「logic design」の検索結果

Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and pilot-data dispersion estimation from DESeq2/edgeR. Covers the biological-versus-technical replication distinction (technical replicates do not add degrees of freedom for biological inference), replicate-number-versus-sequencing-depth budgeting, scRNA-seq sample-versus-cell allocation under a pseudobulk model, and the critique that "n=3" is a publication convention rather than a power calculation. Use when budgeting a sequencing experiment, writing the sample-size justification in a grant, estimating replicates from pilot data, allocating a fixed budget between samples and depth, or planning scRNA-seq cohort size. For clinical-trial sample size see clinical-biostatistics/power-and-sample-size; for the power-given-n direction see experimental-design/power-analysis.

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Designs QC, corrects signal drift, removes batch effects, filters features, normalizes samples, and imputes missing values for untargeted LC-MS/GC-MS metabolomics, framing each step as a measurement model that can create or erase biological signal. Use when processing a peak/feature table before statistical analysis, choosing a drift-correction or sample-normalization method, deciding QC RSD vs D-ratio filtering, or handling left-censored missing values. The feature table is produced by metabolomics/xcms-preprocessing or metabolomics/msdial-preprocessing; transformation/scaling for modeling defers to metabolomics/statistical-analysis; cross-study design issues link to experimental-design/batch-design.

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Structures biological experiments so inference is valid by construction, covering Fisher's principles (randomization, replication, local control), the experimental-vs-observational unit distinction and pseudoreplication (Hurlbert 1984; Lazic 2018), randomization mechanics (complete, restricted, stratified, rerandomization, run-order), blocking layouts (randomized complete block, Latin square, incomplete block), factorial designs and interactions, and the split-plot/nested error strata hidden inside multi-batch genomics. Use when deciding the experimental unit and what counts as a replicate, planning randomization and run order, choosing a blocked/factorial/split-plot/nested layout, avoiding pseudoreplication in cell-culture or animal studies, or specifying the random-effects structure of the analysis model. For assigning samples to sequencing batches/lanes/plates and batch-effect correction see experimental-design/batch-design; for regulated clinical-trial randomization see clinical-biostatistics.

日本語の概要は準備中です。原文の説明を表示しています。

Aligns sample metadata with count matrices and constructs design matrices for downstream DE, handling the alphabetical-reference-level trap (relevel BEFORE DESeq), LRT reduced-model rules, the interaction-term resultsNames trap, continuous-covariate scaling and splines, repeated measures via duplicateCorrelation or dream, high-cardinality categorical pseudo-singular designs, sample swap detection via XIST/RPS4Y1 expression and somalier/NGSCheckMate genotypes, SABV (sex-as-biological-variable) mandate, Simpson's-paradox collapsing of technical replicates, and the `~ 0 + group` parameterization for clean contrasts. Use when building a design matrix, troubleshooting reversed fold-change direction, encoding paired or repeated-measures designs, detecting sample swaps, deciding sex-as-covariate, or aggregating technical replicates.

日本語の概要は準備中です。原文の説明を表示しています。

Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and pilot-data dispersion estimation from DESeq2/edgeR. Covers the biological-versus-technical replication distinction (technical replicates do not add degrees of freedom for biological inference), replicate-number-versus-sequencing-depth budgeting, scRNA-seq sample-versus-cell allocation under a pseudobulk model, and the critique that "n=3" is a publication convention rather than a power calculation. Use when budgeting a sequencing experiment, writing the sample-size justification in a grant, estimating replicates from pilot data, allocating a fixed budget between samples and depth, or planning scRNA-seq cohort size. For clinical-trial sample size see clinical-biostatistics/power-and-sample-size; for the power-given-n direction see experimental-design/power-analysis.

日本語の概要は準備中です。原文の説明を表示しています。

Structures biological experiments so inference is valid by construction, covering Fisher's principles (randomization, replication, local control), the experimental-vs-observational unit distinction and pseudoreplication (Hurlbert 1984; Lazic 2018), randomization mechanics (complete, restricted, stratified, rerandomization, run-order), blocking layouts (randomized complete block, Latin square, incomplete block), factorial designs and interactions, and the split-plot/nested error strata hidden inside multi-batch genomics. Use when deciding the experimental unit and what counts as a replicate, planning randomization and run order, choosing a blocked/factorial/split-plot/nested layout, avoiding pseudoreplication in cell-culture or animal studies, or specifying the random-effects structure of the analysis model. For assigning samples to sequencing batches/lanes/plates and batch-effect correction see experimental-design/batch-design; for regulated clinical-trial randomization see clinical-biostatistics.

日本語の概要は準備中です。原文の説明を表示しています。

Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and pilot-data dispersion estimation from DESeq2/edgeR. Covers the biological-versus-technical replication distinction (technical replicates do not add degrees of freedom for biological inference), replicate-number-versus-sequencing-depth budgeting, scRNA-seq sample-versus-cell allocation under a pseudobulk model, and the critique that "n=3" is a publication convention rather than a power calculation. Use when budgeting a sequencing experiment, writing the sample-size justification in a grant, estimating replicates from pilot data, allocating a fixed budget between samples and depth, or planning scRNA-seq cohort size. For clinical-trial sample size see clinical-biostatistics/power-and-sample-size; for the power-given-n direction see experimental-design/power-analysis.

日本語の概要は準備中です。原文の説明を表示しています。

Aligns sample metadata with count matrices and constructs design matrices for downstream DE, handling the alphabetical-reference-level trap (relevel BEFORE DESeq), LRT reduced-model rules, the interaction-term resultsNames trap, continuous-covariate scaling and splines, repeated measures via duplicateCorrelation or dream, high-cardinality categorical pseudo-singular designs, sample swap detection via XIST/RPS4Y1 expression and somalier/NGSCheckMate genotypes, SABV (sex-as-biological-variable) mandate, Simpson's-paradox collapsing of technical replicates, and the `~ 0 + group` parameterization for clean contrasts. Use when building a design matrix, troubleshooting reversed fold-change direction, encoding paired or repeated-measures designs, detecting sample swaps, deciding sex-as-covariate, or aggregating technical replicates.

日本語の概要は準備中です。原文の説明を表示しています。

Djangoアプリの構成、API設計、データ取得、キャッシュの実装とレビューを支援します。環境別の設定分離や処理の整理、不要な問い合わせを減らす設計例を示します。

• Djangoの構成と設定の整理
• Django REST FrameworkのAPI設計
• 不要なデータベース問い合わせの削減

Node.js、Express、Next.jsのAPIとデータ処理を設計・レビューするスキル。DBへの問い合わせ、キャッシュ、認証、エラー処理を整理します。

• API設計と業務処理・データ取得の分離
• 重複するDB問い合わせを減らしたいとき
• キャッシュと非同期処理の導入

Python design patterns including KISS, Separation of Concerns, Single Responsibility, and composition over inheritance. Use this skill when designing a new service or component from scratch and choosing how to layer responsibilities, when refactoring a God class or monolithic function that has grown too large, when deciding whether to add a new abstraction or live with duplication, when evaluating a pull request for structural issues like tight coupling or leaking internal types, when choosing between inheritance and composition for a new class hierarchy, or when a codebase is becoming hard to test because of entangled I/O and business logic.

日本語の概要は準備中です。原文の説明を表示しています。

Advanced API exploitation methodology focused on business logic abuse and sophisticated attack patterns that bypass traditional security controls. Covers business logic bypass through API call chaining and workflow manipulation. Addresses GraphQL-specific attacks including batching for credential brute-force, query depth exploitation, and introspection abuse. Includes pagination exploitation for data exfiltration, webhook hijacking for SSRF and data interception, and resource exhaustion through algorithmic complexity attacks. Covers race conditions in API transactions using parallel request techniques. Provides comprehensive JWT manipulation including algorithm confusion, kid injection, jku/x5u abuse, and claim tampering. Details API key leakage detection across source repositories, client-side code, and error messages. Covers undocumented endpoint discovery through predictable naming, debug routes, and source map analysis. Tooling includes Arjun, ParamSpider, jwt_tool, and GraphQL Voyager. Designed for authorized penetration testers targeting business logic layers that automated scanners miss.

日本語の概要は準備中です。原文の説明を表示しています。

Designs a structured real-world evidence study using EHR, claims, or registry data, with explicit handling of time zero, eligibility windows, exposure definitions, outcome windows, censoring, confounding control, and target-trial-emulation logic. Use this skill when the user needs study-type design and protocol framing for an observational clinical study based on routine-care data. Do not invent database fields, follow-up completeness, linkage, coding validity, or causal identifiability.

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Designs retrospective or prospective clinical cohort study protocols for biomedical and clinical research. Always use this skill when the user needs a cohort-based study plan rather than a general study idea, evidence summary, or mechanistic experiment design. Focus on cohort appropriateness, enrollment logic, baseline time-zero definition, follow-up structure, endpoint definition, variable collection, confounding control, and a coherent primary statistical analysis line. Do not invent data availability, follow-up completeness, outcome ascertainment quality, sample size adequacy, or causal interpretability.

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Generates complete FAERS-style pharmacovigilance disproportionality research designs from a user-provided drug class, comparator strategy, adverse-event domain, and patient-group stratification. Always use this skill whenever a user wants to design, plan, or build a spontaneous-report safety signal study using FAERS or a similar pharmacovigilance database, especially when the article logic includes product selection, indication-group stratification, MedDRA-based adverse-event extraction, serious-case filtering, suspect-drug and concomitant-exclusion logic, reporting odds ratio analysis, comparator-drug benchmarking, cross-drug comparison, and cautious signal interpretation without causal overclaiming. Covers five study patterns (single-drug disproportionality workflow, multi-drug class comparison workflow, indication-stratified workflow, comparator-controlled signal screening workflow...

日本語の概要は準備中です。原文の説明を表示しています。

Designs primary, secondary, and exploratory endpoints for biomedical and clinical research protocols. Always use this skill when a user needs to translate study aims into operational endpoint definitions with event rules, assessment timing, composite logic, interpretability, and protocol-stage auditability. Focus on endpoint precision, feasibility, clinical meaning, ambiguity reduction, and implementation readiness rather than generic study design advice.

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Designs discovery, modeling, and validation workflows for prognostic biomarkers in biomedical and clinical research. Always use this skill when the user needs a prognostic biomarker study blueprint rather than a diagnostic test protocol, predictive biomarker design, treatment recommendation, or a completed manuscript. Focus on endpoint family, follow-up horizon, time scale, candidate marker strategy, model-building logic, risk stratification framework, and internal/external validation requirements. Do not invent cohort size, event rate, assay readiness, literature support, or validation access.

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Plans confounder control, variable adjustment logic, and bias mitigation strategies at the protocol stage for clinical, epidemiologic, translational, observational, and biomarker studies. Always use this skill when a user needs to identify major confounders, decide which variables should or should not be adjusted for, compare matching/stratification/weighting approaches, anticipate selection or measurement bias, or pressure-test a study design before execution. Focus on bias sensing, causal structure awareness, variable-role classification, and critical design review rather than generic statistical advice.

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Design a budget-vs-actuals tracker that stays alive past February — the category grain that matches real statements, the variance view that answers 'are we okay', the update ritual small enough to survive, and the honest handling of irregular expenses. Use when asked build me a budget spreadsheet, track team spend against budget, why do we always blow the budget invisibly, or design a household/project budget tracker. Produces the tracker structure, the variance logic, the irregulars ledger, and the monthly fifteen-minute ritual.

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Use when designing the study for an Accounting, Organizations and Society (AOS) manuscript — qualitative field studies (access, case logic, interviews, observation), behavioral experiments, surveys, historical/archival inquiry, or theory-laden archival designs, each with the ethics and site-anonymity groundwork done early. Designs the inquiry; it does not run the coding or estimation (aos-data-analysis).

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Designing build-your-own product configurators (Tesla-style, custom-pricing, plan-builders) with constraint logic, real-time pricing, validation, and save-and-share mechanics. Honest about infinite-options (decision paralysis), canned-bundles-only (no real customization), and guided-configuration (smart defaults plus meaningful constraints plus escape hatches) patterns. Triggers on configurator design, build-your-own, custom configuration, plan builder, product customizer, configuration tool. Also triggers when users abandon mid-configuration, when configurator conversion is poor, or when a configurator is being scoped for the first time.

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Designing meeting schedulers and booking experiences that qualify leads, set up calls well, and convert at higher rates than a generic Calendly link. Availability logic, qualification gating, prep automation, follow-up sequencing. Honest about any-time-friction (no qualification, just a booking link), interrogation-gate (so much qualification it scares users off), and qualified-fast-path (just enough qualification to set up the call well) patterns. Triggers on scheduler design, meeting booking, demo scheduling, sales call scheduling, calendar tool, booking page, qualification flow. Also triggers when sales team complains about cold demos, when booking conversion is poor, or when scheduler is being scoped for the first time.

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Design forms that convert, validate well, resist spam, and integrate cleanly with downstream systems. Use this skill when designing or auditing any form (contact, signup, checkout, multi-step, embedded), planning validation logic, fighting spam, choosing form tooling, or improving form conversion. Triggers on form design, form validation, form conversion, multi-step form, form spam, captcha, honeypot, form abandonment, signup form, contact form. Also triggers when form completion rates are low or spam is overwhelming.

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Design an inquiry sequence anchored in a local ecosystem that embeds science or geography curriculum content. Use when teaching through local living systems like gardens, ponds, or hedgerows.

日本語の概要は準備中です。原文の説明を表示しています。