「rest」の検索結果

Render a 'search-grid' (Pinterest search-moodboard) video from a config — a real-DOM page with four continuous beats (masonry search grid + typing hook with counter-drift columns → 3 cards slide in from the right and stack → the top card box-grows to fullscreen then swipe-left ×2 through captioned feature shots → end card), frame-stepped via Chromium and encoded with FFmpeg — deterministic assembly, FREE (real brand photos + logo; the optional music bed comes from create-music-elevenlabs), so type/logo/photos stay pixel-crisp. Use for the search-grid format.

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Assemble an animated character-explainer video ad (any art style — Pixar-style 3D, claymation, anime, paper-cut, felt) (~77s, 9:16) built on an "N types of X" listicle spine — a recurring human protagonist plus a locked cast of N persona characters, one per list item. Given the per-scene i2v clips + a per-scene target-duration table + a narration track, it trims each clip to its scene window, re-encodes every segment to identical 1080x1920/30fps/libx264/yuv420p (decrease+pad, never crop) so the concat demuxer never drops frames, concats, and muxes audio — in RESTYLE mode the source ad's VO+music mix is reused verbatim, in ORIGINAL mode fresh per-scene VO (loudnorm I=-14) is mixed under an optional music bed (loudnorm I=-26). A static-still fallback loops a scene's keyframe when its clip is missing/failed, so the master always assembles; libass captions are burned last. FREE deterministic assembly (Python + ffmpeg, no bash, no paid calls); the recipe supplies the clips, keyframes, VO or source audio, and caption table and gates the paid cast-anchor/keyframe/Kling-i2v/VO/music calls to their own capabilities. Use for the 3d-character-explainer listicle format.

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Governs Microsoft Fabric OneLake catalog health, protection, and trust through Fabric Admin, Core, and Power BI REST APIs. Use for tenant or owner-scoped audits and guarded remediation of domains, workspace assignment, capacity, labels, tags, descriptions, refresh, and item identity. Catalog item discovery belongs to search-consumption-cli.

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Runs the Fabric Git integration lifecycle through fab api or az rest, including connecting a workspace to Azure DevOps or GitHub, committing, updating from Git, reading sync status, resolving conflicts, disconnecting a connected workspace, and automating sync with a service principal. For stage promotion use deployment-pipelines-authoring-cli. Branch switching, fab deploy, fabric-cicd and cross-workspace rebinding are out of scope.

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Install, instrument and verify a web app end to end without pausing for a human. Use in an autonomous or goal-mode agent, in CI, or in any client that asks for approval on every command: it never says "restart your client" or "open a browser", because it takes a route that needs neither. Prefer the normal install-and-verify skill when a human is present and can answer.

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Check that the UI you actually rendered uses the design system, by reading computed styles in the running app against the project's design tokens. Catches hardcoded hex colors, off-palette backgrounds, invisible or unusable controls, and animations that never ran. Use after building or restyling a component, when a design review is wanted, when a UI looks slightly off but nobody can say why, or when a design system exists and nothing checks whether the code follows it.

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Statically analyze a Simulink model for Rapid Accelerator (raccel) mode incompatibilities. Identifies unsupported blocks (Interpreted MATLAB Function, Level-2 S-Functions without TLC), configuration issues, and data type restrictions that prevent code generation. Classifies each issue as BLOCKER (build error) or WARNING (build warning). Use BEFORE calling sim() in rapid-accelerator mode, when buildRapidAcceleratorTarget fails, or when the user asks "why won't my model run in raccel?" TRIGGER: any request explicitly involving rapid accelerator mode, raccel, raccel build errors, or buildRapidAcceleratorTarget failures.

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Use the skill to control and verify the code interface configuration of your model — how Simulink® model elements are represented in the generated C or C++ code. This includes — (1) specifying names, types (storage classes), and placement of variables that represent model elements (for example, making a model parameter tunable as a global extern variable); (2) specifying names, types, and placement of functions that represent model algorithms; (3) selecting the deployment type (Component, Subcomponent, or Automatic); (4) selecting the interface configuration type (data or service interface); (5) linking a shared Embedded Coder dictionary to a model; (6) creating Embedded Coder dictionary entries and setting their properties; (7) for service interface configuration — specifying service interface definitions, including sender, receiver, client, and server services. Items 1 and 2 can be set per element or as a category-wide default. Item 1 applies to GRT and ERT models; the rest to ERT models only.

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Estimate frequency response from Simulink models using frestimate. Use when frequency response should be obtained from simulation rather than model linearization.

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Handles BED-format genomic intervals (BED3 through BED12, narrowPeak/broadPeak) and the coordinate-system substrate the whole interval category rests on, with bedtools (CLI) and pybedtools/pyranges/pandas (Python). Covers the 0-based half-open vs 1-based-closed convention boundary and the start-1/end-unchanged conversion, the silent failures (chrom-name mismatch, CRLF, lexicographic-vs-version sort under -sorted), genome/chrom.sizes generation, sorting contracts, BED12 block invariants, validation, makewindows, cross-assembly liftover (liftOver/CrossMap), and BED<->VCF/BAM/FASTA conversion. Use when reading, creating, validating, sorting, lifting between genome builds, or converting interval files, preparing inputs for bedtools/tabix/bigBed, or debugging an off-by-one or empty-overlap result.

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Calls significant loops from protein-directed and targeted 3C assays (HiChIP, PLAC-seq, Capture Hi-C/PCHi-C, ChIA-PET) where the contact background is peak-anchored and coverage-biased, so generic Hi-C loop callers (cooltools dots, Juicer HiCCUPS) use the wrong null. Covers FitHiChIP (config-driven coverage+distance-decay spline regression, peak-to-peak vs peak-to-all foreground, loose vs stringent background, coverage vs ICE bias), MAPS (positive Poisson regression on bias factors for PLAC-seq/HiChIP), hichipper (restriction-site-distance bias model + library QC), CHiCAGO (Delaporte two-component Brownian+technical background for asymmetric bait x other-end Capture Hi-C), the with/without separate-ChIP anchor decision, and differential loops via diffloop. Use when calling loops from HiChIP/PLAC-seq/Capture Hi-C, choosing FitHiChIP/MAPS/CHiCAGO, picking peak-to-all vs peak-to-peak, setting the loop FDR, supplying ChIP peaks as anchors, QCing a HiChIP library, or comparing loops between conditions.

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Structures biological experiments so inference is valid by construction, covering Fisher's principles (randomization, replication, local control), the experimental-vs-observational unit distinction and pseudoreplication (Hurlbert 1984; Lazic 2018), randomization mechanics (complete, restricted, stratified, rerandomization, run-order), blocking layouts (randomized complete block, Latin square, incomplete block), factorial designs and interactions, and the split-plot/nested error strata hidden inside multi-batch genomics. Use when deciding the experimental unit and what counts as a replicate, planning randomization and run order, choosing a blocked/factorial/split-plot/nested layout, avoiding pseudoreplication in cell-culture or animal studies, or specifying the random-effects structure of the analysis model. For assigning samples to sequencing batches/lanes/plates and batch-effect correction see experimental-design/batch-design; for regulated clinical-trial randomization see clinical-biostatistics.

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Maps between gene identifier systems (Ensembl, Entrez, HGNC symbol, UniProt, RefSeq, MANE) using AnnotationDbi, biomaRt, mygene, pyensembl, and Ensembl REST. Encodes Ensembl version stripping with GENCODE _PAR_Y preservation, the Ziemann 2016 Excel autocorrect debacle and Bruford 2020 HGNC renames (SEPT*->SEPTIN*, MARCH*->MARCHF*, MARC*->MTARC*, DEC1->DELEC1), OCT4/POU5F1 alias resolution, biomaRt archive endpoints for release pinning, the `filters` (plural) gotcha, MANE Select for clinical reporting, cross-species orthology via Ensembl Compara / OMA / OrthoDB, and tx2gene construction for tximport. Use when converting gene IDs across systems, handling renamed symbols, building tx2gene, pinning to a specific Ensembl release for reproducibility, or mapping cross-species orthologs.

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Designs genomics experiments so technical nuisance variation (batch, lane, plate, flow cell, operator, reagent lot, processing day) is balanced against the biological variable of interest and therefore estimable rather than confounded, using constrained sample-to-batch assignment (designit, OSAT), the confounder/mediator/collider distinction, and the principle that no post-hoc correction recovers a fully confounded design. Covers detecting hidden batches with surrogate variable analysis, a decision table for downstream correction (ComBat-seq, RUVSeq, SVA) whose execution is deferred to differential-expression/batch-correction, and reproducibility metadata. Use when assigning samples to sequencing batches/lanes/plates, avoiding batch-condition confounding, deciding whether a design is salvageable by correction, choosing a correction method, or estimating the number of hidden batches. For the experimental unit, randomization, and blocking concepts see experimental-design/randomization-blocking.

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Pull pre-computed ortholog calls from public databases (OrthoDB, Ensembl Compara, OMA browser, eggNOG, PANTHER, KEGG Orthology, HomoloGene) via their REST APIs. Use when orthologs are already curated upstream, when the question is "what is the X ortholog of Y" rather than "how to infer orthology de novo", when batch-mapping gene IDs across species, or when comparing the resources for consensus calls. Encodes confidence-level semantics, 1:1 vs 1:many vs many:many, HomoloGene deprecation, and when to defect to de novo computation.

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Corrects the gene-independent copy-number artifact in CRISPR-Cas9 screens (Aguirre 2016 / Munoz 2016 Cancer Discov) where amplified loci appear essential from DNA-damage burden of simultaneous cuts. Covers the gene-independent DNA-damage / G2-arrest mechanism, CRISPRcleanR (Iorio 2018) unsupervised pre-hoc correction, CERES (Meyers 2017) joint CN + gene-effect model, Chronos (Dempster 2021) DepMap-standard population-dynamics + CN model with lowest residual bias, the decision tree by data availability, the Spearman LFC-vs-CN diagnostic, focal-amplification examples (ERBB2 in HER2+, MYC in colorectal, FGFR1 in head and neck), and CRISPRi/a alternatives that bypass the artifact. Use when screening cancer cell lines, diagnosing essentiality at amplified loci, choosing CRISPRcleanR / CERES / Chronos, deciding whether CN correction is needed before MAGeCK / BAGEL2 / drugZ, or switching from Cas9 to CRISPRi.

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Queries ClinVar for variant pathogenicity classifications, ClinGen VCEP curations, and somatic-vs-germline interpretations via REST API, weekly VCF, or bulk XML. Use when determining clinical significance, triangulating conflicting interpretations, or aggregating evidence against the ACMG/AMP framework with ClinGen SVI specifications.

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Builds QSAR / QSPR models using chemprop D-MPNN, MolFormer, Uni-Mol, ChemBERTa, random forest baselines, and Gaussian processes with explicit handling of OECD 5 principles, applicability domain (kNN, leverage, conformal prediction, Mahalanobis), scaffold-balanced splits, ensemble uncertainty, calibration (Platt, isotonic), feature importance (SHAP, atomic attribution), and prospective validation. Use when building target-specific predictive models from in-house bioassay data, ADMET endpoints, or selectivity profiles.

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Generates 3D conformer ensembles using RDKit ETKDGv3 with knowledge-enhanced distance geometry, MMFF94/UFF force-field optimization, CREST + GFN2-xTB semi-empirical refinement, and macrocycle-aware torsion preferences. Provides explicit decision rules for single vs ensemble conformer use, RMSD pruning, energy windows, conformer count, and force-field choice. Use when preparing 3D ligands for docking, generating descriptor input for 3D QSAR, or sampling macrocycle/peptide conformational ensembles.

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Implements missing-data sensitivity analyses for confirmatory clinical trials including MMRM under MAR (with Kenward-Roger correction), reference-based multiple imputation (J2R, CR, CIR, LMCF per Carpenter-Roger 2013), Permutt delta-adjustment / tipping-point analysis, pattern-mixture identifying restrictions (CCMV, NCMV, ACMV), and the Cro vs Bartlett variance debate. Use when handling missing primary or secondary endpoint data in regulatory submissions following NRC 2010 and ICH E9(R1).

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Computes and interprets treatment effect measures (OR, RR, RD, HR, NNT) with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen, MOVER, profile likelihood, Bender NNT) and reports marginal vs conditional estimands per FDA 2023 covariate adjustment guidance. Use when reporting treatment effects in confirmatory trials, comparing effect sizes across studies, or constructing forest plots.

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Performs subgroup and heterogeneous treatment effect (HTE) analyses for clinical trials. Covers Mantel-Haenszel pooling, Breslow-Day, interaction tests in regression, RERI for additive interaction, modern data-adaptive HTE methods (STEPP, SIDES, causal forests, X/R-learners), Bayesian shrinkage (Dixon-Simon, MAP, EXNEX), graphical multiplicity (Bretz-Maurer), and credibility frameworks (Sun BMJ, EMA 2019). Use when analyzing treatment effects across patient subgroups for regulatory submissions or precision-medicine claims.

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Performs time-to-event analysis for clinical trials including Cox proportional hazards regression with PH diagnostics, restricted mean survival time (RMST) under non-PH, competing risks via Fine-Gray vs cause-specific Cox, weighted log-rank and MaxCombo for non-proportional hazards, recurrent events (Andersen-Gill, PWP, WLW), and interval-censored data. Use when analyzing time-to-event endpoints (OS, PFS, DOR, TTR, TTNT) in oncology or other clinical trials.

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Use when building ANY macOS app — windows, menus, sandboxing, distribution, AppKit bridging or modernization (control events, state restoration, concentric corners), or macOS-specific SwiftUI patterns.

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