677 件 ・ 関連度順
概要と使いどころ
MAGI System v2 — AoT 分解 + MELCHIOR/BALTHASAR/CASPAR 合議 + gabriel adversarial probe による 構造化意思決定フレームワーク。判断ポイント 2+ / 影響レイヤー 3+ / 選択肢 3+ で使用。 Use when facing complex decisions with multiple trade-offs or architectural choices.
Detects A/B chromatin compartments from balanced Hi-C contact matrices via eigenvector decomposition of the distance-normalized, Pearson-correlated cis matrix with cooltools (eigs_cis), then orients (phases) the compartment eigenvector against a GC or gene-density track so the active (A) sign is not arbitrary. Covers the eigenvector-is-a-choice problem (per-arm view_df to remove the centromere gradient; picking the eigenvector by max correlation with activity, not by eigenvalue), GC phasing with bioframe.frac_gc, resolution choice (100kb-1Mb), saddle plots and saddle_strength for compartmentalization strength, the cohesin-loss-strengthens-compartments result, subcompartments (SNIPER/Calder/dcHiC), and cross-condition compartment switching. Use when calling A/B compartments, computing E1/eigenvectors, phasing the eigenvector, building saddle plots, choosing a compartment resolution, quantifying compartment strength, or comparing compartmentalization across conditions.
日本語の概要は準備中です。原文の説明を表示しています。
Identifies super-enhancers from H3K27ac, MED1, or BRD4 ChIP-seq using ROSE, ROSE2, LILY, HOMER -style super, and ENCODE dELS cross-referencing. Handles peak stitching parameters, ranking choices, hockey-stick inflection, marker choice (H3K27ac vs MED1/BRD4), and cross-condition comparison with spike-in normalization. Constructs core regulatory circuitry (Saint-Andre 2016) from SE-encoded TFs. Use when identifying cell-identity / cancer-associated regulatory domains, comparing super-enhancers between conditions, identifying master transcription factor networks, or predicting BET-inhibitor responsiveness.
日本語の概要は準備中です。原文の説明を表示しています。
Assesses RNA-seq data quality specifically for alternative splicing analysis. QC layers include experimental design audit (library prep, read length, depth, replicates), STAR 2-pass cohort-style alignment, junction saturation curves and discovery plateau detection, novel-vs-known junction ratio diagnostics, junction-overhang distribution, splice-site strength scoring (MaxEntScan intrinsic + SpliceAI context-aware), strandedness verification, GENCODE basic vs comprehensive choice, and rRNA contamination screening. Splicing analysis is more demanding than DGE on read length, depth, library prep, alignment strategy, and annotation choice — failures silently bias PSI estimates and inflate novel-junction false positives. Use when evaluating data suitability for splicing analysis, troubleshooting low event detection, or designing sequencing experiments where AS is a primary endpoint.
日本語の概要は準備中です。原文の説明を表示しています。
Capture the "why" behind technical choices to prevent architectural drift. Load when the user makes a major technical decision, chooses a library/framework, defines a system boundary, or changes a core architectural pattern. Also triggers on "record a decision", "write an ADR", "why did we do this", "document this architectural choice", or "architectural decision record". Supports `SYNTHESIS=true` mode for retrospective ADR backfill from observed repo state — used by `retroactive-project-setup` and any future backfill skill. Essential for long-term project maintainability and agent alignment.
日本語の概要は準備中です。原文の説明を表示しています。
Detects A/B chromatin compartments from balanced Hi-C contact matrices via eigenvector decomposition of the distance-normalized, Pearson-correlated cis matrix with cooltools (eigs_cis), then orients (phases) the compartment eigenvector against a GC or gene-density track so the active (A) sign is not arbitrary. Covers the eigenvector-is-a-choice problem (per-arm view_df to remove the centromere gradient; picking the eigenvector by max correlation with activity, not by eigenvalue), GC phasing with bioframe.frac_gc, resolution choice (100kb-1Mb), saddle plots and saddle_strength for compartmentalization strength, the cohesin-loss-strengthens-compartments result, subcompartments (SNIPER/Calder/dcHiC), and cross-condition compartment switching. Use when calling A/B compartments, computing E1/eigenvectors, phasing the eigenvector, building saddle plots, choosing a compartment resolution, quantifying compartment strength, or comparing compartmentalization across conditions.
日本語の概要は準備中です。原文の説明を表示しています。
Identifies super-enhancers from H3K27ac, MED1, or BRD4 ChIP-seq using ROSE, ROSE2, LILY, HOMER -style super, and ENCODE dELS cross-referencing. Handles peak stitching parameters, ranking choices, hockey-stick inflection, marker choice (H3K27ac vs MED1/BRD4), and cross-condition comparison with spike-in normalization. Constructs core regulatory circuitry (Saint-Andre 2016) from SE-encoded TFs. Use when identifying cell-identity / cancer-associated regulatory domains, comparing super-enhancers between conditions, identifying master transcription factor networks, or predicting BET-inhibitor responsiveness.
日本語の概要は準備中です。原文の説明を表示しています。
Assesses RNA-seq data quality specifically for alternative splicing analysis. QC layers include experimental design audit (library prep, read length, depth, replicates), STAR 2-pass cohort-style alignment, junction saturation curves and discovery plateau detection, novel-vs-known junction ratio diagnostics, junction-overhang distribution, splice-site strength scoring (MaxEntScan intrinsic + SpliceAI context-aware), strandedness verification, GENCODE basic vs comprehensive choice, and rRNA contamination screening. Splicing analysis is more demanding than DGE on read length, depth, library prep, alignment strategy, and annotation choice — failures silently bias PSI estimates and inflate novel-junction false positives. Use when evaluating data suitability for splicing analysis, troubleshooting low event detection, or designing sequencing experiments where AS is a primary endpoint.
日本語の概要は準備中です。原文の説明を表示しています。
Use when a carrier asks how to spec a new tractor — engine choice (X15 vs DD16 vs PACCAR MX), transmission (manual vs automated manual vs automatic), axle ratio, sleeper size, fuel tanks, aerodynamic options, electronic features, warranty, fleet-spec vs premium-spec tradeoffs, and how spec choices affect resale value.
日本語の概要は準備中です。原文の説明を表示しています。
Custom-entry fix for pickers with no way to add a choice (Select, Popover list, DropdownMenu). Use when building or touching any choice control (tier, category, tag, status, owner), `pnpm check:picker-add` names a file, running Pattern Patrol P13, or the user says 'no way to add my own' or 'why can't I type a new one'.
日本語の概要は準備中です。原文の説明を表示しています。
Architecture Decision Records (ADR) — a lightweight method for capturing important architectural decisions with context, trade-offs, and rationale. Based on Michael Nygard's ADR pattern and Google/Meta/ByteDance's design documentation culture. USE WHEN: deciding between technology choices, designing new architecture, changing existing architecture, documenting why a decision was made, onboarding new team members, or preserving design context for future maintainers. Triggered by terms like "tech choice", "architecture decision", "why did we choose", "design rationale", "ADR", or "architectural decision record".
日本語の概要は準備中です。原文の説明を表示しています。
Decision tree analysis for complex decision-making across all domains. Use when user needs to evaluate multiple options with uncertain outcomes, assess risk/reward scenarios, or structure choices systematically. Applicable to business, investment, personal decisions, operations, career choices, product strategy, and any situation requiring structured evaluation. Triggers include decision tree, should I, what if, evaluate options, compare alternatives, risk analysis.
日本語の概要は準備中です。原文の説明を表示しています。
Architects the encryption, codec/transport, and premium-feature layer of a group video-calling product, on top of an already-chosen SFU topology. Covers E2EE patterns (Zoom leader-fan-out, Signal pairwise-fan-out, MLS/TreeKEM as in Discord's DAVE, Telegram's ledger consensus), the SFrame (RFC 9605) + WebRTC Insertable Streams mechanism letting an SFU relay encrypted frames it can't read, codec/transport choice (AV1/VP9 SVC vs. simulcast, Opus, congestion control, Media-over-QUIC, WHIP/WHEP), and which "premium" features (virtual backgrounds, live captions, recording, breakout rooms, spatial audio) survive E2EE vs. structurally can't. Use when adding E2EE to an SFU-based call, choosing a 2026 codec/SVC strategy, or deciding which features to disable under E2EE mode. NOT for call topology/platform choice (see webrtc-adhoc-video-chat, which this composes with). NOT for one-way broadcast (see managed-video-streaming-pipeline). NOT for the DM/group-chat text backend (see realtime-messaging-backend-architecture).
日本語の概要は準備中です。原文の説明を表示しています。
OpenClawからDiscordのメッセージ送信やスレッドへの返信を行い、利用可能な操作の範囲で投稿の編集やボタン付きメッセージを扱うスキル。
実装完了後に全テストを確認し、ローカルでのマージ、Pull Request作成、現状維持を選んで進めます。選択と作業環境に応じてブランチや作業領域を整理します。
計画やアイデアを質問で掘り下げ、決定同士の依存関係を整理します。推奨案を添えた質問を段階的に重ね、曖昧な前提や未決事項を確認して共通理解を築くスキルです。
計画や設計を掘り下げる質問を重ね、内容を具体化しながら設計判断の記録と用語集も作ります。検討と文書化を同じ対話の中で進めたいときに使うスキルです。
回答前に詳しさを4段階で選び、文章量の目安となるトークン数を確認するスキル。短い結論から詳細な解説まで、選んだ水準に合わせて回答を調整します。
複数工程の計画書を読み、各工程に合うECCコマンドを貼り付け用に生成します。工程の識別情報や完了条件を含め、対象範囲を渡せないコマンドは保留として示します。
請求書やフォームなどの規則的なテキストから情報を取り出す処理を、正規表現とLLMで設計し、抽出結果の信頼度が低い項目だけを確認・修正する流れを示します。
発表用のメモやPowerPointから、ブラウザで動くHTMLスライドを作ります。見本でデザインを選び、画面に収まるレイアウトとアニメーションを整えます。
正解が一つに定まらない判断を、長期的な影響、前提への疑問、実行の現実性、失敗リスクの四つの視点で検討し、反対意見も見える形で推奨案をまとめるスキル。
Angularの画面やサービスを作り、状態管理・フォーム・画面遷移の設計を支援します。使用バージョンに合わせて実装方針を選び、テストやビルド確認まで扱います。
技術や設計を選んだ理由を、背景・比較案・影響とともにMarkdownへ記録するスキル。連番と索引で整理し、既存の記録から過去の判断理由も確認します。