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CadQuery (Python 製 3D CAD スクリプティングライブラリ) リファレンス。 Workplane API (lineTo / extrude / revolve / sweep / loft / fillet / chamfer / shell)、 Sketch API、Assemblies (Constraint solver)、Free Function API (hollow / prism / draft / offset2D, History)、 Selectors、Shape / Vertex / Edge / Wire / Face / Shell / Solid、 Import / Export (STEP / DXF / STL / glTF / SVG)、Visualization (VTK, cadquery.fig 非ブロッキング, Jupyter)、CQGI。
日本語の概要は準備中です。原文の説明を表示しています。
要件が確定した大きな機能開発（epic）を、並列調査と全体設計判断を経て PR 構成と実装セッション向け計画書に落とし込む。PR を分けるのは AGENTS.md の分割条件に当たる箇所だけ。「実装計画を立てて」「PR 分割して」「計画書を作って」「タスク分割をして」等の依頼時、複数日・複数セッションにわたる実装の着手前に使用。計画確定後に「PR-X を実装して」と担当を指定された実装セッションでも使う。境界: 要件定義は design-feature、1セッションで調査から実装まで進められる規模は Phase 0-5 を直接適用、PR の作成そのものは create-draft-pr。
Lay out how a job search will actually run alongside a current job: the hours available each week and what they go to, how weekday daytime slots for interviews will be found, which routes to use (direct applications, job boards, scout sites, agents, referrals, public employment services) and what each one discloses to whom, how to keep the search from reaching the current employer through public profiles or workplace equipment, a single tracker of every application's stage, next action, and deadline, and a date and conditions for reviewing, reducing, or pausing the search. Use when someone has decided to start looking, or to gather information while employed, and asks how to fit it in, which routes to use, whether the applications they are running fit the time they have, or how to keep track of them; do not use to decide whether to change jobs, to pick or rate employers or job postings, to predict outcomes, or to send applications, publish profiles, or contact agents on the user's behalf.
日本語の概要は準備中です。原文の説明を表示しています。
Help a user talk through whether to change jobs, stay, or change something in their current work, starting from uncertainty, distress, a vague sense of stagnation, an offer in hand, a counter-offer from the current employer, or pressure from family or colleagues. Clarify what matters, separate deadlines that order the next steps from the decision itself, compare conditional options, and agree on a small next step and a time to revisit it. Use when someone asks whether they should quit, wonders whether leaving is just running away, has second thoughts after receiving an offer or being asked to stay, feels stuck because others say it would be a waste, wants to leave soon after joining, or wants advice before deciding to start a job search; do not make the final stay-or-leave decision, evaluate offer terms, plan the resignation, or predict hiring outcomes.
日本語の概要は準備中です。原文の説明を表示しています。
Prepare the internal case for hosting an Otameshi Tenshoku trial: total what it costs the company with candidate pay, staff hours and platform or incidental fees kept apart, compare it with the budget, state what remains if no hire follows, and lay out the risks, stop conditions, decision owners and deadlines. Use when a hiring manager needs approval or budget from a decision maker, a recruiter has to explain the plan to the team that will host, or a small-business owner wants to see the full cost including their own time before posting; do not use to design the work (trial-work-design), to write the listing (trial-listing-draft), to predict whether a hire will follow, to state platform fees, agency fees or market rates from memory, or to submit the request or post the listing on the user's behalf.
日本語の概要は準備中です。原文の説明を表示しています。
Draft or review an employer's Otameshi Tenshoku listing so a candidate can decide whether to apply: check item by item that the work, deliverable, out-of-scope tasks, required experience, support, hours, schedule, location, compensation, contract form and payment timing are stated, find open-ended, unpaid-company-work, guarantee, personal-attribute and unverifiable wording, and confirm that the hours, weekly availability, period, rate and budget hold together. Use when a hiring manager, recruiter or small-business owner wants a listing written from a plan, wants an existing draft or published listing reviewed before or after posting, or wants to know why applications are not coming; do not use to design the work itself (trial-work-design), to reply to applicants (applicant-reply), to state market rates, legal, tax or service conditions from memory, or to post or update the listing on the user's behalf.
日本語の概要は準備中です。原文の説明を表示しています。
Help job seekers use Otameshi Tenshoku to prepare profiles and applications, clarify trial conditions, plan learning visits or paid trial work, and reflect on the experience. Use when a candidate wants to apply for, prepare for, negotiate the scope of, or review an otameshi work experience; do not use to predict whether they will be hired or to judge their aptitude, to state fees, contract terms, or service conditions from memory, or to submit an application, update a profile, or send a message on their behalf. Employer-side requests belong to the employer skills (trial-work-design, trial-listing-draft, applicant-reply and others).
日本語の概要は準備中です。原文の説明を表示しています。
Check whether a user may start side work alongside their current job, by reading the employer's own rules and contract clause by clause: whether side work is prohibited, needs prior permission, or only a notification, and which duties the planned side work could touch (non-compete, confidentiality, exclusive attention to the main job, use of company assets and information, combined working hours). Separate what is confirmed in a document from what is hearsay, and produce the questions to ask the employer plus the facts an application or notification will need. Use when someone with a main job is considering side work, freelance or gyomu-itaku work, a second part-time job, or paid trial work for another company, and needs to know what their own employer's rules require first; do not use to rule on whether a clause is lawful or enforceable, to help conceal side work from an employer or avoid filing obligations, to predict whether permission will be granted, or to submit the application or contact the employer.
日本語の概要は準備中です。原文の説明を表示しています。
Re-analyze an existing GitHub Issue using its current title and body, refresh the implementation plan against the latest code state, and update the Issue in place. Use when the user provides an Issue number (numeric, `#`-prefixed, or Issue URL) and wants to regenerate the code analysis via the explore-agent subagent. For reflecting comment-driven updates, use update-issue. For creating a brand-new Issue from a natural-language task description, use create-issue.
日本語の概要は準備中です。原文の説明を表示しています。
GitHub PRの未解決レビューコメント・会話コメント・CIステータスを確認し、修正プランを作成します。
Create an implementation plan and a GitHub Issue based on the task description provided as an argument. Use this when the user supplies a natural-language task description (not an issue number) and wants a new implementation-ready Issue. If the input is an existing issue number, use create-issue-from-issue-number (re-analyze) or update-issue (reflect comments) instead.
日本語の概要は準備中です。原文の説明を表示しています。
Shakes your mental models with critical rigor, challenges assumptions, exposes blind spots, and provides multi-perspective insights as a strict thinking mentor. Deliberately breaks format conventions to stimulate genuine cognitive discomfort. Use when you want to stress-test an idea, shake your mental model, ask to challenge my assumptions, find blind spots, deepen my thinking, or request critical review with phrases like yusaburi or what do you think of this plan.
日本語の概要は準備中です。原文の説明を表示しています。
Detect articulation gaps in documents using 5W analysis and provide concrete improvement suggestions. Identifies what's missing in explanation, not what's wrong. Default runs detection + improvement; use --check-only for detection only. 旧名 check-articulation。
日本語の概要は準備中です。原文の説明を表示しています。
Identify the first beachhead market segment for a product launch. Evaluates segments against burning pain, willingness to pay, winnable market share, and referral potential. Use when choosing a first market, targeting an initial customer segment, or planning market entry strategy.
日本語の概要は準備中です。原文の説明を表示しています。
Plan and report authorized vulnerability assessments on owned systems. Prioritize evidence, severity, and remediations. Do not deliver exploit payloads.
日本語の概要は準備中です。原文の説明を表示しています。
Plan purple-team / adversary-simulation exercises against systems you are contracted to test. High-level objectives and detection gaps only. No live attack procedures or payloads.
日本語の概要は準備中です。原文の説明を表示しています。
Nominates and assesses CRISPR off-target sites genome-wide. Enumerates candidate sites by mismatch and bulge tolerance with Cas-OFFinder/CRISPRitz, ranks them with the published CFD score (SpCas9-only, relative ranker) or MIT/CRISTA/energy models, runs variant-aware screening against gnomAD/individual genomes (CRISPRme), and frames the empirical genome-wide discovery assays (GUIDE-seq, CIRCLE-seq, CHANGE-seq, DISCOVER-seq, Digenome-seq) and high-fidelity nuclease choice (HiFi Cas9, Sniper-Cas9, eSpCas9, SpCas9-HF1). Use when assessing guide RNA specificity, choosing among candidate guides, screening a therapeutic guide against population variation, or planning empirical off-target validation. Distinguishes predicted vs detected vs validated. On-target activity scoring and deaminase (Cas-independent) base/prime-editor off-targets are separate skills.
日本語の概要は準備中です。原文の説明を表示しています。
Discovers, classifies, and masks repetitive elements and transposable elements with RepeatModeler2 (de novo family library), RepeatMasker (masking against a library), EDTA (plant/structural TEs), or EarlGrey (auto-curating wrapper), and quantifies TE expression from RNA-seq with TEtranscripts/SQuIRE. Covers de-novo-library-as-curation-project, soft-vs-hard masking, the domesticated-gene over-masking massacre, Dfam-vs-RepBase, TE classification (Class I/II, family-vs-copy), Kimura repeat landscapes, LAI, and the RNA-seq multimapping problem. Use when masking repeats before gene prediction, building a TE library for a non-model genome, or analyzing transposable-element content or expression.
日本語の概要は準備中です。原文の説明を表示しています。
Identifies differential m6A methylation between conditions from MeRIP-seq paired IP/input data using exomePeak2 with `bam_ip` + `bam_input` (control arm) and `bam_treated_ip` + `bam_treated_input` (treatment arm) for integrated GC-bias-aware differential calling (Liu 2022 *NAR Genom Bioinform* 4:lqac046), QNB beta-binomial test (Liu 2017 *BMC Bioinformatics* 18:387), MeTDiff HMM-based differential bundled with MeTPeak, RADAR (Zhang 2019 *Genome Biol* 20:294) with its `filterBins -> diffIP -> reportResult` workflow, and the defensible paired-symmetric case of edgeR / DESeq2 on featureCounts-on-peaks matrices when batch / lot covariates need explicit fixed-effect handling (exomePeak2's top-level API does NOT accept arbitrary covariates). Covers paired vs unpaired vs interaction designs, batch confounding (antibody lot, RNA prep, sequencing run) and the per-lot meta-analysis strategy when exomePeak2 is the primary caller, the stoichiometry-vs-expression-vs-IP-efficiency confound that all MeRIP differential methods inherit, normalisation choice (size factor on IP, on input, on per-sample IP/input ratio), the McIntyre 2020 reproducibility caveat, effect-size filtering as a guardrail against under-powered N=2 designs, and orthogonal-validation routes for absolute stoichiometry (GLORI / SAC-seq / m6Anet `mod_ratio`). Use when comparing m6A levels across two or more conditions, choosing between exomePeak2 / QNB / RADAR / MeTDiff for a given design, handling batch confounding when exomePeak2's API is too rigid, normalising against input properly, distinguishing real hyper- / hypo-methylation from expression-level shifts, applying effect-size thresholds, interpreting volcano plots of differential peaks, or planning a follow-up orthogonal stoichiometry validation.
日本語の概要は準備中です。原文の説明を表示しています。
Structures biological experiments so inference is valid by construction, covering Fisher's principles (randomization, replication, local control), the experimental-vs-observational unit distinction and pseudoreplication (Hurlbert 1984; Lazic 2018), randomization mechanics (complete, restricted, stratified, rerandomization, run-order), blocking layouts (randomized complete block, Latin square, incomplete block), factorial designs and interactions, and the split-plot/nested error strata hidden inside multi-batch genomics. Use when deciding the experimental unit and what counts as a replicate, planning randomization and run order, choosing a blocked/factorial/split-plot/nested layout, avoiding pseudoreplication in cell-culture or animal studies, or specifying the random-effects structure of the analysis model. For assigning samples to sequencing batches/lanes/plates and batch-effect correction see experimental-design/batch-design; for regulated clinical-trial randomization see clinical-biostatistics.
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Calculates statistical power for high-dimensional genomics experiments (bulk RNA-seq, scRNA-seq, ATAC-seq, ChIP-seq, methylation, proteomics) under negative-binomial count models using RNASeqPower, PROPER, and simulation via powsimR, distinguishing per-gene from marginal (transcriptome-wide) power, the role of mean expression and dispersion, and the sequencing-depth-versus-replicate tradeoff. Covers simulation as the honest default for overdispersed counts, FDR-aware average power versus single-test power, observed/post-hoc power as an anti-pattern, and the winner's-curse / Type-S / Type-M consequences of underpowering. Use when planning replicate number for a sequencing experiment, deciding whether to add depth or samples, choosing closed-form versus simulation power, estimating power from pilot dispersions, or justifying replication in a grant. For clinical-trial power see clinical-biostatistics/power-and-sample-size; for the inverse sample-size question see experimental-design/sample-size.
日本語の概要は準備中です。原文の説明を表示しています。
Simulate transcription factor perturbation effects on cell state in silico with CellOracle and Dynamo, and predict transcriptional responses to genetic perturbations with GEARS, scGen, and CPA. Covers the direction-not-magnitude principle, local-linear validity, the GRN/velocity error it inherits, baseline discipline (mean and additive baselines), and the validation gap. Use when predicting TF knockout or overexpression effects, ranking driver TFs for fate transitions, or planning perturbation experiments. For GRN construction see multiomics-grn; for experimental Perturb-seq see single-cell/perturb-seq.
日本語の概要は準備中です。原文の説明を表示しています。
Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and pilot-data dispersion estimation from DESeq2/edgeR. Covers the biological-versus-technical replication distinction (technical replicates do not add degrees of freedom for biological inference), replicate-number-versus-sequencing-depth budgeting, scRNA-seq sample-versus-cell allocation under a pseudobulk model, and the critique that "n=3" is a publication convention rather than a power calculation. Use when budgeting a sequencing experiment, writing the sample-size justification in a grant, estimating replicates from pilot data, allocating a fixed budget between samples and depth, or planning scRNA-seq cohort size. For clinical-trial sample size see clinical-biostatistics/power-and-sample-size; for the power-given-n direction see experimental-design/power-analysis.
日本語の概要は準備中です。原文の説明を表示しています。
Query the Ensembl REST API for gene/transcript/protein lookup, sequence retrieval, comparative genomics (Compara), variant effect prediction (VEP), regulatory features, and cross-species ortholog/paralog calls. Use when pulling Ensembl-native data (Ensembl Gene IDs, version-pinned releases, archive endpoints for reproducibility), gene/transcript/exon structure with stable IDs, or VEP for variant annotation. Encodes the 15 req/sec rate limit, archive (e110.rest.ensembl.org) for reproducibility, Ensembl divisions (vertebrates / plants / fungi / metazoa / bacteria), and the symbol-vs-ID stability problem.
日本語の概要は準備中です。原文の説明を表示しています。