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Orchestrates end-to-end autonomous AI research projects using a two-loop architecture. The inner loop runs rapid experiment iterations with clear optimization targets. The outer loop synthesizes results, identifies patterns, and steers research direction. Routes to domain-specific skills for execution, supports continuous agent operation via Claude Code /loop and OpenClaw heartbeat, and produces research presentations and papers. Use when starting a research project, running autonomous experiments, or managing a multi-hypothesis research effort.

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Orchestrator for the full academic research pipeline: research -> write -> integrity check -> review -> revise -> re-review -> re-revise -> final integrity check -> finalize. Coordinates deep-research, academic-paper, and academic-paper-reviewer into a seamless 9-stage workflow with mandatory integrity verification, two-stage peer review, and reproducible quality gates. Triggers on: academic pipeline, research to paper, full paper workflow, paper pipeline, end-to-end paper, research-to-publication, complete paper workflow.

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Systematic peer review toolkit. Evaluate methodology, statistics, design, reproducibility, ethics, figure integrity, reporting standards, for manuscript and grant review across disciplines.

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Structured hypothesis formulation from observations. Use when you have experimental observations or data and need to formulate testable hypotheses with predictions, propose mechanisms, and design experiments to test them. Follows scientific method framework. For open-ended ideation use scientific-brainstorming; for automated LLM-driven hypothesis testing on datasets use hypogenic.

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Academic paper writing skill with 12-agent pipeline. v2.5: Style Calibration (learn author's writing voice from past papers) + Writing Quality Check (writing quality checklist for natural prose). Supports IMRaD, literature review, theoretical, case study, policy brief, and conference paper structures. APA 7.0 (default), Chicago, MLA, IEEE, Vancouver citation formats. Bilingual abstracts (zh-TW + EN). Multi-format output (LaTeX, DOCX, PDF, Markdown). Triggers on: write paper, academic paper, paper outline, write abstract, revise paper, check citations, convert to LaTeX, guide my paper, parse reviews, revision roadmap, 寫論文, 學術論文, 論文大綱, 寫摘要, 修改論文, 檢查引用, 引導我寫論文, 帶我規劃論文, 逐章規劃, 論文架構, 審查意見, 修訂路線圖.

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Universal LaTeX document skill: create, compile, and convert any document to professional PDF with PNG previews. Supports resumes, reports, cover letters, invoices, academic papers, theses/dissertations, academic CVs, presentations (Beamer), scientific posters, formal letters, exams/quizzes, books, cheat sheets, reference cards, exam formula sheets, fillable PDF forms (hyperref form fields), conditional content (etoolbox toggles), mail merge from CSV/JSON (Jinja2 templates), version diffing (latexdiff), charts (pgfplots + matplotlib), tables (booktabs + CSV import), images (TikZ), Mermaid diagrams, AI-generated images, watermarks, landscape pages, bibliography/citations (BibTeX/biblatex), multi-language/CJK (auto XeLaTeX), algorithms/pseudocode, colored boxes (tcolorbox), SI units (siunitx), Pandoc format conversion (Markdown/DOCX/HTML ↔ LaTeX), and PDF-to-LaTeX conversion of handwritten or printed documents (math, business, legal, general). Compile script supports pdflatex, xelatex, lualatex with auto-detection, latexmk backend, texfot log filtering, PDF/A output, and verbosity control (--verbose/--quiet). Empirically optimized scaling: single agent 1-10 pages, split 11-20, batch-7 pipeline 21+. Use when user asks to: (1) create a resume/CV/cover letter, (2) write a LaTeX document, (3) create PDF with tables/charts/images, (4) compile a .tex file, (5) make a report/invoice/presentation, (6) anything involving LaTeX or pdflatex, (7) convert/OCR a PDF to LaTeX, (8) convert handwritten notes, (9) create charts/graphs/diagrams, (10) create slides, (11) write a thesis or dissertation, (12) create an academic CV, (13) create a poster, (14) create an exam/quiz, (15) create a book, (16) convert between document formats (Markdown, DOCX, HTML to/from LaTeX), (17) generate Mermaid diagrams for LaTeX, (18) create a formal business letter, (19) create a cheat sheet or reference card, (20) create an exam formula sheet or crib sheet, (21) condense lecture notes/PDFs into a cheat sheet, (22) create a fillable PDF form with text fields/checkboxes/dropdowns, (23) create a document with conditional content/toggles (show/hide sections), (24) generate batch/mail-merge documents from CSV/JSON data, (25) create a version diff PDF (latexdiff) highlighting changes between documents, (26) create a homework or assignment submission with problems and solutions, (27) create a lab report with data tables, graphs, and error analysis, (28) encrypt or password-protect a PDF, (29) merge multiple PDFs into one, (30) optimize/compress a PDF for web or email, (31) lint or check a LaTeX document for common issues, (32) count words in a LaTeX document, (33) analyze document statistics (figures, tables, citations), (34) fetch BibTeX from a DOI, (35) convert a Graphviz .dot file to PDF/PNG, (36) convert a PlantUML .puml file to PDF/PNG, (37) create a one-pager/fact sheet/executive summary, (38) create a datasheet or product specification sheet, (39) extract pages from a PDF (page ranges, odd/even), (40) check LaTeX package availability before compiling, (41) analyze citations and cross-reference with .bib files, (42) debug LaTeX compilation errors, (43) make a document accessible (PDF/A, tagged PDF), (44) create lecture notes or course handouts, (45) fill an existing PDF form (fillable fields or non-fillable with annotations), (46) extract text or tables from a PDF (pdfplumber, pypdf), (47) OCR a scanned PDF to text (pytesseract), (48) create a PDF programmatically with reportlab (Canvas, Platypus), (49) rotate or crop PDF pages (pypdf), (50) add a watermark to an existing PDF, (51) extract metadata from a PDF (title, author, subject).

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Universal deep research agent team. 13-agent pipeline for rigorous academic research on any topic. 7 modes: full research, quick brief, paper review, lit-review, fact-check, Socratic guided research dialogue, and systematic review with optional meta-analysis. Covers research question formulation, Socratic mentoring, methodology design, systematic literature search, source verification, cross-source synthesis, risk of bias assessment, meta-analysis, APA 7.0 report compilation, editorial review, devil's advocate challenges, ethics review, and post-research literature monitoring. Triggers on: research, deep research, literature review, systematic review, meta-analysis, PRISMA, evidence synthesis, fact-check, guide my research, help me think through, 研究, 深度研究, 文獻回顧, 文獻探討, 系統性回顧, 後設分析, 事實查核, 引導我的研究, 幫我釐清, 幫我想想, 我不確定要研究什麼, 研究方向, 研究主題.

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Conduct comprehensive, systematic literature reviews using multiple academic databases (PubMed, arXiv, bioRxiv, Semantic Scholar, etc.). This skill should be used when conducting systematic literature reviews, meta-analyses, research synthesis, or comprehensive literature searches across biomedical, scientific, and technical domains. Creates professionally formatted markdown documents and PDFs with verified citations in multiple citation styles (APA, Nature, Vancouver, etc.).

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End-to-end statistical writing assistant for LaTeX - draft title/abstract/keywords, expand outlines into sections, audit manuscripts, write reviewer reports and response letters, and scaffold book manuscripts.

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Generate academic research proposals for PhD applications. Use when user asks to "write a research proposal", "create PhD proposal", "generate research plan", "撰写研究计划", "写博士申请", "doctoral proposal", or mentions specific research topics for PhD application. Supports STEM, humanities, and social sciences with field-specific adaptations. Follows Nature Reviews-style academic writing conventions. Supports both English and Chinese output based on user preference.

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Manual for the marginaleffects R and Python package, and guide to the book "Model to Meaning". Use when users ask about predictions, comparisons, slopes, marginal effects, average treatment effects (ATE/ATT/CATE), hypothesis testing, contrasts, counterfactuals, risk ratios, odds ratios, causal inference with G-computation, or need help with marginaleffects functions like predictions(), comparisons(), slopes(), hypotheses(), datagrid(), avg_predictions(), avg_comparisons(), avg_slopes(), or plot functions.

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Production-grade Bayesian causal inference with PyMC, CausalPy, and DoWhy. Enforces DAG-first thinking, mandatory user checkpoints for assumptions, design-specific refutation, and defensible reporting with causal language guardrails. Trigger on: causal inference, causal effect estimation, treatment effects, counterfactuals, difference-in-differences (DiD), synthetic control, regression discontinuity (RDD), interrupted time series (ITS), instrumental variables (IV), propensity scores, DAGs, causal graphs, confounders, backdoor criterion, do-calculus, interventional distributions, pm.do(), pm.observe(), CausalPy, DoWhy, mediation analysis, refutation, sensitivity analysis, parallel trends, placebo tests, or any question of the form "does X cause Y" or "what is the effect of X on Y."

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Remove AI writing patterns from prose. Use when drafting, editing, or reviewing text to eliminate predictable AI tells.

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Classical end-to-end empirical analysis workflow in the traditional Stata ecosystem — native Stata + reghdfe + ivreg2 + csdid + did_imputation + eventstudyinteract + sdid + rdrobust + rddensity + synth + synth_runner + psmatch2 + teffects + ebalance + coefplot + esttab + asdoc + binscatter. **Defaults to economics empirical-paper style** (AER / QJE / AEJ) — every run produces a publication-ready output set with a multi-column regression table (M1→M6 progressive controls/FE) as the centerpiece, plus Table 1 (descriptives), mechanism / heterogeneity / robustness tables, and event-study + coefficient + trend figures. Covers the full 8-step Stata pipeline an applied economist runs on every paper — (1) data import & cleaning (use/import, destring, misstable, duplicates, merge assert), (2) variable construction (gen/egen/winsor2/xtile/xtset with L./F./D.), (3) descriptive statistics & Table 1 (tabstat/balancetable/asdoc), (4) classical diagnostic tests (sktest/swilk/hettest/imtest/xtserial/xttest3/vif/dfuller/kpss/hausman/estat overid), (5) baseline modeling (reg/xtreg/reghdfe/ivreg2/ivregress/csdid/did_imputation/eventstudyinteract/sdid/rdrobust/synth/psmatch2/teffects/heckman/qreg/ppmlhdfe), (6) robustness battery (bacondecomp/honestdid/rwolf/ritest/wildbootstrap/oster), (7) further analysis (subgroup/triple-diff/interactions/medsem/marginsplot/binscatter by group), (8) publication-ready tables & figures (esttab/outreg2/estout/coefplot/marginsplot/rdplot/twoway combined). **Also covers two parallel domain modes that share the same 8-step scaffolding** — **Mode A — Epidemiology / public health** (target-trial emulation, IPTW + g-formula + TMLE doubly-robust triplet via `teffects ipw` / `teffects ipwra` / `teffects aipw` / `eltmle`, Mendelian randomization via `mrrobust` (IVW / Egger / weighted median) and `mregger` / `mrpresso`, KM / Cox / AFT / RMST survival via `sts` / `stcox` / `streg` / `strmst2`, E-value sensitivity via `evalue` (Linden-Mathur), principal stratification — STROBE / TRIPOD reporting), and **Mode B — ML causal inference** (DML via `ddml` / `pdslasso`, S/T/X/R/DR meta-learners via `crforest` and `ddml interactive`, causal forest via `crforest` / `cforest`, BART/BCF via `bart` / `bartCause`-style externals, CATE distribution + policy tree via `crforest`, off-policy evaluation, conformal causal externals, fairness audit, DAG learning via `pcalg` / external Python callouts). Use when the user asks for a complete Stata empirical analysis, wants a reproducible .do-file pipeline, needs a Stata counterpart to the Python StatsPAI / Full-empirical-analysis-skill, or names a specific Stata step in isolation ("run reghdfe with two-way clustering", "csdid event study", "winsor2 at 1%", "esttab to LaTeX", "coefplot with CI", "ivreg2 weak-IV test", "synth_runner placebos", "teffects psmatch balance check"). Mode A triggers on "target trial emulation Stata", "teffects ipw aipw", "eltmle", "mrrobust", "mregger weighted median", "stcox AFT survival", "strmst2", "evalue Stata", "STROBE Stata", "公共健康 Stata", "流行病学 Stata". Mode B triggers on "ddml Stata", "pdslasso", "crforest causal forest Stata", "policy tree Stata", "因果机器学习 Stata".

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Core skill for the deep research and writing tool. Write scientific manuscripts in full paragraphs (never bullet points). Use two-stage process: (1) create section outlines with key points using research-lookup, (2) convert to flowing prose. IMRAD structure, citations (APA/AMA/Vancouver), figures/tables, reporting guidelines (CONSORT/STROBE/PRISMA), for research papers and journal submissions.

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Generate professional slide deck images from academic papers and content. Creates comprehensive outlines with style instructions, auto-detects figures from PDFs, then generates individual slide images. Use when user asks to "create slides", "make a presentation", "generate deck", or "slide deck" for papers.

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中英双语学术降 AIGC / bilingual academic de-AIGC skill. Removes AI-generated writing signatures from empirical papers in economics, management, and the social sciences — in both English and Chinese. Covers Turnitin AI, GPTZero, Originality.ai on the English side and 知网 AMLC, 万方, 维普 on the Chinese side. Uses a six-step loop (intake → audit → claim-evidence check → differentiated rewrite → five-dimension self-score → cold-reader recheck) with two pattern libraries (22 English + 17 Chinese patterns), section-by-section strategies for empirical papers, and hard protections that keep every number, coefficient, and citation intact. Since 2026-08 it also carries a provenance layer (去水印): deterministic, CJK-safe cleaning of invisible-character carriers and file metadata (docx / png / jpg / svg / pdf, incl. C2PA), an honest account of Claude's statistical text watermark, and an author "ownership pass" — it never claims a text is watermark-free.

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Use when the user asks to run a full empirical / causal analysis in Python — by default in the style of an applied economics paper (AER / QJE / JPE / ReStud / AEJ) with DID / RD / IV / SCM / DML / matching, written-out estimating equation + identifying assumption, Table 1 / Table 2 / event-study figure / robustness gauntlet — OR in epidemiology / public health style (target-trial emulation, IPTW + g-formula + TMLE triplet, Mendelian randomization, KM/AFT survival, E-value sensitivity, STROBE/TRIPOD reporting) — OR in ML causal inference style (DML, S/T/X/R/DR meta-learners, causal forest, Dragonnet/TARNet/CEVAE, BCF, CATE distribution, policy learning, conformal causal, fairness audit, causal discovery) — OR in distributional / gap-decomposition style (Oaxaca–Blinder `sp.oaxaca`, Kitagawa `sp.kitagawa_decompose`, DiNardo–Fortin–Lemieux `sp.dfl_decompose`, Gelbach `sp.gelbach`, Fairlie `sp.fairlie`, RIF / FFL `sp.rif_decomposition`, all reachable through the `sp.decompose` dispatcher). Also covers exporting multi-column regression tables to Word / Excel / LaTeX (Stata outreg2 / esttab / R modelsummary equivalent) and bundling an entire replication appendix into one .docx / .xlsx / .tex file. Triggers on keywords "StatsPAI", "statspai", "AER empirical analysis", "applied micro pipeline", "Table 1 balance", "event study", "first-stage F", "Oster bound", "honest_did", "spec_curve", "callaway_santanna", "dragonnet", "text as treatment", "outreg2 in Python", "regression table to Word/Excel", "sp.regtable", "sp.collect", "sp.paper_tables", "sp.feols", "summary_col", "modelsummary", "AER style table", "QJE style table", "epidemiology pipeline", "target trial emulation", "g-formula", "IPTW", "TMLE", "Mendelian randomization", "STROBE", "TRIPOD", "公共健康", "流行病学", "DML", "double machine learning", "causal forest", "meta-learner", "CATE", "conformal causal", "policy learning", "因果机器学习", "ML causal", "decomposition", "Oaxaca-Blinder", "Kitagawa", "DiNardo-Fortin-Lemieux", "DFL", "Gelbach", "RIF decomposition", "wage gap decomposition", "sp.decompose", "sp.oaxaca".

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Integrate AI tools into economic research, teaching, and policy analysis with attention to privacy and reproducibility.

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This skill should be used when the user asks to "implement a DiD regression", "write a causal inference pipeline", "set up an event study", "implement instrumental variables", "run a regression discontinuity design", "build a synthetic control model", "implement propensity score matching", "write parallel trends test", "implement Bacon decomposition", or needs code templates for causal inference methods in Python, R, or Stata. Based on Scott Cunningham's Causal Inference: The Mixtape.

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Comprehensive citation management for academic research. Search Google Scholar and PubMed for papers, extract accurate metadata, validate citations, and generate properly formatted BibTeX entries. This skill should be used when you need to find papers, verify citation information, convert DOIs to BibTeX, or ensure reference accuracy in scientific writing.

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Write comprehensive literature reviews for medical imaging AI research. Use when writing survey papers, systematic reviews, or literature analyses on topics like segmentation, detection, classification in CT, MRI, X-ray, ultrasound, or pathology imaging. Triggers on requests for "review paper", "survey", "literature review", "综述", "systematic review", or mentions of writing academic reviews on deep learning for medical imaging.

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Dense, machine-readable API reference for PyFixest — high-dimensional fixed-effects OLS/WLS/IV and Poisson (feols, fepois, feglm), clustered/robust standard errors, R-style formula syntax, and post-estimation. Use when writing or debugging Python fixed-effects regressions with the pyfixest package.

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Introduction to literature search & review skills - systematic paper finding, screening, extraction, and citation traversal

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