
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Document development environment requirements for team consistency and AI agent understanding during PRD v0.6 Architecture. Triggers on requests to define environment setup, document tooling, create dev setup guide, or when user asks "what tools do I need?", "environment setup", "dev environment", "CLI requirements", "project setup", "onboarding setup". Consumes TECH- (stack selections), ARC- (architecture decisions). Outputs ENV- entries for development, CI/CD, and infrastructure environments. Feeds v0.7 Build Execution.
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"/specify", "specify", "요구사항 정의", "requirements", "스펙 잡기", "뭘 만들어야 하는지", "기획 정리", "인터뷰해서 스펙" Turn a goal into structured requirements through systematic interview. Three phases: Interview → Extract → Cross-check. Writes requirements.md in the cli format (consumed by /blueprint).
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"/blueprint", "blueprint", "task graph", "contract derivation", "execution plan", "plan tasks from requirements", "contract-first planning" Turn requirements.md into an executable blueprint (plan.json + contracts.md). Five phases: Contracts → Tasks → Journeys → Verify Plan → Commit. Sits between /specify and /execute. Scope-adaptive (greenfield → bugfix). Uses hoyeon-cli (plan.json only; requirements.md is read as-is via Read tool).
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Validates PRD, user stories, or feature requirements against SMART criteria. Use when reviewing requirements to catch vagueness before it causes expensive rework.
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Build a basic HTTP request (curl or fetch) for an API. Use when a junior developer needs a quick request example.
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影视编剧 (Scriptwriting / Screenwriting) — 为电影 / 电视 / 流媒体剧集写戏剧蓝本的从业者认知操作系统: 决定「讲什么故事、人物是谁为何转变、场景如何被戏剧化、主题为何重要」的学科 —— 区别于导演 (调度 / 视觉实现)、制片 (融资 / 排期)、小说 (无格式 / 场景 / 视觉动作约束)。覆盖 (a) 故事与结构理论 (亚里士多德《诗学》情节 / 人物 / 思想 + 突转 peripeteia / 发现 anagnorisis + 净化 catharsis; Syd Field 范式 / 三幕 / 情节点; Freytag 金字塔; Egri 前提; McKee《故事》掌控性理念 / 鸿沟 / 价值正负转变 / 激励事件 / 渐进式复杂化; Truby《故事剖析》22 步 + 道德论证; Vogler/Campbell 英雄之旅; Blake Snyder《救猫咪》15 拍节拍表; Dan Harmon 故事环; John Yorke 五幕《进入森林》; Frank Daniel 八序列法; 起承转合东亚戏剧结构), (b) 人物 (想要 vs 需要 / 外在目标 vs 内在缺失, 人物弧光 正 / 负 / 平, flaw-wound-ghost 创伤背景, 主动 vs 被动主角的能动性, Egri 三维人物 生理 / 社会 / 心理, 反派是主角的镜子, 群像与关系网, 人物在压力下的选择中显形), (c) 对白 (潜台词 subtext, 对白即动作与冲突而非信息, 避免太直白 on the nose, 人物独特声口, 信息植入 exposition, Mamet/Sorkin 意图-阻碍式对白, 展示而非告知, 中文剧台词工艺), (d) 场景与序列工艺 (场景是有目标 / 冲突 / 转折的微型故事, 场景价值充能与转折点, 晚进早出, 八序列法, set piece, 转场, 场景头 / 动作行 / 括号提示 格式工艺), (e) 主题与前提 (掌控性理念 / 前提, 主题是被戏剧化的论证而非说教, 道德论证 Truby, 主题统一性, 这到底在讲什么), (f) 类型 (类型惯例是对观众的承诺, Snyder 10 类故事, 颠覆 vs 尊重套路, 类型片 vs 文艺片, 中国类型 主旋律 / 古装 / 年代 / 悬疑 / 甜宠 / 都市 / 军旅 / 历史正剧), (g) 格式与工业流程 (好莱坞剧本格式与 Final Draft, logline 一句话故事, treatment 故事大纲, 节拍表, 分场 / 分集大纲, spec 原创剧本 vs 委托, pitch, coverage, 美剧编剧室与 showrunner 制; 中国 大纲→人物小传→分集大纲→剧本, 长剧集 40 集结构, 网络电影 / 网大, 分账剧, 平台定制剧, 微短剧竖屏短剧), (h) 改稿与开发 (写作就是改写, 改稿 / 润色 / 推倒重写, 处理意见 / 改稿意见, 片方与平台 notes, 杀死你的宝贝, 围读, 开发地狱), (i) 改编 (IP改编 小说 / 漫画 / 游戏改编, 忠于精神而非字句, 压缩, 中国网文 IP 热), (j) 中国影视编剧产业现实 (审查 / 广电总局约束, 备案 / 立项, 平台定制剧 爱优腾芒, 分账, 编剧维权 署名权 / 欠薪 / 枪手, 注水剧, 流量 + 大IP 资本逻辑 vs 原创工艺, 导演中心制 vs 编剧话语权), (k) 编剧职业与工艺生涯 (spec vs 委托, 编剧 vs 编审 / 策划, 单兵 vs 编剧室, 在开发链条中的位置, WGA 与署名仲裁规范, 入行, 中国编剧地位与权益)。跨 电影 / 美剧流媒体 / 中国电影与长剧集。不含 导演 / 摄影 / 制片 / 融资 / 表演 / 电影理论批评为终点 / 泛小说写作 / 纪录片 / 新闻 —— 本 skill 是「戏剧化编剧」工艺: 故事 / 人物 / 场景 / 对白 / 主题 / 结构 / 格式 与围绕它们的产业流程。 (Scriptwriting / Screenwriting for film & TV (影视编剧) — the cognitive operating system of practitioners who write the dramatic blueprint of films, television, and streaming series: the discipline of deciding WHAT story is told, WHO the characters are and why they change, HOW the scenes are dramatized, and WHY it matters thematically — distinct from directing (staging/visual realization), producing (financing/scheduling), and prose fiction (which has no format/scene/visual-action constraints). Covers (a) story & structure theory (Aristotle's Poetics — plot/character/thought + reversal peripeteia/recognition anagnorisis + catharsis; Syd Field's paradigm/three-act/plot points; Freytag's pyramid; Lajos Egri's premise; Robert McKee's Story — controlling idea/the gap/value charge/inciting incident/progressive complications; John Truby's 22 steps & moral argument; Christopher Vogler/Joseph Campbell hero's journey; Blake Snyder's Save the Cat 15-beat sheet; Dan Harmon's story circle; John Yorke's 5-act Into the Woods; Frank Daniel's 8-sequence method; 起承转合 East-Asian dramatic structure), (b) character (want vs need/external goal vs internal lack, character arc positive/negative/flat, 人物弧光, flaw-wound-ghost backstory, agency active vs passive protagonist, Egri's 3-dimensional character physiology/sociology/psychology, antagonist as the protagonist's mirror, ensemble & relationship webs, character revealed through choice under pressure), (c) dialogue (subtext 潜台词, dialogue as action & conflict not information, 'on the nose' avoidance, distinct character voice, exposition handling, Mamet/Sorkin intention-obstacle dialogue, show-don't-tell, 台词 craft in Chinese drama), (d) scene & sequence craft (scene as a mini-story with goal/conflict/turn, scene value charge & turning point, enter-late-leave-early, the 8-sequence method, set pieces, transitions, slug line/action line/parenthetical format craft), (e) theme & premise (controlling idea/premise/前提, theme as dramatized argument not message, moral argument Truby, thematic unity, 'what is this really about'), (f) genre (genre conventions as audience promise, Snyder's 10 story types, subverting vs honoring tropes, 类型片 vs 文艺片, Chinese genres 主旋律/古装/年代/悬疑/甜宠/都市/军旅/历史正剧), (g) format & industry process (Holly
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德州扑克策略 (德州扑克策略 (Texas Hold'em) — solver/GTO 时代的无限注德州扑克竞技打法，牌手/职业视角。覆盖: (a) 理论两极 — GTO 博弈论均衡 (不可剥削的基线策略) vs Exploitative 剥削打法 (针对对手漏洞偏离均衡最大化 EV)，以及二者的实战取舍; (b) solver 时代工作流 — PioSOLVER/GTO Wizard 跑解、范围构建、节点锁定 (node-locking) 做剥削、用 HUD+数据库 (Hold'em Manager/PokerTracker/Hand2Note) 复盘找漏洞 (leak finding); (c) 牌型分层 — 现金局 (cash game) vs 锦标赛 (MTT) 的根本差异，后者叠加 ICM (独立筹码模型) 与跳台/泡沫期博弈; (d) 核心概念栈 — 范围 (range)/权益 (equity)/EV/位置 (position)/翻前开池与 3-bet/4-bet/翻后下注理论 (c-bet、极化 vs 浓缩范围、MDF 最小防守频率、阻断牌 blockers、超池下注 overbet)、SPR、底池赔率; (e) 元层 — 资金管理 (bankroll management)、桌位选择 (table selection)、方差与心态 (mental game/tilt 控制)、抽水 (rake) 与场次选择对长期赢率 (winrate, bb/100) 的影响; (f) 智识演进 — 从 Sklansky 古典手牌价值 → Janda/Tipton 博弈论 → solver 普及 → GTO Wizard 民主化求解 → AI 超人 (Libratus/Pluribus) 对人类策略的反哺。学派分歧: GTO 派 vs 剥削派、现金局 vs 锦标赛、理论自上而下 vs 牌局自下而上、solver 纯学院派 vs 实战感觉派。不含: 线下牌场运营/发牌荷官、博彩合规与赌场管理、扑克之外的牌类 (桥牌/斗地主)、纯概率赌博 (老虎机/轮盘)。) Master OS — automated mastery of 德州扑克策略 (Texas Hold'em) — solver/GTO 时代的无限注德州扑克竞技打法，牌手/职业视角。覆盖: (a) 理论两极 — GTO 博弈论均衡 (不可剥削的基线策略) vs Exploitative 剥削打法 (针对对手漏洞偏离均衡最大化 EV)，以及二者的实战取舍; (b) solver 时代工作流 — PioSOLVER/GTO Wizard 跑解、范围构建、节点锁定 (node-locking) 做剥削、用 HUD+数据库 (Hold'em Manager/PokerTracker/Hand2Note) 复盘找漏洞 (leak finding); (c) 牌型分层 — 现金局 (cash game) vs 锦标赛 (MTT) 的根本差异，后者叠加 ICM (独立筹码模型) 与跳台/泡沫期博弈; (d) 核心概念栈 — 范围 (range)/权益 (equity)/EV/位置 (position)/翻前开池与 3-bet/4-bet/翻后下注理论 (c-bet、极化 vs 浓缩范围、MDF 最小防守频率、阻断牌 blockers、超池下注 overbet)、SPR、底池赔率; (e) 元层 — 资金管理 (bankroll management)、桌位选择 (table selection)、方差与心态 (mental game/tilt 控制)、抽水 (rake) 与场次选择对长期赢率 (winrate, bb/100) 的影响; (f) 智识演进 — 从 Sklansky 古典手牌价值 → Janda/Tipton 博弈论 → solver 普及 → GTO Wizard 民主化求解 → AI 超人 (Libratus/Pluribus) 对人类策略的反哺。学派分歧: GTO 派 vs 剥削派、现金局 vs 锦标赛、理论自上而下 vs 牌局自下而上、solver 纯学院派 vs 实战感觉派。不含: 线下牌场运营/发牌荷官、博彩合规与赌场管理、扑克之外的牌类 (桥牌/斗地主)、纯概率赌博 (老虎机/轮盘)。: top builders' mental models, tool stack, current workflows, jargon, and where to keep up. Trigger this skill when the user works on 德州扑克策略 (Texas Hold'em) — solver/GTO 时代的无限注德州扑克竞技打法，牌手/职业视角。覆盖: (a) 理论两极 — GTO 博弈论均衡 (不可剥削的基线策略) vs Exploitative 剥削打法 (针对对手漏洞偏离均衡最大化 EV)，以及二者的实战取舍; (b) solver 时代工作流 — PioSOLVER/GTO Wizard 跑解、范围构建、节点锁定 (node-locking) 做剥削、用 HUD+数据库 (Hold'em Manager/PokerTracker/Hand2Note) 复盘找漏洞 (leak finding); (c) 牌型分层 — 现金局 (cash game) vs 锦标赛 (MTT) 的根本差异，后者叠加 ICM (独立筹码模型) 与跳台/泡沫期博弈; (d) 核心概念栈 — 范围 (range)/权益 (equity)/EV/位置 (position)/翻前开池与 3-bet/4-bet/翻后下注理论 (c-bet、极化 vs 浓缩范围、MDF 最小防守频率、阻断牌 blockers、超池下注 overbet)、SPR、底池赔率; (e) 元层 — 资金管理 (bankroll management)、桌位选择 (table selection)、方差与心态 (mental game/tilt 控制)、抽水 (rake) 与场次选择对长期赢率 (winrate, bb/100) 的影响; (f) 智识演进 — 从 Sklansky 古典手牌价值 → Janda/Tipton 博弈论 → solver 普及 → GTO Wizard 民主化求解 → AI 超人 (Libratus/Pluribus) 对人类策略的反哺。学派分歧: GTO 派 vs 剥削派、现金局 vs 锦标赛、理论自上而下 vs 牌局自下而上、solver 纯学院派 vs 实战感觉派。不含: 线下牌场运营/发牌荷官、博彩合规与赌场管理、扑克之外的牌类 (桥牌/斗地主)、纯概率赌博 (老虎机/轮盘)。 problems and wants industry-grade thinking, tool selection, or workflow guidance. 触发词：「德州扑克」「德扑」「Texas Hold'em」「poker strategy」「扑克策略」
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For external plan request scenarios, guides the Agent to request a clear, actionable, step-by-step plan from a stronger Agent via list_agents and chat_with_agent, emphasizing that the plan is executed by the requester, not by the consulted Agent.
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Turns open-ended requests into things to think WITH instead of answers to accept. Audits the hidden assumptions inside a topic, inverts them into sharp "what if" provocations, branches each one outward, and delivers a mind map plus written wonderings. Portable version, no vendor-specific tools required, works on any conversational assistant. Fire this when the person signals they want to open up a space and think alongside the assistant: "wonder about X", "what are the weird angles on X", "help me think about what this could be", "I want to explore, not decide yet". Do NOT fire when the same topic is attached to a request for concrete, usable, or decided output: a named deliverable, a count ("give me 5 names"), a deadline, or a "which / what should I pick" question. When it is genuinely unclear which they want, this skill opens by asking one line rather than branching. Not for factual lookups or executing a plan already chosen.
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Generate targeted clarifying questions (2-3 max) that challenge vague requirements and extract missing context. Use after request-analyzer identifies clarification needs, before routing to specialist agents. Helps cto-orchestrator avoid delegating unclear requirements.
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Covers the Neo4j Go Driver v6 — driver lifecycle, ExecuteQuery, managed and explicit transactions, session config, error handling, data type mapping, and connection tuning. Use when writing Go code that connects to Neo4j, setting up NewDriver or ExecuteQuery, debugging sessions/transactions/result handling, or working with neo4j-go-driver v5→v6 migration. Triggers on NewDriver, ExecuteQuery, SessionConfig, ManagedTransaction, neo4j-go-driver. Does NOT handle Cypher query authoring — use neo4j-cypher-skill. Does NOT cover driver version migration steps — use neo4j-migration-skill.
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Comprehensive outbound email strategy skill for cold outreach, email sequences, and multi-channel campaigns. Use when writing cold emails, creating outreach sequences, optimizing response rates, designing follow-up cadences, or building outbound campaigns. Covers prospecting, personalization frameworks, sequence design, subject lines, response handling, compliance, email design, HTML email templates, email layout, email marketing, newsletter design, drip campaigns, email subject lines, email headers, and cold email templates for discovery calls and SDR workflows.
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Prepares a focused code review request for a branch, commit, pull request, or substantial working-tree diff by defining the review boundary, contract, risk areas, evidence, and questions for an independent reviewer. Use before merge or when another agent needs to review an implementation. Not for processing feedback already received or for claiming runtime correctness.
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Use this skill when the user wants intellectual understanding — learning how or why something works, not getting a task done or soliciting Claude's judgment. Trigger for: - Explicit learning requests: teach, explain, ELI5, walk me through, quiz me, flashcards, "I'm rusty on"; definitions ("what is X") - Terse concept names implying "help me understand this": "Galois theory," "transformers, from scratch" - Confusion signals: "won't stick," "keep mixing these up," "not getting it" - Learning-path questions: prerequisites, sequencing, what to study before X - Conceptual questions about mechanisms, causes, or dynamics Don't trigger for: - Tasks: coding, writing, calculation, translation, factual lookup, news updates - Personal troubleshooting; resource/textbook recommendations - Claude's evaluative verdict: opinion prompts ("do you think X", "settle this", "honest take", "is X dead / still taken seriously") and interpretive takes ("was X really as harsh as people say")
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Drive Blender from natural language: create or edit 3D models, materials, lighting, cameras, renders, animation, and exports through Blender MCP. Route complete scenes to domain skills and wireframe/reference requests to reconstruction skills. Also use for 3D requests that do not name Blender. Requires a configured official or ahujasid MCP backend.
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Query patent family information from Nexscope (Nexscope) by patent ID or publication number. Triggered when users mention patent family, patent family search, simple family, INPADOC family, Nexscope family, family patent lookup, patent equivalents, family members, cross-border related patent lookup, patent family, family patents, patent equivalents, cross-border patents, Nexscope, or INPADOC family. Even if the user does not explicitly say "patent family," this skill should be triggered whenever their need involves querying family members, equivalent patents, or related cross-border applications for one or more patents.
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